Article
Oncology
Laura Moonen, Lise Mangiante, Daphne J. G. Leunissen, Lisa M. Lap, Aurelie Gabriel, Lisa M. Hillen, Guido M. Roemen, Alexander Koch, Manon van Engeland, Anne-Marie C. Dingemans, Matthieu Foll, Nicolas Alcala, Lynnette Fernandez-Cuesta, Jules L. Derks, Ernst-Jan M. Speel
Summary: In this study, the expression of Orthopedia Homeobox (OTP) in different tumor types was investigated, with a focus on its association with DNA methylation levels in lung neuroendocrine neoplasms. It was found that loss of OTP expression is a strong indicator of poor prognosis in pulmonary carcinoids. Furthermore, high OTP expression was identified as a unique feature of pulmonary carcinoids with a favorable prognosis, while low OTP expression was associated with worse overall survival and specific molecular characteristics.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Emma N. Rizen, Alexandria T. Phan
Summary: This review summarizes recent findings and updates in the management of neuroendocrine neoplasms (NENs), highlighting the improvement in NENs classification and the expansion of epidemiological understanding through global collaborations and tumor registries. The review also discusses the evolving utility of some NET biomarkers, the increasing knowledge of molecular drivers of tumorigenesis, and the multiple drug approvals for the treatment of advanced NENs. The authors emphasize the importance of further understanding molecular drivers and the role of immunotherapy in transforming care for all NENs patients.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Oncology
Jace P. Landry, Brianne A. Voros, Robert A. Ramirez, J. Philip Boudreaux, Eugene A. Woltering, Ramcharan Thiagarajan
Summary: The study evaluated the metastatic potential of appendiceal neuroendocrine tumors (ANETs) < 2 cm diameter and found that smaller tumors had metastatic capability. Factors like patient age, tumor characteristics were associated with metastatic diseases. Appendectomy alone was deemed sufficient for most ANETs patients, regardless of tumor size.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Mathilde Prieto, Guillaume Chassagnon, Audrey Lupo, Marie-Christine Charpentier, Eglantine Cabanne, Lionel Groussin, Marie Wislez, Marco Alifano, Ludovic Fournel
Summary: DIPNECH-associated carcinoid tumors exhibit negative pathological features and may require specialized perioperative management. Patients with DIPNECH are older, more frequently female, and more likely to have comorbidities such as diabetes or hypertension. Atypical histology and mediastinal lymph nodes involvement are independent factors of pN2 invasion in DIPNECH patients.
Article
Endocrinology & Metabolism
Sami Matrood, Leonidas Apostolidis, Joerg Schrader, Sebastian Krug, Harald Lahner, Annette Ramaswamy, Damiano Librizzi, Zoltan Kender, Anke Kroecher, Simon Kreutzfeldt, Thomas Matthias Gress, Anja Rinke
Summary: The study found that presacral NENs are histopathologically similar to rectal NENs. The majority of tumors are non-functioning, and PRRT shows promising activity in treatment. Further investigation and molecular characterization are needed to understand this rare tumor entity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Laura Moonen, Jules L. Derks, Lisa M. Lap, Britney J. C. A. Marijnissen, Lisa M. Hillen, Michael A. den Bakker, Jan H. von Der Thusen, Robert-Jan Van Suylen, Wim Timens, Maria Bintanel, Eugenia Kuteeva, Anne-Marie C. Dingemans, Ernst-Jan M. Speel
Summary: New monoclonal antibodies specific to OTP have been developed and validated on different automated immunohistochemical staining platforms, allowing their application in routine diagnostics for pulmonary neuroendocrine tumors.
TRANSLATIONAL LUNG CANCER RESEARCH
(2022)
Review
Oncology
M. S. D. Engel, R. J. L. van der Lans, J. C. Jansen, C. R. Leemans, E. Bloemena, B. I. Lissenberg-Witte, J. A. Rijken, C. F. Smit, E. F. Hensen
Summary: MEANTs are rare and unpredictable middle ear tumors, with some having locally invasive and metastatic disease. Treatment mainly consists of surgery, with initial local tumor control being crucial.
Article
Oncology
Daisuke Takayanagi, Hourin Cho, Erika Machida, Atsushi Kawamura, Atsuo Takashima, Satoshi Wada, Takuya Tsunoda, Takashi Kohno, Kouya Shiraishi
Summary: This review provides updates on the epidemiology, diagnosis, and management of gastroenteropancreatic neuroendocrine neoplasms. The incidence of these malignancies originating from the pancreatic and gastrointestinal neuroendocrine cell system has been increasing. Advances in molecular diagnosis, treatment strategies, and liquid biopsy have contributed to personalized management for patients.
Review
Oncology
Yongzheng Li, Zhiyao Fan, Feifei Zhang, Jian Yang, Ming Shi, Shujie Liu, Yufan Meng, Hanxiang Zhan
Summary: Neoadjuvant therapies can decrease the tumor size and stage of some pNENs, providing some patients with the opportunity for radical resection. However, the optimal treatment regimen for neoadjuvant therapy in pNENs remains unknown based on current data.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Zhenglin Yi, Renyu Liu, Jiao Hu, Tongchen He, Zihao Wang, Yangle Li, Xiongbing Zu
Summary: The characteristics of primary renal neuroendocrine neoplasms and their relationships with overall survival were analyzed in the largest cohort to date, with 132 cases. Age, sex, and tumor size and stage were found to be associated with poor prognosis.
CLINICAL GENITOURINARY CANCER
(2021)
Article
Endocrinology & Metabolism
Marta Opalinska, Anna Sowa-Staszczak, Helena Olearska, Magdalena Ulatowska-Bialas, Aleksandra Gilis-Januszewska, Alicja Hubalewska-Dydejczyk
Summary: Ovarian neuroendocrine tumors are rare neoplasms that most commonly occur within mature cystic teratomas, with a minority presenting as monodermal teratomas (strumal carcinoid). The prognosis for patients with ovarian neuroendocrine tumors is good, with surgical intervention proving to be an effective treatment method.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pathology
Julie A. Vrana, Jennifer M. Boland, Simone B. S. P. Terra, Hao Xie, Sarah M. Jenkins, Aaron S. Mansfield, Julian R. Molina, Stephen D. Cassivi, Anja C. Roden
Summary: SATB2 expression was higher in small cell carcinomas compared to carcinoid tumors in the lung, while it was expressed more in atypical carcinoid tumors and large cell neuroendocrine carcinoma than small cell carcinoma in the thymus. SATB2 may not be a reliable marker to identify the origin of neuroendocrine tumors and further validation studies are needed.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Surgery
Yuki Fujii, Ching-Wei Tzeng, Yi-Ju Chiang, Daniel M. Halperin, Arvind Dasari, Michael P. Kim, Matthew H. G. Katz, Jeffrey E. Lee, Naruhiko Ikoma
Summary: The study found that the presence of regional LN metastases and the extent of surgery did not affect overall survival among patients with D-NETs. Radical resection to clear occult LN metastases for nonfunctioning, sporadic D-NETs was not supported by the current study.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Oncology
Laura Moonen, Jules L. Derks, Bregtje C. M. Hermans, Iris M. Bunnik, Lisa M. Hillen, Robert Jan van Suylen, Michael A. den Bakker, Jan H. von der Thusen, Ronald A. Damhuis, Esther C. van den Broek, Wieneke A. Buikhuisen, Anne-Marie C. Dingemans, Ernst Jan M. Speel
Summary: The study suggests that preoperative biopsies are imprecise for predicting the final classification of carcinoids on resection specimens, with a significant discordance between preoperative and resection diagnoses. Patients preoperatively diagnosed as atypical carcinoids (AC) exhibited higher relapse rates, indicating caution in interpreting preoperative biopsy diagnosis for treatment decisions.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Review
Oncology
Philip T. Sobash, Asad Ullah, Nagla Abdel Karim
Summary: There is currently no definitive evidence that adjuvant chemotherapy after resection confers a survival benefit in typical or atypical carcinoids.
Article
Oncology
Nikki de Rouw, Rene J. Boosman, Jacobus A. Burgers, Alwin D. R. Huitema, Anne-Marie C. Dingemans, Hieronymus J. Derijks, David M. Burger, Berber Piet, Lizza E. L. Hendriks, Bonne Biesma, Melinda A. Pruis, Daphne W. Dumoulin, Sander Croes, Ron H. J. Mathijssen, Michel M. van den Heuvel, Rob ter Heine
Summary: This study compared optimized dosing of pemetrexed to standard body surface area-based dosing in patients with non-small cell lung cancer and mesothelioma. The results showed no superiority of optimized dosing in terms of pharmacokinetic endpoint, safety, or quality of life.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2023)
Article
Oncology
J. Remon, B. Besse, S. Ponce Aix, A. Callejo, K. Al-Rabi, R. Bernabe, L. Greillier, M. Majem, N. Reguart, I. Monnet, S. Cousin, P. Garrido, G. Robinet, R. Garcia Campelo, A. Madroszyk, J. Mazieres, H. Curcio, B. Wasag, Y. Pretzenbacher, B. Fournier, A. -M. C. Dingemans, R. Dziadziuszko
Summary: The APPLE trial aimed to evaluate the feasibility of longitudinal plasma EGFR T790M monitoring for the best sequencing strategy of gefitinib and osimertinib. The results showed that serial monitoring of T790M mutation in advanced EGFR-mutant non-small-cell lung cancer was feasible, and molecular progression before RECIST PD led to an earlier switch to osimertinib with satisfactory progression-free survival and overall survival outcomes.
ANNALS OF ONCOLOGY
(2023)
Article
Oncology
Daan A. C. Lanser, Simon P. de Leeuw, Esther Oomen-de Hoop, Peter de Bruijn, Marthe S. Paats, Daphne W. Dumoulin, Stijn L. W. Koolen, Anne -Marie C. Dingemans, Ron H. J. Mathijssen, Marijn Veerman
Summary: This study investigated the influence of different diets on the exposure of alectinib in ALK+ NSCLC patients. The results showed that low-fat yogurt significantly reduced the exposure of alectinib compared to other diets, while a self-chosen lunch did not change the exposure. Therefore, patients and physicians should be cautious about the food-drug interaction between alectinib and low-fat yogurt, as it may lead to reduced exposure.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Article
Oncology
Simon P. de Leeuw, Melinda A. Pruis, Barend J. Sikkema, Mostafa Mohseni, G. D. Marijn Veerman, Marthe S. Paats, Daphne W. Dumoulin, Egbert F. Smit, Annemie M. W. J. Schols, Ron H. J. Mathijssen, Elisabeth F. C. van Rossum, Anne-Marie C. Dingemans
Summary: Alectinib, a standard treatment for metastatic ALK+ NSCLC, can lead to weight gain in approximately 10% of patients. This study analyzed body composition changes in patients treated with alectinib and found increases in waist circumference, visceral adipose tissue, subcutaneous adipose tissue, and skeletal muscle. Furthermore, in-depth analysis of four patients with significant weight gain revealed increased appetite and metabolic syndrome. These findings suggest that alectinib can cause abdominal obesity and various metabolic, physical, and mental disturbances.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Medicine, General & Internal
Adrianus Johannes de Langen, Melissa L. Johnson, Julien Mazieres, Anne -Marie C. Dingemans, Giannis Mountzios, Miklos Pless, Jurgen Wolf, Martin Schuler, Herve Lena, Ferdinandos Skoulidis, Yasuto Yoneshima, Sang-We Kim, Helena Linardou, Silvia Novello, Anthonie J. van der Wekken, Yuanbin Chen, Solange Peters, Enriqueta Felip, Benjamin J. Solomon, Suresh S. Ramalingam, Christophe Dooms, Colin R. Lindsay, Carlos Gil Ferreira, Normand Blais, Cynthia C. Obiozor, Yang Wang, Bhakti Mehta, Tracy Varrieur, Gataree Ngarmchamnanrith, Bjorn Stollenwerk, David Waterhouse, Luis Paz-Ares
Summary: This study compared the efficacy and safety of Sotorasib with standard-of-care treatment in patients with non-small-cell lung cancer (NSCLC) with the KRASG12C mutation. The results showed that compared to docetaxel, Sotorasib significantly increased progression-free survival and had a more favorable safety profile.
Article
Oncology
Naomi Cornelia Anna van der Velden, Paul K. J. Han, Hanneke W. M. van Laarhoven, Filip Y. F. L. de Vos, Lizza E. L. Hendriks, Sjaak A. Burgers, Anne-Marie C. Dingemans, Jan Maarten W. van Haarst, Joyce Dits, Ellen M. A. Smets, Inge Henselmans
Summary: Discordance between physicians' and patients' prognostic perceptions in advanced cancer care threatens informed medical decision-making and end-of-life preparation, yet this phenomenon is poorly understood. This study examines the extent and predictors of physician-patient discordance in prognostic perceptions.
Article
Oncology
Haiyan Zeng, Lizza E. L. Hendriks, Willem J. A. Witlox, Harry J. M. Groen, Anne-Marie C. Dingemans, John Praag, Jose Belderbos, Ruud Houben, Vincent van der Noort, Dirk K. M. De Ruysscher
Summary: The aim of this study was to identify risk factors for self-reported cognitive impairment in stage III non-small cell lung cancer (NSCLC) after radical treatment. Cognitive functioning was assessed at seven pre-specified time points using the EORTC-QLQ-C30. The results showed that baseline cognitive impairment was the most important risk factor for subsequent cognitive impairment in stage III NSCLC.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Puneeth Iyengar, Sean All, Mark F. Berry, Thomas P. Boike, Lisa Brad fi Eld, Anne -Marie C. Dingemans, Jill Feldman, Daniel R. Gomez, Paul J. Hesketh, Salma K. Jabbour, Melenda Jeter, Mirjana Josipovic, Yolande Lievens, Fiona Mcdonald, Bradford A. Perez, Umberto Ricardi, Enrico Ruffini, Dirk De Ruysscher, Hina Saeed, Bryan J. Schneider, Suresh Senan, Joachim Widder, Matthias Guckenberger
Summary: This guideline aims to review the use of local therapy in the management of extracranial oligometastatic non-small cell lung cancer (NSCLC) and provide recommendations. Currently, data is limited, but with increasing evidence supporting the use of local therapy in NSCLC, this guideline attempts to provide recommendations based on the quality of available data.
PRACTICAL RADIATION ONCOLOGY
(2023)
Letter
Oncology
S. F. Oosting, A. A. M. van der Veldt, R. S. N. Fehrmann, A. Bhattacharya, R. S. van Binnendijk, C. H. GeurtsvanKessel, A. -M. C. Dingemans, E. F. Smit, T. J. N. Hiltermann, G. den Hartog, M. Jalving, T. T. Westphal, F. de Wilt, S. M. Ernst, A. Boerma, L. van Zijl, G. F. Rimmelzwaan, P. Kvistborg, C. A. C. M. van Els, N. Y. Rots, D. van Baarle, J. B. A. G. Haanen, E. G. E. de Vries
Article
Medicine, General & Internal
G. D. Marijn Veerman, Rene J. Boosman, Esther Oomen-de Hoop, Anthonie J. van der Wekken, Idris Bahce, Lizza E. L. Hendriks, Sander Croes, Christi M. J. Steendam, Evert de Jonge, Stijn L. W. Koolen, Neeltje Steeghs, Ron H. N. van Schaik, Egbert F. Smit, Anne-Marie C. Dingemans, Alwin D. R. Huitema, Ron H. J. Mathijssen
Summary: This study investigated the relationship between single nucleotide polymorphisms (SNPs) and the central nervous system (CNS) treatment efficacy of osimertinib in patients with EGFRm+ non-small cell lung cancer. The results showed that ABCG2 34G>A and ABCB1 3435C>T were predictors for developing new CNS metastases during osimertinib treatment. ABCG2 421C>A was significantly related to the incidence of severe toxicity.
Letter
Oncology
Anne-Marie C. Dingemans, Ron H. J. Mathijssen, Elisabeth F. C. van Rossum
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Oncology
Christi M. J. Steendam, Sophie M. Ernst, Sushil K. Badrising, Marthe S. Paats, Joachim G. J. V. Aerts, Adrianus J. de Langen, Anne-Marie C. Dingemans
Summary: This study evaluated the efficacy of chemotherapy regimens after progression on EGFR-TKI in patients with EGFR-mutated NSCLC. The results showed substantial benefit of different chemotherapy regimens, particularly in patients treated with PP and CPBA as first-line chemotherapy, and PB in further lines of chemotherapy.
Article
Oncology
Deirdre M. H. J. ten Berge, Ronald A. M. Damhuis, Joachim G. J. V. Aerts, Anne -Marie C. Dingemans
Summary: In patients with ROS1 rearrangement in the Netherlands, only half received primary treatment with TKI and the treatment outcomes were disappointing, mainly due to brain metastasis. Therefore, performing brain MRI as part of the standard diagnostic work up in patients with ROS1+ NSCLC is crucial.
Article
Oncology
F. Akram, J. L. Wolf, T. E. Trandafir, Anne-Marie C. Dingemans, A. P. Stubbs, J. H. von der Thusen
Summary: A statistical model was developed to predict the recurrence of lung adenocarcinoma after surgical resection, and an artificial intelligence (AI) classification model based on convolutional neural networks (CNNs) was trained using transfer learning. Both models were validated using the same biopsy dataset, and the AI classification model outperformed the statistical model in predicting recurrence.
Article
Respiratory System
Iris G. van der Sar, Marlies S. Wijsenbeek, Gert-Jan Braunstahl, Jason O. Loekabino, Anne-Marie C. Dingemans, Johannes C. C. M. In't Veen, Catharina C. Moor
Summary: The study used eNose technology to analyze patients' breath profiles and found that the breath of ILD patients was significantly different from patients with other respiratory diseases, indicating high potential for accurately distinguishing ILD patients with this technology.
RESPIRATORY RESEARCH
(2023)