Article
Radiology, Nuclear Medicine & Medical Imaging
Dunja Simicic, Veronika Rackayova, Lijing Xin, Ivan Tkac, Tamas Borbath, Zenon Starcuk, Jana Starcukova, Bernard Lanz, Cristina Cudalbu
Summary: The study aimed to implement an advanced methodological approach, evaluate the impact of LCModel baseline and MM model, and estimate the T-2 relaxation times for MM components in rat brain. The results showed that prior knowledge on parametrized MM improved MM and metabolite quantification.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sang-Han Choi, Yeun-Chul Ryu, Jun-Young Chung
Summary: The paper suggests an effective preprocessing technique to calibrate baseline distortion caused by water and fat signals in H-1 MRS(I) study of the human brain, utilizing a T-2* selective filtering method based on differential filtering within the frequency domain.
Article
Energy & Fuels
Mohammad Sadegh Zamiri, Bryce MacMillan, Florea Marica, Jiangfeng Guo, Laura Romero-Zeron, Bruce J. Balcom
Summary: Quantitative determination of shale H-1 components can be achieved through 2D MR T-1 - T-2(*) relaxation correlation measurement, which combines nuclear magnetic resonance and gravimetric measurements to differentiate water, oil, and bitumen components, showing significant contrast in relaxation correlation maps.
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew Martin Wright, Saipavitra Murali-Manohar, Tamas Borbath, Nikolai I. Avdievich, Anke Henning
Summary: The study measured T-1 relaxation times of neurochemicals using a macromolecule simulation model and compared metabolite concentrations in gray and white matter voxels. Quantification of metabolites was improved by correcting for contributions from macromolecules in the spectrum.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Teresa Gerhalter, Martijn Cloos, Anna M. Chen, Seena Dehkharghani, Rosemary Peralta, James S. Babb, Alejandro Zarate, Tamara Bushnik, Jonathan M. Silver, Brian S. Im, Stephen Wall, Steven Baete, Guillaume Madelin, Ivan I. Kirov
Summary: The relaxation properties derived from MRF, particularly T-1, showed higher utility for predicting outcomes 3 months after mild traumatic brain injury (mTBI) compared to T-2, fractional anisotropy (FA), and apparent diffusion coefficient (ADC). High T-1 at baseline and serially increasing T-1 were strong indicators of non-recovery at 3 months post-injury.
EUROPEAN RADIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Menghan Liu, Jia Yuan, Gongzheng Wang, Nengyi Ni, Qian Lv, Shuangqing Liu, Yufang Gong, Xinya Zhao, Ximing Wang, Xiao Sun
Summary: The shape effect plays a crucial role in designing novel nanomaterials. Manipulating the shape of nanomaterials is an effective approach to optimize their bioactive performance. Nanomaterials with unique shapes have advantages in blood circulation, tumor targeting, cell uptake, and magnetic properties. This review focuses on the recent developments of nanomaterials with different shapes for T-1-T-2 dual-mode MRI, and discusses the mechanism of how shape influences the relaxation of nanomaterials. It also explores the combination of dual-mode MRI nanoprobes and advanced therapeutic strategies, along with the challenges from basic research to clinical transformation.
Article
Oncology
Marta Micek, David Aebisher, Justyna Surowka, Dorota Bartusik-Aebisher, Michal Madera
Summary: This review summarized the current applications of non-contrast-enhanced quantitative magnetic resonance imaging (qMRI) in tissue differentiation, with a focus on the nervous system, breast tissue, and cartilage. Despite the limited research on tissue relaxation times, qMRI may serve as a diagnostic aid in providing a general insight into the nature of lesions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Physical
Xiaoming Cao, Liyuan Gu, Shike Hu, Aiman Mukhtar, Kaiming Wu
Summary: A Fe/Mn multilayer nanowire with adjustable Fe layer as T-1-T-2 dual-modal contrast agents was synthesized, showing higher r(1) and r(2) values compared to single Fe or Mn nanowires. These findings suggest the potential use of Fe/Mn multilayer nanowires as MRI contrast agents in the future.
Article
Energy & Fuels
Jiangfeng Guo, Mohammad Sadegh Zamiri, Bruce J. Balcom
Summary: This study analyzes the effects of acquisition parameters on T1*-T2* relaxation correlation of shale through numerical simulations and experiments. The optimized measurement method is significantly faster than the simple method and provides a theoretical and practical guide for further research on shale.
JOURNAL OF PETROLEUM SCIENCE AND ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Guijuan Cao, Shubo Gao, Bin Xiong
Summary: This study investigates and compares the values of 3.0 T MRI T1, T2, and T2* mapping quantification techniques in evaluating shoulder joint cartilage degeneration. The results show that the T1, T2, and T2* relaxation values are significantly correlated with the MRI-based grading of cartilage degeneration, and T2 mapping has the highest value among these techniques.
SCIENTIFIC REPORTS
(2023)
Article
Polymer Science
Daniel J. Fesenmeier, Hyun Chang Kim, Seyoung Kim, You-Yeon Won
Summary: This study investigates the dynamic properties of poly(ethylene glycol) (PEG) corona chains in block copolymer (BCP) micelles using H-1 nuclear magnetic resonance (NMR) spectroscopy. The results demonstrate that there is a difference in mobility in PEG segments near to the core and far from the core in BCP micelles, and the overall mobility of the PEG chains in BCP micelles is significantly slower and influenced by the glass transition of the micelle core domain.
Article
Chemistry, Physical
Antonio Aires, Yilian Fernandez-Afonso, Gabriela Guedes, Eduardo Guisasola, Lucia Gutierrez, Aitziber L. Cortajarena
Summary: This study demonstrates the use of protein engineering as a novel approach to design scaffolds for the tunable synthesis of ultrasmall iron oxide nanoparticles (IONPs). The protein-stabilized IONPs showed good physicochemical and magnetic properties, stability, and biocompatibility, making them suitable for biomedical applications, such as magnetic resonance imaging (MRI).
CHEMISTRY OF MATERIALS
(2022)
Article
Multidisciplinary Sciences
Nora Bouhsina, Cyrille Decante, Jean-Baptiste Hardel, Dominique Rouleau, Jerome Abadie, Antoine Hamel, Catherine Le Visage, Julie Lesoeur, Jerome Guicheux, Johann Clouet, Marion Fusellier
Summary: This study aims to determine the most suitable method for assessing lumbar intervertebral disc degeneration (IDD) in sheep by comparing three quantitative MRI sequences with Pfirrmann grading and histology. The results show that T1, T2, and T2* relaxation times measurements correlate well with the grading and histological scoring, indicating their accuracy and efficiency in evaluating IDD.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Suraj D. Serai
Summary: Magnetic resonance imaging is widely used in pediatric body imaging, traditionally for qualitative analysis but now also for simple quantitative analysis. This paper reviews common quantitative MRI techniques and their clinical applications in body imaging.
PEDIATRIC RADIOLOGY
(2022)
Article
Biophysics
Malgorzata Marjanska, Melissa Terpstra
Summary: This study explores the impact of fitting solutions commonly used for quantifying neurochemical concentrations. Results indicate that fitting with an appropriate, fully specified model yields the most accurate quantification, while fitting with moderate spline flexibility or using noncondition-specific MM may lead to differences in quantification. Greater spline flexibility improves goodness of fit but does not replace artifact-free data quantified with a condition-specific MM spectrum.
NMR IN BIOMEDICINE
(2021)
Article
Chemistry, Medicinal
Jiyun Kang, Jung-Won Shin, Yoo-rim Kim, Kelley M. Swanberg, Yooseung Kim, Jae Ryong Bae, Young Ki Kim, Jinwon Lee, Soo-yeon Kim, Nak-Won Sohn, Sungho Maeng
JOURNAL OF NATURAL MEDICINES
(2017)
Article
Biochemical Research Methods
Hyun-Bum Kim, Tong-In Oh, Kelley M. Swanberg, Mun-Bae Lee, Tae-Woo Kim, Eung-Je Woo, Ji-Ho Park, Oh-In Kwon
JOURNAL OF NEUROSCIENCE METHODS
(2016)
Article
Neurosciences
Hyun-Bum Kim, Kelley M. Swanberg, Hee-Sok Han, Jung-Chae Kim, Jun-Woo Kim, Sungon Lee, C. Justin Lee, Sungho Maeng, Tae-Seong Kim, Ji-Ho Park
JOURNAL OF NEUROSCIENCE RESEARCH
(2017)
Article
Biochemical Research Methods
Kelley M. Swanberg, Hetty Prinsen, Daniel Coman, Robin A. de Graaf, Christoph Juchem
JOURNAL OF MAGNETIC RESONANCE
(2018)
Article
Medicine, Research & Experimental
Ju-Yeon Shin, Jung-Won Shin, Sang-Kyu Ha, Yoorim Kim, Kelley M. Swanberg, Suck Lee, Tae-Woo Kim, Sungho Maeng
EXPERIMENTAL NEUROBIOLOGY
(2018)
Article
Medicine, Research & Experimental
Victoria C. Anderson-Barnes, Caitlin McAuliffe, Kelley M. Swanberg, Jack W. Tsao
MEDICAL HYPOTHESES
(2009)
Article
Multidisciplinary Sciences
Im-Joon Shin, Sung Un Son, Hyunwoo Park, Yoorim Kim, Sung Hyun Park, Kelley Swanberg, Joo-Yeon Shin, Sang-Kyu Ha, Yoonju Cho, Soo-Yong Bang, Jae-Hwan Lew, Seung-Hun Cho, Sungho Maeng
Review
Radiology, Nuclear Medicine & Medical Imaging
Karl Landheer, Rolf F. Schulte, Michael S. Treacy, Kelley M. Swanberg, Christoph Juchem
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2020)
Article
Biophysics
Karl Landheer, Kelley M. Swanberg, Christoph Juchem
Summary: This study developed a novel software platform for simulating magnetic resonance spin systems, achieving fast computation on a personal desktop computer. Utilizing density-matrix formalism and coherence pathway filter, the software can simulate multiple spin systems efficiently.
NMR IN BIOMEDICINE
(2021)
Article
Multidisciplinary Sciences
Martin Gajdosik, Karl Landheer, Kelley M. Swanberg, Christoph Juchem
Summary: INSPECTOR software provides comprehensive MRS data processing, simulation, and analytical capabilities for biomedical research and diagnostic applications, with extensive data handling and visualization options for flexible parameter customization and confidence information.
SCIENTIFIC REPORTS
(2021)
Article
Biophysics
Martin Gajdosik, Karl Landheer, Kelley M. Swanberg, Fatemeh Adlparvar, Guillaume Madelin, Wolfgang Bogner, Christoph Juchem, Ivan I. Kirov
Summary: The study investigated the feasibility of measuring hippocampal metabolite concentrations using long TE sLASER single voxel spectroscopy, revealing that this method can provide macromolecule-independent assessment of all major metabolites including Glx and m-Ins.
NMR IN BIOMEDICINE
(2021)
Article
Biophysics
Kelley M. Swanberg, Hetty Prinsen, Katherine DeStefano, Mary Bailey, Abhinav Kurada, David Pitt, Robert K. Fulbright, Christoph Juchem
Summary: The study found that patients with progressive multiple sclerosis have disrupted metabolism in the frontal cortex, with decreased levels of glutamate, GABA, and glutathione, while disease duration in relapsing-remitting patients is negatively correlated with GABA levels. This indicates subtype-specific differences in metabolism levels in multiple sclerosis.
NMR IN BIOMEDICINE
(2021)
Article
Multidisciplinary Sciences
Kelley M. Swanberg, Abhinav Kurada, Hetty Prinsen, Christoph Juchem
Summary: Proton magnetic resonance spectroscopy (H-1 MRS) can be used for the diagnosis and subtype classification of multiple sclerosis, and the visible normal-appearing frontal cortex small-molecule metabolites can differentiate between progressive MS and control, as well as between relapsing and progressive MS phenotypes.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Kelley M. Swanberg, Abigail M. Clark, Julia E. Kline, Ilana R. Yurkiewicz, Brenda L. Chan, Paul F. Pasquina, Kenneth M. Heilman, Jack W. Tsao
NEUROREHABILITATION AND NEURAL REPAIR
(2011)