Article
Cardiac & Cardiovascular Systems
Ange Maguy, Yuvaraj Mahendran, Jean-Claude Tardif, David Busseuil, Jin Li
Summary: This study explores the association between autoantibodies targeting cardiac ion channels and unexplained AF. They found a common autoantibody response against K(ir)3.4 protein in patients with AF, even before the development of clinically apparent AF. Functional studies and a mouse model of K(ir)3.4 autoimmunity support the causal relationship between K(ir)3.4 autoantibodies and AF.
Article
Multidisciplinary Sciences
Mengmeng Chang, Kirin D. Gada, Bojjibabu Chidipi, Athanasios Tsalatsanis, Justin Gibbons, Elizabeth Remily-Wood, Diomedes E. Logothetis, Jenna Oberstaller, Sami F. Noujaim
Summary: This study found that in the aging heart, IKACh is constitutively active in a PKCE-dependent manner, leading to the occurrence of AF. Knocking out PKCE can eliminate the effects of aging on AF and prevent the activation of IKACh.
Article
Pharmacology & Pharmacy
Vladimir Sobota, Giulia Gatta, Arne van Hunnik, Iris van Tuijn, Marion Kuiper, James Milnes, Thomas Jespersen, Ulrich Schotten, Sander Verheule
Summary: The study demonstrates that XAF-1407 has antiarrhythmic effects in a goat model of AF, showing higher cardioversion efficacy and prolonging atrial effective refractory period. Further research with longer periods of AF maintenance is needed to assess the efficacy of XAF-1407 in later time points of AF-induced remodeling.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Florian Straube, Janis Pongratz, Alexander Kosmalla, Benedikt Brueck, Lukas Riess, Stefan Hartl, Christian Tesche, Ullrich Ebersberger, Michael Wankerl, Uwe Dorwarth, Ellen Hoffmann
Summary: Cryoballoon ablation is a reasonable strategy for symptomatic persistent AF in the initial AF ablation procedure, with a high acute isolation success rate. Although there are potential complications and recurrence risks, Cryoballoon ablation has shown good outcomes in the treatment of persistent AF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Genetics & Heredity
Bo Hu, Wen Ge, Yuliang Wang, Xiaobin Zhang, Tao Li, Hui Cui, Yongjun Qian, Yangyang Zhang, Zhi Li
Summary: Atrial fibrillation (AF) is associated with an increased risk of heart failure, dementia, and stroke. Proteomics and metabolomics analyses revealed distinct metabolite and protein profiles between valvular and non-valvular AF patients, indicating potential different mechanisms underlying the two types of AF. The study identified specific biomarkers and metabolic pathways associated with each type of AF, providing insights for prognosis and potential treatment strategies.
FRONTIERS IN GENETICS
(2021)
Article
Cardiac & Cardiovascular Systems
Arwa Younis, Nofrat Nehoray, Michael Glikson, Christopher Bodurian, Eyal Nof, Nicola Luigi Bragazzi, Michael Berger, Wojciech Zareba, Ilan Goldenberg, Roy Beinart
Summary: This study evaluated the changes in QTc over time following electrical cardioversion (ECV) in patients with persistent atrial fibrillation (AF), and compared the effectiveness of continuous Holter monitoring and conventional ECG follow-up. The results showed that ECV was associated with an increased transient risk of QTc prolongation in nearly half of the patients, and Holter monitoring was superior to conventional monitoring in detecting clinically significant QTc prolongation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kaixuan Fu, Xuefeng Zhu, Hongxia Chu, Lin Zhong, Zhen Wang, Wenjing Li, Chunxiao Wang, Jianping Li, Lei Gong, Guangqiang Wang, Rao Yao, Lihong Wang
Summary: This study investigated early recurrence (ER) in patients with persistent atrial fibrillation (AF) after catheter ablation (CA). It found that 32.1% of patients experienced ER, with 50.9% of recurrences occurring within 24 hours after the procedure. ER was the most significant predictor for late recurrence (LR), and early intervention improved short-term outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Rheumatology
Alisha Gupta, Kelly J. Shields, Susan Manzi, Mary Chester Wasko, Tarun S. Sharma
Summary: The study found that the use of hydroxychloroquine (HCQ) in patients with SLE can significantly reduce the risk of new-onset atrial fibrillation, while the association with ventricular arrhythmias is not significant. The results suggest that the use of HCQ in SLE patients may help reduce cardiovascular risk.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Medicine, General & Internal
Fabien Squara, Didier Scarlatti, Sok-Sithikun Bun, Pamela Moceri, Emile Ferrari, Olivier Meste, Vicente Zarzoso
Summary: This study found that Fibrillatory Wave Amplitude (FWA) is unrelated to the complexity of atrial fibrillation (AF) but is mainly determined by the amount of viable atrial myocytes. Therefore, FWA should only be referred as a marker of atrial tissue pathology.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ozan Demirel, Alexander E. Berezin, Moritz Mirna, Elke Boxhammer, Sarah X. Gharibeh, Uta C. Hoppe, Michael Lichtenauer
Summary: Atrial fibrillation (AF) is associated with atrial remodeling, cardiac dysfunction, and poor clinical outcomes. External direct current electrical cardioversion is an effective urgent treatment strategy for recent-onset AF. However, accurate predictive serum biomarkers for AF relapse after cardioversion are lacking. Many biomarkers have been associated with AF occurrence, but their predictive ability for post-cardioversion outcomes remains controversial. Novel circulating biomarkers are needed to improve the predictive tools for AF treatment.
Article
Medicine, General & Internal
Melanie A. Gunawardene, Gerrit Frommeyer, Christian Ellermann, Mario Jularic, Patrick Leitz, Jens Hartmann, Philipp Sebastian Lange, Omar Anwar, Benjamin Rath, Rahin Wahedi, Lars Eckardt, Stephan Willems
Summary: This study aimed to investigate the efficacy and safety of left atrial posterior wall isolation (LAPWI) performed by non-thermal pulsed field ablation (PFA) in catheter ablation (CA) for persistent atrial fibrillation (persAF). The results showed that PFA-guided LAPWI is feasible and safe in patients undergoing CA for persAF and shows favorable outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Riyaz A. Kaba, Aziz Momin, John Camm
Summary: Atrial fibrillation is a global disease associated with various serious complications, making treatment complex and challenging. A large proportion of patients have persistent or long-standing persistent AF, posing greater treatment challenges.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Engineering, Biomedical
Tiago P. Almeida, Diogo C. Soriano, Michela Mase, Flavia Ravelli, Arthur S. Bezerra, Xin Li, Gavin S. Chu, Joao Salinet, Peter J. Stafford, G. Andre Ng, Fernando S. Schlindwein, Takashi Yoneyama
Summary: Utilizing unsupervised classification and AEG-derived markers, five distinct classes of AEGs were identified with significant differences in characteristics, potentially offering a more comprehensive substrate characterization for ablation target identification in future clinical studies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Cardiac & Cardiovascular Systems
Habib Rehman Khan, Haci Yakup Yakupoglu, Ines Kralj-Hans, Shouvik Haldar, Toufan Bahrami, Jonathan Clague, Anthony De Souza, Wajid Hussain, Julian Jarman, David Gareth Jones, Tushar Salukhe, Vias Markides, Dhiraj Gupta, Rajdeep Khattar, Tom Wong, CASA AF Investigators
Summary: This study examined the post-ablation left atrial (LA) function and its impact on AF recurrence in patients with de-novo long-standing persistent AF. The results showed that patients who maintained sinus rhythm had improved LA function and better left ventricular diastolic function compared to those with AF recurrence after ablation.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Xiangyu Li, Mingfang Li, Yongfeng Shao, Weidong Gu, Buqing Ni, Jiaxi Gu, Minglong Chen
Summary: The study aimed to determine whether mini-invasive transthoracic atrial fibrillation ablation can delay the progression of atrial fibrillation from paroxysmal to persistent. The results showed that patients who chose transthoracic atrial fibrillation ablation had a lower incidence of progression to persistent atrial fibrillation compared to patients who chose conservative therapy.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Biochemistry & Molecular Biology
Andres Orozco-Duque, Catalina Tobon, Juan P. Ugarte, Carlos Morillo, John Bustamante
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2019)
Article
Computer Science, Interdisciplinary Applications
Catalina Tobon, Javier Saiz
SIMULATION-TRANSACTIONS OF THE SOCIETY FOR MODELING AND SIMULATION INTERNATIONAL
(2019)
Article
Biophysics
Ashleigh E. Cummings, Jiayuan Miao, Diana P. Slough, Sean M. McHugh, Joshua A. Kritzer, Yu-Shan Lin
BIOPHYSICAL JOURNAL
(2019)
Article
Physics, Multidisciplinary
Juan P. Ugarte, Catalina Tobon, Andres Orozco-Duque
Article
Computer Science, Interdisciplinary Applications
Laura C. Palacio, Juan P. Ugarte, Catalina Tobon
SIMULATION-TRANSACTIONS OF THE SOCIETY FOR MODELING AND SIMULATION INTERNATIONAL
(2019)
Article
Chemistry, Physical
Tedros A. Balema, Nisa Ulumuddin, Colin J. Murphy, Diana P. Slough, Zachary C. Smith, Ryan T. Hannagan, Natalie A. Wasio, Amanda M. Larson, Dipna A. Patel, Kyle Groden, Jean-Sabin McEwen, Yu-Shan Lin, E. Charles H. Sykes
JOURNAL OF PHYSICAL CHEMISTRY C
(2019)
Review
Engineering, Biomedical
Alejandro Gomez-Echavarria, Juan P. Ugarte, Catalina Tobon
BIOCYBERNETICS AND BIOMEDICAL ENGINEERING
(2020)
Article
Cardiac & Cardiovascular Systems
Obada Abouassali, Mengmeng Chang, Bojjibabu Chidipi, Jose Luis Martinez, Michelle Reiser, Manasa Kanithi, Ravi Soni, Thomas McDonald, Bengt Herweg, Javier Saiz, Laurent Calcul, Sami F. Noujaim
Summary: The study indicates that flavored electronic nicotine delivery systems (ENDS) can have potential cardiac toxicity, affecting heart rate variability and duration of field potential in cell lines and animal models. Further research is needed to evaluate the long-term cardiac safety of these products in humans and understand the individual components' impact on cardiac toxicity.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Veera B. Pallaval, Manasa Kanithi, Sangeetha Meenakshisundaram, Achanta Jagadeesh, Mattareddy Alavala, Thanigaimalai Pillaiyar, Manoj Manickam, Bojjibabu Chidipi
Summary: Quinoline derivative drugs, such as Chloroquine and Hydroxychloroquine, have potential anti-SARS-CoV-2 activity and may be of interest in drug development due to their ability to inhibit the virus through multiple mechanisms.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Cell Biology
Bojjibabu Chidipi, Syed Islamuddin Shah, Michelle Reiser, Manasa Kanithi, Amanda Garces, Byeong J. Cha, Ghanim Ullah, Sami F. Noujaim
Summary: The study found that ATRA can increase DRP1 protein levels and affect mitochondrial structure, leading to mitochondrial remodeling and changes in ultrastructure. Numerical modeling suggests that ATRA promotes mitochondrial fission events.
Article
Cell Biology
Laura C. Palacio, Juan P. Ugarte, Javier Saiz, Catalina Tobon
Summary: This study evaluates the impact of different fibrotic cell types on persistent atrial fibrillation, finding that high fibrosis densities significantly affect signal conduction velocity, leading to susceptibility to multiple re-entries and chaotic activity. The configuration of fibrocytes at a high density exhibits the largest proarrhythmic effect.
Article
Computer Science, Information Systems
Miguel A. Becerra, Catalina Tobon, Andres Eduardo Castro-Ospina, Diego H. Peluffo-Ordonez
Summary: This paper provides a comprehensive overview of the current literature on data fusion, focusing on the relationship between data fusion and Information Quality (IQ), research issues, the complexity of data fusion engineering process, and performance evaluation of data fusion systems.
Proceedings Paper
Computer Science, Interdisciplinary Applications
Juan P. Ugarte, Catalina Tobon
APPLIED COMPUTER SCIENCES IN ENGINEERING (WEA 2019)
(2019)