Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival

Dual mechanisms by which miR-125b represses IRF4 to induce myeloid and B-cell leukemias

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Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma

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Argonaute 2 promotes myeloma angiogenesis via microRNA dysregulation

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Mechanism of immunomodulatory drugs' action in the treatment of multiple myeloma

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Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN

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The clinical significance of cereblon expression in multiple myeloma

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Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

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The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

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Cereblon inhibits proteasome activity by binding to the 20S core proteasome subunit beta type 4

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Identification of a Role for CLASP2 in Insulin Action

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Regulation of microRNA biogenesis and function

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Functional modulation of AMP-activated protein kinase by cereblon

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Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide

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Multiple myeloma: 2011 update on diagnosis, risk-stratification, and management

(2010) S. Vincent Rajkumar   AMERICAN JOURNAL OF HEMATOLOGY

Structural assembly of cullin-RING ubiquitin ligase complexes

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Temporal and Spatial Mouse Brain Expression of Cereblon, An Ionic Channel Regulator Involved in Human Intelligence

(2010) Joseph J. Higgins et al.   JOURNAL OF NEUROGENETICS

High-risk myeloma is associated with global elevation of miRNAs and overexpression ofEIF2C2/AGO2

(2010) Yiming Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Primary Target of Thalidomide Teratogenicity

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MiRNAs and Cancer

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Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6

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Cereblon is expressed in the retina and binds to voltage-gated chloride channels

(2009) Bettina Hohberger et al.   FEBS LETTERS

MicroRNAs in the ontogeny of leukemias and lymphomas

(2009) Muller Fabbri et al.   LEUKEMIA & LYMPHOMA

Coexpression of Argonaute-2 enhances RNA interference toward perfect match binding sites

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Protein interactions and complexes in human microRNA biogenesis and function

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