Mechanisms of Collagen Crosslinking in Diabetes and Keratoconus

Structural and Biomechanical Corneal Differences between Type 2 Diabetic and Nondiabetic Patients

(2019) João N. Beato et al.   Journal of Ophthalmology

Matrix metalloproteinases in keratoconus – Too much of a good thing?

(2019) Erica di Martino et al.   EXPERIMENTAL EYE RESEARCH

Measurement of Corneal Biomechanical Properties in Diabetes Mellitus Using the Ocular Response Analyzer and the Corvis ST

(2019) Lisa Ramm et al.   CORNEA

Central Corneal Thickness Increase Due to Stromal Thickening With Diabetic Peripheral Neuropathy Severity

(2018) Navasuja Kumar et al.   CORNEA

Axial mechanical and structural characterization of keratoconus corneas

(2018) Eric Mikula et al.   EXPERIMENTAL EYE RESEARCH

The impact of diabetes on corneal nerve morphology and ocular surface integrity

(2018) Maria Markoulli et al.   Ocular Surface

Collagen cross-linking impact on keratoconus extracellular matrix

(2018) Rabab Sharif et al.   PLoS One

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein

(2018) Rabab Sharif et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Epigenetics and Epigenomics: Implications for Diabetes and Obesity

(2018) Evan D. Rosen et al.   DIABETES

Collagen fiber crimping following in vivo UVA-induced corneal crosslinking

(2018) Samantha M. Bradford et al.   EXPERIMENTAL EYE RESEARCH

Evaluation estrogen, progesteron and androgen receptor expressions in corneal epithelium in keratoconus

(2018) Berna Ayan et al.   Contact Lens & Anterior Eye

Prolactin-Induced Protein is a novel biomarker for Keratoconus

(2018) Rabab Sharif et al.   EXPERIMENTAL EYE RESEARCH

Quercetin and the ocular surface: What we know and where we are going

(2017) Tina B McKay et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Effects of diabetes mellitus on biomechanical properties of the rabbit cornea

(2017) FangJun Bao et al.   EXPERIMENTAL EYE RESEARCH

Mitochondrial dysfunction and oxidative stress in corneal disease

(2017) Neeru A. Vallabh et al.   MITOCHONDRION

U.S. Multicenter Clinical Trial of Corneal Collagen Crosslinking for Treatment of Corneal Ectasia after Refractive Surgery

(2017) Peter S. Hersh et al.   OPHTHALMOLOGY

United States Multicenter Clinical Trial of Corneal Collagen Crosslinking for Keratoconus Treatment

(2017) Peter S. Hersh et al.   OPHTHALMOLOGY

Type 1 diabetes in children and adolescents is not associated with a reduced prevalence of atopy and allergic diseases

(2017) Hildegard Jasser-Nitsche et al.   PEDIATRIC DIABETES

A review of keratoconus: Diagnosis, pathophysiology, and genetics

(2017) Veronica Mas Tur et al.   SURVEY OF OPHTHALMOLOGY

Diabetic complications in the cornea

(2017) Alexander V. Ljubimov   VISION RESEARCH

Effect of systemic insulin treatment on diabetic wound healing

(2017) Nasibeh Vatankhah et al.   WOUND REPAIR AND REGENERATION

The “Metabolic Memory” Theory and the Early Treatment of Hyperglycemia in Prevention of Diabetic Complications

(2017) Roberto Testa et al.   Nutrients

Establishment of a 3D In Vitro Model to Accelerate the Development of Human Therapies against Corneal Diabetes

(2017) Shrestha Priyadarsini et al.   PLoS One

Acute hypoxia influences collagen and matrix metalloproteinase expression by human keratoconus cells in vitro

(2017) Tina B. McKay et al.   PLoS One

Differential Effects of Hormones on Cellular Metabolism in Keratoconus In Vitro

(2017) Tina B. McKay et al.   Scientific Reports

Human in vitro Model Reveals the Effects of Collagen Cross-linking on Keratoconus Pathogenesis

(2017) Rabab Sharif et al.   Scientific Reports

Nationwide reduction in the number of corneal transplantations for keratoconus following the implementation of cross-linking

(2016) Daniel A. Godefrooij et al.   ACTA OPHTHALMOLOGICA

The etiology of human age-related cataract. Proteins don't last forever

(2016) Roger J.W. Truscott et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Role of Thyroxine in the Development of Keratoconus

(2016) Solon Thanos et al.   CORNEA

Effects of Atopic Syndrome on Keratoconus

(2016) Mehdi Shajari et al.   CORNEA

Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus

(2016) Alexandra Kautzky-Willer et al.   ENDOCRINE REVIEWS

Corneal Collagen Crosslinking for Corneal Ectasias: A Review

(2016) David P.S. O’Brart   EUROPEAN JOURNAL OF OPHTHALMOLOGY

Advanced glycation end products and their receptor in age-related, non-communicable chronic inflammatory diseases; Overview of clinical evidence and potential contributions to disease

(2016) Niki L. Reynaert et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Detection of subclinical keratoconus through non-contact tonometry and the use of discriminant biomechanical functions

(2016) Pablo Peña-García et al.   JOURNAL OF BIOMECHANICS

Keratoconus Progression Induced by In Vitro Fertilization Treatment

(2016) Erdem Yuksel et al.   JOURNAL OF REFRACTIVE SURGERY

Enhanced Combined Tomography and Biomechanics Data for Distinguishing Forme Fruste Keratoconus

(2016) Allan Luz et al.   JOURNAL OF REFRACTIVE SURGERY

Abnormal Anterior Corneal Morphology in Diabetes Observed Using In Vivo Laser-scanning Confocal Microscopy

(2016) Cirous Dehghani et al.   Ocular Surface

The Association Between Sociodemographic Factors, Common Systemic Diseases, and Keratoconus

(2016) Maria A. Woodward et al.   OPHTHALMOLOGY

Aldose reductase, ocular diabetic complications and the development of topical Kinostat ®

(2016) Peter F. Kador et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Intranasal delivery of nanomicelle curcumin promotes corneal epithelial wound healing in streptozotocin-induced diabetic mice

(2016) Chuanlong Guo et al.   Scientific Reports

Ocular Complications of Diabetes and Therapeutic Approaches

(2016) Victoria J. Vieira-Potter et al.   Biomed Research International

Endocrine and Metabolic Pathways Linked to Keratoconus: Implications for the Role of Hormones in the Stromal Microenvironment

(2016) Tina B McKay et al.   Scientific Reports

Lamellar changes in the keratoconic cornea

(2015) Jessica H. Mathew et al.   ACTA OPHTHALMOLOGICA

Pharmacologic inhibition of lactate production prevents myofibroblast differentiation

(2015) Robert Matthew Kottmann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

(2015) Na Xie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epidemiological Perspectives of Diabetes

(2015) Ziqi Tao et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Mitochondrial Profile and Responses to TGF-β Ligands in Keratoconus

(2015) Akhee Sarker-Nag et al.   CURRENT EYE RESEARCH

Regulation of corneal stroma extracellular matrix assembly

(2015) Shoujun Chen et al.   EXPERIMENTAL EYE RESEARCH

Tear metabolite changes in keratoconus

(2015) D. Karamichos et al.   EXPERIMENTAL EYE RESEARCH

In Vivo Confocal Microscopy after Corneal Collagen Crosslinking

(2015) Cosimo Mazzotta et al.   Ocular Surface

Cytokine Expression in Keratoconus and its Corneal Microenvironment: A Systematic Review

(2015) Robert P.L. Wisse et al.   Ocular Surface

Corneal structure and transparency

(2015) Keith M. Meek et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Quercetin Attenuates Lactate Production and Extracellular Matrix Secretion in Keratoconus

(2015) T. B. McKay et al.   Scientific Reports

Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth

(2015) Carmela Guido et al.   Oncotarget

Effect of diabetes mellitus on Corvis ST measurement process

(2014) Consuelo Pérez-Rico et al.   ACTA OPHTHALMOLOGICA

Riboflavin (vitamin B2) and oxidative stress: a review

(2014) Marziyeh Ashoori et al.   BRITISH JOURNAL OF NUTRITION

Association Between Diabetes and Keratoconus

(2014) Mohammad Naderan et al.   CORNEA

Another Look at the Association Between Diabetes and Keratoconus

(2014) Mustafa Kosker et al.   CORNEA

Corneal Confocal Microscopy Detects Neuropathy in Subjects With Impaired Glucose Tolerance: Figure 1

(2014) Omar Asghar et al.   DIABETES CARE

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

(2014) Nathalie Esser et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Featured Article: Selective blockade of the OGF–OGFr pathway by naltrexone accelerates fibroblast proliferation and wound healing

(2014) Jessica A Immonen et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Assessment of Ocular Biomechanics Using Dynamic Ultra High-Speed Scheimpflug Imaging in Keratoconic and Normal Eyes

(2014) Lei Tian et al.   JOURNAL OF REFRACTIVE SURGERY

Gross Cystic Disease Fluid Protein-15/Prolactin-Inducible Protein as a Biomarker for Keratoconus Disease

(2014) Shrestha Priyadarsini et al.   PLoS One

Genetic Susceptibility to Type 2 Diabetes and Obesity: Follow-Up of Findings from Genome-Wide Association Studies

(2014) Kevin J. Basile et al.   International Journal of Endocrinology

In vitro model suggests oxidative stress involved in keratoconus disease

(2014) D. Karamichos et al.   Scientific Reports

Race/Ethnic Difference in Diabetes and Diabetic Complications

(2013) Elias K. Spanakis et al.   Current Diabetes Reports

The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly

(2013) Shoujun Chen et al.   FEBS Journal

Repeated monitoring of corneal nerves by confocal microscopy as an index of peripheral neuropathy in type-1 diabetic rodents and the effects of topical insulin

(2013) Debbie K. Chen et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Advanced glycation end-products diminish tendon collagen fiber sliding

(2013) Yufei Li et al.   MATRIX BIOLOGY

Corneal Crosslinking with Riboflavin and Ultraviolet A. I. Principles

(2013) Frederik Raiskup et al.   Ocular Surface

Polymorphism Analysis ofVSX1andSOD1Genes in Greek Patients with Keratoconus

(2013) Marilita M. Moschos et al.   OPHTHALMIC GENETICS

In Vivo Confocal Microscopy Analyses of Corneal Microstructural Changes in a Prospective Study of Collagen Cross-linking in Keratoconus

(2013) Charlotte Jordan et al.   OPHTHALMOLOGY

Efficacy of corneal tomography parameters and biomechanical characteristic in keratoconus detection

(2013) Seyed Mahdi Ahmadi Hosseini et al.   Contact Lens & Anterior Eye

Effect of diabetes mellitus on corneal biomechanics and measurement of intraocular pressure

(2012) Annabelle Scheler et al.   ACTA OPHTHALMOLOGICA

Metabolic remodeling of the tumor microenvironment: Migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth

(2012) Valentina Carito et al.   CELL CYCLE

Changes in Corneal Sensation and Ocular Surface in Patients With Asymmetrical Keratoconus

(2012) Kyong Jin Cho et al.   CORNEA

Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas

(2012) Lubica Dudakova et al.   EXPERIMENTAL EYE RESEARCH

Topical Insulin Accelerates Wound Healing in Diabetes by Enhancing the AKT and ERK Pathways: A Double-Blind Placebo-Controlled Clinical Trial

(2012) Maria H. M. Lima et al.   PLoS One

Metabolic memory: Mechanisms and implications for diabetic retinopathy

(2011) Liwei Zhang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Effects of Ultraviolet-A and Riboflavin on the Interaction of Collagen and Proteoglycans during Corneal Cross-linking

(2011) Yuntao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

Prevalence and Relative Risk of Other Autoimmune Diseases in Subjects with Autoimmune Thyroid Disease

(2010) Kristien Boelaert et al.   AMERICAN JOURNAL OF MEDICINE

Corneal biomechanical characteristics in patients with diabetes mellitus

(2010) Aachal Kotecha et al.   JOURNAL OF CATARACT AND REFRACTIVE SURGERY

Intraocular pressure measurements after corneal collagen crosslinking with riboflavin and ultraviolet A in eyes with keratoconus

(2010) George D. Kymionis et al.   JOURNAL OF CATARACT AND REFRACTIVE SURGERY

Collagen Structure and Stability

(2009) Matthew D. Shoulders et al.   Annual Review of Biochemistry

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

SOD1 Haplotypes in Familial Keratoconus

(2009) Nitin Udar et al.   CORNEA

The Influence of Gender and Hormone Status on the Severity and Progression of Keratoconus

(2009) Barbara A Fink et al.   CORNEA

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Naltrexone and insulin are independently effective but not additive in accelerating corneal epithelial healing in type I diabetic rats

(2009) Matthew S. Klocek et al.   EXPERIMENTAL EYE RESEARCH

Changes of extracellular matrix of the cornea in diabetes mellitus

(2009) A. Hager et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Corneal Biomechanical Changes in Diabetes Mellitus and Their Influence on Intraocular Pressure Measurements

(2009) A. Sahin et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Effect of diabetes mellitus on biomechanical parameters of the cornea

(2009) Yakov Goldich et al.   JOURNAL OF CATARACT AND REFRACTIVE SURGERY

Long-term biomechanical properties of rabbit cornea after photodynamic collagen crosslinking

(2008) Gregor Wollensak et al.   ACTA OPHTHALMOLOGICA

Recurrent ectasia in corneal grafts and outcomes of repeat keratoplasty for keratoconus

(2008) S V Patel et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Keratoconus Clinical Findings According to Different Age and Gender Groups

(2008) Aylin Ertan et al.   CORNEA

Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease

(2008) Deborah J. Smyth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Radiocarbon Dating of the Human Eye Lens Crystallines Reveal Proteins without Carbon Turnover throughout Life

(2008) Niels Lynnerup et al.   PLoS One