Tyrosine kinase inhibitor SU11274 increased tumorigenicity and enriched for melanoma-initiating cells by bioenergetic modulation

Metastatic melanoma treatment: Combining old and new therapies

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The metabolic state of cancer stem cells—a valid target for cancer therapy?

(2015) Erina Vlashi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion

(2015) Hui-Hui Cao et al.   Molecular Cancer

Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine

(2015) Orkhan Isayev et al.   Oncotarget

Targeting c-Met in melanoma

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MET, a driver of invasive growth and cancer clonal evolution under therapeutic pressure

(2014) Carla Boccaccio et al.   CURRENT OPINION IN CELL BIOLOGY

Long-term efficiency of mesenchymal stromal cell-mediated CD-MSC/5FC therapy in human melanoma xenograft model

(2014) L Kucerova et al.   GENE THERAPY

Metabolic regulation of stem cell function

(2014) R. J. Burgess et al.   JOURNAL OF INTERNAL MEDICINE

Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAFV600E inhibition

(2014) Cecilie Abildgaard et al.   Journal of Translational Medicine

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Altered features and increased chemosensitivity of human breast cancer cells mediated by adipose tissue-derived mesenchymal stromal cells

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Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway

(2013) P-P Liu et al.   CELL DEATH AND DIFFERENTIATION

Targeting MET: why, where and how?

(2013) Elena Ghiso et al.   CURRENT OPINION IN PHARMACOLOGY

Stem cells and targeted approaches to melanoma cure

(2013) George F. Murphy et al.   MOLECULAR ASPECTS OF MEDICINE

Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner

(2013) M. Cerezo et al.   MOLECULAR CANCER THERAPEUTICS

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Phenformin enhances the therapeutic benefit of BRAFV600E inhibition in melanoma

(2013) P. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Testing the cancer stem cell hypothesis in melanoma: The clinics will tell

(2012) Olga Shakhova et al.   CANCER LETTERS

3-bromopyruvate: Targets and outcomes

(2012) Maria C. Shoshan   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Plasticity of melanoma cells induced by neural cell crest conditions and three-dimensional growth

(2012) Stephanie Ghislin et al.   MELANOMA RESEARCH

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

(2012) Timothy R. Wilson et al.   NATURE

Combined Drug Action of 2-Phenylimidazo[2,1-b]Benzothiazole Derivatives on Cancer Cells According to Their Oncogenic Molecular Signatures

(2012) Alessandro Furlan et al.   PLoS One

Metformin Accelerates the Growth of BRAF V600E -Driven Melanoma by Upregulating VEGF-A

(2012) Matthew J. Martin et al.   Cancer Discovery

c-Met Is a Marker of Pancreatic Cancer Stem Cells and Therapeutic Target

(2011) Chenwei Li et al.   GASTROENTEROLOGY

Melanoma stem cells: not rare, but well done

(2011) Sasha D Girouard et al.   LABORATORY INVESTIGATION

Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme

(2011) H J Jun et al.   ONCOGENE

c-MET as a potential therapeutic target and biomarker in cancer

(2011) J. Rafael Sierra et al.   Therapeutic Advances in Medical Oncology

Phenotypic Heterogeneity among Tumorigenic Melanoma Cells from Patients that Is Reversible and Not Hierarchically Organized

(2010) Elsa Quintana et al.   CANCER CELL

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

Inhibition of c-Met with the Specific Small Molecule Tyrosine Kinase Inhibitor SU11274 Decreases Growth and Metastasis Formation of Experimental Human Melanoma

(2010) I. Kenessey et al.   CURRENT CANCER DRUG TARGETS

Heterogeneous Phenotype of Human Melanoma Cells with In Vitro and In Vivo Features of Tumor-Initiating Cells

(2010) Michela Perego et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The In Vitro Spheroid Melanoma Cell Culture Assay: Cues on Tumor Initiation?

(2010) Tobias Schatton et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Intravital Imaging Reveals Transient Changes in Pigment Production and Brn2 Expression during Metastatic Melanoma Dissemination

(2009) S. Pinner et al.   CANCER RESEARCH

Showering c-MET-dependent cancers with drugs

(2008) Beatrice S. Knudsen et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice

(2008) Lucia Kucerova et al.   JOURNAL OF GENE MEDICINE