Article
Oncology
Marla Lipsyc-Sharf, Fang-Shu Ou, Matthew B. Yurgelun, Douglas A. Rubinson, Deborah Schrag, Shaker R. Dakhil, Philip J. Stella, Douglas J. Weckstein, Donald B. Wender, Meredith Faggen, Tyler J. Zemla, Erica N. Heying, Samantha R. Schuetz, Stephanie Noble, Jeffrey A. Meyerhardt, Tanios Bekaii-Saab, Charles S. Fuchs, Kimmie Ng
Summary: The study investigated the efficacy of combining bevacizumab with irinotecan and cetuximab in patients with irinotecan-refractory metastatic colorectal cancer. Although there was no significant difference in progression-free survival between the two treatment groups, there was a statistically significant improvement in overall survival favoring the group that received bevacizumab in addition to irinotecan and cetuximab. Further investigation on this combination therapy is warranted.
Article
Oncology
Alberto Sobrero, Heinz-Josef Lenz, Cathy Eng, Werner Scheithauer, Gary Middleton, Wenfeng Chen, Regina Esser, Johannes Nippgen, Howard Burris
Summary: The study investigated the efficacy of cetuximab plus irinotecan in RAS-wild-type metastatic colorectal cancer patients as second-line treatment, showing improvements in progression-free survival, objective response rate, and quality of life. Additionally, almost half of patients in the irinotecan arm received poststudy cetuximab therapy.
Review
Oncology
Louise B. Callesen, Julian Hamfjord, Anders K. Boysen, Niels Pallisgaard, Tormod K. Guren, Elin H. Kure, Karen-Lise G. Spindler
Summary: Plasma ctDNA serves as a strong prognostic biomarker in patients with metastatic colorectal cancer, as high baseline levels are associated with shorter survival and changes in ctDNA levels during treatment can predict outcomes.
BRITISH JOURNAL OF CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martijn R. Meijerink, Alette H. Ruarus, Laurien G. P. H. Vroomen, Robbert S. Puijk, Bart Geboers, Sanne Nieuwenhuizen, Bente A. T. van den Bemd, Karin Nielsen, Jan J. J. de Vries, Krijn P. van Lienden, Birgit Lissenberg-Witte, M. Petrousjka van den Tol, Hester J. Scheffer
Summary: Irreversible electroporation is an effective and relatively safe treatment for colorectal liver metastases measuring 5.0 cm or smaller, especially when unsuitable for surgical resection or thermal ablation. The study showed a 1-year LTP-free survival rate of 68% post-IRE, with good local control and a median overall survival of 2.7 years.
Article
Oncology
Zhan Wang, Bao-Dong Qin, Chen-Yang Ye, Miao-Miao Wang, Ling-Yan Yuan, Wei-Ping Dai, Li Sun, Ke Liu, Wen-Xing Qin, Xiao-Dong Jiao, Xing-Nan Li, Yuan-Sheng Zang
Summary: This study evaluated the safety and efficacy of a new protocol using vemurafenib and cetuximab combined with FOLFIRI in patients with BRAF V600E-mutated colorectal cancer. The results showed promising antitumour activity and tolerable toxicity with this combination therapy.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Jonathan M. Loree, Yucai Wang, Muddassir A. Syed, Alexey Sorokin, Oluwadara Coker, Joanne Xiu, Benjamin A. Weinberg, Ari M. Vanderwalde, Anteneh Tesfaye, Victoria M. Raymond, Benjamin Miron, Gabi Tarcic, Ori Zelichov, Russell R. Broaddus, Patrick Kwok Shing Ng, Kang Jin Jeong, Yiu Huen Tsang, Gordon B. Mills, Michael J. Overman, Axel Grothey, John L. Marshall, Scott Kopetz
Summary: The study identified a high prevalence of atypical RAS mutations in colorectal cancer patients, which were associated with poor prognosis. Activating atypical variants were the most common in clinical cohorts, providing the best evidence to guide treatment.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Hans-Joachim Schmoll, Julia Mann, Fabian Meinert, Benjamin Garlipp, Kersten Borchert, Arndt Vogel, Eray Goekkurt, Ulrich Kaiser, Heinz-Gert Hoeffkes, Joern Ruessel, Stephan Kanzler, Thomas Edelmann, Helmut Forstbauer, Thomas Goehler, Carla Hannig, Bert Hildebrandt, Carsten Roll, Carsten Bokemeyer, Joerg Steighardt, Franziska Cygon, Stefan Ibach, Alexander Stein, Joseph Tintelnot
Summary: The study confirms the effectiveness and tolerability of FOLFOXIRI plus bevacizumab as a first-line treatment for mCRC, but challenges remain in its clinical implementation.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Daniele Rossini, Carlotta Antoniotti, Sara Lonardi, Filippo Pietrantonio, Roberto Moretto, Lorenzo Antonuzzo, Alessandra Boccaccino, Federica Morano, Marco Brugia, Carmelo Pozzo, Federica Marmorino, Francesca Bergamo, Emiliano Tamburini, Alessandro Passardi, Giovanni Randon, Sabina Murgioni, Beatrice Borelli, Angela Buonadonna, Mirella Giordano, Gabriella Fontanini, Veronica Conca, Vincenzo Formica, Massimo Aglietta, Roberto Bordonaro, Giuseppe Aprile, Gianluca Masi, Luca Boni, Chiara Cremolini
Summary: The intensification of upfront chemotherapy backbone with panitumumab does not provide additional benefit in terms of treatment activity in patients with RAS and BRAF wt mCRC, while increasing gastrointestinal toxicity.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Jun Watanabe, Kei Muro, Kohei Shitara, Kentaro Yamazaki, Manabu Shiozawa, Hisatsugu Ohori, Atsuo Takashima, Mitsuru Yokota, Akitaka Makiyama, Naoya Akazawa, Hitoshi Ojima, Yasuhiro Yuasa, Keisuke Miwa, Hirofumi Yasui, Eiji Oki, Takeo Sato, Takeshi Naitoh, Yoshito Komatsu, Takeshi Kato, Masamitsu Hihara, Junpei Soeda, Toshihiro Misumi, Kouji Yamamoto, Kiwamu Akagi, Atsushi Ochiai, Hiroyuki Uetake, Katsuya Tsuchihara, Takayuki Yoshino
Summary: Adding panitumumab to standard first-line chemotherapy significantly improved overall survival in patients with RAS wild-type metastatic colorectal cancer, particularly in those with left-sided tumors.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Oncology
Jonathan M. Loree, Anthony Dowers, Dongsheng Tu, Derek J. Jonker, Daniel L. Edelstein, Hannah Quinn, Frank Holtrup, Timothy Price, John R. Zalcberg, Malcolm J. Moore, Christos S. Karapetis, Chris J. O'Callaghan, Paul Waring, Hagen F. Kennecke, Stanley R. Hamilton, Scott Kopetz
Summary: The study aimed to establish the efficacy of single-agent cetuximab in optimally selected patients using BEAMing analysis. Results showed that cetuximab improved overall survival and progression-free survival in RAS/BRAF wild-type patients, but had no significant effect on patients with KRAS, NRAS, or BRAF mutations. Subclonal RAS/BRAF alterations were found to be rare and of uncertain significance.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Benny Vittrup Jensen, Jakob Schou, Mette Yilmaz, Helle H. Johannesen, Kristin Skougaard, Dorte Linnemann, Estrid Hogdall, Finn O. Larsen, Julia S. Johansen, Per Pfeiffer, Dorte L. Nielsen
Summary: This study investigated the use of cetuximab and irinotecan in third-line treatment for mCRC patients, regardless of RAS or BRAF mutation status, and achieved certain efficacy. Shortening the treatment time while maintaining good treatment outcomes.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
David Sefrioui, Ludivine Beaussire, Andre Gillibert, France Blanchard, Emmanuel Toure, Celine Bazille, Anne Perdrix, Frederic Ziegler, Alice Gangloff, Melanie Hassine, Caroline Elie, Anne-Laure Bignon, Aurelie Parzy, Philippe Gomez, Caroline Thill, Florian Clatot, Jean-Christophe Sabourin, Thierry Frebourg, Jacques Benichou, Karine Bouhier-Leporrier, Marie-Pierre Gallais, Nasrin Sarafan-Vasseur, Pierre Michel, Frederic Di Fiore
Summary: The study confirmed the importance of CEA kinetics in predicting PD, and found that a circulating scoring system combining CEA kinetics, baseline CA19-9, and cfDNA values was independently associated with PD, PFS, and OS in mCRC patients.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Michel Ducreux, Josep Tabernero, Axel Grothey, Dirk Arnold, Peter J. O'Dwyer, Frank Gilberg, Alexander Abbas, Meghna Das Thakur, Hen Prizant, Natsumi Irahara, Anila Tahiri, Hans -Joachim Schmoll, Eric Van Cutsem, Aimery de Gramont
Summary: This study aimed to explore the feasibility of biomarker-driven maintenance therapy in patients with metastatic colorectal cancer. The findings suggest that vemurafenib plus cetuximab plus 5-FU/LV may be further investigated as first-line maintenance treatment for BRAF(mut) mCRC. However, cobimetinib plus atezolizumab had an unfavorable benefit:risk ratio in HER2-/MSS/BRAF(wt) mCRC.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Hiroyuki Arai, Andrew Elliott, Joshua Millstein, Joanne Xiu, Fang-Shu Ou, Federico Innocenti, Jingyuan Wang, Francesca Battaglin, Priya Jayachandran, Natsuko Kawanishi, Shivani Soni, Wu Zhang, Davendra Sohal, Richard M. Goldberg, Michael J. Hall, Aaron J. Scott, Mohd Khushman, Jimmy J. Hwang, Emil Lou, Benjamin A. Weinberg, Albert Craig Lockhart, Anthony Frank Shields, Jim P. Abraham, Daniel Magee, Phillip Stafford, Jian Zhang, Alan P. Venook, W. Michael Korn, Heinz-Josef Lenz
Summary: Loss-of-function alterations in NF1 gene activate RAS, a driver of colorectal cancer. NF1-mutant tumors frequently also have mutations in PIK3CA and PTEN genes. Low NF1 expression may be associated with poor prognosis, while high expression may enhance the efficacy of cetuximab compared to bevacizumab. Further investigation in clinical settings is needed to explore the potential of NF1 alteration as a novel biomarker for targeted therapy.
Article
Gastroenterology & Hepatology
Serdar Arici, Jamshid Hamdard, Abdullah Sakin, Selma Sengiz Erhan, Muhammed Mustafa Atci, Ruhper Cekin, Burcu Saka, Emin Kose, Tuba Saydam, Caglayan Geredeli, Sener Cihan, Ahmet Bilici
Summary: This study investigated the RAS discordance between initial and recurrent metastasectomy specimens in mCRC patients treated with chemotherapy plus biological agents. The results suggest that re-biopsy is necessary for optimal second-line treatment decision in mCRC patients, especially in those with wild-type RAS mCRC.
COLORECTAL DISEASE
(2021)
Article
Surgery
Rebecca Mercieca-Bebber, Renee Eggins, Kilian Brown, Val J. Gebski, Kate Brewer, Lenna Lai, Lisa Bailey, Michael J. Solomon, John W. Lumley, Peter Hewett, Andrew D. Clouston, Kate Wilson, Wendy Hague, Julian Hayes, Stephen White, Matt Morgan, R. John Simes, Andrew R. L. Stevenson
Summary: This study aimed to compare the urinary, bowel, and sexual functioning of rectal cancer patients who underwent open or laparoscopic surgery. The results showed that patients who underwent open surgery had fewer symptoms in bowel and sexual functioning. However, it remains difficult to recommend one surgical approach over the other for rectal resection.
Article
Behavioral Sciences
Lisa Grech, Bao Sheng Loe, Daphne Day, Daniel Freeman, Alastair Kwok, Mike Nguyen, Nathan Bain, Eva Segelov
Summary: This study developed a scale, DIVAS-6, to assess attitudes and concerns related to COVID-19 vaccination in individuals with underlying diseases. The scale was validated in patients with cancer, diabetes, and multiple sclerosis, showing good psychometric properties and convergent validity. DIVAS-6 can assist in guiding information delivery about COVID-19 vaccination in medically vulnerable populations.
BEHAVIORAL MEDICINE
(2023)
Review
Oncology
Silvia Stacchiotti, Hans Roland Duerr, Inga-Marie Schaefer, Klaus Woertler, Rick Haas, Annalisa Trama, Augusto Caraceni, Jyoti Bajpai, Giacomo Giulio Baldi, Nicholas Bernthal, Jean-Yves Blay, Kjetil Boye, Javier-Martin Broto, Wei-Wu Tom Chen, Paolo Angelo Dei Tos, Jayesh Desai, Stephan Emhofer, Mikael Eriksson, Alessandro Gronchi, Hans Gelderblom, Jendrik Hardes, Wolfgang Hartmann, John Healey, Antoine Italiano, Robin L. Jones, Akira Kawai, Andreas Leithner, Herbert Loong, Eric Mascard, Carlo Morosi, Nadine Otten, Emanuela Palmerini, Shreyaskumar R. Patel, Peter Reichardt, Brian Rubin, Piotr Rutkowski, Claudia Sangalli, Kathrin Schuster, Beatrice M. Seddon, Morena Shkcodra, Eric L. Staals, William Tap, Matt van de Rijn, Kirsten van Langevelde, Filip M. M. Vanhoenacker, Andrew Wagner, Lisette Wiltink, Sydney Stern, Michiel Van de Sande, Sebastian Bauer
Summary: Tenosynovial giant cell tumour (TGCT) is a rare, locally aggressive tumor that arises from the joints, bursa, and tendon sheaths. There are two types of TGCT: nodular and diffuse, with the former exhibiting a slow disease course and the latter showing locally aggressive behavior. Although not life-threatening, TGCT can cause chronic pain and negatively impact function and quality of life. CSFR1 inhibitors are effective in treating TGCT but are not widely available. The lack of guidelines and uncertainty in selecting appropriate therapy lead to inconsistent adoption of new treatments and suboptimal outcomes for patients. A global consensus meeting was held in June 2022 to develop evidence-based recommendations for the optimal management of TGCT.
CANCER TREATMENT REVIEWS
(2023)
Article
Oncology
Lavinia Tan, Ben Tran, Jeanne Tie, Ben Markman, Sumi Ananda, Niall C. Tebbutt, Michael Michael, Emma Link, Stephen Q. Wong, Sushma Chandrashekar, Jerick Guinto, David Ritchie, Rachel Koldej, Benjamin J. Solomon, Grant A. McArthur, Rodney J. Hicks, Peter Gibbs, Sarah-Jane Dawson, Jayesh Desai
Summary: BRAF V600E mutant metastatic colorectal cancer is a significant clinical problem. Combination therapy with vemurafenib and small-molecule EGFR inhibitors has shown effectiveness in pre-clinical studies, but clinical investigation is lacking.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Julien Taieb, Sara Lonardi, Jayesh Desai, Gunnar Folprecht, Claire Gallois, Eduardo Polo Marques, Sadya Khan, Claire Castagne, Harpreet Wasan
Summary: The combination of encorafenib and cetuximab is well tolerated in most patients with metastatic colorectal cancer, with the majority of adverse events being mild-to-moderate in severity, occurring early in treatment, and resolving rapidly, except for rare cases of nephrotoxicity.
CLINICAL COLORECTAL CANCER
(2023)
Article
Medicine, General & Internal
Ian M. Collins, Rob Blum, Eva Segelov, Phillip Parente, Craig Underhill
Summary: This study investigated the current medical oncology workforce in Victoria and found a growing workload and inadequate resources to meet the demand, especially during the global pandemic. The study concludes that there is an urgent need to address the shortage of medical oncology workforce to ensure the quality and efficiency of cancer treatment.
INTERNAL MEDICINE JOURNAL
(2023)
Review
Oncology
Sean Tan, Seiyon Sivakumar, Eva Segelov, Stephen J. Nicholls, J. Nelson
Summary: This study reveals the low reporting frequency of traditional cardiovascular risk factors (CVRF) in immune checkpoint inhibitor (ICI) trials, despite the increased risk of myocardial infarction associated with ICI treatment.
CANCER EPIDEMIOLOGY
(2023)
Article
Oncology
Johanna Bendell, Patricia LoRusso, Michael Overman, Anne M. Noonan, Dong-Wan Kim, John H. Strickler, Sang-We Kim, Stephen Clarke, Thomas J. George, Peter S. Grimison, Minal Barve, Manik Amin, Jayesh Desai, Trisha Wise-Draper, Steven Eck, Yu Jiang, Anis A. Khan, Yuling Wu, Philip Martin, Zachary A. Cooper, Nairouz Elgeioushi, Nancy Mueller, Rakesh Kumar, Sandip Pravin Patel
Summary: This study evaluated the use of oleclumab in patients with advanced colorectal cancer, pancreatic ductal adenocarcinoma, and epidermal growth factor receptor-mutant non-small-cell lung cancer. The results showed that oleclumab had a manageable safety profile and demonstrated antitumor activity.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Grace K. K. Dy, Ramaswamy Govindan, Vamsidhar Velcheti, Gerald S. S. Falchook, Antoine Italiano, Jurgen Wolf, Adrian G. G. Sacher, Toshiaki Takahashi, Suresh S. S. Ramalingam, Christophe Dooms, Dong-Wan Kim, Alfredo Addeo, Jayesh Desai, Martin Schuler, Pascale Tomasini, David S. S. Hong, Piro Lito, Qui Tran, Simon Jones, Abraham Anderson, Antreas Hindoyan, Wendy Snyder, Ferdinandos Skoulidis, Bob T. T. Li
Summary: Clinical trials often have multiple end points that mature at different times. The initial report is usually based on the primary end point, without the availability of key planned co-primary or secondary analyses. Clinical Trial Updates allow for the dissemination of additional results from studies that have already reported the primary end point.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Biochemical Research Methods
Michelle Palmieri, Bruno Catimel, Dmitri Mouradov, Anuratha Sakthianandeswaren, Eugene Kapp, Ching-Seng Ang, Nicholas A. Williamson, Cameron J. Nowell, Michael Christie, Jayesh Desai, Peter Gibbs, Antony W. Burgess, Oliver M. Sieber
Summary: The nuclear translocation of PI3K alpha regulates the subcellular levels of PtdIns(3,4,5)P3 in colorectal cancer cell lines, and 867 potential nuclear PtdIns(3,4,5)P3 effector proteins have been identified. These effector proteins are mainly involved in RNA metabolism and may play a role in modulating pre-mRNA splicing. These findings suggest that nuclear PI3K alpha signaling through PtdIns(3,4,5)P3 effector proteins is important for CRC development.
MOLECULAR & CELLULAR PROTEOMICS
(2023)
Review
Oncology
Celine Man Ying Li, Yoko Tomita, Bimala Dhakal, Runhao Li, Jun Li, Paul Drew, Timothy Price, Eric Smith, Guy J. Maddern, Kevin Aaron Fenix
Summary: This review systematically assessed the efficacy of cytokine-induced killer cell (CIK) therapy for colorectal cancer (CRC) treatment and found that CIK therapy improved overall survival, progression-free survival, and overall response rate without increasing toxicity. Further investigation into CIK therapy for CRC treatment is warranted.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Lisa Grech, Alastair Kwok, Mike Nguyen, Antony Winkel, Ernest Butler, Michelle Allan, Nathan Bain, Eva Segelov, MSVACCS Invest
Summary: This study examined the COVID-19 vaccination status, intent, hesitancy, and disease-related beliefs in people with MS. The results showed that most participants had received the COVID-19 vaccine, but some still had hesitations, especially related to their MS symptoms and treatment.
Article
Oncology
Adel Shahnam, Udit Nindra, Jayesh Desai, Rina Hui, Marc Buyse, Ashley M. Hopkins, Michael J. Sorich
Summary: This study evaluated the relationship between progression-free survival (PFS), time to deterioration in quality of life (QOL) or physical function, and overall survival in clinical trials of solid malignancies. The results showed that time to deterioration in physical function had a higher association with overall survival, particularly for immune checkpoint inhibitor treatment. Combining PFS and time to deterioration in physical function may provide better prediction of overall survival benefit in clinical trials of immune checkpoint inhibitors.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Lucjan Wyrwicz, Julien Taieb, Timothy Price, Jean-Baptise Bachet, Meinolf Karthaus, Loick Vidot, Benedicte Chevallier, Timo Reislaender, Lena Weiss, Volker Heinemann
Summary: This study evaluated the association between Eastern Cooperative Oncology Group performance status (ECOG PS) and QLQ-C30 Global Health Status (GHS) in patients with metastatic colorectal cancer (mCRC) receiving trifluridine/tipiracil (FTD/TPI) treatment. The results showed that there was no clinically relevant change in QLQ-C30 GHS score through cycle 7 and 63.0% of patients maintained/improved ECOG PS. The presence of liver metastasis increased the risk of QLQ-C30 GHS score/ECOG PS deterioration.
Article
Oncology
Matthew Anaka, David Chan, Sharon Pattison, Alia Thawer, Bryan Franco, Lesley Moody, Christopher Jackson, Eva Segelov, Simron Singh
Summary: Patients with advanced neuroendocrine tumors have heterogeneous priorities when choosing between treatment options, highlighting the importance of shared decision making for this patient population. Studies suggest that oncologists and patients have different values on treatment attributes, underlining the need for high-quality information to facilitate patient-centered decision making.