Review
Oncology
Ram Kumar Sahu, Sakina Ruhi, Ashok Kumar Jeppu, Husni Ahmed Al-Goshae, Ayesha Syed, Sanjay Nagdev, Retno Widyowati, Wiwied Ekasari, Jiyauddin Khan, Bedanta Bhattacharjee, Manoj Goyal, Sankha Bhattacharya, Rajendra K. Jangde
Summary: Malignant mesothelioma is a rare and aggressive tumor that develops in the mesothelium layer and is highly resistant to standard treatments. Despite the worldwide ban on asbestos, the prevalence of mesothelioma continues to increase. Diagnosis and treatment of mesothelioma are challenging, and current treatments are largely ineffective. However, recent advances in understanding the genetics and molecular pathophysiology of mesothelioma have been made, particularly in the hippo signaling pathway.
FRONTIERS IN ONCOLOGY
(2023)
Review
Genetics & Heredity
Chiara Villa, Andrea Stoccoro
Summary: Alzheimer's disease is a progressive neurodegenerative disorder that leads to cognitive impairment and dementia in older individuals. Detection of altered epigenetic signatures in blood may assist in the early diagnosis and treatment of the disease.
Article
Medicine, General & Internal
Muzaffer Metintas, Guntulu Ak, Cansu Ozbayer, Filiz Bogar, Selma Metintas
Summary: miRNAs may have potential clinical value in the diagnosis and prognosis of patients with MPM.
BALKAN MEDICAL JOURNAL
(2022)
Article
Oncology
Federica Monaco, Laura De Conti, Simone Vodret, Nunzia Zanotta, Manola Comar, Sandra Manzotti, Corrado Rubini, Laura Graciotti, Gianluca Fulgenzi, Massimo Bovenzi, Marco Baralle, Marco Tomasetti, Lory Santarelli
Summary: This study proposes a novel miRNA-based therapy approach to target malignant pleural mesothelioma (MPM) by increasing stemness and inhibiting cell proliferation. It is found that by inhibiting the release of exosomes, miR-126 can accumulate intracellularly and induce cell death and tumor growth arrest. Autophagy and necroptosis are involved in these processes, suggesting the potential of this therapy against cancer stem cells (CSCs).
TRANSLATIONAL ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Ilona Juchnicka, Mariusz Kuzmicki, Magdalena Niemira, Agnieszka Bielska, Iwona Sidorkiewicz, Monika Zbucka-Kretowska, Adam Jacek Kretowski, Jacek Szamatowicz
Summary: This study investigates the changes in miRNA profile in gestational diabetes mellitus (GDM) patients before the onset of hyperglycemia. Circulating miRNAs were measured using the NanoString quantitative assay platform and validated with real-time polymerase chain reaction (RT-PCR). The results demonstrate the significance of miRNAs in the pathophysiology of GDM and their potential as predictive factors for early diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Alex Dipper, Nick Maskell, Anna Bibby
Summary: Malignant pleural mesothelioma (MPM) presents diagnostic challenges, with ancillary diagnostic tests such as immunocytochemical markers, molecular techniques, diagnostic biomarkers, and imaging discussed in cases where histological samples are unavailable or inconclusive. While no single adjunctive test has the sensitivity and specificity to diagnose MPM in isolation, correlation of pleural fluid cytology with radiology and biomarkers can help make an MDT-consensus diagnosis when invasive tests are not feasible.
Review
Oncology
Lei Zhang, Qianghua Zhou, Yan-Qiu Han, Peng Li, Pei-Heng Ouyang, Mei-Ying Wang, Zhi-De Hu
Summary: The pooled diagnostic sensitivity and specificity of circulating miR-126 for MPM were 0.71 and 0.69, respectively. However, there was a high risk of bias in the quality of the studies, indicating the need for further rigorous research.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Edvan do Carmo Santos, Gabriela Imbassahy Valentim Melo, Paulo Vinicius Bispo Santana, Idaiara Graziele Silva Quadros, Setondji Cocou Modeste Alexandre Yahouedehou, Caroline Conceicao da Guarda, Rayra Pereira Santiago, Luciana Magalhaes Fiuza, Suellen Pinheiro Carvalho, Elisangela Vitoria Adorno, Carla Martins Kaneto, Teresa Cristina Cardoso Fonseca, Marilda Souza Goncalves, Milena Magalhaes Aleluia
Summary: This study demonstrates that elevated expression of circulating miR-199a-5p and miR-144 and reduced expression of miR-126 are associated with sickle leg ulcers (SLU) and hemolytic biomarkers. These microRNAs have potential diagnostic and prognostic value in SLU and may play a role in the pathophysiology of the disease.
Article
Biochemistry & Molecular Biology
Elizabeth Cordoba-Lanus, Angelica Dominguez de-Barros, Alexis Oliva, Delia Mayato, Francisca Gonzalvo, Ana Remirez-Sanz, Javier J. Zulueta, Bartolome Celli, Ciro Casanova
Summary: This study aimed to identify potential miRNAs as biomarkers for early detection of lung cancer (LC) in chronic obstructive pulmonary disease (COPD) patients. Over 170 miRNAs were identified, and miR-1246 and miR-206 were found to be significantly dysregulated in COPD patients who developed LC three years before diagnosis. In silico analysis showed that miR-1246 and miR-206 are linked to cancer-related signaling pathways. These findings suggest that miR-1246 and miR-206 have potential value as non-invasive biomarkers for early LC detection in COPD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Emily S. Reardon, Vivek Shukla, Sichuan Xi, Sudheer K. Gara, Yi Liu, David Straughan, Mary Zhang, Julie A. Hong, Eden C. Payabyab, Anju Kumari, William G. Richards, Assunta De Rienzo, Raffit Hassan, Markku Miettinen, Liqiang Xi, Mark Raffeld, Lisa T. Uechi, Xinmin Li, Ruihong Wang, Haobin Chen, Chuong D. Hoang, Raphael Bueno, David S. Schrump
Summary: The study revealed the significant role of UHRF1 in malignant pleural mesothelioma (MPM), with its overexpression affecting patient survival. Experiments such as RNA sequencing showed that inhibiting UHRF1 can reduce DNA hypomethylation, inhibit the growth and spread of MPM cells, and correspond with certain chemotherapeutic agents.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Review
Pathology
Mai A. Abd-Elmawla, Sherif S. Abdel Mageed, Tohada M. AL-Noshokaty, Mohammed S. Elballal, Ahmed I. Abulsoud, Shereen Saeid Elshaer, Ahmed A. El-Husseiny, Doaa Fathi, Heba M. Midan, Nehal I. Rizk, Mahmoud A. Elrebehy, Ghadir A. Sayed, Manar Mohammed El Tabaa, Aya Salman, Osama A. Mohammed, Alaa Ashraf, Emad Gamil Khidr, Reem Khaled, Walaa A. El-Dakroury, Gouda Kamel Helal, Yasser M. Moustafa, Ahmed S. Doghish
Summary: This review summarizes and analyzes the latest scholarly investigations on the role of miRNAs in the dysregulation leading to MPM and their potential clinical usefulness as diagnostic and prognostic biomarkers for MPM.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Dilek Yonar, Mete Severcan, Rafig Gurbanov, Abdulsamet Sandal, Ulku Yilmaz, Salih Emri, Feride Severcan
Summary: This study successfully developed a new approach for the characterization and diagnosis of malignant pleural mesothelioma (MPM) among lung diseases using Fourier transform infrared spectroscopy (FTIR) coupled with multivariate analysis. The results showed that the MPM group could be successfully differentiated from healthy, benign exudative effusion, and lung cancer groups based on the changes in lipid biosynthesis and nucleic acids levels in the malignant serum samples.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Oncology
Barbara Cardinali, Roberta Tasso, Patrizia Piccioli, Maria Chiara Ciferri, Rodolfo Quarto, Lucia Del Mastro
Summary: This review discusses the potential application of circulating microRNAs (miRNAs) as diagnostic and monitoring biomarkers in breast cancer. It highlights the advantages and challenges that need to be addressed. Although further studies are needed to support their clinical utility, miRNAs could represent novel tools for breast cancer management.
Article
Genetics & Heredity
Xiaotong Duan, Simiao Qiao, Dianhe Li, Shangbiao Li, Zhihao Zheng, Qin Wang, Xiaoxia Zhu
Summary: The combination of miR-492, miR-590-3p, and miR-631 can effectively distinguish healthy individuals from early-stage NSCLC patients, making them promising serum biomarkers for the early diagnosis of NSCLC.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Dario Di Stasio, Antonio Romano, Ciro Emiliano Boschetti, Marco Montella, Laura Mosca, Alberta Lucchese
Summary: Management of potentially malignant oral disorders is a challenge. The study found that miR-181b is upregulated in high-grade dysplasia and downregulated in oral squamous cell carcinoma, suggesting its potential as a salivary biomarker for dysplasia. Further studies are needed to confirm the feasibility of miR-27b and miR-181b as biomarkers.
Article
Environmental Sciences
Renata Alleva, Nicola Manzella, Simona Gaetani, Tiziana Bacchetti, Massimo Bracci, Veronica Ciarapica, Federica Monaco, Battista Borghi, Monica Amati, Gianna Ferretti, Marco Tomasetti
ENVIRONMENTAL TOXICOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Md. Abu Sayeed, Massimo Bracci, Veronica Ciarapica, Marco Malavolta, Mauro Provinciali, Ernesta Pieragostini, Simona Gaetani, Federica Monaco, Guendalina Lucarini, Venerando Rapisarda, Roberto Di Primio, Lory Santarelli
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Oncology
Marco Tomasetti, Massimo Re, Federica Monaco, Simona Gaetani, Corrado Rubini, Andrea Bertini, Ernesto Pasquini, Cristiana Bersaglieri, Massimo Bracci, Sara Staffolani, Mariastella Colomba, Armando Gregorini, Matteo Valentino, Adriano Tagliabracci, Massimo Bovenzi, Jiri Neuzil, Monica Amati, Lory Santarelli
Article
Oncology
Lory Santarelli, Simona Gaetani, Federica Monaco, Massimo Bracci, Matteo Valentino, Monica Amati, Corrado Rubini, Armando Sabbatini, Ernesto Pasquini, Nunzia Zanotta, Manola Comar, Jiri Neuzil, Marco Tomasetti, Massimo Bovenzi
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2019)
Article
Public, Environmental & Occupational Health
Simona Gaetani, Federica Monaco, Massimo Bracci, Veronica Ciarapica, Giulia Impollonia, Matteo Valentino, Marco Tomasetti, Lory Santarelli, Monica Amati
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2018)
Article
Oncology
Federica Monaco, Simona Gaetani, Federica Alessandrini, Adriano Tagliabracci, Massimo Bracci, Matteo Valentino, Jiri Neuzil, Monica Amati, Massimo Bovenzi, Marco Tomasetti, Lory Santarelli
Article
Endocrinology & Metabolism
Jessica Perugini, Eleonora Di Mercurio, Giovanni Tossetta, Ilenia Severi, Federica Monaco, Marcella Reguzzoni, Marco Tomasetti, Christian Dani, Saverio Cinti, Antonio Giordano
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Simona Gaetani, Federica Monaco, Federica Alessandrini, Adriano Tagliabracci, Armando Sabbatini, Massimo Bracci, Matteo Valentino, Jiri Neuzil, Monica Amati, Lory Santarelli, Marco Tomasetti
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2020)
Article
Psychiatry
Simona Gaetani, Luca Galzignati, Michela Marcati, Paola Durazzi, Adalgisa Cianella, Valentina Mocheggiani, Federica Monaco, Massimo Bracci, Jiri Neuzil, Marco Tomasetti, Monica Amati, Lory Santarelli
Summary: This study examines the association between psychological distress and radiation exposure as a work-related stressor with mitochondrial function in health care professionals. The results indicate that high psychological distress is associated with lower mitochondrial biogenesis, while exposure to toxic agents (radiation) is primarily associated with mitochondrial metabolism and reduced mtDNA integrity.
PSYCHOSOMATIC MEDICINE
(2022)
Article
Otorhinolaryngology
Massimo Re, Marco Tomasetti, Federica Monaco, Monica Amati, Corrado Rubini, Giacomo Sollini, Arisa Bajraktari, Federico Maria Gioacchini, Lory Santarelli, Ernesto Pasquini
Summary: The study identified that high expression of miR-205 and miR-34c/miR-449 cluster is associated with poor prognosis in patients with ITAC, serving as significant prognostic predictors.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Massimo Re, Marco Tomasetti, Federica Monaco, Monica Amati, Corrado Rubini, Maria P. Foschini, Giacomo Sollini, Federico Maria Gioacchini, Ernesto Pasquini, Lory Santarelli
Summary: The study identified a miRNA cluster in sinonasal inverted papilloma (SNIP) that may help evaluate the risk of transformation into sinonasal squamous cell carcinoma (SNSCC). The miR-449 cluster was found to be upregulated in SNIP and significantly downregulated in SNSCC, suggesting its involvement in the molecular pathogenesis of SNIP and its malignant transformation.
Article
Respiratory System
Albero Murrone, Luca Cantini, Federica Pecci, Valeria Cognigni, Cecilia Copparoni, Silvia Rinaldi, Ilaria Fiordoliva, Federica Monaco, Corrado Rubini, Francesca Barbisan, Alessia Cimadamore, Riccardo Giampieri, Francesca Bianchi, Marco Tomasetti, Monica Amati, Lory Santarelli, Rossana Berardi
Summary: This study found that simultaneous assessment of BAP1 status and miR-31 levels may improve prognostic stratification in e-MPM patients, with BAP1 loss and lower miR-31 levels being associated with better clinical outcomes. The combination of BAP1 and miR-31 was identified as an independent prognostic factor for e-MPM patients, providing valuable information for personalized treatment strategies.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Oncology
Federica Monaco, Laura De Conti, Simone Vodret, Nunzia Zanotta, Manola Comar, Sandra Manzotti, Corrado Rubini, Laura Graciotti, Gianluca Fulgenzi, Massimo Bovenzi, Marco Baralle, Marco Tomasetti, Lory Santarelli
Summary: This study proposes a novel miRNA-based therapy approach to target malignant pleural mesothelioma (MPM) by increasing stemness and inhibiting cell proliferation. It is found that by inhibiting the release of exosomes, miR-126 can accumulate intracellularly and induce cell death and tumor growth arrest. Autophagy and necroptosis are involved in these processes, suggesting the potential of this therapy against cancer stem cells (CSCs).
TRANSLATIONAL ONCOLOGY
(2022)
Article
Biology
Marco Tomasetti, Federica Monaco, Olga Strogovets, Luca Volpini, Matteo Valentino, Monica Amati, Jiri Neuzil, Lory Santarelli
Summary: By evaluating the levels of autophagic factors ATG5 and HMGB1, miRNAs such as miR-126 and miR-222, and the specific biomarker Mesothelin in asbestos-exposed individuals, MPM patients, and healthy subjects, we found that ATG5 is a potential asbestos-related biomarker that can detect MPM with high sensitivity and specificity up to two years before diagnosis.
BMC RESEARCH NOTES
(2023)
