Article
Endocrinology & Metabolism
Pil Sang Song, Kye Taek Ahn, Mi Joo Kim, Seok-Woo Seong, Si Wan Choi, Hyeon-Cheol Gwon, Seung-Ho Hur, Seung-Woon Rha, Chang-Hwan Yoon, Myung Ho Jeong, Jin-Ok Jeong
Summary: This study aimed to investigate whether the impact of diabetes mellitus on clinical outcomes after acute myocardial infarction (AMI) varies by age. The results showed that diabetes mellitus is more common in younger AMI patients, and the relative risk of 3-year mortality is significantly higher in young patients compared to older counterparts.
DIABETES & METABOLISM
(2022)
Article
Clinical Neurology
Alice Chun-Chen Chen, Kuan-Lun Huang, Hong-Ming Chen, Pau-Chung Chen, Vincent Chin-Hung Chen, Wei-Che Chiu
Summary: The study revealed that in diabetic patients, those who used antidepressants for more than 180 days had a lower risk of myocardial infarction, especially when the duration of use exceeded 180 days.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Young Sang Lyu, Seok Oh, Jin Hwa Kim, Sang Yong Kim, Myung Ho Jeong
Summary: This study compared the cardiovascular outcomes of SGLT2 inhibitors and DPP-4 inhibitors in combination with metformin in diabetic patients with acute myocardial infarction (AMI). The results showed that SGLT2 inhibitors did not lower the rate of major adverse composite events (MACEs) compared with DPP-4 inhibitors, but did improve left ventricular ejection fraction.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Tetsuji Miura, Atsushi Kuno, Marenao Tanaka
Summary: This article reviews the mechanisms of cardiorenal syndrome and the influence of diabetes on acute myocardial infarction (AMI) and the susceptibility of kidneys to acute kidney injury (AKI). The review highlights that diabetes increases the susceptibility of renal cells to hypoxia and oxidative stress, and also has detrimental effects on infarct size and contractile function of the heart.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Volker H. Schmitt, Lukas Hobohm, Thomas Munzel, Philip Wenzel, Tommaso Gori, Karsten Keller
Summary: This study found that diabetic patients have a higher in-hospital mortality rate and a higher recurrent MI rate during acute myocardial infarction (MI) compared to non-diabetic patients. Diabetic patients also had lower rates of coronary artery angiography and interventional revascularization compared to non-diabetic patients.
DIABETES & METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Dong-Mei Xie, Qingguo Zhong, Xiaochun Xu, Yuanlong Li, Simin Chen, Mingqiang Li, Chaoquan Peng
Summary: This study developed a new strategy using PLGA copolymers as carriers to achieve controlled release of LA, which effectively reduced ROS damage and restored heart function after myocardial damage in AMI disease. The results demonstrated the great potential of LA drugs in treating AMI.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Medicine, General & Internal
Ygal Plakht, Harel Gilutz, Arthur Shiyovich
Summary: This study evaluated the prognostic significance of HbA(1C) levels and changes among diabetic patients after non-fatal AMI. The results showed that fluctuations in HbA(1C) values, especially rapid increases, were associated with a higher risk of mortality. Monitoring both absolute HbA(1C) values and their changes could help predict long-term outcomes in AMI-DM patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Marta Baviera, Stefano Genovese, Pierluca Colacioppo, Nicola Cosentino, Andreana Foresta, Mauro Tettamanti, Ida Fortino, Maria Carla Roncaglioni, Giancarlo Marenzi
Summary: This study found that the longer the duration of diabetes mellitus in patients with acute myocardial infarction, the higher the risk of in-hospital mortality. The duration of diabetes should be considered as an important early prognostic risk factor in patients with AMI.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Gilles Lemesle, Etienne Puymirat, Laurent Bonello, Tabassome Simon, Philippe-Gabriel Steg, Jean Ferrieres, Francois Schiele, Laurent Fauchier, Patrick Henry, Guillaume Schurtz, Sandro Ninni, Nicolas Lamblin, Christophe Bauters, Nicolas Danchin
Summary: This study aimed to investigate the relationship between diabetes mellitus (DM) status and the risk of heart failure (HF) occurrence in patients with coronary artery disease (CAD). The results showed that patients with DM had a significantly higher risk of HF, whether in the acute myocardial infarction (MI) phase or the chronic stable phase. Therefore, it is crucial to prevent HF occurrence in CAD patients with DM.
DIABETES & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Hiran A. Prag, Dunja Aksentijevic, Andreas Dannhorn, Abigail Giles, John F. Mulvey, Olga Sauchanka, Luping Du, Georgina Bates, Johannes Reinhold, Duvaraka Kula-Alwar, Zhelong Xu, Luc Pellerin, Richard J. A. Goodwin, Michael P. Murphy, Thomas Krieg
Summary: Malonate selectively enters cardiomyocytes during reperfusion in a low pH environment caused by ischemia, protecting against cardiac ischemia/reperfusion injury.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Anne M. Kerola, Anne Grete Semb, Markus Juonala, Antti Palomaki, Paivi Rautava, Ville Kyto
Summary: This study found that patients with type 1 diabetes have significantly poorer long-term cardiovascular prognosis after myocardial infarction compared to patients without diabetes, with a higher incidence of major adverse cardiovascular events. The results highlight the importance of effective secondary prevention after myocardial infarction in patients with type 1 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yun Liu, Mengxue Wang, Yin Liang, Chen Wang, Keiji Naruse, Ken Takahashi
Summary: This article discusses the regulation of oxidative stress in coronary heart disease and the potential of exosomes as targeted carriers for endogenous ROS modulation. Exosomes have potential advantages and can serve as a new direction in the treatment of cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Reka Skoda, Attila Nemes, Gyorgy Barczi, Hajnalka Vago, Zoltan Ruzsa, Istvan F. Edes, Attila Olah, Annamaria Kosztin, Elek Dinya, Bela Merkely, David Becker
Summary: This study aimed to assess the impact of diabetes mellitus (DM) on the clinical outcome and survival of patients with myocardial infarction (MI) who underwent percutaneous coronary intervention (PCI). The results showed that diabetic patients had worse short- and long-term survival compared to non-diabetic patients. The presence of DM was found to be more important than the type of MI in affecting survival, while LV and renal functions had a greater impact on survival than DM.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Suma Elumalai, Udayakumar Karunakaran, Jun-Sung Moon, Kyu-Chang Won
Summary: In type 2 diabetes, metabolic stress negatively affects pancreatic beta-cell function and survival. Imbalance in redox homeostasis causes abnormal tissue damage and beta-cell death, making beta-cells more susceptible to oxidative damage by NADPH oxidase.
Editorial Material
Cardiac & Cardiovascular Systems
Julio C. Santana, Michael Dangl, Michael Albosta, Rosario Colombo
Summary: There is a lack of data on acute myocardial infarction (AMI) outcomes for female patients. This study indicates that in patients with T1DM, women have the same risk of AMI as men but have a higher mortality rate and are less likely to undergo cardiac catheterization and coronary artery bypass grafting.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Daisuke Kitano, Tadateru Takayama, Mitsumasa Sudo, Takaaki Kogo, Keisuke Kojima, Naotaka Akutsu, Toshihiko Nishida, Hironori Haruta, Daisuke Fukamachi, Taro Kawano, Takashi Kanai, Takafumi Hiro, Satoshi Saito, Atsushi Hirayma
JOURNAL OF CARDIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Daisuke Kitano, Masaaki Chiku, Yuxin Li, Yasuo Okumura, Daisuke Fukamachi, Tadateru Takayama, Takafumi Hiro, Satoshi Saito, Atsushi Hirayama
CARDIOVASCULAR DIABETOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Daisuke Kitano, Tadateru Takayama, Daisuke Fukamachi, Suguru Migita, Tomoyuki Morikawa, Takehiro Tamaki, Keisuke Kojima, Takashi Mineki, Nobuhiro Murata, Naotaka Akutsu, Mitsumasa Sudo, Takafumi Hiro, Atsushi Hirayama, Yasuo Okumura
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Daisuke Kitano, Shunichi Yoda, Daisuke Fukamachi, Yasuo Okumura
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2020)
Article
Peripheral Vascular Disease
Daisuke Kitano, Suguru Migita, Yuxin Li, Rie Takahashi, Yoshiki Taniguchi, Takafumi Kurosawa, Mitsumasa Sudo, Hironori Haruta, Takafumi Hiro, Tadateru Takayama, Masako Mitsumata, Taro Matsumoto, Yasuo Okumura, Atsushi Hirayama
Summary: Our study confirms the noninferiority of a combination therapy of rivaroxaban with an antiplatelet drug, particularly the dual therapy using rivaroxaban and clopidogrel, compared to dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Article
Nutrition & Dietetics
Yohei Nakayama, Shinichi Tabe, Arisa Yamaguchi, Yuto Tsuruya, Ryoki Kobayashi, Katsunori Oyama, Daisuke Kitano, Keisuke Kojima, Rikitake Kogawa, Yasuo Okumura, Jun Ogihara, Hidenobu Senpuku, Yorimasa Ogata
Summary: This study examines the associations between nutritional factors, blood biochemical items, and clinical parameters in patients with systemic diseases. Weak negative correlations were found between clinical parameters and nutritional factors, and the frequency of vegetable intake may be used to evaluate periodontal stabilization in these patients.
Article
Nutrition & Dietetics
Shinichi Tabe, Yohei Nakayama, Ryoki Kobayashi, Kstsunori Oyama, Daisuke Kitano, Jun Ogihara, Hidenobu Senpuku, Yorimasa Ogata
Summary: The study examined the effect of nutritional factors on clinical periodontal parameters in patients with periodontitis undergoing supportive periodontal therapy (SPT). Environmental factors were found to be associated with the number of teeth, while nutritional factors were associated with periodontal inflammation. Therefore, both environmental and nutritional factors are useful in evaluating the risk of periodontitis during SPT.
Article
Cardiac & Cardiovascular Systems
Naoki Hashimoto, Daisuke Kitano, Takehiro Tamaki, Yutaka Koyama, Akimasa Yamada, Kinta Hatakeyama, Hiroyuki Hao, Yasuo Okumura
Summary: We present an autopsy case of a 69-year-old female with cervical cancer who received bevacizumab-containing chemotherapy. After two years, she developed congestive heart failure (CHF) with left ventricular dysfunction. Cardiac magnetic resonance (CMR) imaging revealed late gadolinium enhancement (LGE) in the mid-wall area, suggesting bevacizumab-related cardiotoxicity. Autopsy findings showed diffuse fibrosis in the myocardium, and the area of LGE seen on CMR exhibited thinning and wavy changes in cardiomyocytes with diffuse interstitial fibrosis and edema.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)