Article
Neurosciences
Zhizhong Zhang, Shuai Yuan, Susanna C. Larsson, Mengmeng Wang, Xinfeng Liu
Summary: Elevated serum calcium, 25-hydroxyvitamin D, and parathyroid hormone levels were found to be associated with an increased risk of aneurysmal subarachnoid hemorrhage (SAH) in this Mendelian randomization study. The study used genetic variants to predict these hormone levels and found that higher genetically predicted S-Ca and S-PTH levels were associated with an increased risk of aneurysmal SAH. However, there was no association between genetically predicted S-25OHD concentration and aneurysmal SAH.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Maryam Barzin, Amir Ebadinejad, Farnaz Vahidi, Alireza Khalaj, Maryam Mahdavi, Majid Valizadeh, Farhad Hosseinpanah
Summary: Vitamin D metabolism is altered in obese individuals, and surgery-induced weight loss can increase the threshold of vitamin D and suppress the secretion of parathyroid hormone.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Jiao Zuo, Ahmed A. Hasan, Carl-Friedrich Hocher, Philipp Kalk, Burkhard Kleuser, Bernhard K. Kraemer, Berthold Hocher
Summary: This study investigated the relationship between 25(OH)D and 1,25(OH)2D with PTH. The results showed a negative correlation between all forms of PTH and 25(OH)D, while there was no significant correlation between 1,25(OH)2D and PTH. This finding suggests an inhibitory effect of 25(OH)D on the synthesis of all forms of PTH in the chief cells of the parathyroid gland.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Xiaoyun Shan, Yang Cao, Huidi Zhang, Xiayu Zhao, Siran Li, Yichun Hu, Lichen Yang
Summary: The study found that free and bioavailable 25(OH)D correlated well with total 25(OH)D, but only had a threshold effect on P1NP. A total 25(OH)D of < 15.14 ng/mL was marginally associated with a higher risk of reduced HDL-C. Higher levels of free and bioavailable 25(OH)D were associated with a lower risk of reduced HDL-C. PTH and BTMs responded more sensitively to changes in total 25(OH)D than to free or bioavailable 25(OH)D after vitamin D supplementation in Chinese women of childbearing age.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Caroline A. Mcwhorter, Molly J. Mead, Megan D. Rodgers, Myla D. Ebeling, Judy R. Shary, Mathew J. Gregoski, Danforth A. Newton, John E. Baatz, Bruce W. Hollis, Martin Hewison, Carol L. Wagner
Summary: Pregnancy leads to increased synthesis of vitamin D binding protein (DBP) and higher concentrations of total vitamin D and metabolites. The ratio of free 25-hydroxyvitamin D (25(OH)D) to parathyroid hormone (PTH) appears to be a better predictor of pregnancy complications, such as gestational diabetes, compared to total 25(OH)D/PTH. Further research is needed to validate and explore this association.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Nutrition & Dietetics
Bin Wang, Xiaowei Cheng, Shihui Fu, Ding Sun, Weiguang Zhang, Weicen Liu, Xinyu Miao, Qing Luo, Hao Li, Jie Zhang, Xinye Jin, Yali Zhao, Yao Yao, Yizhi Chen
Summary: This longitudinal cohort study examined the relationship between serum levels of 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), beta-C-terminal telopeptide of type 1 collagen (beta-CTX), and all-cause mortality in centenarians. Lower 25(OH)D levels, higher PTH levels, and higher beta-CTX levels were associated with increased mortality in Chinese community-dwelling centenarians. The association with 25(OH)D was linear, while the associations with PTH and beta-CTX were J-shaped.
Article
Biochemistry & Molecular Biology
Xin Chen, Chang Chu, Cornelia Doebis, Yingquan Xiong, Yaochen Cao, Bernhard K. Kramer, Volker Von Baehr, Berthold Hocher
Summary: This study investigated the relationship between 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with intact parathyroid hormone in outpatient population in Germany. The results showed an inverse correlation between 25-hydroxyvitamin D and intact parathyroid hormone, which was independent of age, sex, creatinine, calcium, and phosphate. However, 1,25-dihydroxyvitamin D was only positively associated with intact parathyroid hormone in women and in the subgroup with lower 25-hydroxyvitamin D.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Hussein Abdullah Rajab
Summary: This study found that patients with 25-hydroxyvitamin D (25OHD) levels below 15 ng/mL were more likely to experience symptoms, and there was a correlation between vitamin D level and changes in parathyroid hormone (PTH) and alkaline phosphatase (ALP).
Article
Orthopedics
Z. Qu, F. Yang, Y. Yan, J. Huang, J. Zhao, J. Hong, S. Li, G. Jiang, W. Wang, S. Yan
Summary: This study indicated an inverse causal relationship between serum PTH concentrations and development of OA, especially knee OA, but no evidence of the causal effect of serum 25(OH)D levels on OA was found. Further investigation is needed to explore potential mechanisms by which serum PTH affects OA.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Urology & Nephrology
Xiaoling Zhou, Yidan Guo, Yang Luo
Summary: The study found an association between serum intact parathyroid hormone levels and mortality in hemodialysis patients, showing a U-shaped curve of this relationship. The optimal range of serum iPTH levels conferring the lowest risk of all-cause and cardiovascular mortality may range from 150 pg/mL to 450 pg/mL in this group of incident HD patients.
Article
Biochemistry & Molecular Biology
Shufei Zeng, Chang Chu, Cornelia Doebis, Volker von Baehr, Berthold Hocher
Summary: There is a strong positive linear correlation between free 25(OH)D (f25(OH)D) and total 25(OH)D, making them useful for assessing vitamin D levels. The recommended threshold level for f25(OH)D is 8.499 pg/mL, corresponding to a target concentration of at least 30 ng/mL for t25(OH)D. The upper limit for vitamin D is still unclear, with most experts favoring a upper limit of 100 ng/mL for t25(OH)D.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Transplantation
Joonas Rautavaara, Tuomas Kerola, Kati Kaartinen, Mari Vilpakka, Atte Aitkoski, Olli Anttonen, Jani Ahvonen, Juhani Koistinen, Kati Vaaraniemi, Marja Miettinen, Antti Ylitalo, Kaisa Laine, Seppo Ojanen, Tuomo Nieminen
Summary: The study found that a significant number of patients with end-stage renal disease (ESRD) experienced bradycardia or asystole episodes, but these arrhythmias were not detected by baseline or ambulatory ECG recordings.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Transplantation
Robert Provenzano, Evgeny Shutov, Liubov Eremeeva, Svitlana Korneyeva, Lona Poole, Gopal Saha, Charles Bradley, Meraf Eyassu, Anatole Besarab, Robert Leong, Cameron S. Liu, Thomas B. Neff, Lynda Szczech, Kin-Hung P. Yu
Summary: This study demonstrated the efficacy and safety of roxadustat in treating chronic kidney disease-related anemia. Roxadustat was shown to be as effective as epoetin alfa in correcting and maintaining hemoglobin levels, with comparable rates of adverse events.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Pediatrics
Kriti Joshi, Eshita Bhowmik, Nirupama Singh, Vijayalakshmi Bhatia
Summary: The study shows that vitamin D deficiency is common in prepubertal children, especially girls. Girls have lower levels of vitamin D, calcium intake, and sunlight exposure compared to boys. Duration of sunlight exposure and body surface area are significant factors associated with vitamin D levels.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rahaf AlSadi, Landon C. Aziz, Michael Bohan, Shaheen Dewji, Othmane Bouhali, Mehdi Djekidel
Summary: The study retrospectively reports on RAI treatment in thyroid cancer patients with ESRD undergoing dialysis, highlighting the challenges posed by delayed biological clearance of RAI. Adjusted dose activity and balancing scheduling between RAI therapy and dialysis are recommended to ensure closer radiation exposure in ESRD patients. Pooling data from multiple centers is suggested to establish consensus and substantiated recommendations for RAI treatment in ESRD patients.
CLINICAL NUCLEAR MEDICINE
(2021)
Editorial Material
Urology & Nephrology
Richard A. Plasse, Robert Nee, Stephen W. Olson
CLINICAL KIDNEY JOURNAL
(2020)
Article
Urology & Nephrology
Guofen Yan, Jenny Shen, Rubette Harford, Wei Yu, Robert Nee, Mary Jo Clark, Jose Flaque, Jose Colon, Francisco Torre, Ylene Rodriguez, Jane Georges, Lawrence Agodoa, Keith C. Norris
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Letter
Urology & Nephrology
Crystal J. Forman, Christina M. Yuan, Rahul M. Jindal, Lawrence Y. Agodoa, Kevin C. Abbott, Robert Nee
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Urology & Nephrology
Christina M. Yuan, Dustin J. Little, Eric S. Marks, Maura A. Watson, Rajeev Raghavan, Robert Nee
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Urology & Nephrology
Lisa K. Prince, Anna M. Howle, Jeffrey Mikita, Brian C. Y'Barbo, Sharon E. Maynard, Amy N. Sussman, Laura J. Maursetter, Oliver Lenz, Ross J. Scalese, Stephen M. Sozio, Scott Cohen, Maura A. Watson, Robert Nee, Christina M. Yuan
Summary: The study found that nephrology fellows achieved high scores in interpersonal communication competency early in their training, regardless of their training year. Fellows performed better in the kidney failure scenario compared to the AKI and kidney biopsy scenarios during the simulated clinical examinations.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Urology & Nephrology
Lisa K. Prince, Brian C. Y'Barbo, Robert Nee, Christina M. Yuan
Summary: The study demonstrates that using OSCE is effective in evaluating fellows' proficiency in managing PD-related peritonitis. Validators outperformed fellows, and there are some discrepancies in the practice of managing peritonitis.
PERITONEAL DIALYSIS INTERNATIONAL
(2021)
Letter
Urology & Nephrology
Richard Plasse, Robert Nee, Sanh Gao, Stephen Olson
KIDNEY INTERNATIONAL
(2021)
Article
Rheumatology
Crystal J. Forman, Stephen W. Olson, Sarah M. Gordon, James B. Hughes, Rodger S. Stitt, Wayne T. Bailey, Jess D. Edison, Robert Nee
Summary: Black race is independently associated with a higher risk of developing scleroderma renal crisis (SRC), while non-Black patients are associated with older age, thrombocytopenia, and anti-RNA polymerase III antibody.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Urology & Nephrology
Nilka Rios Burrows, Alain K. Koyama, Devasmita Choudhury, Wei Yu, Meda E. Pavkov, Robert Nee, Alfred K. Cheung, Keith C. Norris, Guofen Yan
Summary: This study investigated the impact of individual comorbidities and multimorbidity on mortality risk among US veterans with new-onset CKD. Results showed that cardiovascular disease was associated with the highest relative risk of death in younger veterans, while dementia was associated with the highest relative risk of death in older veterans. The additive effect of multimorbidity on risk of death was stronger in younger veterans than in older veterans.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Review
Transplantation
Robert Nee, Christina M. Yuan, Andrew S. Narva, Guofen Yan, Keith C. Norris
Summary: Guideline-directed drug therapies have emerged that offer substantial cardiorenal benefits, improved quality of life and longevity in patients with chronic kidney disease and type 2 diabetes. However, their uptake has been slow in routine clinical practice due to various barriers, highlighting the need for a multifaceted approach to optimize kidney care.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Letter
Urology & Nephrology
Richard A. Plasse, Stephen W. Olson, Christina M. Yuan, Lawrence Y. Agodoa, Kevin C. Abbott, Robert Nee
Summary: Prophylactic/early use of eculizumab is significantly associated with improved graft survival among aHUS KTRs, with a 20% reduction in graft loss risk, but there is no significant difference in the risk of death between the two groups. Randomized controlled trials are needed to guide prophylactic strategies due to the high cost of eculizumab.
CANADIAN JOURNAL OF KIDNEY HEALTH AND DISEASE
(2021)
Review
Urology & Nephrology
John S. Thurlow, Megha Joshi, Guofen Yan, Keith C. Norris, Lawrence Y. Agodoa, Christina M. Yuan, Robert Nee
Summary: The global epidemiology of ESKD varies between countries due to unique genetic, environmental, lifestyle, and sociodemographic characteristics. The response to ESKD, particularly regarding KRT, depends on the local disease burden, culture, and socioeconomics. Disparities in access to KRT exist globally, with a treatment gap in LMICs demanding a focus on prevention strategies and affordable KRT options. Achieving global equity in KRT access will require concerted efforts in public policy, health care delivery, workforce capacity, education, research, and support from various organizations.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Benjamin M. Forster, Robert Nee, Dustin J. Little, Peter J. Greasley, James B. Hughes, Sarah M. Gordon, Stephen W. Olson
Summary: Our study found that nephrotic-range proteinuria, eGFR < 60 ml/min per 1.73 m(2), hypoalbuminemia, interstitial fibrosis and tubular atrophy, interstitial inflammation at diagnosis, and the absence of remission were all associated with worse long-term renal survival. IgM, C3, and a combination of IgM/C3 immunofluorescence staining were not associated with reduced renal survival.
Meeting Abstract
Surgery
A. Brar, M. Sattar, A. Gruessner, R. M. Jindal, R. Nee, R. Gruessner, M. Salifu
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
