Article
Medicine, General & Internal
Yung-Liang Liu, Chun- Lee, Chung-Hsien Liu, En-Hui Cheng, Shun-Fa Yang, Hsueh-Yu Tsai, Maw-Sheng Lee, Tsung-Hsien Lee
Summary: This study investigated the effect of single-nucleotide polymorphisms (SNPs) in the leukemia inhibitory factor (LIF) gene on ovarian response in infertile young women. The results showed that the LIF genotype was significantly associated with a reduction in ovarian response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Charlotte Mauries, Noemie Ranisavljevic, Caroline Mollevi, Cecile Brunet, Samir Hamamah, Sophie Brouillet, Tal Anahory
Summary: This study compares the number of oocytes obtained using the SAS stimulation protocol with the previous protocol in poor responder patients. The results show that the SAS protocol can yield a higher number of oocytes and usable embryos, suggesting its potential clinical efficacy for poor responders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Selmo Geber, Luiza P. Geber, Marcello Valle, Marcos Sampaio
Summary: This study demonstrates that using four consecutive minimal COS (TetraStim) followed by oocyte retrieval and vitrification can effectively increase the number of oocytes in poor responders, improving clinical pregnancy rates and live birth rates. Further randomized controlled studies are needed to compare TetraStim with other treatments.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Alessio Paffoni, Sabrina Cesana, Laura Corti, Elisabetta Ballabio, Claudia Salemi, Alessandro Kunderfranco, Marco Claudio Bianchi
Summary: The study aims to evaluate whether an unexpected poor response in women with adequate ovarian reserve leads to a reduction in the pregnancy rate in IVF cycles. The results suggest that the number of available oocytes significantly affects the success rate of IVF cycles with unexpected impaired ovarian response.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Ying Chen, Yifan Chu, Wen Yao, Luyao Wang, Wanjiang Zeng, Jing Yue
Summary: The cumulative live birth rate (CLBR) per oocyte retrieval cycle was compared between a conventional progestin-primed ovarian stimulation (cPPOS) regimen and a flexible progestin-primed ovarian stimulation (fPPOS) regimen in poor ovarian response patients according to POSEIDON criteria. The fPPOS group showed a slightly higher CLBR without a statistically significant difference compared to the cPPOS group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Anahita Mehdizadeh, Mansoureh Soleimani, Fatemehsadat Amjadi, Azadeh Akbari Sene, Mohammad Hassan Sheikhha, Ali Dehghani, Sareh Ashourzadeh, Bibi Shahnaz Aali, Shahriar Dabiri, Zahra Zandieh
Summary: This study aimed to assess the relationship between BMP15 and GDF9 gene variants and poor ovarian response. The results showed that specific variants of BMP15 and GDF9 genes were found in patients with UPOR, which may contribute to the reduced ovarian response to stimulation.
REPRODUCTIVE SCIENCES
(2023)
Article
Endocrinology & Metabolism
Marzieh Farimani, Arash Nazari, Shahrzad Mohammadi, Roghayeh Anvari Aliabad
Summary: The study demonstrated that PRP treatment was effective in increasing total and MII oocyte numbers in patients with POR, but further research is needed.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Barbara Lawrenz, Laura Melado, Shieryl Digma, Junard Sibal, Carol Coughlan, Claus Yding Andersen, Human M. Fatemi
Summary: This study aimed to investigate the impact of systemic FSH concentrations during ovarian stimulation for IVF/intracytoplasmic sperm injection on systemic progesterone concentrations in the late follicular phase. The findings showed that high concentrations of circulatory FSH augment the production of progesterone, while ovarian response seems to be independent from the systemic FSH concentrations on the trigger day.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Endocrinology & Metabolism
Xiaoyun Gong, Yunian Zhang, Yuejie Zhu, Peng Wang, Zhihui Wang, Chen Liu, Manli Zhang, Xiaolin La
Summary: This study developed a nomogram based on POSEIDON criteria to predict live birth in patients with poor ovarian response. Age, BMI, AMH, normal fertilized oocytes, and basal FSH were identified as independent factors predicting live birth in these patients. The nomogram model showed good predictive accuracy in both the training and validation sets.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Gustavo N. Cecchino, Matheus Roque, Maria Cerrillo, Rodrigo da Rosa Filho, Flavia da Silva Chiamba, Juliana Halley Hatty, Juan A. Garcia-Velasco
Summary: The study compared follicular phase stimulation (FPS) and luteal phase stimulation (LPS) in double ovarian stimulation (DuoStim), finding that LPS resulted in a higher number of retrieved oocytes and blastocysts obtained.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
N. Massin, I Abdennebi, G. Porcu-Buisson, N. Chevalier, E. Descat, C. Pietin-Vialle, S. Goro, M. Brussieux, M. Pinto, M. Pasquier, H. Bry-Gauillard
Summary: This study compares the effectiveness of two treatment protocols in assisting conception for patients with poor ovarian response, and the results show that there is no significant difference in the number of oocytes retrieved between the dual ovarian stimulation in the same cycle and two consecutive antagonist cycles.
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Fei Li, Tian Ye, Huijuan Kong, Jing Li, Linli Hu, HaiXia Jin, YiHong Guo, Gang Li
Summary: In POR patients classified by the POSEIDON criteria, female age, BMI, AFC, and COH protocol were identified as independent predictive factors for live birth. Threshold analysis revealed a sharp decline in live birth probability when female age exceeded 34 years old and when BMI exceeded 23.4 kg/m(2).
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Hsin-Ta Lin, Meng-Hsing Wu, Li-Chung Tsai, Ta-Sheng Chen, Huang-Tz Ou
Summary: This retrospective study found that the co-administration of clomiphene citrate and letrozole in mild ovarian stimulation may increase the ratio of high-quality oocytes and yield comparable fertilization rate and pregnancy outcomes for POSEIDON Group 4 patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biology
Romualdo Sciorio, Federica Cariati, Steven Fleming, Carlo Alviggi
Summary: This paper provides an analytical review of the current literature on the correlation between ovarian stimulation procedures and oocyte/embryo quality. It discusses various aspects of oocyte quality, including morphological features, oocyte competence, and the surrounding environment. It also introduces the main noninvasive features and novel approaches to biomechanical parameters that may be correlated with the competence of embryos to produce a healthy pregnancy and live birth.
Article
Obstetrics & Gynecology
Isao Tamura, Mai Kawamoto-Jozaki, Taishi Fujimura, Yumiko Doi-Tanaka, Haruka Takagi, Yuichiro Shirafuta, Yumiko Mihara, Toshiaki Taketani, Hiroshi Tamura, Norihiro Sugino
Summary: In Japanese women, fertilization rates are significantly lower in oocytes from small follicles compared to those from large follicles, but if fertilized successfully, the developmental potential of oocytes from small follicles is comparable to those from large follicles. In ICSI, the developmental potential of mature oocytes is not related to follicular size.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2021)
Review
Endocrinology & Metabolism
R. Mazzilli, S. Medenica, A. M. Di Tommaso, G. Fabozzi, V. Zamponi, D. Cimadomo, L. Rienzi, F. M. Ubaldi, M. Watanabe, A. Faggiano, S. La Vignera, G. Defeudis
Summary: This article provides an overview of the impact of impaired thyroid function on male and female fertility. In females, thyroid dysfunction is detrimental to pregnancy and fetal outcomes, and the reference range of TSH has recently become a topic of debate. The impact of thyroid function on the male reproductive system is still unclear, but it may play a role in modulating Sertoli and Leydig cells function and spermatogenesis.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Obstetrics & Gynecology
Esra Uyanik, Sezcan Mumusoglu, Mehtap Polat, Irem Yarali Ozbek, Sandro C. Esteves, Peter Humaidan, Hakan Yarali
Summary: A drop in serum P-4 level from oocyte pick-up (OPU) + 3 days to OPU + 5 days may result in a decrease in ongoing pregnancy rates. This decrease may be associated with lower initial pregnancy rates rather than increased overall pregnancy loss rates.
HUMAN REPRODUCTION
(2023)
Review
Andrology
Sandro C. Esteves, Igor Coimbra, Jorge Hallak
Summary: Intracytoplasmic sperm injection (ICSI) using surgically retrieved spermatozoa outside the classic context of azoospermia has shown improvement in pregnancy and miscarriage rates, possibly due to lower levels of DNA damage in testicular spermatozoa compared to ejaculated spermatozoa. However, data is limited and mainly focuses on males with confirmed sperm DNA damage. Further research is needed to assess the health of ICSI offspring resulting from surgically retrieved spermatozoa of non-azoospermic males. A comprehensive evaluation and treatment of underlying male infertility factors contributing to sperm DNA damage is crucial for safer and more effective ICSI utilization.
Article
Endocrinology & Metabolism
Giuseppe Defeudis, Rossella Mazzilli, Cristiano Scandurra, Alfonso Maria Di Tommaso, Danilo Cimadomo, Rocky Strollo, Antongiulio Faggiano, Silvia Migliaccio, Nicola Napoli
Summary: The purpose of this study was to evaluate the relationships between health literacy, unrealistic optimism, and adherence to glycometabolic disease management related to erectile dysfunction (ED) in male patients with type 2 diabetes (T2D) or preDM. The results showed a close relationship between health literacy, unrealistic optimism, and treatment adherence.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Letter
Obstetrics & Gynecology
Filippo Maria Ubaldi, Alberto Vaiarelli, Danilo Cimadomo, Maria Cerrillo, Laura Rienzi, Juan A. Garcia-Velasco
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Hakan Yarali, Sezcan Mumusoglu, Mehtap Polat, Murat Erden, Irem Yarali Ozbek, Sandro C. Esteves, Peter Humaidan
Summary: This study compared the effectiveness of subcutaneous progesterone and vaginal progesterone in frozen embryo transfer cycles. The results showed that subcutaneous progesterone was effective in maintaining an adequate serum progesterone level, while some patients who received vaginal progesterone required a rescue protocol to supplement progesterone levels. Both routes of administration had comparable ongoing pregnancy rates.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Malene Tanderup, Amrita Pande, Lone Schmidt, Birgitte B. Nielsen, Peter Humaidan, Charlotte Krolokke
Summary: This study examines the experiences of Danish permanently infertile couples when undergoing surrogacy abroad and the impact of the Ukraine war and COVID-19 pandemic. The findings reveal that most couples went to Ukraine due to the availability of enforceable contracts, professional advice, and the option to use the eggs of the intended mother. Current Danish legislation prevents the intended mother from obtaining legal motherhood, leading to feelings of inadequacy. The study highlights the importance of understanding cross-border experiences to inform legal policies and ensure reproductive opportunities for permanently infertile couples are not missed.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Genetics & Heredity
Carlo Alviggi, Salvatore Longobardi, Enrico Papaleo, Daniele Santi, Simona Alfano, Valeria Stella Vanni, Maria Rosaria Campitiello, Pasquale De Rosa, Ida Strina, Ilpo Huhtaniemi, Juha-Pekka Pursiheimo, Thomas D'Hooghe, Peter Humaidan, Alessandro Conforti
Summary: Specific polymorphisms can influence the response to ovarian stimulation in women undergoing assisted reproductive technologies. However, further studies are needed to determine the clinical utility of genotype analysis before ovarian stimulation.
Article
Obstetrics & Gynecology
A. Ahlstroem, K. Lundin, D. Cimadomo, G. Coticchio, U. Selleskog, G. Westlander, J. Winerdal, C. Stenfelt, S. Callender, C. Nyberg, M. Astroem, K. Loefdahl, L. Nolte, M. Sundler, M. Kitlinski, I. Liljeqvist Soltic, T. Bohlin, J. Baumgart, K. E. Lindgren, F. Guelen Yaldir, L. Rienzi, A. K. Lind, C. Bergh
Summary: This Swedish study investigated whether embryo culture in a closed time-lapse system is associated with any differences in perinatal and maternal outcomes compared to conventional culture and spontaneous conceptions. The study found no significant differences between time-lapse and conventional incubation systems in terms of preterm birth, low birth weight, and hypertensive disorders of pregnancy. However, singletons born from time-lapse incubation had a higher risk of preterm birth and low birth weight compared to singletons from spontaneous conceptions.
HUMAN REPRODUCTION
(2023)
Editorial Material
Obstetrics & Gynecology
Munevver Serdarogullari, George Liperis, Kashish Sharma, Omar F. Ammar, Julia Uraji, Danilo Cimadomo, Alessandra Alteri, Mina Popovic, Juan J. Fraire-Zamora
HUMAN REPRODUCTION
(2023)
Review
Endocrinology & Metabolism
Stefano Palomba, Flavia Costanzi, Scott M. Nelson, Donatella Caserta, Peter Humaidan
Summary: This study reviewed and analyzed different interventions for preventing and reducing OHSS in IVF patients. The most effective interventions were found to be GnRH-ant co-treatment and GnRH agonist triggering, with moderate evidence. Mild ovarian stimulation and dopaminergic agonists were also effective and safe interventions.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Editorial Material
Urology & Nephrology
Sandro C. Esteves
INTERNATIONAL BRAZ J UROL
(2023)
Article
Medicine, General & Internal
Maria Buhl Borgstrom, Anne Ahrendt Bjerregaard, Sjurdur F. Olsen, Anette Gabrielsen, Peter Humaidan, Ulrik Schioler Kesmodel
Summary: This study aims to investigate the possible association between food intake and semen quality in men, as well as pregnancy and live birth rates in women undergoing intrauterine insemination or assisted reproductive technology treatment. Data will be collected through a web-based questionnaire and medical records, with a total of 4000 participants recruited. The results will be disseminated and published through various channels.
Article
Medicine, General & Internal
Michael L. Eisenberg, Sandro C. Esteves, Dolores J. Lamb, James M. Hotaling, Aleksander Giwercman, Kathleen Hwang, Yu-Sheng Cheng
Summary: Clinical infertility refers to the inability of a couple to conceive after 12 months of trying. Male factors contribute to 30-50% of infertility cases. Infertility can be caused by testicular dysfunction, endocrinopathies, lifestyle factors, congenital anatomical factors, gonadotoxic exposures, and aging among others. The evaluation of male infertility includes history taking, physical examination, and laboratory testing. Treatments include lifestyle optimization, medical therapy, and surgical interventions.
NATURE REVIEWS DISEASE PRIMERS
(2023)