Article
Medical Laboratory Technology
Zhi-jian Ren, Yang Zhao, Guan Wang, Le-le Miao, Zheng-chao Zhang, Long Ma, Mu-zhou Teng, Yu-min Li
Summary: This study identified differentially expressed microRNAs (DEMs) in serum exosomes between gastric cancer (GC) patients and healthy individuals, and predicted their target genes and pathways. Among them, three DEMs showed excellent diagnostic ability and eight target genes demonstrated perfect prognostic ability. The findings provide new targets for the diagnosis and treatment of GC.
CLINICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Daniel G. Henriques, Renan Lyra Miranda, Romulo Sperduto Dezonne, Luiz Eduardo Wildemberg, Aline Helen da Silva Camacho, Leila Chimelli, Leandro Kasuki, Elisa B. Lamback, Alexandro Guterres, Monica R. Gadelha
Summary: This study identified miRNAs associated with resistance to fg-SRLs treatment in acromegaly using miRNA sequencing and bioinformatic analysis. It was found that miR-181a-5p, miR-181b-5p, and miR-383-5p were differentially expressed, with miR-181a-5p and miR-181b-5p downregulated and miR-383-5p upregulated in the uncontrolled group. ROC curve analysis showed that miR-383-5p had an NPV of 84.3% and a PPV of 84.5%. Thus, these miRNAs can serve as biomarkers and tools to guide clinical decisions in response to fg-SRLs treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Xia Gao, Guangxin Wang, Min Zhang, Xinxin Zhang, Shuosheng Zhang, Haocheng Long
Summary: LINC01485 plays an important role in the development of colorectal cancer (CRC) by regulating the expression of the miR-383-5p/KRT80 axis and enhancing the proliferative capacity of CRC cells.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Mansheng Zhu, Qixiang Liang, Tao Chen, Qian Kong, Gengtai Ye, Shitong Yu, Xunjun Li, Qinglie He, Hao Liu, Yanfeng Hu, Jiang Yu, Guoxin Li
Summary: This study revealed the significant suppression of miRNA miR-129-2-3p in EBVaGC due to hypermethylation, and its role in promoting GC cell functions was demonstrated. The comprehensive analysis integrated multi-source data and provided insights into the relationships between methylated miRNA, differentially expressed genes (DEGs), and immune cell infiltration. Further experimental and clinical investigations are needed to validate these findings and explore the underlying mechanisms.
CLINICAL EPIGENETICS
(2021)
Article
Cell Biology
Yali Zhang, Liang Liu, Katherine A. Pillman, John Hayball, Yu-Wen Su, Cory J. Xian
Summary: The study confirmed the bone/fat switch post-MTX treatment, identified miRNAs such as miR-6315 associated with bone and marrow fat formation, and constructed a comprehensive miRNA-mRNA regulatory network for potential pathogenesis/prognosis of MTX-related bone loss and marrow adiposity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Huyan Ting, Lina Gao, Na Gao, Chaochao Wang, Wuli Guo, Xiaojie Zhou, Qi Li
Summary: Bladder cancer impairs NK cell function and immune surveillance through exosomes. Specific miRNAs in exosomes may interfere with gene stability in NK cells and can be potential targets for BC therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Meigui Wang, Jiahao Shao, Xiaoxiao Zhang, Zheliang Liu, Tao Tang, Guanhe Chen, Siqi Xia, Kaisen Zhao, Zhe Kang, Wenqiang Sun, Xianbo Jia, Jie Wang, Songjia Lai
Summary: Obesity is a global health issue and there is increasing evidence supporting the role of microRNAs (miRNAs) in its development. In this study, miR-383-5p was found to be highly expressed in the perirenal fat of rabbits fed a high-fat diet, and it was discovered that miR-383-5p may be involved in lipid metabolism and adipogenesis by targeting RAD51AP1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Xiaolong Sun, Xu Wang, Guang Dong, Zhenyu Zhao, Jibo Song
Summary: This study aimed to detect the expression level of miR-383-5p in CRC patients following chemotherapy and its influence on prognosis. The serum levels of miR-383-5p in CRC patients before and after chemotherapy were measured using RT-PCR. Cox hazard analysis showed that the level of miR-383-5p was closely related to differentiation, TNM staging, lymphatic metastasis, and vascular infiltration in CRC. High level of miR-383-5p was favorable for overall survival in CRC.
Article
Medicine, Research & Experimental
Tingting Xu, Mengyan Xie, Xinming Jing, Huning Jiang, Xi Wu, Xinzhu Wang, Yongqian Shu
Summary: In this study, bioinformatic analysis and experimental validation revealed that miR-26b-5p was downregulated in Helicobacter pylori-infected gastric cancer (GC) cells and GC tissues. Low expression of miR-26b-5p promoted GC proliferation in vitro and in vivo and was associated with poor prognosis in GC patients. Mechanistically, miR-26b-5p directly targeted PDE4B and CDK8, leading to decreased phosphorylation and nuclear translocation of STAT3, which regulated GC proliferation. Importantly, miR-26b-5p was transcriptionally suppressed by STAT3, forming a miR-26b-5p-PDE4B/CDK8-STAT3 positive feedback loop. This newly identified feedback loop may serve as a promising therapeutic target for inflammation-related GC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Min Zhong, Zhi Fang, Bin Ruan, Jianping Xiong, Junhe Li, Zhiwang Song
Summary: LINC01128 is highly expressed in pancreatic cancer (PC) and is associated with poor prognosis in patients. LINC01128 promotes proliferation, migration, invasion, and EMT in PC by regulating the miR-561-5p/LDHA axis.
CANCER CELL INTERNATIONAL
(2022)
Article
Cell Biology
Min Liang, Wenxia Yao, Boyun Shi, Xiongjie Zhu, Rui Cai, Zhongjian Yu, Weihong Guo, Huaiming Wang, Zhijie Dong, Mingzhen Lin, Xinke Zhou, Yanfang Zheng
Summary: The study identified hsa_circ_0110389 as a novel upregulated circRNA in malignant-transformed gastric cancer cells, and found that it promotes gastric cancer progression via the miR-127-5p/miR-136-5p-SORT1 pathway. This circRNA may serve as a diagnostic/prognostic biomarker and therapeutic target for gastric cancer.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Yuyu Zhang, Wei Huo, Lidi Sun, Jie Wu, Chengbin Zhang, Huanhuan Wang, Bin Wang, Jinlong Wei, Chao Qu, Hongshi Cao, Xin Jiang
Summary: This study identified miR-148b-5p as downregulated in gastric cancer, with its overexpression inhibiting cell proliferation and invasion, reprogramming metabolic properties, altering the immune microenvironment, and affecting patient prognosis and drug sensitivity. Targeting miR-148b-5p could inhibit immune microenvironment and gastric cancer progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Ruixin Li, Zhihao Hu, Zhuoyin Wang, Tianyu Zhu, Guojun Wang, Bulang Gao, Jingtao Wang, Xiumei Deng
Summary: MiR-125a-5p can promote gastric cancer growth and invasion by upregulating the expression of EphA2, TAZ, and TEAD2, while also reversing the EMT process.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Oncology
Yi Gao, Yanfeng Wang, Xiaofei Wang, Changan Zhao, Fenghui Wang, Juan Du, Huahua Zhang, Haiyan Shi, Yun Feng, Dan Li, Jing Yan, Yan Yao, Weihong Hu, Ruxin Ding, Mengjie Zhang, Lumin Wang, Chen Huang, Jing Zhang
Summary: Recent studies have shown that the aberrant expression of miR-335-5p in gastric cancer leads to inhibition of cell proliferation and migration, induction of apoptosis, and arrest of the cell cycle at the G1/S phase through its target gene MAPK10, suggesting that miR-335-5p acts as a tumor suppressor in gastric cancer progression.
CANCER CELL INTERNATIONAL
(2021)