Journal
ACTA OTO-LARYNGOLOGICA
Volume 136, Issue 1, Pages 1-7Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/00016489.2015.1083120
Keywords
Adenoid cystic carcinoma; BIP; PERK; ER stress; prognosis
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Funding
- Grants-in-Aid for Scientific Research [15K10798, 26670736] Funding Source: KAKEN
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Conclusion: A high GRP78/BiP expression was proved to be a significant marker for predicting poor outcome after surgery. GRP78/BiP may be a promising molecular target for treatment of ACC. Background: The glucose-regulated protein GRP78/BiP plays a crucial role in the endoplasmic reticulum (ER) stress. The level of GRP78 is highly elevated in various human cancers, but the clinicopathological significance of GRP78/BiP remains controversial in patients with adenoid cystic carcinoma (ACC). Methods: A total of 26 ACC patients were analyzed, and tumor specimens were stained by immunohistochemistry for GRP78/BiP, PERK, Ki-67, and microvessel density (MVD) determined by CD34. Results: GRP78/BiP and PERK were highly expressed in 58% (15/26) and 35% (9/26), respectively. The high expression of GRP78/BiP was significantly associated with PERK, cell proliferation and angiogenesis.
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