Article
Surgery
Chia-Ying Lin, Chao-Chun Chang, Yi-Sheng Liu, Ying-Yuan Chen, Wu-Wei Lai, Yau-Lin Tseng, Yi-Ting Yen
Summary: This study compared stapled segmentectomy (SS) and non-stapled segmentectomy (NSS) techniques in terms of perioperative outcomes, lung volume preservation, and postoperative lung function, finding that lung volume preservation was not significantly influenced by different segmentectomy techniques. Surgeons should consider individual patient characteristics when choosing a segmentectomy technique.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Oncology
Savvas Lampridis, Alessandro Maraschi, Corinne Le Reun, Tom Routledge, Andrea Bille
Summary: This study compared robot-assisted thoracic surgery (RATS) and video-assisted thoracic surgery (VATS) for lung cancer. RATS took longer but had less bleeding than VATS. The two surgeries had similar outcomes in terms of complications, hospital stay, readmissions, and deaths. Further research is needed to determine the benefits of one surgical approach over the other.
Article
Oncology
Yudong Tang, Chengwu Liu, Chenglin Guo, Qiang Pu, Jiandong Mei, Yunke Zhu, Lin Ma, Patrick Zardo, Paolo A. Ferrari, Kyoji Hirai, Hitoshi Igai, Zeead M. AlGhamdi, Lunxu Liu
Summary: This study retrospectively analyzed the outcomes of 49 patients who underwent uniportal video-assisted thoracic surgery (VATS) basal segmentectomy. The results showed that uniportal VATS basal segmentectomy is a feasible and reliable technique. The use of a single-direction approach allows for easy exposure of the targeted segmental bronchi and vessels, avoiding lung turnover.
TRANSLATIONAL LUNG CANCER RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Dong Xie, Junqi Wu, Xuefei Hu, Diego Gonzalez-Rivas, Yunlang She, Qiankun Chen, Yuming Zhu, Gening Jiang, Chang Chen
Summary: The study compared the feasibility and safety of uniportal thoracoscopic segmentectomy (UTS) with multiportal thoracoscopic segmentectomy (MTS). Results showed UTS as a feasible and safe surgical technique, with minor differences between UTS and MTS in both simple and complex segmentectomy groups, which were clinically irrelevant.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Surgery
Ashorne K. Mahenthiran, Brian C. Brajcich, Samuel Kim, Ankit Bharat, David D. Odell
Summary: This study analyzed data from 14,418 patients who underwent elective thoracoscopic lung resection, finding that shorter postoperative length of stay did not increase the risk of readmission or postoperative complications. The most common readmission diagnoses were pneumothorax and wound complications, and each one-day increase in length of stay was associated with a higher risk of readmission.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Oncology
Jianglei Ma, Xiaoyao Li, Shifu Zhao, Jiawei Wang, Wujia Zhang, Guangyuan Sun
Summary: The meta-analysis results showed that RATS had more advantages over VATS in the treatment of NSCLC, including less blood loss, lower conversion rate, more lymph node harvest, and shorter postoperative chest tube drainage time.
Article
Cardiac & Cardiovascular Systems
Alan D. L. Sihoe
Summary: The greatest disruptive innovation in lung cancer surgery has been the switch from open thoracotomy to video-assisted thoracic surgery (VATS). More recently, the transition from multiportal VATS (MVATS) to uniportal VATS (UVATS) has further reduced surgical access trauma. Numerous promising candidates, including screening, sublobar resections, 3D technology, and multi-modality management, have emerged for the next breakthrough in lung cancer surgery. However, the possibility of uniportal robotic surgery achieving further minimization of surgical access trauma requires systematic evaluation of its benefits and costs.
ANNALS OF CARDIOTHORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Alan D. L. Sihoe
Summary: The switch from open thoracotomy to video-assisted thoracic surgery (VATS) has been the greatest disruptive innovation in modern lung cancer surgery. In recent years, the transition from multiportal VATS (MVATS) to uniportal VATS (UVATS) has further reduced surgical access trauma. Promising candidates for the next breakthrough in lung cancer surgery include screening, sublobar resections, 3D technology, enhanced peri-operative care pathways, ablative therapy, and multi-modality management. However, the possibility of minimizing surgical access trauma even further through uniportal robotic surgery is also being explored. The emergence of a winning candidate will depend on a systematic evaluation of the evidence for the benefits and costs of each approach.
ANNALS OF CARDIOTHORACIC SURGERY
(2022)
Article
Respiratory System
Natsumi Matsuura, Hitoshi Igai, Fumi Ohsawa, Tomohiro Yazawa, Mitsuhiro Kamiyoshihara
Summary: This study compared the safety and feasibility of uniportal video-assisted thoracoscopic surgery (U-VATS) uncommon segmentectomy with U-VATS common segmentectomy and M-VATS uncommon segmentectomy. The results showed that in U-VATS, there were no significant differences between common and uncommon segmentectomy in operation time, postoperative drainage, postoperative hospitalization, and postoperative complications. Additionally, U-VATS shortened operation time and postoperative hospitalization in uncommon segmentectomy compared with conventional M-VATS, indicating that it is a useful approach for uncommon segmentectomy.
JOURNAL OF THORACIC DISEASE
(2021)
Review
Oncology
Linlin Wang, Lihui Ge, Shiyuan Song, Yi Ren
Summary: In recent years, advancements in video-assisted thoracoscopic surgery (VATS) techniques and surgical instruments have led to significant progress in minimally invasive thoracic surgery. Uniportal VATS, as a new exploration area, offers advantages such as reduced trauma, less pain, improved cosmesis, fewer complications, shorter hospital stays, and faster rehabilitation, ultimately benefiting patient quality of life.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Respiratory System
Takahiro Ochi, Hidemi Suzuki, Yuki Hirai, Takahiro Yamanaka, Hiroki Matsumoto, Taisuke Kaiho, Terunaga Inage, Takamasa Ito, Kazuhisa Tanaka, Yuichi Sakairi, Ichiro Yoshino
Summary: This study aimed to compare the perioperative outcomes of video-assisted thoracic surgery (VATS) and robot-assisted thoracic surgery (RATS) for mediastinal procedures. The results showed that RATS is as safe as VATS and may result in a shorter operative time and postoperative hospital stay.
JOURNAL OF THORACIC DISEASE
(2023)
Review
Oncology
Shibo Huang, Xiaolong Huang, Zhilong Huang, Raoshan Luo, Weiming Liang
Summary: This meta-analysis compares the clinical outcomes of robot-assisted thoracic surgery (RATS) and video-assisted thoracic surgery (VATS) for patients with lung cancer. The results show that RATS achieves better surgical outcomes compared to VATS in the short-term, particularly in terms of lymphadenectomy and intraoperative bleeding control. However, further large-scale and long-term randomized clinical trials are needed to better demonstrate the advantages of RATS in lung cancer treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Monica Casiraghi, Alessio Vincenzo Mariolo, Shehab Mohamed, Giulia Sedda, Patrick Maisonneuve, Antonio Mazzella, Giorgio Lo Iacono, Francesco Petrella, Lorenzo Spaggiari
Summary: This study compared the impact of three different surgical approaches on stage I NSCLC patients, finding no significant differences in overall survival and cancer-specific survival between VATS, RATS, and open surgery. However, VATS had a higher recurrence rate compared to RATS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Joep J. J. Ouwerkerk, Elaine P. X. van Ee, Tommy A. Brown II, Ander Dorken-Gallastegi, Anthony Gebran, Dias Argandykov, Jefferson A. Proano-Zamudio, John O. Hwabejire, Haytham M. A. Kaafarani, George C. Velmahos, Jonathan Parks
Summary: The current guidelines recommend video-assisted thoracic surgery (VATS) within 4 days for retained hemothorax in trauma patients, but these recommendations are based on small observational studies. This study aimed to evaluate the association between the timing of VATS and clinical outcomes in retained hemothorax. The results showed that delaying VATS was associated with increased hospital length of stay and other secondary outcomes. However, the clinical significance of these increases was less dramatic compared to other studies, suggesting that the urgency of evacuation may not be as high. Additionally, there was no association found between the timing of VATS and mortality or the need for additional procedures. Therefore, in the appropriate clinical context, the evacuation of retained hemothorax through VATS can be delayed if clinically necessary, without an associated increase in mortality or the requirement for additional procedures.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Cardiac & Cardiovascular Systems
Mahmoud Ismail, Benjamin R. Waterhouse, Alyx Colman, Diego Gonzalez-Rivas, Joel Dunning
Summary: We have compiled a comprehensive atlas of videos of uniportal robotic lobectomies for surgeons considering this technique. The videos provide an opportunity to see and assess the differences and similarities between their usual technique and the novel technique. By fully narrating the videos, we aim to guide surgeons through each procedure, allowing them to visualize the upcoming operation.
ANNALS OF CARDIOTHORACIC SURGERY
(2023)
Review
Immunology
Matteo Vecchio, Angela Koutsokera, Brice Touilloux, Jean-Yannis Perentes, Oriol Manuel, Leslie Noirez, John-David Aubert, Alexandra Lenoir
Summary: This report discusses a case of donor-derived Mycoplasma hominis infection in a lung transplant recipient with bilateral bronchial anastomoses dehiscence and stenosis. The infection was managed using a multidisciplinary approach, including surgical revision, targeted antibiotic therapy, and continuous ventilatory support. Diagnosis and timely treatment of this organism is challenging due to its rare nature, difficult detection in conventional cultures, and innate resistance to beta-lactams, highlighting the importance of screening and monitoring with PCR in transplant centers.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Oncology
Marc Darras, Amaya Ojanguren, Celine Forster, Matthieu Zellweger, Jean Yannis Perentes, Thorsten Krueger, Michel Gonzalez
Summary: This study compared short-term oncological results and local control in solid non-small cell lung cancers <2 cm treated with intentional VATS segmentectomy or lobectomy. Results showed no significant difference in demographics, outcomes, lymph node dissection, upstaging, or adjuvant chemotherapy between the two surgeries.
Article
Oncology
Celine Forster, Valerie Doucet, Jean Yannis Perentes, Etienne Abdelnour-Berchtold, Matthieu Zellweger, Mohamed Faouzi, Hasna Bouchaab, Solange Peters, Carlo Marcucci, Thorsten Krueger, Lorenzo Rosner, Michel Gonzalez
Summary: The study demonstrated that adopting an ERAS pathway for NSCLC patients undergoing VATS lobectomy can significantly reduce the length of hospital stay and decrease cardiopulmonary complication rate, without impacting readmission rate.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Pierre-Benoit Ancey, Caroline Contat, Gael Boivin, Silvia Sabatino, Justine Pascual, Nadine Zangger, Jean Yannis Perentes, Solange Peters, E. Dale Abel, David G. Kirsch, Jeffrey C. Rathmell, Marie-Catherine Vozenin, Etienne Meylan
Summary: The study highlights the importance of GLUT1 in tumor-associated neutrophils (TAN) within lung tumors, with increased glucose uptake mediated by GLUT1 impacting tumor growth and radiotherapy resistance. Targeting metabolic vulnerabilities to support anti-tumor neutrophils may be a promising strategy for cancer treatment.
Article
Immunology
Gregoire Caudron de Coquereaumont, Jade Couchepin, Jean Y. Perentes, Thorsten Krueger, Alban Lovis, Samuel Rotman, Frederic Lamoth
Summary: Invasive mold infections are challenging to diagnose, with a particularly high rate of missed diagnosis among nonhematologic cancer patients.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Arpad Hasenauer, Benoit Bedat, Roumen Parapanov, Jerome Lugrin, Anne Debonneville, Etienne Abdelnour-Berchtold, Michel Gonzalez, Jean Y. Perentes, Lise Piquilloud, Csaba Szabo, Thorsten Krueger, Lucas Liaudet
Summary: This study found that the occurrence of sterile lung inflammation during lung transplantation is significantly dependent on the conditions, and EVLP may promote inflammation, while factors such as HMGB1 and S100A8 may play important roles in the pathogenesis of LTx.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Editorial Material
Respiratory System
Celine Forster, Charles Beniere, Justine Lattion, Jean Yannis Perentes, Michel Christodoulou
Article
Cardiac & Cardiovascular Systems
Celine Forster, Jean Yannis Perentes, Amaya Ojanguren, Etienne Abdelnour-Berchtold, Matthieu Zellweger, Hasna Bouchaab, Solange Peters, Thorsten Krueger, Michel Gonzalez
Summary: This study identified factors associated with early discharge after VATS anatomical resection for NSCLC, including body mass index, cardiopathy history, pulmonary function, enhanced recovery protocol, chest tube use, as well as age, ASA score, and epidural catheter use. Early discharge did not increase the readmission rates.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2021)
Review
Medicine, Research & Experimental
Jonathan Tschopp, Jean Yannis Perentes, Catherine Beigelman-Aubry, Sabina Berezowska, Alban Lovis, Olivier Spertini, Pierre-Yves Bochud, Frederic Lamoth
Summary: Hormographiella aspergillata is a rare cause of invasive mold infection, but can be successfully managed through complete surgical resection of lesions and antifungal therapy.
MEDICAL MYCOLOGY CASE REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Celine Forster, Amaya Ojanguren, Jean Yannis Perentes, Matthieu Zellweger, Thorsten Krueger, Etienne Abdelnour-Berchtold, Michel Gonzalez
Summary: Retrospective analysis of patients undergoing single pulmonary metastasectomy revealed that non-colorectal tumors, age < 70 years, and previous extra-thoracic metastases were prognostic factors for recurrence. Surgical resection showed low morbidity rate and acceptable long-term survival, making it the standard treatment for single pulmonary metastases.
JOURNAL OF CARDIOTHORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Benoit Bedat, Evangelos Koliakos, Marco S. Demarchi, Jean Perentes, Marc-Joseph Licker, Frederic Triponez, Thorsten Krueger, Wolfram Karenovics, Michel Gonzalez
Summary: This study found that a V.E/V.CO2 slope >35 is significantly associated with an increased risk of cardiopulmonary complications after video-assisted thoracic surgery.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Respiratory System
Sara Federici, Benoit Bedat, Justine Hayau, Michel Gonzalez, Frederic Triponez, Thorsten Krueger, Wolfram Karenovics, Jean Y. Perentes
Summary: Surgical management of PPE results in shorter chest tube and hospital duration, as well as better control of pleural effusion compared to fibrinolytic approach. Fibrinolytic approach may require longer treatment duration and additional surgeries in some patients. Prospective randomized studies are needed for further evaluation.
JOURNAL OF THORACIC DISEASE
(2021)
Review
Respiratory System
Louis-Emmanuel Chriqui, Celine Forster, Alban Lovis, Hasna Bouchaab, Thorsten Krueger, Jean Yannis Perentes, Michel Gonzalez
Summary: Sleeve lobectomy is a lung-sparing surgery for centrally-located tumors, although induction therapy before surgery may lead to increased anastomotic complications and poorer 5-year survival prognosis.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Michel Gonzalez, Wolfram Karenovics, Benoit Bedat, Celine Forster, Marc-Olivier Sauvain, Frederic Triponez, Michel Christodoulou, Thorsten Krueger, Jean Yannis Perentes
Summary: This study assessed the accuracy of 3 validated lobectomy scoring systems in predicting prolonged air leak (PAL) in patients undergoing video-assisted thoracoscopic surgery (VATS) segmentectomy. The results showed that all 3 scoring systems were correlated with PAL > 5 days following the VATS segmentectomies, with the European Society of Thoracic Surgeons (ESTS) scores appearing to be easier to introduce in clinical practice. However, further validation with a multicentre cohort is necessary.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Surgery
Amaia Ojanguren, Roumen Parapanov, Anne Debonneville, Jerome Lugrin, Csaba Szabo, Arpad Hasenauer, Lorenzo Rosner, Michel Gonzalez, Jean-Yannis Perentes, Thorsten Krueger, Lucas Liaudet
Summary: Ex vivo lung perfusion (EVLP) serves as a platform for pharmacologic repair before lung transplantation (LTx). This study demonstrates that transient heat application during EVLP can effectively recondition damaged lungs and improve their outcomes after transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)