Journal
FRONTIERS IN IMMUNOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.02461
Keywords
macrophage; immunometabolism; mitochondria; bacterial infection; cell polarization
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Funding
- INSERM
- CNRS
- Universite Paris Descartes Paris Cite Sorbonne
- l'Agence Nationale de la Recherche [ANR-15-CE15-0017]
- Agence Nationale de la Recherche (ANR) [ANR-15-CE15-0017] Funding Source: Agence Nationale de la Recherche (ANR)
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Mitochondria are essential organelles that act as metabolic hubs and signaling platforms within the cell. Numerous mitochondrial functions, including energy metabolism, lipid synthesis, and autophagy regulation, are intimately linked to mitochondrial dynamics, which is shaped by ongoing fusion and fission events. Recently, several intracellular bacterial pathogens have been shown to modulate mitochondrial functions to maintain their replicative niche. Through selected examples of human bacterial pathogens, we will discuss how infection induces mitochondrial changes in infected macrophages, triggering modifications of the host metabolism that lead to important immunological reprogramming.
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