Article
Oncology
Atsushi Sugimoto, Tomohisa Okuno, Yuichiro Miki, Gen Tsujio, Tomohiro Sera, Yurie Yamamoto, Shuhei Kushiyama, Sadaaki Nishimura, Kenji Kuroda, Shingo Togano, Koji Maruo, Hiroaki Kasashima, Masaichi Ohira, Masakazu Yashiro
Summary: Peritoneal metastasis of gastric cancer has a poor prognosis, with interactions between gastric cancer cells and peritoneal mesothelial cells potentially playing a key role. Extracellular vesicles (EVs) from peritoneal mesothelial cells (PMCs) were found to promote the invasion of diffuse-type GC cells by stimulating EMMPRIN, which is associated with worse cancer-specific survival and peritoneal-recurrence-free survival. EMMPRIN in EVs from PMCs might be a useful prognostic marker for recurrence in GC patients.
Article
Oncology
Hengfei Gao, Kangkang Ji, Linsen Bao, Hao Chen, Chen Lin, Min Feng, Liang Tao, Meng Wang
Summary: A prediction nomogram for occult peritoneal metastasis in gastric cancer has been developed, which shows excellent diagnostic performance and has the potential to enhance diagnostic accuracy for occult peritoneal metastasis in gastric cancer patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Immunology
Jie Wang, Wei Xia, Yujie Huang, Haoran Li, Yuchen Tang, Ye Li, Bin Yi, Zixiang Zhang, Jian Yang, Zhifei Cao, Jian Zhou
Summary: In this study, a novel risk score model and nomogram were constructed for gastric cancer (GC), showing satisfactory predictive performance. The study also confirmed the association between vascular mimicry (VM) and immune infiltration, and identified SERPINF1 and TFPI2 as immunologic and prognostic biomarkers related to VM in GC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
In-Seob Lee, Heonyi Lee, Hoon Hur, Mitsuro Kanda, Jeong-Hwan Yook, Byung-Sik Kim, Yanghee Woo, Yasuhiro Kodera, Kwangsoo Kim, Ajay Goel
Summary: The study identified a 12-gene panel and a 6-gene panel through genomic analysis for predicting peritoneal recurrence in gastric cancer patients and detecting peritoneal metastasis. Combining tumor morphology and depth of invasion improved the accuracy of the prediction model in both cohorts.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Songyao Chen, Jiannan Xu, Songcheng Yin, Huabin Wang, Guangyao Liu, Xinghan Jin, Junchang Zhang, Huijin Wang, Han Wang, Huan Li, Jianming Liang, Yulong He, Changhua Zhang
Summary: A prognostic model based on the expression of MEF2C and TRIM15 was established and validated using multiple datasets, showing good performance in predicting overall survival in diffuse-type gastric cancer.
Article
Oncology
Shuxiang Chen, Huijuan Zhang, Hong Wei, Yongxiu Tong, Xiaofang Chen
Summary: This study aimed to develop a practical nomogram based on comprehensive CT texture analysis and conventional CT signs to predict occult peritoneal metastasis (PM) in patients with gastric cancer (GC). The study found that specific CT signs and texture features of the primary tumor and peritoneum could be used as independent predictors for occult PM. A nomogram was constructed, and different prediction models were developed. The joint model, including CT signs and texture parameters, showed the best predictive performance. The nomogram demonstrated good consistency between the predicted and observed PM.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shingo Miyamoto, Yoshiko Nagano, Makoto Miyazaki, Yuko Nagamura, Kazuki Sasaki, Takeshi Kawamura, Kazuyoshi Yanagihara, Toshio Imai, Rieko Ohki, Masakazu Yashiro, Masato Tanaka, Ryuichi Sakai, Hideki Yamaguchi
Summary: The study revealed that integrin alpha 5 plays a crucial role in mediating the heterotypic cancer cell-fibroblast interaction during peritoneal dissemination of DGC, suggesting it may be a potential therapeutic target.
Article
Oncology
Jia Yang, Hongtao Su, Tao Chen, Xinhua Chen, Hao Chen, Guoxin Li, Jiang Yu
Summary: This study aimed to develop a clinical radiomics nomogram to better predict peritoneal metastases in patients with gastric cancer. The results showed that the clinical predictive models combined with clinical risk factors and radiomics features had good performance in predicting peritoneal metastasis in gastric cancer.
Article
Oncology
Yanyan Chen, Guoxin Cai, Junjie Jiang, Chao He, Yiran Chen, Yongfeng Ding, Jun Lu, Wenyi Zhao, Yan Yang, Yiqin Zhang, Guanghao Wu, Haiyong Wang, Zhan Zhou, Lisong Teng
Summary: This study examined the heterogeneity of primary and peritoneal metastasis (PM) samples in gastric cancer (GC) patients using quantitative proteomics and whole-exome sequencing. Proteomic features enriched in RNA binding and extracellular exosomes were observed in PM samples. A ten-protein signature was derived by machine learning, which was significantly associated with patient prognosis. This signature could guide risk stratification and individualized treatment.
Article
Surgery
Tadanobu Shimura, Shusuke Toden, Raju Kandimalla, Yuji Toiyama, Yoshinaga Okugawa, Mitsuro Kanda, Hideo Baba, Yasuhiro Kodera, Masato Kusunoki, Ajay Goel
Summary: This study identified five miRNAs that can potentially identify peritoneal metastasis in gastric cancer patients, with three of them showing significant overexpression in primary tumors from patients with peritoneal metastasis. These miRNAs not only distinguished patients with and without peritoneal metastasis, but also associated with poor prognosis. The combination of miRNA signature with Borrmann's type score provided superior diagnostic value in all three cohorts.
Article
Oncology
Annamaria Agnes, Alberto Biondi, Roberto Persiani, Antonio Laurino, Rossella Reddavid, Maurizio De Giuli, Federico Sicoli, Ferdinando Cananzi, Stefano De Pascale, Uberto Fumagalli, Federica Galli, Stefano Rausei, Laura Lorenzon, Domenico D'Ugo
Summary: Two risk models (PERI-Gastric 1 and 2) were developed to assess the risk of peritoneal recurrence after curative-aim gastrectomy, based on multivariable logistic regression results and discrimination evaluation using the area under the receiver operating curve. These models could guide the use of prophylactic treatments.
Article
Biotechnology & Applied Microbiology
Liqiang Zhou, Hao Lu, Fei Zeng, Qi Zhou, Shihao Li, You Wu, Yiwu Yuan, Lin Xin
Summary: The research team identified multiple genes associated with prognosis in gastric cancer through analysis of original sequencing data, and constructed a prognostic risk proportion signature, confirming its moderate predictive ability in gastric cancer prognosis. Verification through calibration curve showed higher prediction accuracy.
Article
Oncology
Xian-qing Song, Zhi-xian Liu, Qing-yuan Kong, Zhen-hua He, Sen Zhang
Summary: This study successfully developed and validated a nomogram for effectively predicting the risk of peritoneal metastasis in colorectal cancer, providing a basis for early diagnosis. Through a retrospective analysis of 1284 patients with colorectal cancer, independent risk factors influencing peritoneal metastasis risk were identified. Internal validation showed that the nomogram has high predictive accuracy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xianhe Shen, Huilan Liu, Haihua Zhou, Zhiyi Cheng, Guiyuan Liu, Chuanjiang Huang, Rongrong Dou, Fuxing Liu, Xiaolan You
Summary: This study revealed the regulatory role of Galectin-1 in gastric cancer (GC) cell peritoneal metastasis. Galectin-1 enhanced the adhesion ability of GC cells to peritoneal mesothelial cells and promoted the expression of collagen, leading to the occurrence of peritoneal metastasis.
Article
Oncology
Zifeng Yang, Yong Li, Xiusen Qin, Zejian Lv, Huaiming Wang, Deqing Wu, Zixu Yuan, Hui Wang
Summary: A predictive nomogram was developed using multicenter data to predict the overall survival in CRC patients with S-PM, showing good discriminative ability and high accuracy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Jiahui Yuan, Xiaomei Li, Yuqi Zhang, Gongye Zhang, Weipeng Cheng, Weiwei Wang, Yongbin Lei, Gang Song
Summary: This study reveals that USP39 is associated with the sensitivity of colon cancer cells to Cisplatin. Depletion of USP39 enhances Cisplatin-induced apoptosis, while overexpression of USP39 attenuates apoptosis. Further studies demonstrate that USP39 depletion promotes apoptosis induced by Cisplatin, which is related to the induction of oxidative stress and DNA damage response. Additionally, the regulation of USP39 depends on p53, as knocking down USP39 results in p53 upregulation and prolonged half-life.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
En Long, Dongling You, Shubin Wang, Shun Lu, Peng Xu, Jie Zhou, Lu Li, Jian Wu, Biqin Zhang, Guiquan Zhu, Jinyi Lang
Summary: This study investigates the prognostic factors and treatment of primary intraosseous carcinoma (PIOC). The results suggest that surgery combined with adjuvant therapy is the superior treatment strategy for PIOC, and radiotherapy plays a positive role in the treatment of PIOC.
Article
Oncology
Mili Zhang, Can Cao, Xu Li, Qisheng Gu, Yixin Xu, Ziyan Zhu, Duogang Xu, Shanshan Wei, Haonan Chen, Yuqin Yang, Hugh Gao, Liang Yu, Jikun Li
Summary: This study identified the EMT signaling pathway as a representative pathway for predicting the survival of MSI-H gastric cancer (GC) patients. A novel five-gene signature (CALU, PCOLCE2, PLOD2, SGCD, and THBS2) was established from the EMT signaling gene set for disease outcome prediction. The five genes were found to be abundantly expressed in cancer-associated fibroblasts, and patients with different risk groups based on the five-gene signature showed distinct patterns of tumor immune microenvironment.
Editorial Material
Dermatology
Zhijun Zhou, Na Li, Huicheng Li, Luhuai Shi, Yangmin Gao, Weijun Liu, Xiaobing Wang, Hua Qian, Xiaoguang Li
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Liangdeng Yu, Sakhorn Rimjaem
Summary: This article discusses the development of mid-infrared free-electron laser and terahertz (THz) radiation, with a focus on THz safety and its association with 5G safety. It is pointed out that radiation safety depends not only on photon energy but also on radiation power. The study confirms the safety of 5G based on the currently used transmission station power, while the safety of THz is still uncertain. Further research suggestions are provided.
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Yuzhu Wang, Peng Wang, Hao Wang, Bingqian Xu, Hui Li, Mo Cheng, Wang Feng, Ruofan Du, Luying Song, Xia Wen, Xiaohui Li, Junbo Yang, Yao Cai, Jun He, Zhenxing Wang, Jianping Shi
Summary: An ingenious space-confined chemical vapor deposition strategy was used to synthesize atomically thin non-layered epsilon-Fe2O3 single crystals and revealed the room-temperature long-range ferrimagnetic order. Strong ferroelectricity and its switching behavior were discovered in atomically thin epsilon-Fe2O3, along with an anomalous thickness-dependent coercive voltage. The robust room-temperature magnetoelectric coupling was uncovered by controlling the magnetism with an electric field, demonstrating the multiferroic feature of atomically thin epsilon-Fe2O3. This work represents a substantial leap in the controllable synthesis of 2D multiferroics with robust magnetoelectric coupling, and also paves the way for practical applications in low-energy-consumption electric-writing/magnetic-reading devices.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Bo Jiang, Wang Yang, Chaonan Wang, Hengxuan Bai, Guang Ma, Zhengxuan Li, Chengxiao Zhang, Siyuan Li, Neng Chen, Na Ta, Xiaobai Wang, Yongfeng Li
Summary: In this study, novel bamboo-like carbon nanotubes wrapped with controllable-sized Co magnetic nanoparticles were successfully prepared. The electromagnetic wave absorbing properties of the material were effectively tuned by adjusting filler loading, calcination temperature, and template usage. The optimized Co@CNT exhibited superior absorption performance and improved stability through hydrophobic modification.
Article
Chemistry, Physical
Yu Zhou, Xinyu Song, Shenggang Yan, Chunhua Ni, Li Xu, Liangmin Yu, Xia Li
Summary: Biomass-derived carbon is highly valued for its unique form, wide range of sources, and low cost. However, the construction of efficient biomass-based microwave absorbers with hierarchical structures and multicomponent magnetic/dielectric structures is still a significant challenge. In this study, CoNi-MOF was self-assembled in situ on Juncus effusus, and CoNi/NC/C composites were prepared by in situ pyrolysis. The morphology, electromagnetic parameters, specific surface area, and porous structure of the composites were controlled by the pyrolysis temperature. The composite exhibited excellent microwave absorption performance, attributed to various mechanisms such as conduction loss, dipole polarization, interface polarization, magnetic loss, and impedance matching.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Plant Sciences
Zhi-Hao Dong, Anoop Kumar Srivastava, Qi-Ling Tan, Muhammad Riaz, Xiao-Le Lv, Xiao-Dong Liu, Yu Gao, Min Chen, Guo-Zhen Gao, Xue-Cheng Sun, Song-Wei Wu, Cheng-Xiao Hu
Summary: The amount and time of fertilization are crucial for the quality and yield of citrus. This study demonstrates that the proportion of spring fertilization, particularly 80/20, significantly affects fruit yield and quality, with higher overall nutrient concentrations and increased yield.
JOURNAL OF PLANT NUTRITION
(2023)
Article
Astronomy & Astrophysics
Haoxuan Jiang, Jianghui Ji, Liangliang Yu, Bin Yang, Shoucun Hu, Yuhui Zhao
Summary: In this study, Interamnia, one of the largest asteroids in the outer main-belt region, was observed and analyzed using data from multiple telescopes. The analysis revealed the presence of water ice beneath its surface, along with details about its thermal properties and surface characteristics. The study also provided insights into the seasonal and diurnal temperature variations on Interamnia, as well as estimates of the volume fraction of water ice present on the asteroid.
ASTROPHYSICAL JOURNAL
(2023)
Article
Thermodynamics
Wei Zhou, Yueying Liang, Xinzhe Pei, Yongxiang Zhang, Liang Yu, Xingcai Lu
Summary: The autoignition characteristics of methyl palmitate, a waxy solid at room temperature, were investigated using a heated rapid compression machine. The results showed that the increase in compressed pressure, equivalence ratio, and oxygen mole fraction had a negative effect on ignition delay times, and the dependence on compressed pressure and equivalence ratio decreased with increasing temperature. The simulation results revealed a negative temperature coefficient (NTC) behavior at compressed temperatures of 780-830 K.
COMBUSTION AND FLAME
(2023)
Article
Agronomy
Jie Cheng, Lin Zhu, Fang Zhu, Peng Zhao, Qiong-Xi Li, Zi-Hang Lu, Song-Dou Zhang, Zhen Li, Xiao-Xia Liu
Summary: A study found that the antioxidant protein GmolPrx1 secreted by the male accessory gland plays a crucial role in protecting and maintaining the quality of stored sperm in Grapholita molesta females. Knocking down GmolPrx1 significantly reduces fertility and impairs sperm quality. This finding may have implications for controlling G. molesta populations by manipulating male reproductive genes.
PEST MANAGEMENT SCIENCE
(2023)
Article
Chemistry, Applied
Yi Qin, Guangling He, Yunlong Li, Yuhua Liu, Wenyan Liu, Lei Dong, Liangmin Yu, Li Wang
Summary: Composite amphiphilic hydrogel anti-fouling materials were prepared by mixing two different hydrogel prepolymers, which strengthened adhesion and improved anti-fouling performance through the hydrophobic and hydrophilic interactions.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Chemistry, Physical
Enhui He, Liying Xue, Zheng Wang, Xuefeng Yan, Liangmin Yu
Summary: Nowadays, multifunction is considered as an advanced development direction for new-generation electromagnetic wave absorption (EMWA) materials to meet the increasing demands in complex environments. Environmental pollution and electromagnetic pollution have always been difficult problems for humans. However, there are currently no multifunctional materials available for the simultaneous treatment of environmental and electromagnetic pollution. Therefore, this study opens up new possibilities for the development of multifunctional materials to address these issues.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Siyuan Sun, Weijie Bao, Fan Yang, Xingru Yan, Yang Sun, Ge Zhang, Wang Yang, Yongfeng Li
Summary: A novel strategy was developed to fabricate FeNx-doped carbon quantum dots (Fe-N-CQDs) for selective detection of Cu2+ ions as a fluorescence probe. The Fe-N-CQDs were synthesized through efficient electrolysis of a carbon cloth electrode, which was coated with monoatomic iron-anchored nitrogen-doped carbon (Fe-N-C). The obtained Fe-N-CQDs showed blue fluorescence with a quantum yield (QY) of 7.5% and exhibited a wide linear relationship between Cu2+ concentration and fluorescence intensity.
GREEN ENERGY & ENVIRONMENT
(2023)