Article
Oncology
Alyce Mei-Shiuan Kuo, Stephanie Gu, Joseph Stoll, Andrea P. Moy, Stephen W. Dusza, Allison Gordon, Elena C. Haliasos, Yelena Janjigian, Lukas Kraehenbuehl, Elizabeth A. Quigley, Paul Chapman, Mario E. Lacouture, Alina Markova
Summary: Immune checkpoint inhibitors (ICI) can effectively target cancer cells, but they may also cause immune-related cutaneous adverse events (ircAEs) in a significant number of patients. This study examined the use of dupilumab for treating ICI-associated ircAEs and found that 87% of patients responded to the treatment, with 44.1% achieving complete resolution of the adverse events.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Patrick Demkowicz, Renelle Pointdujour-Lim, Sofia Miguez, Yesung Lee, Bailey S. C. L. Jones, Christopher A. Barker, Marcus Bosenberg, David H. Abramson, Alexander N. Shoushtari, Harriet Kluger, Jasmine H. Francis, Mario Sznol, Mathieu F. Bakhoum
Summary: This study retrospectively analyzed clinical data of patients with metastatic uveal melanoma and found that female sex, treatment with immune checkpoint inhibitors, and the absence of liver metastasis were associated with better survival outcomes. These findings highlight the potential of immunotherapy in treating metastatic uveal melanoma.
Review
Oncology
Kaushal Parikh, Lizza E. L. Hendriks, Paolo Bironzo, Jordi Remon
Summary: Malignant pleural mesothelioma is a rare and aggressive thoracic malignancy with poor prognosis, but the recent approval of immune checkpoint inhibitors has brought hope for treatment. However, there are still unresolved challenges, such as determining the best upfront immune approach and utilizing predictive biomarkers.
CANCER TREATMENT REVIEWS
(2021)
Article
Immunology
W. J. Mullally, F. J. Cooke, I. M. Crosbie, S. Kumar, V. E. Abernethy, E. J. Jordan, M. O'Connor, A. M. Horgan, R. Landers, J. Naidoo, P. M. Calvert
Summary: This is a case of a man in his early 50s who presented with small bowel obstruction and was found to have metastatic melanoma without a primary lesion. After receiving immunotherapy, the patient developed a series of symptoms and eventually died from immune-related thrombotic thrombocytopenic purpura (TTP).
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Sergio Di Molfetta, Andrea Dotto, Giuseppe Fanciulli, Tullio Florio, Tiziana Feola, Annamaria Colao, Antongiulio Faggiano
Summary: Medullary thyroid carcinoma is a rare neuroendocrine neoplasm that usually requires surgery for treatment. Recent interest in immune checkpoint inhibitors has sparked hope for new treatment options for patients with this type of cancer.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
L. Susok, S. Said, D. Reinert, R. Mansour, C. H. Scheel, J. C. Becker, T. Gambichler
Summary: The pan-immune-inflammation value (PIV) and systemic immune-inflammation index (SII) in patients with cutaneous melanoma (CM) under immune checkpoint inhibitor (ICI) therapy do not seem to be significant predictors for clinical outcome measures of CM patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Spencer C. Wei, Wouter C. Meijers, Margaret L. Axelrod, Nana-Ama A. S. Anang, Elles M. Screever, Elizabeth C. Wescott, Douglas B. Johnson, Elizabeth Whitley, Lorenz Lehmann, Pierre-Yves Courand, James J. Mancuso, Lauren E. Himmel, Benedicte Lebrun-Vignes, Matthew J. Wleklinski, Bjorn C. Knollmann, Jayashree Srinivasan, Yu Li, Oluwatomisin T. Atolagbe, Xiayu Rao, Yang Zhao, Jing Wang, Lauren I. R. Ehrlich, Padmanee Sharma, Joe-Elie Salem, Justin M. Balko, Javid J. Moslehi, James P. Allison
Summary: This study presents a robust preclinical model of ICI-associated myocarditis that recapitulates the clinical syndrome. Using this model, researchers demonstrate that CTLA4 and PD-1 (ICI targets) functionally interact in the development of myocarditis, and intervention with CTLA4-Ig (abatacept) attenuates myocarditis, providing mechanistic rationale and preclinical support for therapeutic clinical studies.
Article
Oncology
Charlotte Nuebel, Teresa Amaral, Ulrike Leiter, Lukas Flatz, Andrea Forschner
Summary: The combined immune checkpoint inhibition with ipilimumab 1 mg/kg and nivolumab 3 mg/kg is an equally effective but better-tolerated therapy regimen for patients with metastatic melanoma, as supported by the results of the CheckMate 511 study.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Helene Salaun, Leanne de Koning, Mathilde Saint-Ghislain, Vincent Servois, Toulsie Ramtohul, Agathe Garcia, Alexandre Matet, Nathalie Cassoux, Pascale Mariani, Sophie Piperno-Neumann, Manuel Rodrigues
Summary: Although the combined PD-1/CTLA-4 inhibition therapy with nivolumab/ipilimumab does not improve clinical outcomes compared to other therapies, it is more toxic and should be considered as an option rather than a standard treatment for metastatic uveal melanoma patients.
Article
Biochemistry & Molecular Biology
Ming-Wei Kao, Yao-Hung Kuo, Kun-Chou Hsieh, Ching-Tai Lee, Shih-Chi Wu, Wen-Chi Yang
Summary: For patients with unresectable esophageal squamous cell carcinoma (SCC), combination therapy of nivolumab and chemotherapy demonstrates a better overall response rate and longer overall survival compared to chemotherapy alone or with radiotherapy. The expression of PD-L1 in esophageal cancer is associated with poor prognosis. Nivolumab with chemotherapy provides a more effective treatment option with fewer adverse effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Daniel Roessler, Osman Oecal, Alexander B. Philipp, Daniel Markwardt, Stefan Munker, Julia Mayerle, Leonie S. Jochheim, Katharina Hammer, Christian M. Lange, Andreas Geier, Max Seidensticker, Florian P. Reiter, Enrico N. De Toni, Najib Ben Khaled
Summary: This retrospective study demonstrates that the combination of ipilimumab and nivolumab can be effective and well-tolerated after the failure of prior ICI-based combination therapies in patients with advanced HCC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sonja Vukadin, Farah Khaznadar, Tomislav Kizivat, Aleksandar Vcev, Martina Smolic
Summary: Immune checkpoint inhibitors have revolutionized the treatment of advanced melanoma, but a significant proportion of patients still experience primary and acquired resistance. Mechanisms of primary drug resistance are not fully understood, while acquired resistance may arise from various alterations in ICI-resistant melanomas.
Article
Medicine, Research & Experimental
Bettina Sobottka, Marta Nowak, Anja Laura Frei, Martina Haberecker, Samuel Merki, Mitchell P. Levesque, Reinhard Dummer, Holger Moch, Viktor Hendrik Koelzer
Summary: CD8+ tumor-infiltrating T cells play a crucial role in predicting responses to immune checkpoint inhibitors in immune-oncology. A computational diagnostic algorithm was established to quantitatively measure the spatial densities of these cells in tumor compartments, leading to the successful classification into immune diagnostic categories. This approach allows for efficient immune phenotyping of metastatic lesions, even in the absence of material from the invasive margin, providing valuable insights for immunotherapy strategies in metastatic melanoma.
LABORATORY INVESTIGATION
(2021)
Article
Medicine, General & Internal
Alexander S. Watson, Siddhartha Goutam, Igor Stukalin, Benjamin W. Ewanchuk, Michael Sander, Daniel E. Meyers, Aliyah Pabani, Winson Y. Cheung, Daniel Y. C. Heng, Tina Cheng, Jose G. Monzon, Vishal Navani
Summary: This study examines the association between immune-related adverse events (irAEs) and survival in patients with metastatic melanoma, particularly those receiving combination immune checkpoint blockade (ICB).
Article
Oncology
Bianca Gautron Moura, Camille L. Gerard, Nathalie Testart, Marian Caikovski, Alexandre Wicky, Veronica Aedo-Lopez, Gregoire Berthod, Krisztian Homicsko, John O. Prior, Clarisse Dromain, Lana E. Kandalaft, Michel A. Cuendet, Olivier Michielin
Summary: In stage IV melanoma, the combination of ipilimumab and nivolumab significantly improves outcomes but has a major financial impact on healthcare. This study analyzes the costs associated with ipilimumab-nivolumab combination, focusing on immune-related adverse events (irAE). Surprisingly, toxicity costs are insignificant compared to the total treatment costs, and patients with higher toxicity grades have lower costs and better outcomes. These findings provide important information for clinicians and healthcare organizations making treatment decisions in immunotherapy.
Letter
Critical Care Medicine
Catherine A. Gao, Michael J. Cuttica, Elizabeth S. Malsin, A. Christine Argento, Richard G. Wunderink, Sean B. Smith, A. Christine Argento, Ajay A. Wagh, Alexandra C. McQuattie-Pimentel, Alexis Rose Wolfe, Ankit Bharat, Anne R. Levenson, Anthony M. Joudi, Arjun Sinha, Ashley N. Budd, Benjamin D. Singer, Betty Tran, Catherine A. Gao, Chiagozie O. Pickens, Chitaru Kurihara, Christopher J. Soriano, Clara J. Schroedl, Daniel Meza, David Alexander Kidd, David W. Kamp, Elizabeth S. Malsin, Emily M. Leibenguth, Eric P. Cantey, Gabrielle Y. Liu, Giang T. Quach, G. R. Scott Budinger, Jacqueline M. Kruser, James M. Walter, Jane E. Dematte, Jason A. Bonomo, John M. Coleman, Joseph Isaac Bailey, Joseph S. Deters, Joseph Sun, Justin A. Fiala, Kaitlyn Vitale, Kara M. Joseph, Katharine Secunda, Khalilah L. Gates, Kristy Todd, Lindsey D. Gradone, Lindsey N. Textor, Lisa F. Wolfe, Luisa Morales-Nebreda, Madeline L. Rosenbaum, Manu Jain, Marc A. Sala, Mark Saine, Marysa V. Leya, Michael J. Alexander, Michael J. Cuttica, Michelle Hinsch Prickett, Natalie Jensema, Paul A. Reyfman, Peter H. S. Sporn, Rachel B. Kadar, Rachel M. Kaplan, Rade Tomic, Radhika Patel, Rafael Garza-Castillon, Ravi Kalhan, Richard G. Wunderink, Romy Lawrence, Ruben J. Mylvaganam, Samuel S. Kim, Sanket Thakkar, Sean B. Smith, SeungHye Han, Sharon R. Rosenberg, Susan R. Russell, Sydney M. Hyder, Taylor A. Poor, Theresa A. Lombardo
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Engineering, Biomedical
Chitaru Kurihara, Adwaiy Manerikar, Catherine Aiyuan Gao, Satoshi Watanabe, Viswajit Kandula, Alexandra Klonis, Vanessa Hoppner, Azad Karim, Mark Saine, David D. Odell, Kalvin Lung, Rafael Garza-Castillon, Samuel S. Kim, James McCauley Walter, Richard G. Wunderink, G. R. Scott Budinger, Ankit Bharat
Summary: Comparison of outcomes between COVID-19 and non-COVID-19 patients undergoing V-V ECMO support showed similar survival rates despite longer support duration for COVID-19 patients. Late initiation of ECMO in COVID-19 patients led to extremely high mortality rates, emphasizing the importance of early initiation for improved outcomes.
Article
Multidisciplinary Sciences
Masahiro Yoshida, Kaylee B. Worlock, Ni Huang, Rik G. H. Lindeboom, Colin R. Butler, Natsuhiko Kumasaka, Cecilia Dominguez Conde, Lira Mamanova, Liam Bolt, Laura Richardson, Krzysztof Polanski, Elo Madissoon, Josephine L. Barnes, Jessica Allen-Hyttinen, Eliz Kilich, Brendan C. Jones, Angus de Wilton, Anna Wilbrey-Clark, Waradon Sungnak, J. Patrick Pett, Elena Prigmore, Henry Yung, Puja Mehta, Aarash Saleh, Anita Saigal, Vivian Chu, Jonathan M. Cohen, Clare Cane, Aikaterini Iordanidou, Soichi Shibuya, Ann-Kathrin Reuschl, Ivan T. Herczeg, A. Christine Argento, Richard G. Wunderink, Sean B. Smith, Taylor A. Poor, Catherine A. Gao, Jane E. Dematte, Gary Reynolds, Muzlifah Haniffa, Georgina S. Bowyer, Matthew Coates, Menna R. Clatworthy, Fernando J. Calero-Nieto, Berthold Goettgens, Christopher O'Callaghan, Neil J. Sebire, Clare Jolly, Paolo de Coppi, Claire M. Smith, Alexander Misharin, Sam M. Janes, Sarah A. Teichmann, Marko Z. Nikolic, Kerstin B. Meyer
Summary: Higher innate interferon responses in children may restrict viral replication and disease progression, while the response to SARS-CoV-2 infection differs between children and adults.
Article
Medicine, General & Internal
Catherine A. Gao, James M. Walter, Jane E. Dematte D'Amico
Summary: This case highlights the possibility of rash and multisystem inflammation in coronavirus disease, which may not always present with prominent respiratory symptoms. It reminds physicians to consider atypical presentations when diagnosing coronavirus disease.
JOURNAL OF MEDICAL CASE REPORTS
(2021)
Review
Multidisciplinary Sciences
Joao B. Xavier, Jonathan M. Monk, Saugat Poudel, Charles J. Norsigian, Anand Sastry, Chen Liao, Jose Bento, Marc A. Suchard, Mario L. Arrieta-Ortiz, Eliza J. R. Peterson, Nitin S. Baliga, Thomas Stoeger, Felicia Ruffin, Reese A. K. Richardson, Catherine A. Gao, Thomas D. Horvath, Anthony M. Haag, Qinglong Wu, Tor Savidge, Michael R. Yeaman
Summary: Mathematical models are widely used in the study of infectious diseases to predict outbreaks and design containment strategies. This review explores different models and identifies commonalities among them, aiming to provide essential information for their use and prediction to better combat pathogens and the associated diseases.
Article
Infectious Diseases
Roxane Rohani, Marc H. Scheetz, Helen K. Donnelly, Alvaro Donayre, Mengjia Kang, Estefani Diaz, Kay Dedicatoria, Alan R. Hauser, Egon A. Ozer, Sophia Nozick, Chao Qi, Anna E. Pawlowski, Michael N. Neely, Alexander Misharin, Richard G. Wunderink, Nathaniel J. Rhodes
Summary: Critical illness affects the attainment of pharmacokinetic/pharmacodynamic (PK/PD) targets. This study aimed to quantify PK/PD attainment in patients with hospital-acquired pneumonia. The results showed that individualized treatment is required to achieve suggested PK/PD targets.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Health Care Sciences & Services
Bryan Brown, Katherine A. Gielissen, Sarita Soares, Catherine A. Gao, Jeremy Moeller, Donna Windish
Summary: Background animation in medical education has seen significant growth, and this study compared the efficacy of two animated video styles in a diabetes pharmacotherapy curriculum for internal medicine residents. The results showed that both styles of animation were effective for learning, but Sugar-Coated Science (SCS) significantly enhanced learner experience and telepresence.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Critical Care Medicine
Shuang A. Guo, Georgina S. Bowyer, John R. Ferdinand, Mailis Maes, Zewen K. Tuong, Eleanor Gillman, Mingfeng Liao, Rik G. H. Lindeboom, Masahiro Yoshida, Kaylee Worlock, Hudaa Gopee, Emily Stephenson, Catherine A. Gao, Paul A. Lyons, Kenneth G. C. Smith, Muzlifah Haniffa, Kerstin B. Meyer, Marko Z. Nikolic, Zheng Zhang, Richard G. Wunderink, Alexander Misharin, Gordon Dougan, Vilas Navapurkar, Sarah A. Teichmann, Andrew Conway Morris, Menna R. Clatworthy
Summary: Obesity has a negative impact on respiratory tract immunity in both adult and pediatric COVID-19 patients, leading to suppressed immune cell responses. Obese individuals show decreased expression of interferon and tumor necrosis factor in lung epithelial and immune cells. These findings have important implications for treatment strategies and recommend the specific application of recombinant interferons in obese patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Immunology
Catherine A. Gao, Luisa Morales-Nebreda, Chiagozie Pickens
Summary: Pneumonia is a major cause of disease burden and mortality worldwide, primarily caused by Gram-negative bacteria. Traditional antibiotic treatment strategies face challenges due to the rise of multidrug-resistant and hypervirulent strains. Therefore, alternative approaches focusing on immune resistance and tissue resilience are needed. Adaptive immunity plays a crucial role in modulating the incidence and severity of pneumonia. This review discusses the adaptive T cell responses to pneumonia induced by Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii, highlighting potential therapeutic targets and areas for future research.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Critical Care Medicine
Catherine A. A. Gao, Chiagozie I. Pickens, Luisa Morales-Nebreda, Richard G. Wunderink
Summary: Community-acquired pneumonia (CAP) is a common and serious condition that leads to a significant number of infection-related deaths worldwide. The causes are diverse and often unknown. The emergence of COVID-19 in 2019 has caused a devastating pandemic with similar clinical features to CAP, making it difficult to distinguish. This article highlights the unique clinical features of COVID-19 pneumonia and its distinct imaging appearance.
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Health Care Sciences & Services
Catherine A. Gao, Frederick M. Howard, Nikolay S. Markov, Emma C. Dyer, Siddhi Ramesh, Yuan Luo, Alexander T. Pearson
Summary: Researchers used ChatGPT to generate medical research abstracts, which were mostly detected as fake by an AI output detector. The generated abstracts scored lower in plagiarism detection and human review, but it was difficult for reviewers to differentiate between the generated and original ones. AI output detectors can be used as editorial tools to maintain scientific standards.
NPJ DIGITAL MEDICINE
(2023)
Article
Immunology
Chiagozie Pickens, Catherine A. Gao, Justin Bodner, James M. Walter, Jacqueline M. Kruser, Helen K. Donnelly, Alvaro Donayre, Katie Clepp, Nicole Borkowski, Richard G. Wunderink, Benjamin D. Singer, N. U. S. C. R. I. P. T. Study Investigators NU SCRIPT Study Investigators
Summary: This study aimed to develop an adjudication protocol for severe bacterial and/or viral pneumonia and evaluate its effectiveness. The results showed that achieving clinical cure by day 7-8 was associated with more favorable hospital discharge dispositions. However, the interobserver agreement among the adjudicators was only moderate.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Medicine, Research & Experimental
Catherine A. Gao, Nikolay S. Markov, Thomas Stoeger, Anna Pawlowski, Mengjia Kang, Prasanth Nannapaneni, Rogan A. Grant, Chiagozie Pickens, James M. Walter, Jacqueline M. Kruser, Luke Rasmussen, Daniel Schneider, Justin Starren, Helen K. Donnelly, Alvaro Donayre, Yuan Luo, G. R. Scott Budinger, Richard G. Wunderink, Alexander V. Misharin, Benjamin D. Singer
Summary: This study aimed to determine the contribution of unsuccessful treatment of ventilator-associated pneumonia (VAP) to mortality for patients with severe pneumonia. By observing 585 mechanically ventilated patients with severe pneumonia and respiratory failure, it was found that the unsuccessful treatment of VAP was associated with higher mortality.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Meeting Abstract
Critical Care Medicine
Catherine Gao, Hyojun Ada Lee, Heliodoro Tejedor Navarro, Meagan Bechel, Olivia Keaveny, Curtis Weiss, Luis Amaral
CRITICAL CARE MEDICINE
(2022)
Letter
Respiratory System
Catherine A. Gao, Joseph I. Bailey, James M. Walter, John M. Coleman, Elizabeth S. Malsin, A. Christine Argento, Michelle H. Prickett, Richard G. Wunderink, Sean B. Smith
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)