Article
Medicine, Research & Experimental
Yan Sun, Lang Xiong, Xiaoran Wang, Liping Wang, Baoxin Chen, Jingqi Huang, Mi Huang, Jieping Chen, Jing Wu, Shan Huang, Yizhi Liu
Summary: This study demonstrated that TGF-beta 2 induces autophagy flux during EMT progression of LECs, with autophagy activation enhancing fibrogenic responses and cell migration, while autophagy inhibition alleviates EMT markers and cell migration. Additionally, modulation of Smad signaling by autophagy was observed, and ATG7-silenced LECs showed antifibrosis effect induced by TGF-beta 2. Overall, intervention/inhibition of autophagy could attenuate TGF-beta 2-induced EMT in LECs, providing insights for preventing and treating fibrotic cataracts and other fibrotic diseases.
Article
Medicine, Research & Experimental
Ning Zhao, Minwei He, Wei Chen, Peng Jin, Lulu Cao, Jinhai Deng, Xu Cheng, Lu Wang
Summary: Our study identified FAM96A as a crucial regulator of tumor metastasis and epithelial-mesenchymal transition (EMT) by inhibiting the TGF-beta signaling pathway.
Article
Multidisciplinary Sciences
Shunhao Wang, Jingchao Li, Mei Chen, Liting Ren, Wenya Feng, Lining Xu, Xiaolan Chen, Tian Xia, Nanfeng Zheng, Sijin Liu
Summary: Palladium nanoplates inhibit lung metastasis by suppressing EMT signaling in breast cancer cells and interacting with TGF-beta proteins, leading to reduced downstream signaling activation. NIR irradiation enhances the inhibitory effects of PdPL on both primary tumors and metastasis.
NATIONAL SCIENCE REVIEW
(2021)
Article
Pharmacology & Pharmacy
Maha-Hamadien Abdulla, Aminah Ahmad Alzailai, Mansoor-Ali Vaali-Mohammed, Rehan Ahmad, Sabiha Fatima, Ahmed Zubaidi, Thamer bin Traiki, Amer Mahmood, Reem Hamoud Alrashoudi, Zahid Khan
Summary: This study investigated the impact of a novel platinum complex on the invasion and migration of colorectal cancer cell lines. The results showed that the complex reduced cell motility and the expression of EMT markers involved in cell invasion and migration. This complex can potentially be used as an effective treatment for reducing metastasis in colorectal cancer.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Young Yun Jung, Chakrabhavi Dhananjaya Mohan, Huiyan Eng, Acharan S. Narula, Ojas A. Namjoshi, Bruce E. Blough, Kanchugarakoppal S. Rangappa, Gautam Sethi, Alan Prem Kumar, Kwang Seok Ahn
Summary: This study demonstrates that 2,3,5,6-Tetramethylpyrazine (TMP) can suppress the EMT program in colon cancer cells by regulating MnSOD and related proteins, and inhibit the proliferation, migration, and invasion of tumor cells.
Article
Oncology
Xiaowu Liu, Guannan Zhao, Xueyun Huo, Yaohong Wang, Gabor Tigyi, Bing-Mei Zhu, Junming Yue, Wenjing Zhang
Summary: Adipose-derived stem cells (ADSC) play a promoting role in ovarian cancer metastasis by inducing epithelial to mesenchymal transition (EMT) in OC cells, leading to proliferation, survival, migration, and invasion. Experimental evidence shows that ADSC contributes to ovarian tumor growth and metastasis by activating the TGF-beta pathway. Targeting ADSC with TGF-beta inhibitor has therapeutic potential in blocking EMT and OC metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Katsuhiko Warita, Takuro Ishikawa, Akihiro Sugiura, Jiro Tashiro, Hiroaki Shimakura, Yoshinao Z. Hosaka, Ken-ichi Ohta, Tomoko Warita, Zoltan N. Oltvai
Summary: Statins, such as atorvastatin, can delay metastasis formation in vivo and attenuate the growth and proliferation of tumor cells, especially in those with a mesenchymal-like phenotype. In epithelial cancer cells treated with TGF-beta, atorvastatin-induced growth inhibition is stronger, and pre-treatment with atorvastatin can enhance this effect further by reducing HMGCR expression. Targeting HMGCR pharmacologically can strongly inhibit the growth of epithelial cancer cells treated with TGF-beta and potentially improve statin therapy-mediated attenuation of metastasis formation in vivo.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yue Pu, Yao Wu, Yan Zhou, Li-hong Wan
Summary: Azithromycin (AZM) targets RACK1 to inhibit TGF-beta 1 mediated EMT in bronchial epithelial cells, leading to the suppression of cell migration and reversal of EMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Lauren A. Griggs, Christopher A. Lemmon
Summary: Epithelial to Mesenchymal Transition (EMT) is a process in which epithelial cells transition to a motile and invasive mesenchymal phenotype. The EMT process is associated with an increase in fibronectin (FN) assembly and the localization of Transforming Growth Factor-beta 1 (TGF-beta 1) to FN fibrils. This study investigated the spatial gradients of EMT and FN fibrillogenesis in mammary epithelial cells cultured on square micropatterns in response to TGF-beta 1. The results showed that increasing TGF-beta 1 concentration induced a spatial gradient of both E-Cadherin and FN fibrils, and inhibition of FN fibril assembly globally reduced both E-Cadherin-containing adherens junctions and FN fibrillogenesis, but did not eliminate the spatial gradients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Integrative & Complementary Medicine
Mo Jie, Zhao-Qi Zhang, Ning Deng, Qiu-Meng Liu, Chao Wang, Qian-Yun Ge, Peng-Chen Du, Sha-Sha Song, Xue-Wu Zhang, Long-Xin, Hui-Fang Liang, Liang Chu, Lei Mang, Xiao-Ping Chen, Jin Chen, Han-Hua Dong, Bi-Xiang Zhang
Summary: 18 beta-glycyrrhetinic acid (GA) inhibits TGF-beta-induced epithelial-mesenchymal transition (EMT) and metastasis of hepatocellular carcinoma (HCC) cells by reducing the phosphorylation of signal transducer and activator of transcription 3 (STAT3). This provides a potential therapeutic target for HCC management.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
Article
Respiratory System
Shengding Zhang, Yu Fan, Lu Qin, Xiaoyu Fang, Cong Zhang, Junqing Yue, Wenxue Bai, Gang Wang, Zhihong Chen, Harld Renz, Chrysanthi Skevaki, Xiansheng Liu, Min Xie
Summary: Neutrophilic asthmatics (NA) show less improvement in lung function after treatment, which is associated with increased IL-1β levels in sputum. Additionally, IL-1β may enhance steroid-resistant EMT induced by TGF-β1 via the MAPK signaling pathway.
RESPIRATORY RESEARCH
(2021)
Article
Cell & Tissue Engineering
Le Phuong Hoang Anh, Ken Nishimura, Akihiro Kuno, Nguyen Thuy Linh, Tetsuo Kato, Manami Ohtaka, Mahito Nakanishi, Eiji Sugihara, Taka-Aki Sato, Yohei Hayashi, Aya Fukuda, Koji Hisatake
Summary: Somatic cell reprogramming proceeds through a series of events to generate induced pluripotent stem cells (iPSCs). In this study, the researchers found that the downregulation of Osr2 is crucial for efficient reprogramming by using a cell-based model. Osr2 acts as a novel EMT regulator and its downregulation diminishes TGF-beta signaling and activates Wnt signaling, promoting MET and acquiring pluripotency.
Article
Oncology
Hyun-Wook Lee, Cynthia C. Jose, Suresh Cuddapah
Summary: Nickel compounds, prevalent in the atmosphere due to industrial processes and fossil fuel burning, are associated with chronic inflammatory lung diseases, including asthma and lung cancer, primarily through the mechanism of epithelial-mesenchymal transition (EMT).
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Biology
Ashish Kumar-Singh, Malgorzata Maria Parniewska, Nikolina Giotopoulou, Joman Javadi, Wenwen Sun, Tunde Szatmari, Katalin Dobra, Anders Hjerpe, Jonas Fuxe
Summary: Metastasis of tumor cells to vital organs is a major cause of cancer death, with inflammatory signals influencing an identity switch in tumor cells. Syndecan-1 plays a crucial role in regulating this switch, with nuclear localization of SDC1 associated with the regulation of EMT.