The Effects of Hypoxia on the Immune-Modulatory Properties of Bone Marrow-Derived Mesenchymal Stromal Cells

Hypoxia preconditioning promotes bone marrow mesenchymal stem cells survival by inducing HIF-1α in injured neuronal cells derived exosomes culture system

(2019) Zucheng Luo et al.   Cell Death & Disease

Cancer-Cell-Intrinsic Mechanisms Shaping the Tumor Immune Landscape

(2018) Max D. Wellenstein et al.   IMMUNITY

Evaluation of the effects of ascorbic acid on metabolism of human mesenchymal stem cells

(2018) Koichi Fujisawa et al.   Stem Cell Research & Therapy

Microvesicles derived from human bone marrow mesenchymal stem cells promote U2OS cell growth under hypoxia: the role of PI3K/AKT and HIF-1α

(2018) Shanshan Lin et al.   Human Cell

Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatory macrophages in cell-to-cell contact-independent and -dependent manners under hypoxic culture

(2017) Naoki Takizawa et al.   EXPERIMENTAL CELL RESEARCH

Effects Of Hypoxia in Long-Term In Vitro Expansion of Human Bone Marrow Derived Mesenchymal Stem Cells

(2017) Annelise Pezzi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Autophagy mediates the beneficial effect of hypoxic preconditioning on bone marrow mesenchymal stem cells for the therapy of myocardial infarction

(2017) Zheng Zhang et al.   Stem Cell Research & Therapy

Autophagy regulates the apoptosis of bone marrow-derived mesenchymal stem cells under hypoxic condition via AMP-activated protein kinase/mammalian target of rapamycin pathway

(2016) Zheng Zhang et al.   CELL BIOLOGY INTERNATIONAL

Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II)

(2016) José M. Lamo-Espinosa et al.   Journal of Translational Medicine

Effect of the PI3K/AKT signaling pathway on hypoxia-induced proliferation and differentiation of bone marrow-derived mesenchymal stem cells

(2016) Lingling Sheng et al.   Experimental and Therapeutic Medicine

Mesenchymal Stem Cell Treatment for Steroid Refractory Graft-versus-Host Disease in Children: A Pilot and First Study from Turkey

(2016) Fatih Erbey et al.   Stem Cells International

REST is a hypoxia-responsive transcriptional repressor

(2016) Miguel A. S. Cavadas et al.   Scientific Reports

Hypoxia promotes bone marrow-derived mesenchymal stem cell proliferation through apelin/APJ/autophagy pathway

(2015) L. Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Bone Marrow Mesenchymal Stromal Cells from Patients with Acute and Chronic Graft-versus-Host Disease Deploy Normal Phenotype, Differentiation Plasticity, and Immune-Suppressive Activity

(2015) Ian B. Copland et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Single and Multiple Dose MultiStem (Multipotent Adult Progenitor Cell) Therapy Prophylaxis of Acute Graft-versus-Host Disease in Myeloablative Allogeneic Hematopoietic Cell Transplantation: A Phase 1 Trial

(2015) Richard T. Maziarz et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Differential Effects of Culture Senescence and Mechanical Stimulation on the Proliferation and Leiomyogenic Differentiation of MSC from Different Sources: Implications for Engineering Vascular Grafts

(2015) Maxwell T. Koobatian et al.   TISSUE ENGINEERING PART A

Mesenchymal stem cells alleviate airway inflammation and emphysema in COPD through down-regulation of cyclooxygenase-2 via p38 and ERK MAPK pathways

(2015) Wen Gu et al.   Scientific Reports

Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial

(2015) Jennifer G Wilson et al.   Lancet Respiratory Medicine

Analysis of results of acute graft-versus-host disease prophylaxis with donor multipotent mesenchymal stromal cells in patients with hemoblastoses after allogeneic bone marrow transplantation

(2014) I. N. Shipounova et al.   BIOCHEMISTRY-MOSCOW

Sequential Third-Party Mesenchymal Stromal Cell Therapy for Refractory Acute Graft-versus-Host Disease

(2014) Fermín Sánchez-Guijo et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Hypoxia Induces Autophagy of Bone Marrow-Derived Mesenchymal Stem Cells via Activation of ERK1/2

(2014) Junfang Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Autophagy induction is a survival response against oxidative stress in bone marrow–derived mesenchymal stromal cells

(2014) Chunjuan Song et al.   CYTOTHERAPY

Overexpression of FABP3 inhibits human bone marrow derived mesenchymal stem cell proliferation but enhances their survival in hypoxia

(2014) Suna Wang et al.   EXPERIMENTAL CELL RESEARCH

Effects of Apelin-13 on Rat Bone Marrow-Derived Mesenchymal Stem Cell Proliferation Through the AKT/GSK3β/Cyclin D1 Pathway

(2014) Lanfang Li et al.   International Journal of Peptide Research and Therapeutics

Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53

(2014) David Quigley et al.   MOLECULAR CANCER RESEARCH

Adipose tissue-derived mesenchymal stem cells differentiated into hepatocyte-like cells in vivo and in vitro

(2014) LIBO YIN et al.   Molecular Medicine Reports

Basic fibroblast growth factor modifies the hypoxic response of human bone marrow stromal cells by ERK-mediated enhancement of HIF-1α activity

(2014) Zsolt Fábián et al.   Stem Cell Research

Injectable Cultured Bone Marrow–Derived Mesenchymal Stem Cells in Varus Knees With Cartilage Defects Undergoing High Tibial Osteotomy: A Prospective, Randomized Controlled Clinical Trial With 2 Years' Follow-up

(2013) Keng Lin Wong et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Hydroxylase-dependent regulation of the NF-κB pathway

(2013) Carsten C. Scholz et al.   BIOLOGICAL CHEMISTRY

A Placebo-Controlled, Randomized Trial of Mesenchymal Stem Cells in COPD

(2013) Daniel J. Weiss et al.   CHEST

Gas chromatography–mass spectrometry analysis of human mesenchymal stem cell metabolism during proliferation and osteogenic differentiation under different oxygen tensions

(2013) Nathalie Muñoz et al.   JOURNAL OF BIOTECHNOLOGY

Hypoxia Promotes Dopaminergic Differentiation of Mesenchymal Stem Cells and Shows Benefits for Transplantation in a Rat Model of Parkinson’s Disease

(2013) Yue Wang et al.   PLoS One

Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages

(2013) Sara M. Melief et al.   STEM CELLS

Analysis of Surface Protein Expression in Human Bone Marrow Stromal Cells: New Aspects of Culture-Induced Changes, Inter-Donor Differences and Intracellular Expression

(2013) Luisa Marilena Schäck et al.   STEM CELLS AND DEVELOPMENT

Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action

(2012) Lavinia Ionescu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Double Allogenic Mesenchymal Stem Cells Transplantations Could Not Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus

(2012) Dandan Wang et al.   Clinical & Developmental Immunology

Exposure to supernatants of macrophages that phagocytized dead mesenchymal stem cells improves hypoxic cardiomyocytes survival

(2012) Wenbin Lu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mesenchymal stem cells protect cigarette smoke-damaged lung and pulmonary function partly via VEGF-VEGF receptors

(2012) Xiao-Jun Guan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study

(2012) Peter Connick et al.   LANCET NEUROLOGY

Heterotrimeric GAIT Complex Drives Transcript-Selective Translation Inhibition in Murine Macrophages

(2012) A. Arif et al.   MOLECULAR AND CELLULAR BIOLOGY

Continuous and Uninterrupted Oxygen Tension Influences the Colony Formation and Oxidative Metabolism of Human Mesenchymal Stem Cells

(2012) Girish Pattappa et al.   TISSUE ENGINEERING PART C-METHODS

Autologous Mesenchymal Stem Cell Therapy in Progressive Multiple Sclerosis: An Open Label Study

(2012) Mandana Mohyeddin Bonab et al.   Current Stem Cell Research & Therapy

Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion

(2012) E. Eggenhofer et al.   Frontiers in Immunology

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis

(2011) J C Estrada et al.   CELL DEATH AND DIFFERENTIATION

Mesenchymal-stem-cell-based experimental and clinical trials: current status and open questions

(2011) Jin Wang et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Mesenchymal stem cells expanded in vitro with human serum for the treatment of acute and chronic graft-versus-host disease: results of a phase I/II clinical trial

(2011) J. A. Perez-Simon et al.   HAEMATOLOGICA

Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia

(2011) Jessica M. Cassavaugh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-α-induced protein 6

(2011) Svitlana Danchuk et al.   Stem Cell Research & Therapy

Effects of hypoxia and/or lack of glucose on cellular energy metabolism and cytokine production in stimulated human CD4+ T lymphocytes

(2010) R. Dziurla et al.   IMMUNOLOGY LETTERS

The Role of Hypoxia in Development of the Mammalian Embryo

(2009) Sally L. Dunwoodie   DEVELOPMENTAL CELL

Ex vivo expansion of human mesenchymal stem cells: A more effective cell proliferation kinetics and metabolism under hypoxia

(2009) Francisco dos Santos et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma

(2009) Etienne Meylan et al.   NATURE

Mesenchymal Stem Cell Transplantation Reverses Multiorgan Dysfunction in Systemic Lupus Erythematosus Mice and Humans

(2009) Lingyun Sun et al.   STEM CELLS

Growth, Metabolism, and Growth Inhibitors of Mesenchymal Stem Cells

(2009) Deborah Schop et al.   TISSUE ENGINEERING PART A

Short-Time Survival and Engraftment of Bone Marrow Stromal Cells in an Ectopic Model of Bone Regeneration

(2009) Paolo Giannoni et al.   TISSUE ENGINEERING PART A

Donor-Derived Mesenchymal Stem Cells Remain Present and Functional in the Transplanted Human Heart

(2008) M. J. Hoogduijn et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Transplantation of ex-vivo culture-expanded parental haploidentical mesenchymal stem cells to promote engraftment in pediatric recipients of unrelated donor umbilical cord blood: results of a phase I–II clinical trial

(2008) M L MacMillan et al.   BONE MARROW TRANSPLANTATION

Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

(2008) Krisztián Németh et al.   NATURE MEDICINE

Pulmonary Passage is a Major Obstacle for Intravenous Stem Cell Delivery: The Pulmonary First-Pass Effect

(2008) Uwe M. Fischer et al.   STEM CELLS AND DEVELOPMENT