Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [18F]FAZA PET In Vivo

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

[18F]-FMISO PET study of hypoxia in gliomas before surgery: correlation with molecular markers of hypoxia and angiogenesis

(2017) Lien Bekaert et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In Vivo Relationship Between Hypoxia and Angiogenesis in Human Glioblastoma: A Multimodal Imaging Study

(2017) Keven Ferreira da Ponte et al.   JOURNAL OF NUCLEAR MEDICINE

ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells

(2017) Giulia Cesi et al.   Molecular Cancer

Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit

(2017) Claudia R. Oliva et al.   Oncotarget

The Warburg effect: 80 years on

(2016) Michelle Potter et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Hallmarks of cancer stem cell metabolism

(2016) Patricia Sancho et al.   BRITISH JOURNAL OF CANCER

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Genotypes Affecting the Pharmacokinetics of Anticancer Drugs

(2016) Daphne Bertholee et al.   CLINICAL PHARMACOKINETICS

Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype

(2016) Gregg L Semenza   EMBO JOURNAL

Identification of Small Molecule Inhibitors of Human CytochromecOxidase That Target Chemoresistant Glioma Cells

(2016) Claudia R. Oliva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measurement of Tumor Hypoxia in Patients with Advanced Pancreatic Cancer Based on 18F-Fluoroazomyin Arabinoside Uptake

(2016) C. Metran-Nascente et al.   JOURNAL OF NUCLEAR MEDICINE

SF2312 is a natural phosphonate inhibitor of enolase

(2016) Paul G Leonard et al.   Nature Chemical Biology

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

(2015) S. Sriskanthadevan et al.   BLOOD

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

(2015) Kıvanç Birsoy et al.   CELL

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

(2015) Patricia Sancho et al.   Cell Metabolism

Molecular Pathways: A Novel Approach to Targeting Hypoxia and Improving Radiotherapy Efficacy via Reduction in Oxygen Demand

(2015) A. Lin et al.   CLINICAL CANCER RESEARCH

Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

(2015) Katherine Sellers et al.   JOURNAL OF CLINICAL INVESTIGATION

Assessment of hypoxic subvolumes in laryngeal cancer with 18F-fluoroazomycinarabinoside (18F-FAZA)-PET/CT scanning and immunohistochemistry

(2015) Leonie Bruine de Bruin et al.   RADIOTHERAPY AND ONCOLOGY

Importance of Glutamine Metabolism in Leukemia Cells by Energy Production Through TCA Cycle and by Redox Homeostasis

(2014) Mineaki Goto et al.   CANCER INVESTIGATION

Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1  and Oxidative Phosphorylation in Melanoma

(2014) Y. N. V. Gopal et al.   CANCER RESEARCH

18F-FAZA PET Imaging Response Tracks the Reoxygenation of Tumors in Mice upon Treatment with the Mitochondrial Complex I Inhibitor BAY 87-2243

(2014) E. Chang et al.   CLINICAL CANCER RESEARCH

A prospective clinical study of 18 F-FAZA PET-CT hypoxia imaging in head and neck squamous cell carcinoma before and during radiation therapy

(2014) Stéphanie Servagi-Vernat et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

Pyruvate Induces Transient Tumor Hypoxia by Enhancing Mitochondrial Oxygen Consumption and Potentiates the Anti-Tumor Effect of a Hypoxia-Activated Prodrug TH-302

(2014) Yoichi Takakusagi et al.   PLoS One

Detecting functional changes with [18F]FAZA in a renal cell carcinoma mouse model following sunitinib therapy

(2014) David W Chapman et al.   EJNMMI Research

Oxygen consumption dynamics in steady-state tumour models

(2014) D. R. Grimes et al.   Royal Society Open Science

Quantitative mapping of hemodynamics in the lung, brain, and dorsal window chamber-grown tumors using a novel, automated algorithm

(2013) Andrew N. Fontanella et al.   MICROCIRCULATION

Catabolism of Exogenous Lactate Reveals It as a Legitimate Metabolic Substrate in Breast Cancer

(2013) Kelly M. Kennedy et al.   PLoS One

Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma

(2012) Pilar Caro et al.   CANCER CELL

Hypoxia-Induced Gene Expression in Chemoradioresistant Cervical Cancer Revealed by Dynamic Contrast-Enhanced MRI

(2012) C. Halle et al.   CANCER RESEARCH

18F-Fluoromisonidazole positron emission tomography may differentiate glioblastoma multiforme from less malignant gliomas

(2012) Kenji Hirata et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Image-Guided PO2 Probe Measurements Correlated with Parametric Images Derived from 18F-Fluoromisonidazole Small-Animal PET Data in Rats

(2012) R. M. Bartlett et al.   JOURNAL OF NUCLEAR MEDICINE

Passenger deletions generate therapeutic vulnerabilities in cancer

(2012) Florian L. Muller et al.   NATURE

Hypoxia imaging with the nitroimidazole 18F-FAZA PET tracer: A comparison with OxyLite, EPR oximetry and 19F-MRI relaxometry

(2012) Ly-Binh-An Tran et al.   RADIOTHERAPY AND ONCOLOGY

FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: Results from the DAHANCA 24 trial

(2012) Lise Saksø Mortensen et al.   RADIOTHERAPY AND ONCOLOGY

Highlighting the versatility of the tracerlab synthesis modules. Part 1: fully automated production of [18F]labelled radiopharmaceuticals using a Tracerlab FXFN

(2011) Xia Shao et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

In vivo oxygen-17 NMR for imaging brain oxygen metabolism at high field

(2011) Xiao-Hong Zhu et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Theoretical analysis of the dose dependence of the oxygen enhancement ratio and its relevance for clinical applications

(2011) Tatiana Wenzl et al.   Radiation Oncology

Evaluating repetitive18F-fluoroazomycin-arabinoside (18FAZA) PET in the setting of MRI guided adaptive radiotherapy in cervical cancer

(2010) Matthias Schuetz et al.   ACTA ONCOLOGICA

Oligomycin-induced Bioenergetic Adaptation in Cancer Cells with Heterogeneous Bioenergetic Organization

(2010) Wenshan Hao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Iron Uptake Is Responsible for Differential Sensitivity to V-ATPase Inhibitors in Several Cancer Cell Lines

(2010) Sarah Straud et al.   PLoS One

Pharmacologically Increased Tumor Hypoxia Can Be Measured by 18F-Fluoroazomycin Arabinoside Positron Emission Tomography and Enhances Tumor Response to Hypoxic Cytotoxin PR-104

(2009) R. A. Cairns et al.   CLINICAL CANCER RESEARCH

Initial results of hypoxia imaging using 1-α-d-(5-deoxy-5-[18F]-fluoroarabinofuranosyl)-2-nitroimidazole (18F-FAZA)

(2009) Ernst J. Postema et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Complex I Is Rate-limiting for Oxygen Consumption in the Nerve Terminal

(2009) Jayne E. Telford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular Imaging of Hypoxia

(2008) K. A. Krohn et al.   JOURNAL OF NUCLEAR MEDICINE