Article
Pharmacology & Pharmacy
Chengfeng Gao, Yufeng Yu, Chunxia Wen, Zhifeng Li, Menghuai Sun, Shu Gao, Shuhan Lin, Shenjiao Wang, Peng Zou, Zheng Xing
Summary: Severe fever with thrombocytopenia syndrome (SFTS) is an acute infectious disease caused by a novel phlebovirus (SFTSV) with high mortality. Peptides SGc1 and SGc8 derived from the SFTSV glycoprotein Gc have shown potential as specific antiviral therapeutics by inhibiting SFTSV replication effectively.
ANTIVIRAL RESEARCH
(2021)
Article
Virology
Chengfeng Gao, Yufeng Yu, Chunxia Wen, Zhifeng Li, Haida Ding, Xian Qi, Carol J. Cardona, Zheng Xing
Summary: Infection with SFTS virus can activate the NLRP3 inflammasome and induce IL-1 beta secretion in the brains of infected newborn mice. This study reveals a novel mechanism by which SFTSV dysregulates host responses through its nonstructural protein, providing insights into viral neuropathogenesis in SFTS patients.
JOURNAL OF VIROLOGY
(2022)
Article
Medicine, General & Internal
Mi-Seon Bang, Choon-Mee Kim, Dong-Min Kim, Na Ra Yun
Summary: This study investigated the antiviral activity of 41 drugs against SFTS virus (SFTSV), and found that peramivir, nitazoxanide, and favipiravir had inhibitory effects on SFTSV at concentrations below the maximum plasma concentration. Future studies should include animal models, clinical trials, and evaluation of combination therapy with other potential antivirals.
FRONTIERS IN MEDICINE
(2022)
Article
Microbiology
Seok-Min Yun, Tae-Young Lee, Hee-Young Lim, Jungsang Ryou, Joo-Yeon Lee, Young-Eui Kim
Summary: The study established a T7 RNA polymerase-driven reverse genetics system for rescuing the infectious clone of Severe fever with thrombocytopenia syndrome virus (SFTSV). Through evaluating the biological properties of the rescued virus, it was confirmed to be similar to the parental virus, showing the effectiveness of the system for identifying viral determinants and facilitating vaccine and antiviral development.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Virology
Xuan Chuong Tran, Sung Hye Kim, Jeong-Eun Lee, So-Hee Kim, Su Yeon Kang, Nguyen D. Binh, Pham Duc, Phan T. K. Phuong, Nguyen T. P. Thao, Wonwoo Lee, Joon-Yong Bae, Man-Seong Park, Misun Kim, Jeong Rae Yoo, Sang Taek Heo, Kyeong Ho An, Jung Mogg Kim, Nam-Hyuk Cho, Sun-Ho Kee, Keun Hwa Lee
Summary: The seroprevalence rate of severe fever with thrombocytopenia syndrome virus (SFTSV) in Vietnam is reported for the first time, revealing a similar rate to Pakistan and suggesting a potential increase in SFTS patients in Vietnam.
Article
Virology
Shengyao Chen, Minjun Xu, Xiaoli Wu, Yuan Bai, Junming Shi, Min Zhou, Qiaoli Wu, Shuang Tang, Fei Deng, Bo Qin, Shu Shen
Summary: A new immunoprecipitation assay was established in this study to investigate antibody responses to SFTSV, and the results suggested a higher incidence of SFTS in Shaoxing City in 2019 compared to the reported levels.
Review
Microbiology
Jiawen Sun, Yuan-Qin Min, Yunjie Li, Xiulian Sun, Fei Deng, Hualin Wang, Yun-Jia Ning
Summary: Animal models are crucial for studying the pathogenic processes, developing treatments and prevention strategies for severe fever with thrombocytopenia syndrome (SFTS) caused by SFTS bunyavirus. This review summarizes the current progress in SFTSV animal models, including the susceptibility of various animals to SFTSV, clinical manifestations, histopathological changes, and the use of animal models in studying molecular mechanisms, vaccine candidates, and antiviral drugs. The strengths, limitations, and future directions for SFTSV animal models are also discussed, highlighting the importance of further exploration and optimization of these models.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Mingyue Xu, Bo Wang, Fei Deng, Hualin Wang, Manli Wang, Zhihong Hu, Jia Liu
Summary: The establishment of a reverse genetics system based on a SFTSV C4 strain has revealed insights into virus replication and protein expression, and provides a valuable tool for the development of vaccines and antivirals against SFTS.
Article
Hematology
Lei Fang, Sicong Yu, Xiaoxu Tian, Wanrong Fu, Lingxuan Su, Zhi Chen, Chunlan Yan, Ji He, Jin Hong, Wenwen Lian, Gangqiong Liu, Yanjun Zhang, Jiancang Zhou, Liang Hu
Summary: This study demonstrates that platelets can harbor and produce severe fever with thrombocytopenia syndrome virus (SFTSV) particles. SFTSV binds to platelet glycoprotein VI to enhance platelet activation and contribute to thrombocytopenia. The interaction between platelets and macrophages plays a role in SFTSV clearance, but unwanted SFTSV replication in macrophages can worsen the infection.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Virology
Jun-Won Seo, Dayoung Kim, Nara Yun, Dong-Min Kim
Summary: SFTS is an acute febrile illness caused by the SFTSV virus, primarily transmitted by tick bites, with a high mortality rate and lack of established treatment strategies. Current treatments for SFTS include antiviral agents and other specific methods.
Article
Virology
Huimin Fu, Yanhong Wang, Chuanfei Yuan, Yuhang Zhang, Aihua Zheng, Zhen Zou, Qianfeng Xia
Summary: A newly discovered tick-borne virus called SFTSV can cause severe fever with thrombocytopenia syndrome. In this study, RNA-Seq was used to sequence HEK 293 cells infected with SFTSV at different time points, and differentially expressed genes were identified. The results showed that SFTSV infection induced cytokine-related pathways and inhibited platelet activation signaling pathway, providing further understanding of the interaction between SFTSV and the host.
Article
Virology
Xiaoli Wu, Mingyue Li, Yanfang Zhang, Boyun Liang, Junming Shi, Yaohui Fang, Zhengyuan Su, Mengmeng Li, Wenjing Zhang, Ling Xu, Jun Wang, Qiaoli Wu, Shuang Tang, Hualin Wang, Tao Zhang, Cheng Peng, Xin Zheng, Fei Deng, Shu Shen
Summary: This study isolated 11 new SFTSV strains from patients in Hubei Province in 2017 and identified five different SFTSV genotypes circulating in the region. Additionally, 15 reassortment patterns and migration pathways correlated with each genotype were identified, indicating more complexity than previously recognized. Hubei Province was found to be more involved in the evolutionary events of SFTSV than previously thought, with significant amino acid variations observed between different genotypes.
Article
Virology
Shuzo Urata, Jiro Yasuda, Masaharu Iwasaki
Summary: Loperamide inhibited SFTSV propagation in cell lines by blocking post-entry steps and restricting calcium influx. This suggests that loperamide, an FDA-approved drug, has potential as a treatment option for SFTS.
Article
Microbiology
Mi-Young Moon, Hyeon Kyu Kim, Se-Jin Chung, Jae Hwan Byun, Ha-Na Kim, Woan Lee, Soon-Won Lee, Sezim Monoldorova, Sungkyeong Lee, Bo-Young Jeon, Eun-Joo Lim
Summary: This study investigated the clinical and epidemiological characteristics of severe fever with thrombocytopenia syndrome (SFTS) in Gangwon Province, Korea, from 2019 to 2021. The findings revealed that SFTS occurred throughout the province, with Hwacheon having the highest incidence density. Multiple genotypes of SFTS were identified, with B2 and A being the most common. These findings provide important insights for the understanding and management of SFTS in this region.
Article
Microbiology
Yuanyuan Wei, Zilong Wang, Luyang Kang, Lingling He, Nan Sheng, Jiangfeng Qin, Shuangshuang Ma, Honghai Xu, Lifen Hu, Guizhou Zou, Yufeng Gao, Jiabin Li
Summary: This study aimed to identify a convenient early-warning biomarker of fatal outcomes in patients with SFTS to reduce mortality. The results showed that SFTSV viral load and NLR were effective indicators for predicting the fatal outcome of patients with SFTS. Gamma-globulin treatment also showed significant differences, providing new ideas for the treatment of SFTS.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Environmental Sciences
Yuqin Duan, Wei Wu, Qiuzi Zhao, Sihua Liu, Hongyun Liu, Mengqian Huang, Tao Wang, Mifang Liang, Zhiyun Wang
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Energy & Fuels
Jiao Wang, Xiaohui Zhang, Yang Li, Peng Liu, Xiaochen Chen, Pingping Zhang, Zhiyun Wang, Xianhua Liu
Summary: A study has constructed an alkaline fuel cell that successfully uses different sweet drinks as fuel, with carbonated soft drinks showing the best performance, providing a promising energy source for low-power electronics.
Article
Chemistry, Multidisciplinary
Yexin Dai, Jie Ding, Jingyu Li, Yang Li, Yanping Zong, Pingping Zhang, Zhiyun Wang, Xianhua Liu
Summary: In this study, reduced graphene oxide nanocomposites doped with nitrogen, sulfur, and transitional metals were successfully synthesized via a one-step in-situ hydrothermal approach. The rGO-NS-Ni catalyst exhibited the best performance for glucose oxidation in direct alkaline fuel cells, attributed to the synergistic effect of N, S-doped rGO and metallic redox couples. This research provides insights for the development of environmentally friendly catalysts and the advancement of DGAFC applications.
Article
Chemistry, Multidisciplinary
Qiuzi Zhao, Ping Du, Xiaoyong Wang, Mengqian Huang, Ling-Dong Sun, Tao Wang, Zhiyun Wang
Summary: A new FRET system using novel fluorescent probes and graphene oxide was developed for detecting H5N1 IAV hemagglutinin, showing promising potential for clinical applications due to its excellent sensing performance and sensitivity.
Letter
Microbiology
Feifei Li, Sihua Liu, Boyu Luo, Mengqian Huang, Yue Teng, Tao Wang
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Jun Kang, Mengqian Huang, Jinyu Li, Keke Zhang, Cheng Zhu, Sihua Liu, Zhenwei Zhou, Tao Wang, Zhiyun Wang
Summary: EV-D68 is a globally emerging pathogen causing severe respiratory illnesses mainly in children. The structural protein VP3 of EV-D68 interacts with IRF7 and inhibits its phosphorylation and nuclear translocation, resulting in the repression of IFN production. VP3 also inhibits the ubiquitination of IRF7 induced by TRAF6 through competitive interaction. The control of IRF7 by VP3 may contribute to the subversion of host innate immune responses by EV-D68.
MICROBIOLOGY SPECTRUM
(2023)
Article
Virology
Yuling Zhang, Leling Xu, Zhe Zhang, Xin Su, Zhiyun Wang, Tao Wang
Summary: This study reveals a novel mechanism by which EV-D68 inhibits ISG transcription and antagonizes the antiviral responses of host type I interferon. SOCS3 plays a key role in this process by inhibiting the phosphorylation of STAT3. A designed SOCS3 inhibitor can significantly reduce the levels of EV-D68.
Article
Chemistry, Multidisciplinary
Yanan Xu, Bin Zheng, Mengqian Huang, Xianhuang Li, Zhiyun Wang, Jin Chang, Tao Wang
Summary: The combination of non-pathogenic Sendai virus and CD47 blocker nanocomposites can effectively stimulate DCs and macrophages, leading to activation of T lymphocytes, formation of humoral immunity and immune memory, providing a new strategy for personalized anti-tumor immunotherapy.
MATERIALS CHEMISTRY FRONTIERS
(2021)