Effects and Safety of an Oral Adsorbent on Chronic Kidney Disease Progression: A Systematic Review and Meta-Analysis

Review of the efficacy of AST-120 (KREMEZIN®) on renal function in chronic kidney disease patients

(2019) Mayumi Asai et al.   RENAL FAILURE

Indoxyl Sulfate: A Novel Cardiovascular Risk Factor in Chronic Kidney Disease

(2017) Szu‐Chun Hung et al.   Journal of the American Heart Association

A Randomized, Controlled Trial of Oral Intestinal Sorbent AST-120 on Renal Function Deterioration in Patients with Advanced Renal Dysfunction

(2016) R.-h. Cha et al.   Clinical Journal of the American Society of Nephrology

Indoxyl sulfate suppresses endothelial progenitor cell–mediated neovascularization

(2016) Szu-Chun Hung et al.   KIDNEY INTERNATIONAL

The effects of AST-120 on chronic kidney disease progression in the United States of America: a post hoc subgroup analysis of randomized controlled trials

(2016) Gerald Schulman et al.   BMC Nephrology

Global Prevalence of Chronic Kidney Disease – A Systematic Review and Meta-Analysis

(2016) Nathan R. Hill et al.   PLoS One

Worldwide access to treatment for end-stage kidney disease: a systematic review

(2015) Thaminda Liyanage et al.   LANCET

Uremic Retention Solute Indoxyl Sulfate Level Is Associated with Prolonged QTc Interval in Early CKD Patients

(2015) Wei-Hua Tang et al.   PLoS One

Impact of the oral adsorbent AST-120 on oxidative stress and uremic toxins in high-risk chronic kidney disease patients

(2014) Shigeru Toyoda et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Uremic Toxin Indoxyl Sulfate Increases Pulmonary Vein and Atrial Arrhythmogenesis

(2014) WEI-TA CHEN et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

The Uremic Toxicity of Indoxyl Sulfate and p-Cresyl Sulfate: A Systematic Review

(2014) R. Vanholder et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Randomized Placebo-Controlled EPPIC Trials of AST-120 in CKD

(2014) G. Schulman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Oral adsorbent AST-120 potentiates the effect of erythropoietin-stimulating agents on Stage 5 chronic kidney disease patients: a randomized crossover study

(2014) I.-W. Wu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway

(2013) Bertrand Gondouin et al.   KIDNEY INTERNATIONAL

Retained organic solutes, patient characteristics and all-cause and cardiovascular mortality in hemodialysis: results from the retained organic solutes and clinical outcomes (ROSCO) investigators

(2013) Michal L Melamed et al.   BMC Nephrology

Relation of Plasma Indoxyl Sulfate Levels and Estimated Glomerular Filtration Rate to Left Ventricular Diastolic Dysfunction

(2012) Bummei Sato et al.   AMERICAN JOURNAL OF CARDIOLOGY

KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update

(2012)   AMERICAN JOURNAL OF KIDNEY DISEASES

Chronic Kidney Disease-Induced Cardiac Fibrosis Is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uremic Toxin, Indoxyl Sulfate

(2012) Suree Lekawanvijit et al.   PLoS One

Indoxyl Sulfate Is a Nephro-Vascular Toxin

(2010) Toshimitsu Niwa   JOURNAL OF RENAL NUTRITION

Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis

(2010)   LANCET

Effect of a Carbonaceous Oral Adsorbent on the Progression of CKD: A Multicenter, Randomized, Controlled Trial

(2009) Tadao Akizawa et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Indoxyl Sulfate Inhibits Nitric Oxide Production and Cell Viability by Inducing Oxidative Stress in Vascular Endothelial Cells

(2009) Zohra Tumur et al.   AMERICAN JOURNAL OF NEPHROLOGY

Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients

(2009) F. C. Barreto et al.   Clinical Journal of the American Society of Nephrology

Indoxyl Sulfate Promotes Proliferation of Human Aortic Smooth Muscle Cells by Inducing Oxidative Stress

(2009) Gulinuer Muteliefu et al.   JOURNAL OF RENAL NUTRITION

AST-120 (Kremezin®) initiated in early stage chronic kidney disease stunts the progression of renal dysfunction in type 2 diabetic subjects

(2008) Kazunori Konishi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE