Article
Oncology
Magdalena Chrabanska, Magdalena Rynkiewicz, Pawel Kiczmer, Bogna Drozdzowska
Summary: CD44, MMP-2, and MMP-9 are potential molecular prognostic markers in renal cell carcinoma (RCC). The expression of CD44, MMP-2, and MMP-9 in association with the histopathological subtype of RCC affects the survival of patients with renal cancer. CD44 expression and the histopathological subtype of clear-cell RCC are independent risk factors for patient death.
Article
Medicine, General & Internal
Magdalena Chrabanska, Magdalena Rynkiewicz, Pawel Kiczmer, Bogna Drozdzowska
Summary: This study investigated the significance of CD44, MMP2, MMP9, and Ki-67 in predicting the clinicopathologic features and prognosis of papillary and chromophobe RCCs. The results showed that the expression of CD44 and MMP-9 were closely associated with the prognosis of papillary RCC, while Ki-67 expression was negatively correlated with tumor staging in chromophobe RCC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Rongrong Xu, Xiaoyue Zhang, Yan Xu, Junqin Wang, Zhihui Li, Xiaoming Cui
Summary: The study revealed that lncRNA MST1P2 is significantly overexpressed in cervical cancer tissues and cells, with Si-Lnc MST1P2 inhibiting cell growth, migration, and invasion both in vivo and in vitro. Up-regulation of miR-133b inhibited cell viability and metastasis, while its inhibition decreased the anticancer effect of si-Lnc MST1P2. Overall, lncRNA MST1P2 acts as an oncogene in cervical cancer by interacting with miR-133b.
Article
Oncology
Grzegorz Mlynarczyk, Monika Gudowska-Sawczuk, Barbara Mroczko, Marta Bruczko-Goralewska, Lech Romanowicz, Anna Tokarzewicz
Summary: Gelatinases A and B, also known as matrix metalloproteinase-2 and matrix metalloproteinase-9 respectively, play a crucial role in breaking down collagen in the extracellular matrix. This study examined the presence, activity, and expression of these gelatinases in human renal cancer. The results showed that MMP-9 had higher content but lower specific activity compared to MMP-2 in renal cancer. The study also revealed changes in the gelatinases in healthy and cancerous tissues of renal cell carcinoma, suggesting the potential of MMPs in the diagnosis and treatment of renal carcinoma.
Article
Biochemistry & Molecular Biology
Jacek Kudelski, Anna Tokarzewicz, Monika Gudowska-Sawczuk, Barbara Mroczko, Piotr Chlosta, Marta Bruczko-Goralewska, Przemyslaw Mitura, Grzegorz Mlynarczyk
Summary: This study aimed to evaluate the expression and activity of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) in urinary bladder cancer at different stages. The results showed that the content and activity of MMP-9 were higher than MMP-2, especially in high-grade cancer tissue. MMP-9 may have higher clinical utility as a potential therapeutic option and a diagnostic biomarker for urinary bladder cancer.
Article
Oncology
Jingyu Zhang, Qingbo Lu, Haigang Pang, Min Zhang, Wenhai Wei
Summary: miR-103a-3p promotes renal cell carcinoma cell progression by regulating TMEM33. This finding may offer new insights into the identification of prognostic markers and therapeutic targets for RCC.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Cheng-Peng Gui, Bing Liao, Cheng-Gong Luo, Yu-Hang Chen, Lei Tan, Yi-Ming Tang, Jia-Ying Li, Yi Hou, Hong-De Song, Hai-Shan Lin, Quan-Hui Xu, Gao-Sheng Yao, Hao-Hua Yao, Xi-Liu, Jun-Hang Luo, Jia-Zheng Cao, Jin-Huan Wei
Summary: The study identified circCHST15 as a potential prognostic biomarker and therapeutic target for ccRCC, demonstrating its role in promoting proliferation, migration, and invasion of ccRCC cells by sponging miR-125a-5p to regulate EIF4EBP1 expression. CircCHST15 was found to be highly expressed in ccRCC tissues and cell lines, correlating with aggressive clinicopathological characteristics and serving as an independent prognostic indicator for overall survival and progression-free survival in patients with ccRCC after surgical resection. The study suggests further investigation of circCHST15 for its clinical implications in ccRCC management.
Article
Biochemistry & Molecular Biology
Magdalena Izdebska, Wioletta Zielinska, Adrian Krajewski, Marta Halas-Wisniewska, Klaudia Mikolajczyk, Maciej Gagat, Alina Grzanka
Summary: Metastasis is a pressing issue in breast cancer patients, with ECM remodeling playing a key role in cell migration. High levels of MMPs, particularly MMP-9, have been linked to aggressive tumors. Research suggests that CP treatment can reduce breast cancer cell survival, with downregulation of MMP-9 enhancing this effect through apoptosis induction. Combination therapy targeting MMP-9 alongside CP might improve treatment effectiveness. Additionally, a relationship between MMP-9 levels and cytokeratin 19 (CK19) has been confirmed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Nianyong Yuan, Guowei Li
Summary: In this study, hsa_circ_0037858 was identified as a potential circRNA related to ccRCC metastasis. It was significantly downregulated in ccRCC and further decreased in metastatic ccRCC. MiR-5000-3p was predicted to be the most potential binding miRNA of hsa_circ_0037858. Protein-protein interaction analysis revealed several hub genes associated with miR-5000-3p, and FMR1 was identified as the most potential downstream gene. Hsa_circ_0037858 suppressed metastasis and enhanced FMR1 expression in ccRCC through the miR-5000-3p/FMR1 axis.
Article
Biology
Maeva Dufies, Annelies Verbiest, Lindsay S. Cooley, Papa Diogop Ndiaye, Xingkang He, Nicolas Nottet, Wilfried Souleyreau, Anais Hagege, Stephanie Torrino, Julien Parola, Sandy Giuliano, Delphine Borchiellini, Renaud Schiappa, Baharia Mograbi, Jessica Zucman-Rossi, Karim Bensalah, Alain Ravaud, Patrick Auberger, Andreas Bikfalvi, Emmanuel Chamorey, Nathalie Rioux-Leclercq, Nathalie M. Mazure, Benoit Beuselinck, Yihai Cao, Jean Christophe Bernhard, Damien Ambrosetti, Gilles Pages
Summary: Dufies et al. found high Plk1 expression levels in aggressive clear cell renal cell carcinoma and discovered that Plk1 is transcriptionally upregulated in a manner dependent on HIF-2. They also found that high Plk1 expression is correlated to a poor prognosis and resistance to tyrosine kinase inhibitor against VEGF receptor, suggesting a critical role for hypoxia/HIF-2-induced Plk1 in disease progression.
COMMUNICATIONS BIOLOGY
(2021)
Article
Medicine, General & Internal
Gaetano Aurilio, Giovanni Mauri, Duccio Rossi, Paolo Della Vigna, Guido Bonomo, Gianluca Maria Varano, Daniele Maiettini, Maria Cossu Rocca, Elena Verri, Daniela Cullura, Franco Nole, Franco Orsi
Summary: Renal cell carcinoma is a common tumor with high recurrence and metastasis rates. Image-guided ablation techniques, such as microwave, radiofrequency, cryo, and laser, can effectively control tumor progression. Systemic treatment can be initiated at a certain time after the ablation. The primary success and efficacy rates were high, and no significant complications occurred.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Anna Pliszka, Sebastian Rajda, Agata Wawrzyniak, Jerzy Walocha, Michal Polguj, Grzegorz Wysiadecki, Edward Clarke, Michal Golberg, Michal Zarzecki, Krzysztof Balawender
Summary: This systematic review aimed to summarize current knowledge on testicular metastasis of renal cell carcinoma (RCC). It was found that approximately one-third of RCC cases are recognized in its metastatic stage. Testicular metastasis suggests advanced disease stage, with swelling and enlargement of the affected testis as the main symptoms. Understanding the possibility of such RCC metastases is crucial for making an appropriate diagnosis and implementing timely treatment in the management of neoplastic disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Shaobin Liu, Zichen Liu, Changjuan Meng, Cuili Zhang, Wei Yu
Summary: The study found that miR-140-5p can induce apoptosis of OSCC cell line Tca8113, potentially achieved by reducing the expression of MMP-9.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Yu-Hsiang Chang, Yuan-Li Huang, Hsiao-Chi Tsai, An-Chen Chang, Chih-Yuan Ko, Yi-Chin Fong, Chih-Hsin Tang
Summary: This study aims to investigate the role of miRNAs in CCL2-mediated MMP expression and cell motility in human osteosarcoma. The results demonstrate a positive correlation between CCL2 or MMP-3 levels and osteosarcoma metastasis, and stimulation of osteosarcoma cells with CCL2 enhances migration and invasion abilities. Additionally, CCL2 enhances MMP-3-dependent cell motility by inhibiting miR-3659 synthesis.
Article
Oncology
Zhenzhao Luo, Yue Fan, Xianchang Liu, Shuiyi Liu, Xiaoyu Kong, Zhonghuan Ding, Ying Li, Liqing Wei
Summary: MiR-188-3p and miR-133b exert a suppressive effect on hepatocellular carcinoma proliferation, invasion, and migration through downregulation of NDRG1.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Environmental Sciences
Hsin-Le Lin, Chia-Yi Lee, Jing-Yang Huang, Po-Chen Tseng, Shun-Fa Yang
Summary: This study utilized Taiwan's National Health Insurance Research Database to assess the impact of androgen deprivation therapy (ADT) on the development of retinal vascular occlusion (RVO) in prostate cancer patients. The findings indicated that patients who received ADT had a significantly lower incidence of RVO compared to those who did not receive ADT.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Ophthalmology
Chia-Chen Lin, Chia-Yi Lee, Jing-Yang Huang, Sheng-Min Hsu, Jia-Horung Hung, Shun-Fa Yang
Summary: This study provides an in-depth analysis of the trends in DR, DME, and related comorbidities in patients with T2DM. It shows that the prevalence and incidence of DR and PDR decreased over time, while the prevalence and incidence of DME increased. Additionally, the percentage of patients with hyperlipidaemia increased in all forms of DR, while the percentage of patients with ESRD increased only in DME.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Environmental Sciences
Chung-Yuan Lee, Yung-Chuan Ho, Chiao-Wen Lin, Min-Chieh Hsin, Po-Hui Wang, Ya-Cheng Tang, Shun-Fa Yang, Yi-Hsuan Hsiao
Summary: The synthetic curcumin analog, EF-24, has been shown to have enhanced bioavailability and stronger anti-inflammatory and anti-cancer activity compared to curcumin. This study investigated the effects of EF-24 on TPA-induced cellular migration of cervical cancer and found that EF-24 significantly reduced cellular migration and invasion. Further analysis revealed that EF-24 modulated MMP-9 expression by inhibiting the phosphorylation of the p38 signaling pathway. These findings suggest that EF-24 may have potential as a chemopreventive agent for cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Ophthalmology
Hsiang-Wen Chien, Chia-Yi Lee, Jing-Yang Huang, Hung-Chi Chen, Kai Wang, Shun-Fa Yang
Summary: This study, using the National Health Insurance Research Database of Taiwan, found a relationship between congenital cytomegalovirus (CMV) infection and late-onset keratitis. Severe congenital CMV infection was found to be significantly correlated with late-onset keratitis in individuals with congenital CMV infection.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Oncology
Hung-Ju Chien, Chung-Jung Liu, Tsung-Ho Ying, Pei-Ju Wu, Jiunn-Wei Wang, Yi-Hsuan Ting, Yi-Hsien Hsieh, Shih-Chiang Wang
Summary: This study aimed to evaluate Timosaponin AIII (TSAIII) as a potential therapeutic approach for cervical cancer. The results showed that TSAIII suppresses cell migration, invasion, p38 activation, and uPA expression in cervical cancer. Additionally, TSAIII demonstrated antimetastatic properties and inhibited the growth of cervical cancer stem cells. These findings suggest that TSAIII may be a potential auxiliary therapy for cervical cancer.
Article
Cell Biology
Chu-Che Lee, Jen-Pi Tsai, Hsiang-Lin Lee, Yung-Jen Chen, Yong-Syuan Chen, Yi-Hsien Hsieh, Jin-Cherng Chen
Summary: In this study, Timosaponin AIII (TSAIII) was found to inhibit the growth of glioma cells by inducing cell death, mitochondrial dysfunction, and autophagy activation. The results suggest that TSAIII exhibits antitumor effects and may have potential as a therapy for glioma.
Article
Chemistry, Medicinal
Je-Chiuan Ye, Yih-Shou Hsieh, Pei-Ni Chen, Jer-Yuh Liu, Yi-Hsien Hsieh
Summary: Our study shows that PKCa regulates the PA and MMPs systems in liver cancer cells through the p38 MAPK signaling pathway, promoting cell progression. MMP-1 and u-PA play critical roles in this pathway, and targeting these genes may be a potential treatment approach for liver cancer.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Environmental Sciences
Pei-Ju Wu, Hui-Ling Chiou, Yi-Hsien Hsieh, Chia-Liang Lin, Hsiang-Lin Lee, I-Chun Liu, Tsung-Ho Ying
Summary: Licoricidin, an active compound of Glycyrrhiza uralensis, was found to significantly inhibit cell viability and induce apoptosis in cervical cancer cells. It also triggered endoplasmic reticulum stress and upregulated the protein expression of GRP78 (Bip), CHOP, and IRE1 alpha, ultimately leading to immunogenic cell death. These findings suggest that Licoricidin may be a potential inducer of immunotherapy in advanced cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tsai-Yi Tseng, Chien-Hsing Lee, Hsiang-Lin Lee, Chien-Yu Su, Cheng-Yen Kao, Jen-Pi Tsai, Yi-Hsien Hsieh
Summary: Licochalcone A (LicA) is a potent anti-inflammatory, antioxidant, and anticarcinogenic substance that shows therapeutic potential against renal cell carcinoma (RCC). LicA limits cell growth, induces cell cycle arrest, promotes autophagy and LC3B expression, and inhibits migration and invasion of RCC cells. The chemotherapeutic effects of LicA on RCC are mediated through the activation of LC3B expression, ultimately modulating the FAK/Src signaling pathway-mediated Sp1 expression.
Article
Environmental Sciences
Kuan-Chun Hsueh, Po-Chung Ju, Yi-Hsien Hsieh, Shih-Chi Su, Chao-Bin Yeh, Chiao-Wen Lin
Summary: HO-3867 triggers cell cycle arrest and apoptotic responses in liver cancer, possibly involving p38-mediated activation of caspase cascades.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Tsai-Kun Wu, Tung-Wei Hung, Yong-Syuan Chen, Ying-Ru Pan, Yi-Hsien Hsieh, Jen-Pi Tsai
Summary: Corosolic acid inhibits the migration and invasion of renal cell carcinoma cells by reducing MMP2 expression and stimulating ERK1/2 phosphorylation.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wen-Chun Sun, Chia-Liang Lin, Tzong-Huei Lee, Chia-Hao Chang, Ann-Zhi Ong, Yen-Hsiu Yeh, Chen-Lin Yu, Guang-Wei Chen, Yi-Hsien Hsieh, Shih-Wei Wang
Summary: In this study, Chaetoglobosin A (ChA) was identified as a potent and selective antitumor agent in human colorectal cancer (CRC). ChA inhibited CRC cell growth and induced apoptotic cell death through mitochondrial intrinsic and caspase-dependent pathways. The expression of Heme oxygenase-1 (HO-1) was found to be associated with ChA-induced cell death, and inhibition of HO-1 increased the sensitivity of CRC cells to ChA.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Environmental Sciences
Jia-Sin Yang, Chia-Hsuan Chou, Yi-Hsien Hsieh, Peace Wun-Ang Lu, Ya-Chiu Lin, Shun-Fa Yang, Ko-Hsiu Lu
Summary: The study found that Morin can suppress the migration and invasion capabilities of human osteosarcoma cells, playing an anti-metastatic role by reducing uPA expression. Therefore, Morin may be a potential drug candidate for the treatment of human osteosarcoma.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Huang-Ming Hu, Hsiang-Lin Lee, Chung-Jung Liu, Yi-Hsien Hsieh, Yong-Syuan Chen, Kuan-Chun Hsueh
Summary: The study found that MTA2 regulates HCC progression through the MTA2-FAK-MMP7 pathway. PTK7, as a downstream factor of MTA2, affects the migration and invasion abilities of HCC cells by regulating MMP7 expression. The expression level of PTK7 is correlated with tumor stage, grade, and overall survival in HCC patients, and may have diagnostic value for HCC patients.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Shun-Fa Yang, Yu-Chen Su, Chen-Chee Lim, Jing-Yang Huang, Sheng-Min Hsu, Li-Wha Wu, Yi-Sheng Chang, Jia-Horung Hung
Summary: A retrospective cohort study using the Taiwan's National Health Insurance Research Database found that patients with retinal diseases who received intravitreal anti-vascular endothelial growth factor (VEGF) agents had an increased risk of becoming dialysis dependent, especially those with diabetic macular edema.