An Improved Enzyme-Linked Focus Formation Assay Revealed Baloxavir Acid as a Potential Antiviral Therapeutic Against Hantavirus Infection

Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018

(2019) Emi Takashita et al.   Eurosurveillance

Baloxavir: First Global Approval

(2018) Young-A Heo   DRUGS

Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil

(2018) Shinya Omoto et al.   Scientific Reports

Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents

(2018) Frederick G. Hayden et al.   NEW ENGLAND JOURNAL OF MEDICINE

In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit

(2018) Takeshi Noshi et al.   ANTIVIRAL RESEARCH

Combination treatment with the cap-dependent endonuclease inhibitor baloxavir marboxil and a neuraminidase inhibitor in a mouse model of influenza A virus infection

(2018) Keita Fukao et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase

(2017) Rana Abdelnabi et al.   JOURNAL OF VIROLOGY

In-Cell Western Assays to Evaluate Hantaan Virus Replication as a Novel Approach to Screen Antiviral Molecules and Detect Neutralizing Antibody Titers

(2017) Hong-Wei Ma et al.   Frontiers in Cellular and Infection Microbiology

Hantavirus infection: a global zoonotic challenge

(2017) Hong Jiang et al.   VIROLOGICA SINICA

Conserved Endonuclease Function of Hantavirus L Polymerase

(2016) Sylvia Rothenberger et al.   Viruses-Basel

Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases

(2016) Juan Reguera et al.   PLoS Pathogens

Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein

(2016) Yaiza Fernández-García et al.   PLoS Pathogens

Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter

(2015) Piotr Gerlach et al.   CELL

Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy

(2015) Bo Liang et al.   CELL

Development of a novel plaque reduction neutralisation test for hantavirus infection

(2015) Michelly de Pádua et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Structural insight into cap-snatching and RNA synthesis by influenza polymerase

(2014) Stefan Reich et al.   NATURE

Induction of Specific Humoral and Cellular Immune Responses in a Mouse Model following Gene Fusion of HSP70C and Hantaan Virus Gn and S0.7 in an Adenoviral Vector

(2014) Linfeng Cheng et al.   PLoS One

Antiviral Efficacy of Favipiravir against Two Prominent Etiological Agents of Hantavirus Pulmonary Syndrome

(2013) David Safronetz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Favipiravir (T-705), a novel viral RNA polymerase inhibitor

(2013) Yousuke Furuta et al.   ANTIVIRAL RESEARCH

A rapid method for infectivity titration of Andes hantavirus using flow cytometry

(2013) Gonzalo P. Barriga et al.   JOURNAL OF VIROLOGICAL METHODS

Quantification of Hantaan Virus with a SYBR Green Ⅰ-Based One-Step qRT-PCR Assay

(2013) Wei Jiang et al.   PLoS One

Hantaan Virus Triggers TLR4-Dependent Innate Immune Responses

(2012) Hai-Tao Yu et al.   VIRAL IMMUNOLOGY

Establishment of SYBR green-based qPCR assay for rapid evaluation and quantification for anti-Hantaan virus compounds in vitro and in suckling mice

(2012) Fei Wei et al.   VIRUS GENES

A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease

(2010) C. B. Jonsson et al.   CLINICAL MICROBIOLOGY REVIEWS

Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription

(2010) Juan Reguera et al.   PLoS Pathogens