Article
Medicine, General & Internal
Yu-Cheng Lu, Kao-Lang Liu, Vin-Cent Wu, Shuo-Meng Wang, Yen -Hung Lin, Shih-Chieh Jeff Chueh, Kwan-Dun Wu, Yann-Rong Su, Kuo-How Huang
Summary: This study compared the outcomes of unilateral adrenalectomy in patients with bilateral adrenal hyperplasia (BAH) and aldosterone-producing adenoma (APA). It found that patients with BAH had a higher failure rate, while patients with APA showed better biochemical success. However, significant improvements in aldosterone-renin ratio (ARR) and hypokalemia were observed in patients with BAH after surgery. Therefore, unilateral adrenalectomy could be considered as a treatment option in selected patients.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Carmina Teresa Fuss, Katharina Brohm, Martin Fassnacht, Matthias Kroiss, Stefanie Hahner
Summary: Postural stimulation testing (PST) is a simple and noninvasive method for differentiating between unilateral and bilateral primary aldosteronism (PA). A study showed that when the aldosterone plasma concentration decreased by at least 28% after 4 hours in the upright position, PST had a specificity of 100% for identifying unilateral disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Celso E. Gomez-Sanchez, Desmare van Rooyen, William E. Rainey, Kazutaka Nanba, Amy R. Blinder, Radhakrishna Baliga
Summary: Aldosterone-producing adenoma is a rare cause of hypertension in children. This study describes a novel somatic KCNJ5 p.I157S mutation in an aldosterone-producing adenoma from a 16-year-old black female. Prompt diagnosis and early identification of gene mutations can lead to appropriate therapy and reduce cardiovascular sequelae.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Martina Tetti, Siyuan Gong, Franco Veglio, Martin Reincke, Tracy Ann Williams
Summary: Primary aldosteronism is the most common surgically curable form of hypertension. Recent advances in our understanding of the disease have focused on the underlying genetic variants that cause excess aldosterone production. The mechanisms of increased adrenal cortex mass are still not well understood, but the application of transcriptomics, metabolomics, and epigenetics has provided valuable insights.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Peripheral Vascular Disease
Ute Scholl
Summary: Primary aldosteronism is the most common cause of secondary hypertension, largely due to genetic mutations in ion channels and pumps. Somatic mutations are responsible for sporadic cases, while germline mutations cause familial hyperaldosteronism.
Article
Endocrinology & Metabolism
Eleftheria Gkaniatsa, Augustinas Sakinis, Magnus Palmer, Andreas Muth, Penelope Trimpou, Oskar Ragnarsson
Summary: The study found that imaging studies inaccurately predicted laterality in a significant number of young patients with PA. In contrast to current clinical guidelines, the results support the use of AVS for subtype evaluation in young adults with PA, including patients 35 years or younger.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Oncology
Scott M. MacKenzie, Hannah Saunders, Josie C. van Kralingen, Stacy Robertson, Alexandra Riddell, Maria-Christina Zennaro, Eleanor Davies
Summary: Many patients are at increased risk of primary aldosteronism (PA) due to difficulties in accurate diagnosis. Circulating microRNAs are being explored as potential biomarkers for PA, but reproducibility of studies has been a challenge due to technical reasons.
Article
Endocrinology & Metabolism
Yi-Ju Chen, Kang-Yung Peng, Jeff S. Chueh, Hung-Wei Liao, Tsung-Yi Hsieh, Vin-Cent Wu, Shuo-Meng Wang
Summary: This study reported a PA patient with concomitant ACS, showing that bilateral APM may coexist with histopathologically classical and non-classical PA adenomas with different somatic mutations.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Fatin Athirah Pauzi, Elena Aisha Azizan
Summary: Primary aldosteronism is a common curable form of secondary hypertension, often caused by the overproduction of aldosterone in the adrenal glands. The detection of aldosterone synthase through immunohistochemistry can identify aldosterone-producing cell clusters, potentially contributing to hyperaldosteronism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Peripheral Vascular Disease
Lucie S. Meyer, Laura Handgriff, Jung Soo Lim, Aaron M. Udager, Isabella-Sabrina Kinker, Roland Ladurner, Moritz Wildgruber, Thomas Knoesel, Martin Bidlingmaier, William E. Rainey, Martin Reincke, Tracy Ann Williams
Summary: In surgically treated patients with unilateral primary aldosteronism, there are differences in histopathology, genotype, and postsurgical outcomes between classical and nonclassical groups. Patients with nonclassical histopathology have a higher incidence of postsurgical disease persistence and increased aldosterone production from the unresected gland.
Article
Endocrinology & Metabolism
Linghui Kong, Jin Zhang, Lei Dong, Jianzhong Xu, Ping-Jin Gao, Ji-Guang Wang, Limin Zhu
Summary: This case report describes a 29-year-old female patient who underwent complete adrenalectomy for left aldosterone-producing adenoma in 2004 and partial right adrenalectomy for recurrent primary aldosteronism in 2018. Sanger sequencing revealed that both left and right adenomas carried the same aldosterone-driver KCNJ5 gene mutation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Minggang Huang, Di Yang, Yan Zhang, Yuqing Zhang, Yue Mu
Summary: This study investigates the feasibility of dual-energy CT energy imaging parameters as a novel biomarker in identifying bilateral adrenal dominant lesions in patients with primary aldosteronism (PA). The results show that the dual-energy CT energy spectrum imaging parameters have high sensitivity and specificity in distinguishing bilateral adrenal lesions, and can serve as a complementary method to adrenal venous sampling (AVS) in the diagnosis of PA.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Fabrizio Buffolo, Jacopo Pieroni, Federico Ponzetto, Vittorio Forestiero, Denis Rossato, Paolo Fonio, Antonello Nonnato, Fabio Settanni, Paolo Mulatero, Giulio Mengozzi, Silvia Monticone
Summary: This study assessed the impact of asymmetrical cortisol secretion on the lateralization index during adrenal venous sampling, and the effectiveness of metanephrines as a normalization factor for aldosterone levels. The results showed that 18% of patients with primary aldosteronism had asymmetrical cortisol secretion, and the use of metanephrines as a normalization factor improved the accuracy of diagnosis compared to aldosterone to cortisol lateralization index.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Oncology
Jui-Hsiang Lin, Kang-Yung Peng, Yu-Ping Kuo, Hsuan Liu, Chin-Ming Bertrand Tan, Yuh-Feng Lin, Hui-Wen Chiu, Yen-Hung Lin, Yung-Ming Chen, Jeff S. Chueh, Vin-Cent Wu
Summary: This study found that one-third of patients with unilateral primary aldosteronism (uPA) also had autonomous cortisol secretion (ACS). The presence of multiple aldosterone-producing nodules/micronodules (mAPN/mAPM) in these patients was associated with larger tumor sizes and the interaction between them. Transcriptome analysis and bioinformatics revealed the significance of the HSD3B7/CYP11B1 signaling pathway in uPA adenomas with surrounding mAPN/mAPM. Furthermore, patients with concomitant mAPN/mAPM had lower rates of biochemical success after surgery.
ENDOCRINE-RELATED CANCER
(2022)
Review
Biochemistry & Molecular Biology
Kiyotaka Itcho, Kenji Oki, Haruya Ohno, Masayasu Yoneda
Summary: Primary aldosteronism (PA) is the most common form of secondary hypertension, with two main subtypes: aldosterone-producing adenoma (APA) and bilateral idiopathic hyperaldosteronism. Recent advancements in genetic analysis have led to the discovery of mutations in causative genes, contributing to a better understanding of the mechanism of excess aldosterone synthesis.
Article
Endocrinology & Metabolism
F. Bioletto, A. M. Berton, E. Varaldo, D. Cuboni, C. Bona, M. Parasiliti-Caprino, N. Prencipe, E. Ghigo, S. Grottoli, M. Maccario, V Gasco
Summary: This study developed an integrated model for the prediction of central adrenal insufficiency (CAI) when morning cortisol is in the grey zone. The model showed better diagnostic performance than using morning cortisol alone, and a new predictive score (CAI-score) was proposed, which can help reduce the number of patients who need stimulation tests for the assessment of HPA axis function.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Mitsuhide Naruse, Masanori Murakami, Takuyuki Katabami, Tomaz Kocjan, Mirko Parasiliti-Caprino, Marcus Quinkler, Matthieu St-Jean, Sam O'Toole, Filippo Ceccato, Ivana Kraljevic, Darko Kastelan, Mika Tsuiki, Jaap Deinum, Edelmiro Menendez Torre, Troy Puar, Athina Markou, George Piaditis, Kate Laycock, Norio Wada, Marianne Aardal Grytaas, Hiroki Kobayashi, Akiyo Tanabe, Chin Voon Tong, Nuria Valdes Gallego, Sven Gruber, Felix Beuschlein, Lydia Kuerzinger, Norlela Sukor, Elena A. B. Aisha Azizan, Oskar Ragnarsson, Michiel F. Nijhoff, Giuseppe Maiolino, Guido Di Dalmazi, Valentina Kalugina, Andre Lacroix, Raluca Maria Furnica, Tomoko Suzuki
Summary: This study investigated the diversity of approaches utilized for each diagnostic step in different expert centers regarding primary aldosteronism (PA). The results showed significant variations in blood sampling conditions, assay methods, screening and confirmatory tests among centers. This diversity may lead to inconsistent diagnosis of PA and limit comparison of evidence between centers. Standardization of the diagnostic process and revisiting the concept of mild PA are necessary.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Peter Igaz
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Federico Ponzetto, Mirko Parasiliti-Caprino, Fabio Settanni, Antonello Nonnato, Giulio Mengozzi, Ezio Ghigo, Roberta Giordano
Summary: The simultaneous measurement of dexamethasone and cortisol has shown to improve the diagnostic performance of the overnight dexamethasone-suppression test. Additionally, monitoring the levels of corticosteroid drugs can help investigate unexpected changes in steroid hormone levels. This study developed and validated an LC-MS/MS method for quantifying cortisol, cortisone, dexamethasone, and other corticosteroids in serum/plasma samples. The method was successfully applied to patients undergoing the dexamethasone-suppression test and those receiving immunosuppressive treatment after kidney transplant.
Review
Endocrinology & Metabolism
Fabio Bioletto, Marco Barale, Nunzia Prencipe, Alessandro Maria Berton, Mirko Parasiliti-Caprino, Valentina Gasco, Ezio Ghigo, Massimo Procopio, Silvia Grottoli
Summary: This meta-analysis investigated the role of trabecular bone score (TBS) in assessing bone quality and fracture risk in patients with acromegaly. The results showed that TBS was significantly lower in acromegalic patients compared to controls, and acromegalic patients with vertebral fractures had lower TBS. These findings suggest that TBS could be valuable in evaluating and managing skeletal fragility in acromegalic patients.
NEUROENDOCRINOLOGY
(2023)
Letter
Endocrinology & Metabolism
M. Parasiliti-Caprino, E. Ghigo, M. Maccario
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Oncology
Alexandra Kalmar, Orsolya Galamb, Gitta Szabo, Orsolya Pipek, Anna Medgyes-Horvath, Barbara K. Bartak, Zsofia B. Nagy, Krisztina A. Szigeti, Sara Zsigrai, Istvan Csabai, Peter Igaz, Bela Molnar, Istvan Takacs
Summary: By analyzing tissue biopsies and plasma-derived cfDNA samples, we found that liquid biopsy using whole-exome sequencing and targeted sequencing is a suitable and potentially preferred method for genetic characterization of colorectal cancer patients in the future.
Review
Biochemistry & Molecular Biology
Chiara Lopez, Chiara Bima, Martina Bollati, Fabio Bioletto, Matteo Procopio, Stefano Arata, Daniele Giuseppe Candela, Guglielmo Beccuti, Ezio Ghigo, Mauro Maccario, Mirko Parasiliti-Caprino
Summary: Glycemic alterations are common in patients with PPGL, but the incidence of secondary DM is uncertain due to lack of prospective multicenter studies. The main mechanisms of glucose homeostasis alterations in PPGL are impaired insulin and GLP-1 secretion and increased insulin resistance. Different pathways leading to glucose intolerance may be related to the secretory phenotype of the tumor. Predictive factors for glucose intolerance in PPGL patients include higher age, more anti-hypertensive drugs, and secreting neoplasms. Tumor resection is strongly associated with resolution of DM and improved glycemic control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Holger Schneider, Anna-Lina Sarkis, Lisa Sturm, Vera Britz, Andreas Lechner, Anne L. Potzel, Lisa Marie Mueller, Daniel A. Heinrich, Heike Kuenzel, Hanna F. Nowotny, Thomas Marchant Seiter, Sonja Kunz, Martin Bidlingmaier, Martin Reincke, Christian Adolf
Summary: This study aimed to investigate the antihypertensive impact of a moderate dietary salt restriction in patients with primary aldosteronism (PA). The results showed that the dietary salt restriction significantly reduced blood pressure and depressive symptoms in patients. Furthermore, the study found that an adequate dosage of renin-angiotensin-aldosterone-system (RAAS) blockers enhanced the effects of salt restriction on blood pressure and cardiovascular risk.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Chemistry, Analytical
Federico Ponzetto, Mirko Parasiliti-Caprino, Iacopo Gesmundo, Lorenzo Marinelli, Antonello Nonnato, Raul Nicoli, Tiia Kuuranne, Giulio Mengozzi, Ezio Ghigo, Fabio Settanni
Summary: The urinary steroidal module of Athlete Biological Passport is currently used to detect anti-doping rule violations related to the abuse of endogenous anabolic androgenic steroids. However, alternative strategies such as the measurement of blood concentrations of endogenous steroid hormones by LC-MS have been proposed due to limitations of the urine test. This study presents a UHPLC-MS/MS method for quantifying major circulating steroid hormones and their metabolites, showing promising results for measuring blood steroid profile markers.
Article
Neurosciences
Alessandro Maria Berton, Mirko Parasiliti-Caprino, Nunzia Prencipe, Fabio Bioletto, Chiara Lopez, Chiara Bona, Marina Caputo, Francesca Rumbolo, Federico Ponzetto, Fabio Settanni, Valentina Gasco, Giulio Mengozzi, Ezio Ghigo, Silvia Grottoli, Mauro Maccario, Andrea Silvio Benso
Summary: In patients with type 2 diabetes, SGLT2i drugs increase plasma AVP levels to balance osmotic diuresis. This process is mainly driven by intracellular dehydration rather than extracellular dehydration. The extent of fluid reduction is affected by the patient's baseline volume conditions.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Vekony Balint, Igaz Peter
Summary: One of the most common causes of secondary hypertension is primary aldosteronism, which is caused by autonomous aldosterone production of the adrenal cortex. The disease leads to elevated aldosterone levels, hypertension, and hypokalemia, and if untreated, can result in various pathophysiological complications. The diagnosis and treatment of primary aldosteronism are crucial, as intervention can lead to patient recovery, but the illness often remains underdiagnosed due to diagnostic difficulties.
Article
Endocrinology & Metabolism
Fabio Bioletto, Chiara Lopez, Martina Bollati, Stefano Arata, Matteo Procopio, Federico Ponzetto, Guglielmo Beccuti, Giulio Mengozzi, Ezio Ghigo, Mauro Maccario, Mirko Parasiliti-Caprino
Summary: This study investigated the feasibility of using aldosterone-to-renin ratio (ARR) as a diagnostic criteria for primary aldosteronism (PA) in patients with resistant hypertension (RH). The results showed that in normokalemic patients, ARR had a lower diagnostic accuracy and may not accurately differentiate between PA and essential RH. However, in patients with hypokalemia, ARR had a higher diagnostic accuracy and may serve as a diagnostic criterion for PA.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Henriett Butz, Petra Nagy, Janos Papp, Aniko Bozsik, Vince Kornel Grolmusz, Timea Pocza, Edit Olah, Attila Patocs
Summary: The detection rate and characteristics of pathogenic/likely pathogenic (P/LP) variants in PALB2 gene may vary between different populations. In this study, PALB2 was analyzed in three independent cohorts and P/LP PALB2 variants were found in 1.4% of breast and/or ovarian cancer patients and in only 0.17% of patients with other cancers. The most common variant in our patients was NM_024675.4:c.509_510delGA.
Article
Oncology
Filippo Crimi, Elena Agostini, Alessandro Toniolo, Francesca Torresan, Maurizio Iacobone, Irene Tizianel, Carla Scaroni, Emilio Quaia, Cristina Campi, Filippo Ceccato
Summary: Radiomics is a promising research field that combines big data analysis from tissue texture analysis with clinical questions. We studied the application of CT texture analysis in adrenal pheochromocytomas to define the correlation between the extracted features and the secretory pattern, histopathological data, and natural history of the disease.