Major obstacles to doxorubicin therapy: Cardiotoxicity and drug resistance

Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals

(2019) Hamdan S. Al-malky et al.   Cancer Cell International

Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review

(2018) Mohammad Mohajeri et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Natural history of myocardial deformation in children, adolescents, and young adults exposed to anthracyclines: Systematic review and meta-analysis

(2018) Mirela Tuzovic et al.   ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES

The HER2 inhibitor lapatinib potentiates doxorubicin-induced cardiotoxicity through iNOS signaling

(2018) Wan-Tseng Hsu et al.   Theranostics

FOXO Signaling Pathways as Therapeutic Targets in Cancer

(2017) Mohd Farhan et al.   International Journal of Biological Sciences

Administration of Dexrazoxane Improves Cardiac Indices in Children and Young Adults With Acute Myeloid Leukemia (AML) While Maintaining Survival Outcomes

(2017) Nathan J. Schloemer et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Polyphenols, autophagy and doxorubicin-induced cardiotoxicity

(2017) S. Shabalala et al.   LIFE SCIENCES

Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity

(2017) Navid Koleini et al.   Oncotarget

Comparative effects of doxorubicin and a doxorubicin analog, 13-deoxy, 5-iminodoxorubicin (GPX-150), on human topoisomerase IIβ activity and cardiac function in a chronic rabbit model

(2016) Nicole E. Frank et al.   INVESTIGATIONAL NEW DRUGS

The role of p53 in cancer drug resistance and targeted chemotherapy

(2016) Karin Hientz et al.   Oncotarget

MicroRNA Profile in Response to Doxorubicin Treatment in Breast Cancer

(2015) Eduardo Tormo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Paradoxically, iron overload does not potentiate doxorubicin-induced cardiotoxicity in vitro in cardiomyocytes and in vivo in mice

(2015) Charles Guenancia et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Iron metabolism and iron supplementation in cancer patients

(2015) Heinz Ludwig et al.   WIENER KLINISCHE WOCHENSCHRIFT

Role of MRP transporters in regulating antimicrobial drug inefficacy and oxidative stress-induced pathogenesis during HIV-1 and TB infections

(2015) Upal Roy et al.   Frontiers in Microbiology

Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron

(2014) Tomáš Šimůnek et al.   Pharmacological Reports

Targeting p53 for Novel Anticancer Therapy

(2014) Zhen Wang et al.   Translational Oncology

New Mechanistic and Functional Insights into DNA Topoisomerases

(2013) Stefanie Hartman Chen et al.   Annual Review of Biochemistry

Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance

(2013) Ana R. Gomes et al.   Chinese Journal of Cancer

Mechanisms and insights into drug resistance in cancer

(2013) Hiba Zahreddine et al.   Frontiers in Pharmacology

Overview of P-glycoprotein inhibitors: a rational outlook

(2012) Kale Mohana Raghava Srivalli et al.   Brazilian Journal of Pharmaceutical Sciences

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

(2012) Wynand P. Roos et al.   CANCER LETTERS

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib - the role of extracellular signal-regulated kinase counteraction

(2011) Irena Manov et al.   FEBS Journal

Role of heat shock factor-1 activation in the doxorubicin-induced heart failure in mice

(2010) Kaushik Vedam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway

(2010) Takahiro Horie et al.   CARDIOVASCULAR RESEARCH

Diclofenac Sodium, a Nonselective Nonsteroidal Anti-Inflammatory Drug Aggravates Doxorubicin-Induced Cardiomyopathy in Rats

(2010) Bhulan Kumar Singh et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Alteration of Topoisomerase II–Alpha Gene in Human Breast Cancer: Association With Responsiveness to Anthracycline-Based Chemotherapy

(2010) Michael F. Press et al.   JOURNAL OF CLINICAL ONCOLOGY

Doxorubicin pathways

(2010) Caroline F. Thorn et al.   Pharmacogenetics and Genomics

Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy

(2010) Rui A. Carvalho et al.   TOXICOLOGY

Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro

(2009) Partha Mukhopadhyay et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NADPH oxidases participate to doxorubicin-induced cardiac myocyte apoptosis

(2009) Mylène Gilleron et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overview of the Molecular Bases of Resistance to Chemotherapy in Liver and Gastrointestinal Tumours

(2009) J. Marin et al.   CURRENT MOLECULAR MEDICINE

Transcription Factor GATA4 Inhibits Doxorubicin-induced Autophagy and Cardiomyocyte Death

(2009) Satoru Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice

(2008) Alexander Riad et al.   EUROPEAN JOURNAL OF HEART FAILURE

TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance

(2008) Nathalie Wong et al.   INTERNATIONAL JOURNAL OF CANCER

Doxorubicin, Cardiac Risk Factors, and Cardiac Toxicity in Elderly Patients With Diffuse B-Cell Non-Hodgkin's Lymphoma

(2008) Dawn L. Hershman et al.   JOURNAL OF CLINICAL ONCOLOGY

Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells

(2008) R. C-Y. Hui et al.   MOLECULAR CANCER THERAPEUTICS