Systematic Dual Targeting of Dendritic Cell C-Type Lectin Receptor DC-SIGN and TLR7 Using a Trifunctional Mannosylated Antigen

Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

(2019) D. Scott Wilson et al.   NATURE MATERIALS

Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells

(2019) Gijs G. Zom et al.   BIOCONJUGATE CHEMISTRY

Peptides conjugated to 2-alkoxy-8-oxo-adenine as potential synthetic vaccines triggering TLR7

(2019) Geoffroy P.P. Gential et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mapping the Relationship between Glycosyl Acceptor Reactivity and Glycosylation Stereoselectivity

(2018) Stefan van der Vorm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toll-like Receptor Agonist Conjugation: A Chemical Perspective

(2018) Bob J. Ignacio et al.   BIOCONJUGATE CHEMISTRY

Preclinical evaluation of mRNA trimannosylated lipopolyplexes as therapeutic cancer vaccines targeting dendritic cells

(2018) A. Le Moignic et al.   JOURNAL OF CONTROLLED RELEASE

Binding of the Bacterial Adhesin FimH to Its Natural, Multivalent High-Mannose Type Glycan Targets

(2018) Maximilian M. Sauer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Mannosylated Lipopeptides with Receptor Targeting Properties

(2016) Bita Sedaghat et al.   BIOCONJUGATE CHEMISTRY

Advances in Fmoc solid-phase peptide synthesis

(2016) Raymond Behrendt et al.   JOURNAL OF PEPTIDE SCIENCE

Arginine side-chain modification that occurs during copper-catalysed azide–alkyne click reactions resembles an advanced glycation end product

(2016) Anne C. Conibear et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Pseudo-Mannosylated DC-SIGN Ligands as Immunomodulants

(2016) Angela Berzi et al.   Scientific Reports

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

(2015) Stefania Ordanini et al.   CHEMICAL COMMUNICATIONS

Lipophilic Muramyl Dipeptide-Antigen Conjugates as Immunostimulating Agents

(2015) Marian M. J. H. P. Willems et al.   ChemMedChem

Cross-presentation through langerin and DC-SIGN targeting requires different formulations of glycan-modified antigens

(2015) Cynthia M. Fehres et al.   JOURNAL OF CONTROLLED RELEASE

In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model

(2015) Joana M. Silva et al.   JOURNAL OF CONTROLLED RELEASE

Convergent chemo-enzymatic synthesis of mannosylated glycopeptides; targeting of putative vaccine candidates to antigen presenting cells

(2015) Julie D. McIntosh et al.   Chemical Science

Targeted Delivery of Fluorescent High-Mannose-Type Oligosaccharide Cathepsin Inhibitor Conjugates

(2015) Chung S. Wong et al.   ChemPlusChem

Toll-like receptor agonists shape the immune responses to a mannose receptor-targeted cancer vaccine

(2014) Li-Zhen He et al.   Cellular & Molecular Immunology

N-Tetradecylcarbamyl Lipopeptides as Novel Agonists for Toll-like Receptor 2

(2014) Marian M. J. H. P. Willems et al.   JOURNAL OF MEDICINAL CHEMISTRY

Presentation modality of glycoconjugates modulates dendritic cell phenotype

(2014) N. A. Hotaling et al.   Biomaterials Science

Directed Evolution of 2G12-Targeted Nonamannose Glycoclusters by SELMA

(2013) J. Sebastian Temme et al.   CHEMISTRY-A EUROPEAN JOURNAL

Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells

(2012) B. Chatterjee et al.   BLOOD

Multivalent glycoconjugates as anti-pathogenic agents

(2012) Anna Bernardi et al.   CHEMICAL SOCIETY REVIEWS

Synthesis and Biological Evaluation of a Library of Glycoporphyrin Compounds

(2012) Robin Daly et al.   CHEMISTRY-A EUROPEAN JOURNAL

Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation

(2012) Yvette van Kooyk et al.   MOLECULAR IMMUNOLOGY

Convergent Synthesis of Homogeneous Glc1Man9GlcNAc2-Protein and Derivatives as Ligands of Molecular Chaperones in Protein Quality Control

(2011) Mohammed N. Amin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Second generation of fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin

(2011) Manuel Andreini et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Targeted Delivery of Antigen Processing Inhibitors to Antigen Presenting CellsviaMannose Receptors

(2010) Eun-Ang Raiber et al.   ACS Chemical Biology

Synthesis and Immunological Characterization of Toll-Like Receptor 7 Agonistic Conjugates

(2009) Michael Chan et al.   BIOCONJUGATE CHEMISTRY

The C-type lectin DC-SIGN internalizes soluble antigens and HIV-1 virionsviaa clathrin-dependent mechanism

(2009) Alessandra Cambi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DC-SIGN Neck Domain Is a pH-sensor Controlling Oligomerization

(2009) Georges Tabarani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis of Novel DC-SIGN Ligands with an α-Fucosylamide Anchor

(2008) Gabriele Timpano et al.   CHEMBIOCHEM