Corticotropin releasing factor-binding protein (CRF-BP) as a potential new therapeutic target in Alzheimer’s disease and stress disorders

Recovery of stress-impaired social behavior by an antagonist of the CRF binding protein, CRF 6−33, in the bed nucleus of the stria terminalis of male rats

(2018) Mailton Vasconcelos et al.   BEHAVIOURAL BRAIN RESEARCH

Anxiety-like behavior as an early endophenotype in the TgF344-AD rat model of Alzheimer's disease

(2018) Nathan S. Pentkowski et al.   NEUROBIOLOGY OF AGING

Corticotrophin Releasing Factor Accelerates Neuropathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease

(2018) Hongxin Dong et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased Tau Phosphorylation and Aggregation in the Hippocampus of Mice Overexpressing Corticotropin-Releasing Factor

(2018) Shannon N. Campbell et al.   JOURNAL OF ALZHEIMERS DISEASE

The Corticotropin-Releasing Factor Family: Physiology of the Stress Response

(2018) Jan M. Deussing et al.   PHYSIOLOGICAL REVIEWS

Selectivity determinants of GPCR–G-protein binding

(2017) Tilman Flock et al.   NATURE

Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?

(2017) Sami Piirainen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Don’t stress about CRF: assessing the translational failures of CRF1antagonists

(2017) Samantha R. Spierling et al.   PSYCHOPHARMACOLOGY

Corticotropin-releasing hormone-binding protein and stress: from invertebrates to humans

(2017) Kyle D. Ketchesin et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Trajectories of Depressive Symptoms Before Diagnosis of Dementia

(2017) Archana Singh-Manoux et al.   JAMA Psychiatry

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

(2017) Rodrigo E. González-Reyes et al.   Frontiers in Molecular Neuroscience

Effects of Stress and Stress Hormones on Amyloid-β Protein and Plaque Deposition

(2017) Hongxin Dong et al.   JOURNAL OF ALZHEIMERS DISEASE

The corticotropin releasing factor binding protein: A strange case of Dr. Jekyll and Mr. Hyde in the stress system?

(2017) Carolina L. Haass-Koffler   ALCOHOL

Corticotropin-releasing factor receptor-1 antagonism mitigates beta amyloid pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease

(2016) Cheng Zhang et al.   Alzheimers & Dementia

The road to restoring neural circuits for the treatment of Alzheimer's disease

(2016) Rebecca G. Canter et al.   NATURE

Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014

(2015) Michael W. Weiner et al.   Alzheimers & Dementia

Anxiety Symptoms in Amnestic Mild Cognitive Impairment Are Associated with Medial Temporal Atrophy and Predict Conversion to Alzheimer Disease

(2015) Linda Mah et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

The stress response neuropeptide CRF increases amyloid-  production by regulating  -secretase activity

(2015) H.-J. Park et al.   EMBO JOURNAL

Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice

(2015) David Baglietto-Vargas et al.   JOURNAL OF NEUROCHEMISTRY

Building hippocampal circuits to learn and remember: Insights into the development of human memory

(2013) Pierre Lavenex et al.   BEHAVIOURAL BRAIN RESEARCH

Behavioral, biological, and chemical perspectives on targeting CRF1 receptor antagonists to treat alcoholism

(2013) Eric P. Zorrilla et al.   DRUG AND ALCOHOL DEPENDENCE

Early-life stress and HPA axis trigger recurrent adulthood depression

(2013) Mario F. Juruena   EPILEPSY & BEHAVIOR

Corticotropin-releasing factor peptide antagonists: Design, characterization and potential clinical relevance

(2013) Jean E. Rivier et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Depressive Symptoms in Mild Cognitive Impairment Predict Greater Atrophy in Alzheimer's Disease-Related Regions

(2012) Grace J. Lee et al.   BIOLOGICAL PSYCHIATRY

Corticotropin-releasing factor and urocortin regulate spine and synapse formation: structural basis for stress-induced neuronal remodeling and pathology

(2012) N V Gounko et al.   MOLECULAR PSYCHIATRY

Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling

(2012) Y Chen et al.   MOLECULAR PSYCHIATRY

Sculpting the hippocampus from within: stress, spines, and CRH

(2012) Pamela M. Maras et al.   TRENDS IN NEUROSCIENCES

Chronic Stress Exacerbates Tau Pathology, Neurodegeneration, and Cognitive Performance through a Corticotropin-Releasing Factor Receptor-Dependent Mechanism in a Transgenic Mouse Model of Tauopathy

(2011) J. C. Carroll et al.   JOURNAL OF NEUROSCIENCE

Biomimetic Screening of Class-B G Protein-Coupled Receptors

(2011) Christian Devigny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling

(2011) Femke L. Groeneweg et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Epidemiology of Alzheimer disease

(2011) Christiane Reitz et al.   Nature Reviews Neurology

3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress

(2011) Sarah M. Rothman et al.   NEUROBIOLOGY OF AGING

Chronic stress, cognitive functioning and mental health

(2011) Marie-France Marin et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

(2011) Todd E. Golde et al.   NEURON

Stress- and Allostasis-Induced Brain Plasticity

(2010) Bruce S. McEwen et al.   Annual Review of Medicine

Prenatal stress and brain development

(2010) Arnaud Charil et al.   BRAIN RESEARCH REVIEWS

Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder

(2010) Vladimir Coric et al.   DEPRESSION AND ANXIETY

Morning Cortisol Levels and Cognitive Abilities in People With Type 2 Diabetes: The Edinburgh Type 2 Diabetes Study

(2010) R. M. Reynolds et al.   DIABETES CARE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic utility of non-peptidic CRF1 receptor antagonists in anxiety, depression, and stress-related disorders: Evidence from animal models

(2010) John H. Kehne et al.   PHARMACOLOGY & THERAPEUTICS

Regulation of the stress response in rats by central actions of glucocorticoids

(2009) Deborah A. Scheuer   EXPERIMENTAL PHYSIOLOGY

The neuro-symphony of stress

(2009) Marian Joëls et al.   NATURE REVIEWS NEUROSCIENCE

A 6-Week Randomized, Placebo-Controlled Trial of CP-316,311 (a Selective CRH1Antagonist) in the Treatment of Major Depression

(2008) Brendon Binneman et al.   AMERICAN JOURNAL OF PSYCHIATRY

Corticotropin-Releasing Factor in the Basolateral Amygdala Enhances Memory Consolidation via an Interaction with the  -Adrenoceptor-cAMP Pathway: Dependence on Glucocorticoid Receptor Activation

(2008) B. Roozendaal et al.   JOURNAL OF NEUROSCIENCE

Rapid Loss of Dendritic Spines after Stress Involves Derangement of Spine Dynamics by Corticotropin-Releasing Hormone

(2008) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

Do early-life insults contribute to the late-life development of Parkinson and Alzheimer diseases?

(2008) Diane B. Miller et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Deletion of corticotropin-releasing factor binding protein selectively impairs maternal, but not intermale aggression

(2008) S.C. Gammie et al.   NEUROSCIENCE