Article
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Elham Badrlou, Atefe Abak, Mohammad Taheri
Summary: miRNAs play a significant role in CRC by influencing the expression and activity of CRC-related pathways and interacting with long non-coding RNAs. Levels of miRNAs can be used to distinguish CRC patients from healthy controls. Despite evaluation of therapeutic application of miRNAs in CRC in animal models, it has not been verified in clinical settings.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jen-Tai Lin, Kuo-Wang Tsai
Summary: The study showed that certain miRNAs in urine could potentially serve as noninvasive biomarkers for diagnosing bladder cancer, with implications for early detection and patient survival. Further validation in larger cohorts is necessary to confirm the clinical utility of urinary miRNAs in bladder cancer diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lucia Dansero, Fulvio Ricceri, Laura De Marco, Valentina Fiano, Ginevra Nesi, Lisa Padroni, Lorenzo Milani, Saverio Caini, Giovanna Masala, Claudia Agnoli, Carlotta Sacerdote
Summary: Colorectal cancer is a common cancer worldwide, and prevention is the key to reducing its burden. Certain miRNAs may be related to CRC diagnosis and could serve as biomarkers. However, there is inconsistency across studies and further validation is needed.
Article
Medicine, General & Internal
Farah J. Nassar, Zahraa S. Msheik, Maha M. Itani, Remie El Helou, Ruba Hadla, Firas Kreidieh, Rachelle Bejjany, Deborah Mukherji, Ali Shamseddine, Rihab R. Nasr, Sally N. Temraz
Summary: CRC is the second leading cause of cancer deaths worldwide, with poor prognosis for Stage IV patients and liver metastasis as the main cause of mortality. miRNA shows potential as non-invasive diagnostic biomarkers for CRC, with specific panels of miRNA having diagnostic accuracy for advanced CRC and liver metastasis.
Article
Health Care Sciences & Services
Jiang Li, Anshul Tiwari, Hooman Mirzakhani, Alberta L. Wang, Alvin T. Kho, Michael J. McGeachie, Augusto A. Litonjua, Scott T. Weiss, Kelan G. Tantisira
Summary: MicroRNAs show potential as biomarkers for incident asthma, particularly when considering vitamin D levels. Meta-analysis across cohorts and logistic regression models were used to predict asthma occurrence based on miRNA expression levels and vitamin D interactions. A specific miRNA, hsa-miR-574-5p, showed good prognostic ability for incident asthma.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Jacek Kabzinski, Monika Maczynska, Ireneusz Majsterek
Summary: This article discusses the potential use of microRNAs in the diagnosis of head and neck squamous cell carcinoma, highlighting their application in radiotherapy and immunotherapy, as well as addressing the challenges and future research directions in developing this promising technology.
Article
Anatomy & Morphology
Yuntao Shi, Yingying Zhuang, Jialing Zhang, Mengxue Chen, Shangnong Wu
Summary: The study identified serum exosomal miRNAs as potential biomarkers for early diagnosis of CRC, especially miR-126, miR-1290, miR-23a, and miR-940, which showed high diagnostic values in differentiating CRC patients at TNM stage I from healthy controls.
Review
Oncology
Soudeh Ghafouri-Fard, Ali Khanbabapour Sasi, Atefe Abak, Hamed Shoorei, Ali Khoshkar, Mohammad Taheri
Summary: miRNAs play a significant role in breast carcinogenesis by modulating key processes and potentially affecting treatment outcomes. Their presence in the peripheral blood of patients also offers a new avenue for non-invasive diagnosis of breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Justyna Raczkowska, Agnieszka Bielska, Adam Kretowski, Magdalena Niemira
Summary: Non-small cell lung cancer (NSCLC) is a malignant condition resistant to advanced-stage treatment and the leading cause of cancer death worldwide. Current diagnostic methods cannot detect the disease at an early stage or predict its development. Micro RNAs (miRNAs) show significant differences in NSCLC tissues and can be easily detected in biofluids without invasive collection techniques. Many studies support the importance of miRNAs as a promising biomarker for detecting and predicting NSCLC. This review discusses the role of biofluid miRNAs as a diagnostic tool in NSCLC and highlights future areas of interest.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lui Ng, Ryan Wai-Yan Sin, David Him Cheung, Wai-Keung Leung, Abraham Tak-Ka Man, Oswens Siu-Hung Lo, Wai-Lun Law, Dominic Chi-Chung Foo
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease that is increasing worldwide, and it is associated with colorectal polyps. This study aimed to investigate the potential of serum microRNAs (miRNAs) in identifying NAFLD in colorectal polyp patients. The results showed that a serum miRNA panel composed of four miRNA pairs significantly identified NAFLD in colorectal polyp patients, and its performance improved when patients with other concurrent metabolic disorders were removed from the analysis. The serum miRNA panel could be a potential diagnostic biomarker for screening NAFLD in colorectal polyp patients for early diagnosis and prevention of disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Martin Brundin, Dick Wagsater, Urban Alehagen, Carl-Johan Carlhall
Summary: This study compared serum levels of specific miRs and cardiac magnetic resonance imaging parameters between patients with DCM and IHD, finding that miR-29-5p levels were increased in DCM and miR-320a levels were elevated in DCM compared to healthy controls.
Article
Cardiac & Cardiovascular Systems
Xiao-long Mi, Yu-ping Gao, Da-jie Hao, Zhi-jun Zhang, Zheng Xu, Tong Li, Xue-wen Li
Summary: This study aimed to determine the diagnostic accuracy of circulating miR-21-5p and miR-126 as biomarkers for patients with AMI and IR-ATO. The results showed that miR-21-5p and miR-126 exhibited considerable diagnostic accuracy for IR-ATO AMI, suggesting their potential as promising prognostic biomarkers for AMI and IR-ATO patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Jonas Dohmen, Alexander Semaan, Makbule Kobilay, Martin Zaleski, Vittorio Branchi, Anja Schlierf, Karina Hettwer, Steffen Uhlig, Gunther Hartmann, Jorg C. Kalff, Hanno Matthaei, Philipp Lingohr, Stefan Holdenrieder
Summary: The study compared the use of exosomal and free circulating microRNAs in colorectal adenocarcinoma, showing higher levels of microRNAs in the exosomal compartment with significant differences from the healthy control group. Combining multiple exosomal miRNAs can further enhance diagnostic sensitivity and specificity.
Article
Chemistry, Analytical
Xuzhi Wang, Shuzhi Tang, Shengnan Ye, Zhou Cheng, Jianhua Xu, Bo-wen Li, Zhuo Chen
Summary: Circulating miR-195-5p has been proposed as a promising peripheral biomarker for various diseases, but there is currently a lack of sensitive and convenient quantification methods. In this study, a one-pot isothermal approach utilizing triple strand displacement amplification (SDA) cascade was developed to detect miR-195-5p with high sensitivity. The method demonstrated potential for clinical point-of-care assay and could promote the wide application of miR-195-5p as a non-invasive biomarker.
Article
Pharmacology & Pharmacy
Nadine De Godoy Torso, Julia Coelho Franca Quintanilha, Maria Aparecida Cursino, Eder De Carvalho Pincinato, Pia Loren, Luis A. Salazar, Carmen Silvia Passos Lima, Patricia Moriel
Summary: The use of miRNAs as renal biomarkers shows promise for evaluating cisplatin-induced nephrotoxicity.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Surgery
Vladimir Prochazka, Filip Marek, Lumir Kunovsky, Roman Svaton, Martina Farkasova, Martin Potrusil, Petr Moravcik, Zdenek Kala
JOURNAL OF MINIMAL ACCESS SURGERY
(2019)
Editorial Material
Gastroenterology & Hepatology
Lumir Kunovsky, Zdenek Kala, Martin Potrusil, Ivo Novotny, Vaclav Kubes, Vladimir Prochazka
GASTROINTESTINAL ENDOSCOPY
(2019)
Article
Biochemistry & Molecular Biology
Petra Vychytilova-Faltejskova, Alena Svobodova Kovarikova, Tomas Grolich, Vladimir Prochazka, Katerina Slaba, Tana Machackova, Jana Halamkova, Marek Svoboda, Zdenek Kala, Igor Kiss, Ondrej Slaby
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Gastroenterology & Hepatology
Karolina Poredska, Lumir Kunovsky, Filip Marek, Zdenek Kala, Vladimir Prochazka, Jiri Dolina, Vladimir Zboril, Petra Kovalcikova, Tomas Pavlik, Petr Jabandziev, Zdenek Pavlovsky, Jakub Vlazny, Ladislav Mitas
JOURNAL OF CROHNS & COLITIS
(2020)
Article
Genetics & Heredity
Alexandra Kondelova, Begona Alburquerque-Gonzalez, Petra Vychytilova-Faltejskova, Jose Garcia-Solano, Vladimir Prochazka, Zdenek Kala, Fernando Perez, Ondrej Slaby, Pablo Conesa-Zamora
Article
Medicine, General & Internal
Natalia Gablo, Karolina Trachtova, Vladimir Prochazka, Jan Hlavsa, Tomas Grolich, Igor Kiss, Josef Srovnal, Alona Rehulkova, Martin Lovecek, Pavel Skalicky, Ioana Berindan-Neagoe, Zdenek Kala, Ondrej Slaby
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Oncology
Radek Kroupa, Ivana Katinova, Tomas Pavlik, Lumir Kunovsky, Vladimir Prochazka, Petra Borilova Linhartova, Barbora Packova, Zdenek Kala, Jiri Dolina
CANCER EPIDEMIOLOGY
(2020)
Article
Oncology
Tana Machackova, Petra Vychytilova-Faltejskova, Kamila Souckova, Karolina Trachtova, Dominika Brchnelova, Marek Svoboda, Igor Kiss, Vladimir Prochazka, Zdenek Kala, Ondrej Slaby
Article
Oncology
Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Tomas Pavlik, Monika Mazalova, Zdenek Kala
Summary: The study aimed to evaluate whether patients treated for rectal cancer who had pathological complete response to neoadjuvant therapy develop worse postoperative outcomes after TaTME. The results indicated that pCR after neoadjuvant therapy did not affect postoperative morbidity in rectal cancer after TaTME.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Review
Medicine, General & Internal
Jitka Vaculova, Radek Kroupa, Zdenek Kala, Jiri Dolina, Tomas Grolich, Jakub Vlazny, David Said, Lydie Izakovicova Holla, Petra Borilova Linhartova, Vladimir Prochazka, Marek Joukal, Petr Jabandziev, Ondrej Slaby, Lumir Kunovsky
Summary: Confocal laser endomicroscopy (CLE) is a real-time microscopic imaging technique used mainly in gastroenterology, particularly in the diagnosis of Barrett's esophagus and esophageal adenocarcinoma. Although many studies have shown that CLE increases diagnostic accuracy in detecting neoplastic transformation of BE, it is still not widely used as a standard diagnostic tool in BE surveillance due to a lack of scientific evidence.
Article
Surgery
Roman Svaton, Vladimir Prochazka, Marketa Hanslianova, Zdenek Kala
Summary: Periampullary tumours (PAT) that cause obstruction of the distal choledochus can be managed surgically or non-operatively with biliary drain or stent (BDS). However, the use of BDS is associated with increased microbial colonisation of bile and a higher incidence of post-operative infectious complications, particularly wound infections.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Oncology
V Prochazka, J. Hlavsa, L. Kunovsky, M. Farkasova, M. Potrusil, T. Andrasina, A. Litavcova, J. Mazanec, J. Dolina, L. Ostrizkova, M. Eid, P. Kovalcikova, T. Pavlik, Z. Kala
Article
Oncology
Tana Machackova, Karolina Trachtova, Vladimir Prochazka, Tomas Grolich, Martina Farkasova, Lukas Fiala, Roman Sefr, Igor Kiss, Matej Skrovina, Michal Dosoudil, Ioana Berindan-Neagoe, Marek Svoboda, Ondrej Slaby, Zdenek Kala
CANCER GENOMICS & PROTEOMICS
(2020)