Article
Nutrition & Dietetics
Maja Cvek, Dean Kalicanin, Ana Baric, Marko Vuletic, Ivana Gunjaca, Vesela Torlak Lovric, Veselin Skrabic, Ante Punda, Vesna Boraska Perica
Summary: Our study found no significant association between vitamin D and HT, but there may be a slight decrease in vitamin D levels associated with overt hypothyroidism. A significant correlation was identified between vitamin D and TSH in all HT patients, as well as a correlation between vitamin D and systolic blood pressure in OVERT HT patients.
Review
Nutrition & Dietetics
Filip Lebiedzinski, Katarzyna Aleksandra Lisowska
Summary: Hashimoto's thyroiditis (HT) is an autoimmune disease affecting the thyroid gland and often requires lifelong treatment. Vitamin D deficiency is associated with a higher prevalence of thyroid autoimmunity, and vitamin D supplementation shows promise in reducing antibody levels and improving thyroid function in HT patients. Studies suggest that vitamin D may impact various immune mechanisms and improve clinical outcomes, but further research is needed.
Review
Medicine, General & Internal
Agata Czarnywojtek, Ewa Florek, Krzysztof Pietronczyk, Nadia Sawicka-Gutaj, Marek Ruchala, Ohad Ronen, Iain J. Nixon, Ashok R. Shaha, Juan Pablo Rodrigo, Ralph Patrick Tufano, Mark Zafereo, Gregory William Randolph, Alfio Ferlito
Summary: Vitamin D deficiency has received significant attention in medical research due to its role in regulating calcium-phosphorus metabolism and its potential impact on the immune system. Studies have shown that Vitamin D deficiency can affect autoimmune diseases, coeliac disease, infections, and cancer. Recent research has also highlighted its significant role in autoimmune thyroid diseases such as Hashimoto thyroiditis, Graves' disease, and postpartum thyroiditis. This review summarizes the current state of knowledge on the role of Vitamin D in autoimmune thyroid diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Diana Grove-Laugesen, Eva Ebbehoj, Torquil Watt, Anne Lene Riis, Torben Ostergard, Bjarke Johannessen Bruun, Jens Juel Christiansen, Klavs Wurgler Hansen, Lars Rejnmark
Summary: This study investigated the role of vitamin D in the treatment of Graves' disease (GD). The results showed that high-dose vitamin D supplementation did not improve the treatment outcome in patients with GD.
Article
Biochemistry & Molecular Biology
Mustafa Genco Erdem, Ozge Unlu, Fatma Ates, Denizhan Karis, Mehmet Demirci
Summary: The study found that the oral microbiota of male patients with treated and untreated hyperthyroidism differ, while the treatment method has no impact on the oral microbiota. By conducting extensive multicenter studies to identify the core oral microbiota and long-term monitoring of hyperthyroidism, important data for understanding the pathogenesis of the disease may be obtained.
Article
Biochemistry & Molecular Biology
Nikola Ralchev Ralchev, Aleksandar Mishel Markovski, Inna Angelova Yankova, Iliyan Konstantinov Manoylov, Irini Atanas Doytchinova, Nikolina Mihaylova Mihaylova, Alexander Dimitrov Shinkov, Andrey Ivanov Tchorbanov
Summary: This study aims to selectively suppress anti-thyroglobulin IgG antibody-producing B lymphocytes in Hashimoto's thyroiditis patients using a chimeric protein molecule. The results show that this treatment method can reduce B-cell autoreactivity and promote apoptosis in targeted cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Hui Xiao, Jianqing Liang, Sunqiang Liu, Qiongyue Zhang, Famin Xie, Xingyu Kong, Shanshan Guo, Ruwen Wang, Rong Fu, Zhiqi Ye, Yun Li, Shuang Zhang, Li Zhang, Keneilwe Kenny Kaudimba, Ru Wang, Xingxing Kong, Bing Zhao, Xuqin Zheng, Tiemin Liu
Summary: The study used mass spectrometric analysis of thyroid tissue from HT patients and healthy individuals, identifying 44 differentially expressed proteins and providing an in-depth understanding of the pathogenesis of HT. Patient-derived HT and PTC organoids were developed as a new preclinical model to validate potential markers.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Alessio Mazzieri, Pia Montanucci, Giuseppe Basta, Riccardo Calafiore
Summary: In Hashimoto's thyroiditis, the genetic basis, particularly the HLA genes, play a significant role in the development of the disease. Other genes and transcription factors, including BACH2, are also involved in the autoimmune background of HT. The interaction between these genes and environmental factors leads to autoimmunity and ultimately damage to the thyroid gland. The role of Th17 and Treg cells in HT is still not well-defined compared to Th1 cells and cytotoxic lymphocytes. imbalanced Th17/Treg ratio serves as a prognostic factor for gland damage. Genetic panels and immunotherapy may provide better targeted treatment and preventive interventions for individuals with potential or early stage HT.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
A. P. Weetman
Summary: Recent studies have provided new insights into the genetic, environmental, and pathogenic mechanisms of HT, including the identification of multiple cytokine networks, various defects in T regulatory cells, and possible disease associations. Additionally, there is growing evidence suggesting a direct role of the autoimmune process in causing persistent symptoms in a subset of patients with levothyroxine-treated HT.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
B. Sigman, D. F. Linder, J. L. Waller, W. B. Bollag, S. L. Baer, S. Tran, M. Kheda, L. Young, A. Mohammed, C. M. Isales, B. Siddiqui
Summary: The purpose of this study is to examine the association of Hashimoto's thyroiditis (HT) with the risk of renal transplant failure. The results showed that patients with HT had a significantly increased risk of renal transplant failure. These findings suggest that thyroid health and HT may play a significant role in the development of increased risk of renal transplant failure.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Nutrition & Dietetics
Robert Krysiak, Karolina Kowalcze, Witold Szkrobka, Boguslaw Okopien
Summary: This study compared sexual functioning and depressive symptoms in women with Hashimoto's thyroiditis receiving different treatments. Untreated women had lower sexual functioning scores than those receiving vitamin D, selenomethionine, and myo-inositol. Women treated with vitamin D had higher sexual functioning scores than those receiving the remaining micronutrients.
Review
Medicine, Research & Experimental
Jingwen Zhang, Yuting Chen, Hongyan Li, Hong Li
Summary: Vitamin D supplementation can reduce thyroid autoantibody levels in patients with Hashimoto's thyroiditis, especially when administered for more than 3 months.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Jialu Wu, Hui Huang, Xijie Yu
Summary: Hashimoto's thyroiditis has long-term effects on bone metabolism and is related to thyroid immunity and osteoimmunology.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Immunology
Haitao Zheng, Jie Xu, Yongli Chu, Wenzhou Jiang, Wenjie Yao, Shaowen Mo, Xicheng Song, Jin Zhou
Summary: This study reveals that abnormal interactions between immune cells in patients with Hashimoto's thyroiditis (HT) and Graves' disease (GD) activate relevant immune pathways, exacerbating the immune response and potentially leading to the targeting of thyroid tissue and disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Yutong Liu, Xiuyan Liu, Na Wu
Summary: This article compares Hashimoto's thyroiditis (HT) and Graves' disease (GD), finding that they have very similar clinical symptoms, making it difficult to diagnose them. In order to accurately diagnose, it is recommended to first conduct serological tests, followed by imaging exams and thyroid I131 uptake measurements, and finally fine needle aspiration cytology. In addition, cellular immunology and genetics can also assist in the diagnosis.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Laura Croce, Luca Chiovato, Massimo Tonacchera, Elena Petrosino, Maria Laura Tanda, Mariacarla Moleti, Flavia Magri, Antonella Olivieri, Elizabeth N. Pearce, Mario Rotondi
Summary: The study aimed to review the available evidence from meta-analyses on iodine supplementation during pregnancy in areas with mild-moderate deficiency. The findings suggest a U-shaped correlation between iodine status and maternal and neonatal outcomes, but the results of intervention trials are inconclusive. More high-quality studies are needed to further clarify this issue.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Endocrinology & Metabolism
G. Agresta, A. Campione, P. Veiceschi, D. Gallo, E. Agosti, L. Massimi, G. Piatelli, A. Consales, S. Linsler, J. Oertel, F. Pozzi, M. L. Tanda, P. Castelnuovo, D. Locatelli
Summary: This study compared the outcomes of a staged surgical approach and a single-stage radical approach in children with craniopharyngiomas. The results showed that a staged approach led to higher rates of gross total resection and progression-free survival compared to the single-stage approach, with no significant differences in other outcomes.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Oncology
Marco Ballestri, Emanuela Marras, Enrico Caruso, Fabrizio Bolognese, Miryam Chiara Malacarne, Elisa Martella, Matilde Tubertini, Marzia Bruna Gariboldi, Greta Varchi
Summary: Photodynamic therapy (PDT) is a minimally invasive and highly selective technique for treating solid tumors and other malignancies. This study demonstrates that BODIPYs photosensitizers loaded onto polymethyl methacrylate nanoparticles can effectively reduce tumor cell viability and lower their migratory ability. These findings suggest that this approach has the potential to reduce the risk of metastatic tumors.
Review
Biochemistry & Molecular Biology
Marzia Bruna Gariboldi, Emanuela Marras, Nicole Ferrario, Veronica Vivona, Pamela Prini, Francesca Vignati, Gianpaolo Perletti
Summary: Edible/medicinal mushrooms have gained attention in both Asian and European countries for their health and nutritional benefits. They have been found to have various pharmacological activities, including anticancer effects on breast cancer cells. This article reviews the mushrooms that show antineoplastic activity, highlights their bioactive compounds and mechanisms of action, and discusses the relationship between dietary consumption of mushrooms and breast cancer risk as well as clinical studies on the effects of fungal extracts on breast cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Miryam Chiara Malacarne, Maristella Mastore, Marzia Bruna Gariboldi, Maurizio Francesco Brivio, Enrico Caruso
Summary: In photodynamic therapy (PDT), a photosensitizer excited by a specific wavelength and oxygen leads to photochemical reactions and cell damage. This article reports preliminary studies on G. mellonella larvae to evaluate the stress response induced by a porphyrin photosensitizer (TPPOH). The tests showed the impact of photosensitizer administration and irradiation on larvae's survival rate and immune system cells, and observed a maximum peak of cellular uptake at 8 hours. The results suggest G. mellonella as a promising model for preclinical photosensitizer tests.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Daniela Gallo, Denisa Baci, Natasa Kustrimovic, Nicola Lanzo, Bohdan Patera, Maria Laura Tanda, Eliana Piantanida, Lorenzo Mortara
Summary: Vitamin D plays a vital role in bone health and is involved in various cellular processes. It has been found to have clinical implications in immune surveillance against infections and autoimmune/inflammatory diseases. Recent research has focused on the role of innate immune cells and their interaction with vitamin D and acquired immune cells in the onset and regulation of certain autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Daniela Gallo, Antonino Bruno, Matteo Gallazzi, Simona Antonia Maria Cattaneo, Giovanni Veronesi, Angelo Genoni, Maria Laura Tanda, Luigi Bartalena, Alberto Passi, Eliana Piantanida, Lorenzo Mortara
Summary: This study suggests that supplementation with vitamin D and selenium in patients with Graves' disease receiving MMI treatment can modulate the frequency of Treg and NK cells, leading to better control of hyperthyroidism symptoms.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Daniela Gallo, Yusuf Ali
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Polymer Science
Pawel Kubik, Daniela Gallo, Maria Laura Tanda, Jerzy Jankau, Raffaele Rauso, Wojciech Gruszczynski, Aleksandra Pawlowska, Pawel Chrapczynski, Maciej Malinowski, Dariusz Grzanka, Marta Smolinska, Paulina Antosik, Maria-Luiza Piesiakow, Bartlomiej Lukasik, Agnieszka Pawlowska-Kubik, Giorgio Stabile, Stefania Guida, Lukasz Kodlubanski, Tom Decates, Nicola Zerbinati
Summary: The study aimed to test the effect of Neauvia Stimulate on patients with Hashimoto's disease, which is a contraindication for hyaluronic acid fillers and calcium hydroxyapatite biostimulants. Histopathological analysis showed a significant reduction in inflammatory infiltration and T lymphocytes after the procedure, with no effect on antibody levels. Risk analysis confirmed the safety of using hyaluronic acid fillers cross-linked with polyethylene glycol in patients with Hashimoto's disease.
Article
Chemistry, Inorganic & Nuclear
Elisabetta Gabano, Marzia Bruna Gariboldi, Emanuela Marras, Francesca Barbato, Mauro Ravera
Summary: The complex [PtCl2(cyclohexane-1R,2R-diamine)] was combined with two different bioactive molecules to obtain multiaction antiproliferative agents. Microwave-assisted heating was used to speed up their preparation. The synthesized complexes showed significant antiproliferative activity, pro-apoptotic and pro-necrotic effects, cell cycle alterations, downregulation of histone deacetylase activity, and antimigratory activity.
DALTON TRANSACTIONS
(2023)
Review
Biochemistry & Molecular Biology
Natasa Kustrimovic, Daniela Gallo, Eliana Piantanida, Luigi Bartalena, Adriana Lai, Nicola Zerbinati, Maria Laura Tanda, Lorenzo Mortara
Summary: Maintaining the delicate balance between immune response and tolerance is crucial for health. T regulatory cells play a pivotal role in preserving self-tolerance and suppressing inflammation. In Graves' disease, these cells are likely impaired or reduced in frequency. Understanding the role of Tregs in Graves' disease is important for developing new treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Daniela Gallo, Annarosaria De Vito, Rossella Roncoroni, Antonino Bruno, Eliana Piantanida, Luigi Bartalena, Maria Laura Tanda, Lorenzo Mortara, Francesco Acquati
Summary: This study found that the levels of RNASET2 protein were significantly higher in patients with Graves' disease compared to healthy controls, and after methimazole treatment, the levels decreased and became similar to those in healthy controls. These preliminary results suggest that RNASET2 may serve as an alarm signal to alert the immune system under specific conditions.
