Journal
FRONTIERS IN CHEMISTRY
Volume 7, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2019.00744
Keywords
i-motif; DNA; ruthenium; melting; stabilization; luminescence
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Funding
- Biotechnology and Biological Sciences Research Council [BB/M004635/1, BB/P021328/1]
- BBSRC [BB/M004635/1, BB/P021328/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/M004635/1, BB/P021328/1] Funding Source: researchfish
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A spectroscopic study of the interactions of ?- and Delta-[Ru(phen)(2)(dppz)](2+) with i-motif DNA containing thymine loops of various lengths. In the presence of i-motifs, the luminescence of the ? enantiomer was enhanced much more than the Delta. Despite this, the effect of each enantiomer on i-motif thermal stability was comparable. The sequences most affected by [Ru(phen)(2)(dppz)](2+) were those with long thymine loops; this suggests that long-looped i-motifs are attractive targets for potential transition metal complex drugs and should be explored further in drug design.
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