Leveraging protein quaternary structure to identify oncogenic driver mutations

TP53 loss creates therapeutic vulnerability in colorectal cancer

(2015) Yunhua Liu et al.   NATURE

A spatial simulation approach to account for protein structure when identifying non-random somatic mutations

(2014) Gregory A Ryslik et al.   BMC BIOINFORMATICS

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia

(2014) Terrence N. Wong et al.   NATURE

Drugging the p53 pathway: understanding the route to clinical efficacy

(2014) Kian Hoe Khoo et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting p53 for Novel Anticancer Therapy

(2014) Zhen Wang et al.   Translational Oncology

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

(2014) Xiang Chen et al.   Cell Reports

Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1

(2013) D H Pham et al.   ONCOGENE

Ran GTPase-Activating Protein 1 Is a Therapeutic Target in Diffuse Large B-Cell Lymphoma

(2013) Kung-Chao Chang et al.   PLoS One

Proteasome inhibitors in multiple myeloma: 10 years later

(2012) P. Moreau et al.   BLOOD

Synergy of Peptide and Sugar in O-GlcNAcase Substrate Recognition

(2012) Marianne Schimpl et al.   CHEMISTRY & BIOLOGY

TP53 Mutations in Nonsmall Cell Lung Cancer

(2011) Akira Mogi et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Reorganizing the protein space at the Universal Protein Resource (UniProt)

(2011)   NUCLEIC ACIDS RESEARCH

Predicting the functional impact of protein mutations: application to cancer genomics

(2011) Boris Reva et al.   NUCLEIC ACIDS RESEARCH

Identifying cancer driver genes in tumor genome sequencing studies

(2010) Ahrim Youn et al.   BIOINFORMATICS

Statistical method on nonrandom clustering with application to somatic mutations in cancer

(2010) Jingjing Ye et al.   BMC BIOINFORMATICS

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Cancer-Specific High-Throughput Annotation of Somatic Mutations: Computational Prediction of Driver Missense Mutations

(2009) H. Carter et al.   CANCER RESEARCH

Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

(2009) Jorg Hartmann et al.   CURRENT DRUG METABOLISM

An atlas of chaperone–protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell

(2009) Yunchen Gong et al.   Molecular Systems Biology

Prediction of Cancer Driver Mutations in Protein Kinases

(2008) A. Torkamani et al.   CANCER RESEARCH

Detecting Clusters of Mutations

(2008) Tong Zhou et al.   PLoS One