Article
Medicine, General & Internal
Zhiya Hu, Ziyi Zuo, Han Miao, Zhijie Ning, Youyuan Deng
Summary: This study developed two nomograms for predicting the prognosis of patients with T4a gastric cancer. The results showed that age, tumor size, race, histologic type, N stage, surgery status, radiotherapy, and chemotherapy were identified as independent prognostic factors for both overall survival and cancer-specific survival in these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
Dandan Li, Lingyun Xia, Pan Huang, Zidi Wang, Qiwei Guo, Congcong Huang, Weidong Leng, Shanshan Qin
Summary: We found that IGFBP7 enhances the stability of oncogenic lncRNA UBE2CP3 by RNA-RNA interaction in gastric cancer. Clinical analysis demonstrated that IGFBP7 is associated with poor prognosis and macrophage infiltration in gastric cancer. Mechanistically, IGFBP7 promotes gastric cancer progression by regulating tumor-associated macrophage polarization through the FGF2/FGFR1/PI3K/AKT axis.
CELL DEATH DISCOVERY
(2023)
Article
Surgery
Ho-Jung Shin, Sang-Yong Son, Bo Wang, Chul Kyu Roh, Hoon Hur, Sang-Uk Han
Summary: This study compared the long-term outcomes of robotic and LG approaches in patients with gastric cancer. The results showed that after balancing covariates, there were no significant differences in long-term survival and recurrence-free survival between the two surgical methods, and robotic gastrectomy showed advantages in reducing blood loss.
Article
Multidisciplinary Sciences
Yoh-ichiro Iwasa, Moeka Shimizu, Kazuki Matsuura, Kentaro Hori, Ken Hiramatsu, Kenjiro Sugiyama, Yoh Yokota, Tomohiro Kitano, Ryosuke Kitoh, Yutaka Takumi
Summary: This study aimed to investigate the prognostic value of hematological biomarkers measured before and after treatment in patients with head and neck cancer (HNC). The pretreatment C-reactive protein/albumin ratio (pre-CAR) and post-treatment prognostic nutritional index (post-PNI) showed the highest area under the curve with cutoff values of 0.0945 and 34.9, respectively.
SCIENTIFIC REPORTS
(2023)
Article
Surgery
Tomoyuki Nagata, Yuki Adachi, Akihiro Taniguchi, Yu Kimura, Daisuke Iitaka, George Iwata, Nobuki Yamaoka
Summary: This study investigated the impact of postoperative complications on the prognosis of patients who underwent gastrectomy. The results showed that postoperative complications were associated with both gastric cancer-specific death and death from other causes. The major complications were classified into C-com and N-com groups based on their prognostic impact on cancer-specific survival and non-specific survival, respectively. Different postoperative complications worsened patient prognosis after gastrectomy in different ways, highlighting the importance of improved treatment strategies for different complication types.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Alexander Gaiger, Simone Lubowitzki, Katharina Krammer, Elisabeth L. Zeilinger, Andras Acel, Olivera Cenic, Andrea Schrott, Matthias Unseld, Anahita Paula Rassoulian, Cathrin Skrabs, Peter Valent, Heinz Gisslinger, Christine Marosi, Matthias Preusser, Gerald Prager, Gabriela Kornek, Robert Pirker, Gunther G. Steger, Rupert Bartsch, Markus Raderer, Ingrid Simonitsch-Klupp, Renate Thalhammer, Christoph Zielinski, Ulrich Jaeger
Summary: This study aimed to examine the impact of psychological and social indicators on the survival of patients with cancer or hematologic malignancies, while controlling for important biological factors. The study found that cancer site, metastatic disease, symptoms of depression, female sex, and anemia significantly influenced survival. These indicators were combined to develop the Cancer Survival Index, which identified three distinct groups of patients with different estimated survival times. The study highlights the importance of considering both psychosocial and biological factors in estimating individual patient survival.
Article
Nutrition & Dietetics
Shanjun Tan, Qiulin Zhuang, Zhige Zhang, Shuhao Li, Jiahao Xu, Junjie Wang, Yanni Zhang, Qiulei Xi, Qingyang Meng, Yi Jiang, Guohao Wu
Summary: This study investigated the link between postoperative loss of skeletal muscle mass and survival following gastric cancer surgery, finding that patients with postoperative skeletal muscle index loss >= 5% had poorer overall survival and disease-free survival. Further research is needed to determine whether stabilizing or enhancing skeletal muscle mass after surgery improves survival outcomes.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Min Jiang, Changyin Fang, Yongping Ma
Summary: This study aimed to determine the correlation between pyroptosis-related lncRNAs and gastric cancer prognoses. A predictive signature including six pyroptosis-related lncRNAs was established and confirmed to possess good predictive performance. High-risk gastric cancer patients were found to benefit from the combination of immunotherapy and chemotherapy. These findings highlight the potential of pyroptosis-related lncRNAs as novel biomarkers for the prognosis and treatment of gastric cancer.
Article
Oncology
Ali Guner, Minah Cho, Yoo-Min Kim, Jae-Ho Cheong, Woo Jin Hyung, Hyoung-Il Kim
Summary: This study found that the neutrophil count and albumin level one month after surgery are independent prognostic factors for long-term prognosis in gastric cancer patients, helping to stratify patients into different prognostic groups.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pathology
Junliang Li, Cheng Chen, Bo Chen, Tiankang Guo
Summary: This study investigated the expression pattern of FN1 in gastric cancer and its association with clinical characteristics, survival, MMR genes, and immune checkpoints. The results showed that high E-FN1 expression predicted poor overall survival, while high S-FN1 expression was associated with gastric cancer progression. FN1 expression was not correlated with MMR genes or immune checkpoints.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Pathology
Mingxia Jiang, Ling Qi, Kexin Jin, Lisha Li, Yiming Wu, Dongfeng Song, Junqing Gan, Mei Huang, Yanjing Li, Chengxin Song
Summary: The study revealed that high expression of eEF2K is associated with lymph node metastasis and serves as an independent prognostic indicator for overall survival and disease-free survival in surgically resected STAD patients. These findings suggest that eEF2K could be a potential therapeutic target for gastric cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Immunology
Qiu-Yue Han, Xia Zhang, Jian-Gang Zhang, Wen-Jun Zhou, Qiong-Yuan Chen, Yuan-Yuan Chen, Wei-Hua Yan, Aifen Lin
Summary: Pre-operative NLR is an independent prognostic factor for patients with gastric cancer and has stratified prognostic value for patients with AJCC stage III.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Liqiao Chen, Gang Ma, Pengliang Wang, Yinping Dong, Yong Liu, Zhenzhen Zhao, Jiamei Guo, Han Liang, Liyuan Yang, Jingyu Deng
Summary: Autophagy plays a significant role in cancer development. This study explores the value of autophagy-associated genes (AAGs) in gastric cancer using RNA sequencing data from TCGA, screening 28 discrepantly expressed AAGs and establishing a prognostic model with 5 prognostic AAGs. Patients at high risk identified by the model showed significantly worse overall survival rates in both training and test groups, with AUC of 0.736 and 0.809 respectively, indicating the model's potential for individualized treatment and improved prognosis in gastric cancer patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Yonghoon Choi, Nayoung Kim, Ki Wook Kim, Hyeong Ho Jo, Jaehyung Park, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Hyeon Jeong Oh, Hye Seung Lee, Young Suk Park, Sang-Hoon Ahn, Yun-Suhk Suh, Do Joong Park, Hyung-Ho Kim, Ji-Won Kim, Jin Won Kim, Keun-Wook Lee, Won Chang, Ji Hoon Park, Yoon Jin Lee, Kyoung Ho Lee, Young Hoon Kim
Summary: This study analyzed the differences in gastric cancer characteristics according to sex in patients who underwent surgical treatment. Female patients were found to have a younger age at diagnosis, higher prevalence of cancer in the gastric body and diffuse histology, and higher overall survival rate. However, the difference in gastric cancer-specific survival rate was not significant. Older age, upper location of cancer, and diffuse or mixed histology were identified as risk factors for gastric cancer-related mortality. Males had a higher mortality rate from diseases other than gastric cancer, while females had a higher mortality rate from cardiovascular or cerebrovascular diseases.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medical Laboratory Technology
Jun Yang, Yingjing Wang, Rong Ge, Xiupeng Jia, Congshan Ge, Youqing Cen, Deng Pan
Summary: This study found that overexpression of Copines-1 in gastric cancer is significantly associated with poor prognosis, suggesting that CPNE1 may be a potential biomarker for prognosis in gastric cancer patients.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)