A Pan-Cancer Approach to Predict Responsiveness to Immune Checkpoint Inhibitors by Machine Learning

Correlate tumor mutation burden with immune signatures in human cancers

(2019) Xiaosheng Wang et al.   BMC IMMUNOLOGY

Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis

(2019) Michael Schulz et al.   Frontiers in Immunology

Tumor-induced escape mechanisms and their association with resistance to checkpoint inhibitor therapy

(2019) Michael Friedrich et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Plasma Biomarkers and Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer: New Tools for Better Patient Selection?

(2019) Adrien Costantini et al.   Cancers

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

(2018) Jianfang Liu et al.   CELL

A Pan-cancer Landscape of Interactions between Solid Tumors and Infiltrating Immune Cell Populations

(2018) David Tamborero et al.   CLINICAL CANCER RESEARCH

The Immune Landscape of Cancer

(2018) Vésteinn Thorsson et al.   IMMUNITY

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

(2018) Kyle Ellrott et al.   Cell Systems

Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA)

(2018) Patrick Danaher et al.   Journal for ImmunoTherapy of Cancer

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

Topography of cancer-associated immune cells in human solid tumors

(2018) Jakob Nikolas Kather et al.   eLife

High and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors

(2018) Saman Maleki Vareki   Journal for ImmunoTherapy of Cancer

Immunotherapy for colorectal cancer: where are we heading?

(2017) Debora Basile et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The between Now and Then of Lung Cancer Chemotherapy and Immunotherapy

(2017) Roberta Visconti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

(2017) Pornpimol Charoentong et al.   Cell Reports

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

(2017) Zachary R. Chalmers et al.   Genome Medicine

Immunotherapy for gastric cancers: emerging role and future perspectives

(2017) Marta Bonotto et al.   Expert Review of Clinical Pharmacology

CTLA-4 and PD-1 Pathways

(2016) Elizabeth I. Buchbinder et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Immunotherapy for genitourinary cancer

(2016) Carlo Cattrini et al.   ANTI-CANCER DRUGS

Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy

(2016) Weijie Ma et al.   Journal of Hematology & Oncology

Landscape of tumor-infiltrating T cell repertoire of human cancers

(2016) Bo Li et al.   NATURE GENETICS

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

(2016) N. McGranahan et al.   SCIENCE

Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy

(2015) Mihaela Angelova et al.   GENOME BIOLOGY

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

A Comparison of MCC and CEN Error Measures in Multi-Class Prediction

(2012) Giuseppe Jurman et al.   PLoS One