Article
Multidisciplinary Sciences
Anna Maria Nuzzo, Domenica Giuffrida, Laura Moretti, Paola Re, Giorgio Grassi, Guido Menato, Alessandro Rolfo
Summary: This study compared the expression of anti-angiogenic sFlt1 and pro-angiogenic PlGF in placenta and maternal blood in GDM, GDM-PE, CTRL, and PE cases. The results showed higher sFlt1/PlGF values in GDM-PE maternal blood, decreased PlGF gene expression in GDM, PE, and GDM-PE placentae, and increased PlGF protein levels in GDM and GDM-PE placentae. Additionally, sFlt1 gene expression was higher in PE placentae, while sFlt1 protein expression was lower in GDM-PE placentae. These findings suggest a potential link between sFlt1 overproduction and PE onset in GDM pregnancies.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Xiujun Fan, Shanmugam Muruganandan, Philemon D. Shallie, Sabita Dhal, Matthew Petitt, Nihar R. Nayak
Summary: VEGF signaling is crucial for maintaining the homeostasis of the maternal vascular space in mouse placenta through modulation of TGC development and differentiation, similar to its effect on endothelial cells in other vascular beds.
Article
Medical Laboratory Technology
Hao Yang, Fang Guo, Qin Guo, Yifei Wang, Ping He, Hongbo Zhang, Shuaiyu Wang
Summary: The sFlt1/PlGF ratio is a useful parameter for the diagnosis of preeclampsia, showing good performance in distinguishing preeclampsia from other hypertensive disorders of pregnancy and predicting adverse outcomes. PlGF and sFlt1/PlGF ratio are worth implementing in the clinical management of women with preeclampsia.
CLINICA CHIMICA ACTA
(2022)
Article
Obstetrics & Gynecology
Ulla Sovio, Francesca Gaccioli, Emma Cook, D. Stephen Charnock-Jones, Gordon C. S. Smith
Summary: Slowing of fetal growth and biomarkers of placental insufficiency were associated with an increased probability of early onset of spontaneous term labor.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Medicine, General & Internal
Ioakeim Sapantzoglou, Angeliki Rouvali, Antonios Koutras, Maria Ioanna Chatziioannou, Ioannis Prokopakis, Zacharias Fasoulakis, Eleftherios Zachariou, Athanasios Douligeris, Anastasia Mortaki, Paraskevas Perros, Thomas Ntounis, Vasilios Pergialiotis, Ekaterini Domali, Stavros Athanasiou, George Daskalakis, Alexandros Rodolakis, Periklis Panagopoulos, Kalliopi I. I. Pappa
Summary: Twin pregnancies have a higher risk of developing PE compared to singletons, and the sFLT1/PIGF ratio is strongly associated with PE, adverse pregnancy outcomes, and timing of delivery. This systematic review aimed to summarize the data on sFLT1, PlGF, and their ratios in twin pregnancies and investigate their association with PE development, adverse pregnancy outcomes, and timing of delivery. The review found that sFLT1 levels and the sFLT1/PIGF ratio were higher in twins, especially in the third trimester, while PlGF levels were higher before the third trimester and then showed no difference or were even lower than in singletons. The sFLT1/PIGF ratio is an independent marker of adverse outcomes and is inversely associated with the mean time until delivery. Further research is needed to establish optimal sFLT1/PIGF cut-off values and stratify the risk in twin pregnancies.
MEDICINA-LITHUANIA
(2023)
Article
Obstetrics & Gynecology
Catarina R. Palma R. dos Reis, Sofia Bras, Tania Meneses, Ana S. S. Cerdeira, Manu Vatish, Ana T. T. Martins
Summary: The sFlt1/PlGF ratio can predict faster deterioration in early fetal growth restriction, regardless of preeclampsia.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Review
Biochemistry & Molecular Biology
Nataliia Sergeevna Karpova, Olga Pavlovna Dmitrenko, Tatyana Sergeevna Budykina
Summary: One of the main causes of maternal and neonatal morbidity and mortality is pre-eclampsia, characterized by a high sFlt1/PlGF ratio. Pregestational diseases in mothers may increase the risk, but few studies have looked at the connection between maternal comorbidities and the sFlt1/PlGF ratio. This review summarizes the latest information on the association between maternal pregestational diseases and the ratio of sFlt1/PlGF, as well as the link between changes in pregnancy hormones/metabolites and a high sFlt1/PlGF ratio. Debate remains on the association between the ratio and maternal disorders, calling for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Alexandra Sneider, Ashley Kiemen, Joo Ho Kim, Pei-Hsun Wu, Mehran Habibi, Marissa White, Jude M. Phillip, Luo Gu, Denis Wirtz
Summary: While cell and tissue mechanics are important for understanding solid tumor progression, they have not been widely used in clinical practice. In this study, we bridge the gap between clinical and mechanical markers of breast cancer by using deep learning and mechanical measurements to identify key factors contributing to tissue stiffness.
Article
Medicine, Research & Experimental
Guohong Liu, Liping Wang, Lili Ji, Dan He, Lihua Zeng, Guangzheng Zhuo, Qian Zhang, Dujuan Wang, Yunbao Pan
Summary: By utilizing GeoMx Digital Spatial Profiling (DSP) technology, we analyzed transcripts from 107 regions of interest in 65 untreated breast cancer tissue samples to gain deeper insights into the microenvironment of breast cancer. Our study revealed spatial heterogeneity in the expression of marker genes in tumor cell enriched, immune cell enriched, and normal epithelial areas. Through our investigations, we discovered specific diagnostic and prognostic markers in breast cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Baert Jonathana, McCarey Catherine, Berkane Nadia, Martinez-de-Tejada Begona, Vial Yvan, Rieder Wawrzyniec
Summary: Preeclampsia is a major cause of maternal and fetal morbidity and mortality. Early recognition of the disease may be challenging and result in delayed medical intervention. Serum biomarkers are being studied as potential early indicators of preeclampsia.
SWISS MEDICAL WEEKLY
(2021)
Article
Oncology
Peter A. Barry, Kathryn Harborough, Victoria Sinnett, Anna Heeney, Edward Robert St John, Tanja Gagliardi, Basrull N. Bhaludin, Kate Downey, Romney Pope, Rachel L. O'Connell, Marios K. Tasoulis, Fiona MacNeill, Jennifer E. Rusby, Gerald Gui, Aikaterini Micha, Samantha Chen, Katherine Dorothy Claudia Krupa
Summary: This study reports the experience of using the paramagnetic MAGSEED for axillary lymph node marking, and found it to be a safe and reliable method with a high success rate.
Article
Medicine, Research & Experimental
Yan Li, Meng-Zhao Zhang, Shu-Jing Zhang, Xin Sun, Can Zhou, Juan Li, Jie Liu, Jun Feng, Shao-Ying Lu, Liu Pei-Jun, Ji-Chang Wang
Summary: Triple negative breast cancer (TNBC) is a subtype of breast cancer with limited treatment options. In this study, it was found that an HIF-1 alpha inhibitor called YC-1 could inhibit TNBC growth by inducing apoptosis and reducing blood vessel density. Further experiments revealed that YC-1 could shift the polarization of tumor-associated macrophages (TAMs) from the M2 phenotype to the M1 phenotype, thereby suppressing TNBC angiogenesis and growth. These findings provide a potential treatment option for TNBC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Biomedical
Mouhita Humayun, Jose M. Ayuso, Raven A. Brenneke, Maria Virumbrales-Munoz, Karina Lugo-Cintron, Sheena Kerr, Suzanne M. Ponik, David J. Beebe
Summary: In cancer metastasis, tumor cells exit the bloodstream by crossing the endothelium and engaging in crosstalk with other active players, leading to changes in functional behavior. Upregulated secretion of factors from cancer-vascular interactions affects the invasive/metastatic potential of breast cancer cells. Therapeutic inhibitors were used to assess the independent and combined role of multiple signaling factors on promoting extravasation in cancer metastasis.
Article
Oncology
Mohd Fazirul Mustafa, Suhainizam Muhamad Saliluddin, Sharida Fakurazi, Nur Maya Sabrina Tizen Laim, Suria Hayati Md Pauzi, Nik Hasimah Nik Yahya, Navarasi S. Raja Gopal, Maizaton Atmadini Abdullah, Sandra Maniam
Summary: This study measured autophagy, mitophagy, oxidative stress, and apoptosis levels in invasive breast carcinoma tissues using immunohistochemistry. Positive staining scores of Beclin-1 and Parkin were significantly higher in tumor tissues compared to other markers. Positive associations were also observed between BNIP-3 and Beclin-1, as well as LC-3 and cleaved caspase-3 immunostaining. The findings suggest potential new cancer biomarkers and the application of anti-autophagy therapies for breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Klaudia Katarzyna Brogowska, Monika Zajkowska, Barbara Mroczko
Summary: Breast cancer is the most common and lethal malignancy in women. Its development is influenced by factors such as age, genetic mutations, and body weight. Currently, there is a lack of sensitive and specific screening tests, but researchers are exploring new diagnostic biomarkers. The VEGF family of proteins and their receptors play a significant role in the pathogenesis of breast cancer and could potentially be used as diagnostic biomarkers and therapeutic targets.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Sanja Loeb, Aurelia Vattai, Christina Kuhn, Elisa Schmoeckel, Sven Mahner, Achim Woeckel, Thomas Kolben, Christiane Keil, Udo Jeschke, Theresa Vilsmaier
Summary: This study revealed significant changes in the expression of PZP and GdA in decidual tissue in patients experiencing spontaneous miscarriage and recurrent miscarriage, with a negative correlation between the two proteins. A balanced expression of GdA and PZP in the decidua appears crucial for successful ongoing pregnancy.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Patricia Fraungruber, Till Kaltofen, Sabine Heublein, Christina Kuhn, Doris Mayr, Alexander Burges, Sven Mahner, Philipp Rathert, Udo Jeschke, Fabian Trillsch
Summary: The study found a correlation between Dkk2 and GPER expression in epithelial ovarian cancer, with combined high expression associated with improved overall survival. These findings suggest a potential prognostic impact and treatment strategies targeting estrogen and Wnt signaling interactions in ovarian cancer.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Nan Han, Sabine Heublein, Udo Jeschke, Christina Kuhn, Anna Hester, Bastian Czogalla, Sven Mahner, Miriam Rottmann, Doris Mayr, Elisa Schmoeckel, Fabian Trillsch
Summary: The study found a positive correlation between GPER and H3K4me3 expression in ovarian cancer patients, with patients overexpressing both having improved overall survival. Activation of GPER led to increased H3K4me3 and p-ERK1/2 levels, as well as decreased cell proliferation and migration, while antagonizing GPER activity had opposite effects. The interaction between GPER and H3K4me3 is of prognostic significance and GPER agonists like G1 have potential as a therapeutic approach for ovarian cancer.
Article
Medicine, General & Internal
Nadine Ansorge, Christian Dannecker, Udo Jeschke, Elisa Schmoeckel, Doris Mayr, Helene H. Heidegger, Aurelia Vattai, Maximiliane Burgmann, Bastian Czogalla, Sven Mahner, Sophie Fuerst
Summary: The study found that the expression of COX-2 and PPAR gamma in vulvar cancer tissues is associated with survival rate, with cytoplasmic expression leading to reduced survival and nuclear expression associated with better survival. The combined expression of both COX-2 and PPAR gamma in the cytoplasm is considered an independent negative prognostic factor for vulvar cancer patients.
Article
Immunology
Sanja Loeb, Niklas Amann, Christina Kuhn, Elisa Schmoeckel, Achim Woeckel, Alaleh Zati Zehni, Till Kaltofen, Simon Keckstein, Jan-Niclas Mumm, Sarah Meister, Thomas Kolben, Sven Mahner, Udo Jeschke, Theresa Vilsmaier
Summary: The study found a significant upregulation of IL-1 beta in the decidua of recurrent miscarriage specimens, as well as in the decidua of spontaneous abortion cases, suggesting its potential role in early pregnancy loss. Double-immunofluorescence revealed that decidual stroma cells are the major IL-1 beta expressing cells at the fetomaternal interface.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Oncology
Anna Buchholz, Aurelia Vattai, Sophie Furst, Theresa Vilsmaier, Christina Kuhn, Elisa Schmoeckel, Doris Mayr, Christian Dannecker, Sven Mahner, Udo Jeschke, Helene H. Heidegger
Summary: EP4 was found to be commonly expressed in vulvar cancer tissue, with significant correlations to tumor size and FIGO classification, as well as poorer overall survival and disease-free survival. EP4 was identified as an independent prognostic factor, and it was shown in vitro to attenuate viability and proliferation of vulvar cancer cells. Further research on the influence of EP4 in the tumor microenvironment and its potential as a therapeutic target is needed.
Article
Oncology
Mingjun Zheng, Junyu Long, Anca Chelariu-Raicu, Heather Mullikin, Theresa Vilsmaier, Aurelia Vattai, Helene Hildegard Heidegger, Falk Batz, Simon Keckstein, Udo Jeschke, Fabian Trillsch, Sven Mahner, Till Kaltofen
Summary: In this study, a prognostic 11-gene signature for advanced serous ovarian cancer was developed using lasso regression on tumor microenvironment-related genes. The established risk score showed improved accuracy in predicting the prognosis of ovarian cancer patients and the potential response to immunotherapy. This model was also found applicable to other cancer types, suggesting its broad usability in predicting biological responses to immunotherapy.
Article
Cell Biology
Wanting Shao, Melitta B. Koepke, Theresa Vilsmaier, Alaleh Zati Zehni, Mirjana Kessler, Sophie Sixou, Mariella Schneider, Nina Ditsch, Vincent Cavailles, Udo Jeschke
Summary: The cytoplasmic co-expression of RXR alpha and PPAR gamma in breast cancer patients is associated with shorter survival and tumor aggressiveness markers. This finding is clinically relevant for identifying high-risk breast cancer patients, especially those with early and node-negative disease.
Article
Cell Biology
Qun Wang, Kritika Sudan, Elisa Schmoeckel, Bernd Peter Kost, Christina Kuhn, Aurelia Vattai, Theresa Vilsmaier, Sven Mahner, Udo Jeschke, Helene Hildegard Heidegger
Summary: This study suggests that CCL22 may affect cervical cancer by regulating macrophage polarization, indicating that CCL22 could be a potential target for cervical cancer treatment.
Article
Oncology
Melitta B. Koepke, Marie-Christine Chateau, Florence Boissiere-Michot, Mariella Schneider, Fabian Garrido, Alaleh Zati-Zehni, Theresa Vilsmaier, Mirjana Kessler, Nina Ditsch, Vincent Cavailles, Udo Jeschke
Summary: This study investigates the correlation between tumor-infiltrating lymphocytes (TILs), nuclear receptor expression, and prognosis in breast cancer. It reveals a significant relationship between TIL levels, nuclear receptor expression, and overall survival, providing important insights for breast cancer prognosis.
Article
Medicine, General & Internal
Franziska Sciuk, Theresa Vilsmaier, Marie Kramer, Magdalena Langer, Brenda Kolbinger, Pengzhu Li, Andre Jakob, Nina Rogenhofer, Robert Dalla-Pozza, Christian Thaler, Nikolaus Alexander Haas, Felix Sebastian Oberhoffer
Summary: Children conceived through assisted reproductive technologies (ART) may have impaired left ventricular (LV) diastolic function. This study found that young ART subjects had lower LV diastolic function compared to their spontaneously conceived peers. However, when adjusted for age, birth weight percentile, and gestational age, there were no significant differences between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Magdalena Langer, Pengzhu Li, Theresa Vilsmaier, Marie Kramer, Franziska Sciuk, Brenda Kolbinger, Andre Jakob, Nina Rogenhofer, Nikolaus Alexander Haas, Robert Dalla-Pozza, Christian Thaler, Felix Sebastian Oberhoffer
Summary: Multiple studies have reported signs of vascular dysfunction in subjects conceived through assisted reproductive technologies (ART). In this study, regional and global arterial stiffness were evaluated in ART subjects and spontaneously conceived peers, and no significant differences were found. However, a higher tendency of brachial systolic blood pressure was observed in the ART cohort.
Review
Medicine, General & Internal
Fabian Garrido, Carl Mathis Wild, Johanna Mittelberger, Franziska Dobler, Mariella Schneider, Nadine Ansorge, Melitta Koepke, Annamarie Strieder, Nina Ditsch, Udo Jeschke, Christian Dannecker
Summary: Chemokines play a key role in activating immune checkpoints in cervical cancer progression, affecting prognosis in various aspects. Understanding chemokines and immune checkpoint modulators is crucial for effective treatment of the disease.
MEDICINA-LITHUANIA
(2021)