Article
Oncology
Yun Qian, Huaying Liu, Junhai Pan, Weihua Yu, Jiemin Lv, Jiafei Yan, Jiaqi Gao, Xianfa Wang, Xiaolong Ge, Wei Zhou
Summary: The preoperative CONUT score is a reliable predictor of short-term outcomes in gastric cancer patients undergoing laparoscopic gastrectomy. Patients with high CONUT scores had a significantly higher incidence of overall complications, and the CONUT score was identified as an independent risk predictor of postoperative complications after multivariate analysis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Jian Lin, Huiping Liang, Huanhuan Zheng, Shengqi Li, Huaying Liu, Xiaolong Ge
Summary: Compared with young patients, elderly patients with gastric cancer have higher risk of postoperative complications. This study found that CONUT score, age, and preoperative RBC were independent risk factors for predicting postoperative complications in elderly gastric cancer patients.
Article
Biochemistry & Molecular Biology
Aurelio Lo Buglio, Giulia Scioscia, Francesco Bellanti, Pasquale Tondo, Piera Soccio, Matteo Pio Natale, Donato Lacedonia, Gianluigi Vendemiale
Summary: The study aimed to investigate the role of the CONUT score in predicting frequent exacerbations in older patients with COPD. The results showed that a CONUT score >= 5 was the best independent predictor of >= 2 exacerbations (or 1 hospitalization) during the previous year.
Article
Health Care Sciences & Services
Aurelio Lo Buglio, Francesco Bellanti, Cristiano Capurso, Gianluigi Vendemiale
Summary: The Controlling Nutritional Status (CONUT) score is a simple screening tool that can detect nutritional status and predict adverse clinical outcomes in specific populations. This study aimed to investigate the predictive role of the CONUT score on mortality and length of stay (LOS) in frail patients admitted to an Internal Medicine Department. The results showed that high CONUT scores were associated with longer LOS, but did not significantly predict mortality.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Cristina Dalmiglio, Lucia Brilli, Michele Campanile, Cristina Ciuoli, Alessandra Cartocci, Maria Grazia Castagna
Summary: This study found that the baseline Controlling Nutritional Status (CONUT score) is significantly associated with the prognosis of advanced thyroid cancer patients treated with tyrosine kinase inhibitors (TKI). The CONUT score can serve as a useful screening tool to predict the prognosis of thyroid cancer patients before the initiation of anti-tumoral treatment.
Article
Otorhinolaryngology
Teresa Brown, Anna Edwards, Alice Pashley, Belinda Lehn, Sarju Vasani, Robert Hodge, Judith Bauer
Summary: The aim of this study was to determine the relationship between nutritional status and post-operative complications and length of stay in head and neck cancer patients. The results showed that pre-operative malnutrition was associated with higher incidences of complications and longer hospital stays. Early identification and management of malnutrition should be a key component of prehabilitation programs to reduce post-operative risks.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Medicine, General & Internal
Davide Agnoletti, Guido Arcaro, Giuliana Scaturro, Emanuela Turcato, Elisa Grison, Elena Ferrari, Stefano Bonapace, Giovanni Targher, Filippo Valbusa
Summary: Malnutrition, assessed by the CONUT score, is common among elderly patients admitted for acute HF and is strongly related to increased long-term risk of all-cause death and re-hospitalizations.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Oncology
Zeynep Gulsum Guc, Canan Altay, Hakan Abdullah Ozgul, Hulya Ellidokuz, Tugba Yavuzsen
Summary: GNRI and CONUT scores are elementary and practical predictors for sarcopenia, a condition which is associated with poor outcomes in mCRC patients.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Gastroenterology & Hepatology
Feng Sun, Chen Zhang, Zhijian Liu, Shichao Ai, Wenxian Guan, Song Liu
Summary: The study demonstrated that preoperative CONUT score was an independent predictor for short-term complications following gastrectomy of GC. Patients with high CONUT scores had prolonged hospital stay and higher total hospital charges postoperatively.
BMC GASTROENTEROLOGY
(2021)
Review
Oncology
Jiting Zhao, Zhen Sun, Junwei Liang, Song Guo, Di Huang
Summary: ESD for early gastric cancer in elderly patients has comparable enbloc and histological complete resection rates to non-elderly patients. There is a slight tendency of increased perforation risk in elderly patients, with significantly higher rates in those aged ≥80 years. The risk of pneumonia is significantly higher in elderly patients, while bleeding rates do not differ. The certainty of evidence is very low, highlighting the need for high-quality studies to enhance the quality of evidence.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Asahi Sato, Toshihiko Masui, Akihiro Kaneda, Akitada Yogo, Yuichiro Uchida, Takayuki Anazawa, Kazuyuki Nagai, Etsuro Hatano
Summary: This study aimed to verify the different utility of biomarkers by patients' age. They found that neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), controlling nutrition (CONUT) score, carci-noembryonic antigen (CEA), and carbohydrate antigen (CA) 19-9 had different impact on survivals in aged and young patients. NLR and CEA stratified overall survival (OS) in aged patients, whereas CONUT score and CA19-9 could stratify OS in young patients.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Naoya Yoshida, Kojiro Eto, Tomo Horinouchi, Kazuto Harada, Hiroshi Sawayama, Katsuhiro Ogawa, Yohei Nagai, Masaaki Iwatsuki, Shiro Iwagami, Takatsugu Ishimoto, Yoshifumi Baba, Yuji Miyamoto, Hideo Baba
Summary: This study found that a sufficient preoperative smoking cessation period of more than 2 months may contribute to the improvement of prognosis after esophageal cancer surgery and reduce post-operative complications.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Cameron Law, Nazim Bhimani, David Mitchell, Mia Yue Yu, Priscilla Chan, Steven Leibman, Garett Smith
Summary: In this study, it was found that patients over the age of 75 could undergo oesophageal and gastric resection with curative intent with acceptable post-operative morbidity and mortality.
WORLD JOURNAL OF SURGERY
(2023)
Article
Surgery
Wei-Zhe Chen, Qian-Tong Dong, Feng-Min Zhang, Hui-Yang Cai, Jing-Yi Yan, Cheng-Le Zhuang, Zhen Yu, Xiao-Lei Chen
Summary: The study aimed to explore the feasibility and effectiveness of laparoscopic-assisted radical gastrectomy in elderly patients with gastric cancer. The laparoscopic-assisted group had lower rates of surgical complications, shorter postoperative hospital stay, and lower readmission rates compared to the open radical gastrectomy group.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Article
Geriatrics & Gerontology
Tetsuto Yamaura, Fumihiro Arizumi, Keishi Maruo, Kazuya Kishima, Norichika Yoshie, Tomoyuki Kusukawa, Fumiaki Imamura, Toshiya Tachibana
Summary: This study reveals that 81% of hospitalized elderly patients with AOVF are malnourished and the CONUT score is a useful predictor of their functional prognosis.
Article
Biochemistry & Molecular Biology
Yang Li, Hong-Chang Wang, Jin-Shen Wang, Bo Sun, Le-Ping Li
Article
Andrology
Liqiang Guo, Shengtian Zhao, Weiguang Li, Yong Wang, Leping Li, Shujuan Jiang, Wanhua Ren, Qun Yuan, Fubin Zhang, Feng Kong, Jie Lei, Mingzhen Yuan
Summary: In this study, no SARS-CoV-2 RNA was detected in semen samples from patients with recent infection or recovering from COVID-19, indicating the unlikely possibility of viral transmission through semen about 1 month after initial detection.
Review
Surgery
Mingfei Wang, Leping Li, Yuezhi Chen, Guodong Lian, Jinshen Wang, Jizhun Zhang, Keshu Shan, Liang Shang, Feng Tian, Changqing Jing
Summary: Research has shown that bariatric surgery can significantly improve insulin resistance, the most common pathophysiological change in patients with type 2 diabetes mellitus. This effect may be related to changes in the gut microbiome and microbial metabolites after bariatric surgery. Further exploration is needed to discuss the prospect of bariatric surgery as a treatment for type 2 diabetes mellitus.
Article
Gastroenterology & Hepatology
Zhen Fang, Fengying Du, Liang Shang, Jin Liu, Fuxin Ren, Yubo Liu, Hao Wu, Yang Liu, Peijuan Li, Leping Li
Summary: The study found that low skeletal muscle mass (LSMM) was not significantly correlated with postoperative complications in patients with gastric cancer. However, severe LSMM and obesity-related LSMM were identified as unfavorable factors for postoperative complications after gastrectomy for gastric cancer.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Oncology
Jun Ji, Jiahui Chen, Anqiang Wang, Wei Zhang, Hongge Ju, Yang Liu, Leping Li
Summary: Our study showed that KK-LC-1 expression was higher in GC tissues compared to normal tissues, and higher KK-LC-1 expression was associated with longer overall survival (OS) in GC patients. KK-LC-1 can serve as a biomarker for a favorable prognosis in GC patients.
Review
Oncology
Meng Kong, Guotao Liu, Hongqing Zhuo, Yingying Xin, Hongyuan Chen, Hongguang Sheng, Leping Li
Summary: This meta-analysis concludes that R1 resection does not have an impact on the survival outcome of GISTs, when the confounding factor of tumor rupture is excluded.
Article
Oncology
Wenting Pei, Huaiping Cui, Zhenjun Liu, Feng Zhao, Xuezhang Zhu, Leping Li, Changqing Jing, Tao Xu, Lipan Peng, Hongqing Zhuo, Yuezhi Chen, Jizhun Zhang
Summary: The study found that the one-stitch method (OM) of protective loop ileostomy in laparoscopic low anterior resection had advantages over the traditional method (TM) specifically in BMI obesity patients, showing shorter operative times, lower peristomal adhesion extent, and shorter postoperative hospital stays.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhaoyu Jiang, Huaiping Cui, Shujie Zeng, Leping Li
Summary: miR-885-5p is significantly downregulated in gastric cancer, and its overexpression inhibits invasion and metastasis of GC by targeting ME1, suggesting its potential role as a biomarker and therapeutic target in GC.
DNA AND CELL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hao Wu, Mengdi Fu, Jin Liu, Wei Chong, Zhen Fang, Fengying Du, Yang Liu, Liang Shang, Leping Li
Summary: sEVs, especially exosomes, play crucial roles in GC by influencing the tumor microenvironment, cell-to-cell communication, and immunotherapeutic efficacy, showing potential clinical applications in the future.
Article
Oncology
Xiaotian Zhang, Han Liang, Ziyu Li, Yingwei Xue, Yanong Wang, Zhiwei Zhou, Jiren Yu, Zhaode Bu, Lin Chen, Yian Du, Xinbao Wang, Aiwen Wu, Guoli Li, Xiangqian Su, Gang Xiao, Ming Cui, Dan Wu, Li Chen, Xiaojiang Wu, Yanbing Zhou, Lianhai Zhang, Chengxue Dang, Yulong He, Zhongtao Zhang, Yihong Sun, Yong Li, Huanqiu Chen, Yuxian Bai, Changsong Qi, Peiwu Yu, Guanbao Zhu, Jian Suo, Baoqing Jia, Leping Li, Changming Huang, Fei Li, Yingjiang Ye, Huimian Xu, Xin Wang, Yannan Yuan, E. Jian-Yu, Xiangji Ying, Chen Yao, Lin Shen, Jiafu Ji
Summary: The study found that perioperative SOX treatment was more effective than adjuvant CapOx treatment in patients with locally advanced gastric cancer; adjuvant SOX treatment was non-inferior to adjuvant CapOx treatment in these patients, with similar safety profiles.
Review
Gastroenterology & Hepatology
Jianqiao Yang, Zixiao Wang, Kangdi Dong, Ronghua Zhang, Kun Xiao, Liang Shang, Leping Li
Summary: This meta-analysis of 622 patients from six cohort studies demonstrated that ICG fluorescence imaging-guided gastrectomy is superior to conventional radical gastrectomy in terms of lymph node dissection completion, intraoperative blood loss reduction, and postoperative hospitalization length. However, further research is needed to explore the potential long-term survival benefits of ICG fluorescence imaging in gastric cancer patients.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Cell Biology
Huaiping Cui, Zhaoyu Jiang, Shujie Zeng, Hao Wu, Zihao Zhang, Xiaobo Guo, Kangdi Dong, Jinshen Wang, Liang Shang, Leping Li
Summary: In this study, a novel lncRNA WFDC21P derived from pseudogenes was identified and found to promote proliferation and metastasis of gastric cancer cells by activating the Akt/GSK3 beta/beta-catenin pathway. It may serve as a potential biomarker and therapeutic target for gastric cancer.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Hao Wu, Mengdi Fu, Xiaozhou Xie, Jianqiao Yang, Yang Liu, Fengying Du, Zhen Fang, Liang Shang, Leping Li
Summary: The study demonstrates that the Naples prognostic score (NPS) can independently predict disease progression and survival among patients with high- and intermediate-risk gastrointestinal stromal tumors (GISTs). The NPS could potentially serve as a convenient and effective preoperative risk stratification tool in the future.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Cell Biology
Zihao Zhang, Hao Wu, Wei Chong, Liang Shang, Changqing Jing, Leping Li
Summary: Gastric cancer is a high-incidence cancer worldwide, and early diagnosis and precise treatment are crucial. Liquid biopsy, especially the detection of circulating tumor cells, circulating tumor DNA, and circulating free DNA, has shown promising potential in monitoring gastric cancer occurrence and recurrence, evaluating prognosis, and assessing treatment response.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Wei Chong, Liang Shang, Jin Liu, Zhen Fang, Fengying Du, Hao Wu, Yang Liu, Zhe Wang, Yang Chen, Shengtao Jia, Liming Chen, Leping Li, Hao Chen
Summary: Recent studies have shown that m(6)A modification is significantly associated with TME diversity, and different m(6)A modification patterns in colon cancer are correlated with distinct clinical outcomes and biological pathways.
