Review
Immunology
Shen Lu, Yanrong Li, Zhaojun Qian, Tiesuo Zhao, Zhiwei Feng, Xiaogang Weng, Lili Yu
Summary: This article reviews the role and research progress of the inflammasome in insulin resistance (IR) and type 2 diabetes mellitus (T2DM), emphasizing on the structure, activation, and regulation of several main inflammasomes. The therapeutic options associated with inflammasome for the treatment of T2DM, particularly NLRP3-related agents, are also discussed. In summary, this review provides insights into the involvement of the inflammasome in IR and T2DM and highlights its potential as a therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Food Science & Technology
Mengjiao Wang, Min Chen, Rui Guo, Yangyang Ding, Haihui Zhang, Yuanqing He
Summary: This review summarizes the role of sulforaphane in improving T2DM and its potential mechanisms, especially in insulin resistance, glucose metabolism, lipid metabolism, oxidative stress, and inflammatory factors. It also emphasizes the effects of sulforaphane on T2DM complications and provides evidence for further research and development as a hypoglycemic drug.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Benjamin Schroeder, Sabine Kahl, Michael Roden
Summary: Individuals with obesity or type 2 diabetes have an increased risk of developing non-alcoholic fatty liver disease, with altered adipose tissue function and hepatic mitochondrial dysfunction playing key roles in the pathogenesis. Genetic testing for high-risk individuals, particularly for the rs738409(G) SNP of the PNPLA3 gene, could improve future screening strategies.
LIVER INTERNATIONAL
(2021)
Review
Immunology
Zheng Zhou, Bao Sun, Dongsheng Yu, Chunsheng Zhu
Summary: Type 2 diabetes mellitus, a common metabolic disease, is associated with gut microbiota dysbiosis. Remodeling the gut microbiota may be a potential strategy for treating T2DM and its complications.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Mohammad Reza Nazem, Mojgan Asadi, Maryam Adelipour, Niloofar Jabbari, Abdolamir Allameh
Summary: This study evaluated the effects of zinc supplementation on oxidative status and glycaemic parameters in overweight patients with type 2 diabetes mellitus (T2DM). The results showed that zinc supplementation for 8 weeks significantly improved the oxidative balance and controlled the glycaemic indices in these patients.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Review
Nutrition & Dietetics
Wanbao Yang, Wen Jiang, Shaodong Guo
Summary: This article reviews the effects of different components of macronutrients on insulin sensitivity and their underlying mechanisms, highlighting the importance of adjusting the intake of beneficial food compounds for the prevention of insulin resistance and type 2 diabetes.
Article
Endocrinology & Metabolism
Hana Alzamil, Laila Aldokhi
Summary: This study aimed to investigate the relationship of leptin and leptin SR with adiposity indices and glycemic indices in type 2 diabetes mellitus (T2DM) patients. It was found that leptin SR level was significantly higher in T2DM patients and correlated with beta-cell function, body fat mass, and HbA1c. The independent predictors for leptin SR in T2DM patients were TG and HbA1c.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Sarantis Livadas, Rodis Paparodis, Panagiotis Anagnostis, Alessandra Gambineri, Jelica Bjekic-Macut, Tijana Petrovic, Bulent O. Yildiz, Dragan Micic, George Mastorakos, Djuro Macut
Summary: Women with polycystic ovary syndrome (PCOS) are at higher risk for dysglycemia and type 2 diabetes compared to healthy BMI-matched women of reproductive age. The incidence of this disorder varies among studies, and there is no consensus on the best screening method and frequency. Universal screening with oral glucose tolerance test is suggested to identify and manage glycemic abnormalities in young women with PCOS, regardless of age or BMI status. Regular follow-up and lifestyle interventions, such as balanced diet and exercise, are important for this specific population.
Article
Multidisciplinary Sciences
Shaza B. Zaghlool, Anna Halama, Nisha Stephan, Valborg Gudmundsdottir, Vilmundur Gudnason, Lori L. Jennings, Manonanthini Thangam, Emma Ahlqvist, Rayaz A. Malik, Omar M. E. Albagha, Karsten Suhre, Abdul Badi Abou-Samra
Summary: This study translates T2D subtypes previously identified in European individuals to an Arab population and identifies specific metabolic and proteomic signatures for each subtype, providing further understanding of the pathogenesis of these subtypes.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Desh Deepak Singh, Ali A. Shati, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Ihn Han, Eun-Ha Choi, Dharmendra K. Yadav
Summary: There are common molecular mechanisms and underlying pathology, such as insulin resistance and impaired synaptic plasticity, between type 2 diabetes mellitus and dementia. Analyzing risk factors is crucial for disease development and clinical management.
Review
Cell & Tissue Engineering
Shuang Gao, Yuanyuan Zhang, Kaini Liang, Ran Bi, Yanan Du
Summary: This review provides an overview of the current status of mesenchymal stem/stromal cell (MSC) therapy in treating type 2 diabetes mellitus (T2DM) based on animal and clinical studies. The potential mechanisms of MSC intervention in various pathological processes of T2DM are discussed, along with the importance of understanding the pharmacokinetics (PK) of transplanted cells and the challenges in MSC-based T2DM therapy for future clinical applications.
STEM CELLS INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
Vittoria Russo, Rui Chen, Reina Armamento-Villareal
Summary: Chronic hyperglycemia and insulin resistance from type 2 diabetes mellitus may lead to hypogonadotropic hypogonadism in men, which in turn affects bone health and increases fracture risk. Having both hypogonadism and T2DM may predispose men to a higher risk of fractures, but there is limited research on this topic to date.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Michalis Michailidis, Despina Moraitou, Despina A. Tata, Kallirhoe Kalinderi, Theodora Papamitsou, Vasileios Papaliagkas
Summary: This review article discusses the shared pathophysiological connections between Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM), emphasizing the role of insulin in the brain and the mechanistic interplay between the two diseases. The findings highlight the need for routine evaluation and treatment of cognitive impairment in T2DM patients and the evaluation of insulin levels or T2DM in AD patients. The hypothesis of AD as a type 3 diabetes is strongly supported.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
A. G. Unnikrishnan, R. K. Sahay, Uday Phadke, S. K. Sharma, Parag Shah, Rishi Shukla, Vijay Viswanathan, S. K. Wangnoo, Santosh Singhal, Mathew John, Ajay Kumar, Mala Dharmalingam, Subodh Jain, Shehla Shaikh, Willem J. Verberk
Summary: Through studying newly diagnosed T2DM patients in India, it is found that they have high cardiovascular disease risk. This indicates the need for further extension of ASCVD risk identification programs and prevention strategies to reduce the occurrence of cardiovascular diseases.
Review
Biochemistry & Molecular Biology
Angelica Artasensi, Angelica Mazzolari, Alessandro Pedretti, Giulio Vistoli, Laura Fumagalli
Summary: Obesity and T2DM are major public health concerns associated with adipose tissue dysfunction. This dysfunction leads to chronic inflammation, dysregulated glucose homeostasis, and impaired adipogenesis, which result in ectopic fat accumulation and insulin resistance. Weight loss of at least 15% is effective in ameliorating this dysfunctional state and improving glycemic control, reducing the likelihood of cardiometabolic disease and enhancing overall quality of life. Lifestyle modifications and pharmacotherapy, including bariatric surgery and various drugs, such as metformin, GLP-1 receptor agonists, amylin analogs, and SGLT2 inhibitors, have been shown to induce significant weight loss and improve glycemic control in obese individuals with T2DM.
Article
Endocrinology & Metabolism
Jun Song, Chuan Wang, Aixia Ma, Huizhen Zheng, Wenjian Zheng, Xinguo Hou, Cheng Hu, Li Chen, Weiping Jia
JOURNAL OF DIABETES INVESTIGATION
(2019)
Article
Urology & Nephrology
Aixia Ma, Fuqiang Liu, Chuan Wang, Kai Liang, Fei Yan, Xinguo Hou, Jinbo Liu, Li Chen
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2018)
Article
Neurosciences
Wenjun Zhou, Yanlin He, Atteeq U. Rehman, Yan Kong, Sungguan Hong, Guolian Ding, Hari Krishna Yalamanchili, Ying-Wooi Wan, Basil Paul, Chuhan Wang, Yingyun Gong, Wenxian Zhou, Hao Liu, John Deans, Emmanuel Scalais, Mary O'Driscoll, Jenny E. Morton, Nadia Akawi, Saeed Al-Turki, Kirsty Ambridge, Jeffrey Barrett, Daniel Barrett, Tanya Bayzetinova, Nigel Carter, Stephen Clayton, Eve Coomber, Helen Firth, Tomas Fitzgerald, David FitzPatrick, Sebastian Gerety, Susan Gribble, Matthew Hurles, Philip Jones, Wendy Jones, Daniel King, Netravathi Krishnappa, Laura Mason, Jeremy McRae, Parker Michael, Anna Middleton, Ray Miller, Katherine Morley, Vijaya Parthiban, Elena Prigmore, Diana Rajan, Alejandro Sifrim, Tarjinder Singh, Adrian Tivery, Margriet van Kogelenberg, Caroline Wright, Xinguo Hou, Qi Wu, Qingchun Tong, Zhandong Liu, Pengfei Liu, Yong Xu, Zheng Sun
NATURE NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Jinbang Wang, Huiqing Hu, Jia Song, Fei Yan, Jun Qin, Xinghong Guo, Chen Cui, Qin He, Xinguo Hou, Fuqiang Liu, Li Chen
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Meijian Wang, Xinguo Hou, Wenchao Hu, Li Chen, Shihong Chen
LIPIDS IN HEALTH AND DISEASE
(2019)
Article
Biochemical Research Methods
Peng Lin, Zhina Yao, Yu Sun, Wenjuan Li, Yan Liu, Kai Lang, Yuan Liu, Jun Qin, Xinguo Hou, Li Chen
JOURNAL OF PROTEOMICS
(2019)
Correction
Neurosciences
Wenjun Zhou, Yanlin He, Atteeq U. Rehman, Yan Kong, Sungguan Hong, Guolian Ding, Hari Krishna Yalamanchili, Ying-Wooi Wan, Basil Paul, Chuhan Wang, Yingyun Gong, Wenxian Zhou, Hao Liu, John Dean, Emmanuel Scalais, Mary O'Driscoll, Jenny E. V. Morton, Xinguo Hou, Qi Wu, Qingchun Tong, Zhandong Liu, Pengfei Liu, Yong Xu, Zheng Sun
NATURE NEUROSCIENCE
(2019)
Article
Endocrinology & Metabolism
Jiajia Wang, Wenjuan Li, Chuan Wang, Lingshu Wang, Tianyi He, Huiqing Hu, Jia Song, Chen Cui, Jingting Qiao, Li Qing, Lili Li, Nan Zang, Kewei Wang, Chuanlong Wu, Lin Qi, Aixia Ma, Huizhen Zheng, Xinguo Hou, Fuqiang Liu, Li Chen
JOURNAL OF DIABETES RESEARCH
(2020)
Article
Endocrinology & Metabolism
Xinghong Guo, Danyang Li, Jia Song, Qibing Yang, Meng Wang, Yang Yang, Lingshu Wang, Xinguo Hou, Li Chen, Xiangzhi Li
METABOLISM-CLINICAL AND EXPERIMENTAL
(2020)
Article
Cell & Tissue Engineering
Qin He, Lingshu Wang, Ruxing Zhao, Fei Yan, Sha Sha, Chen Cui, Jia Song, Huiqing Hu, Xinghong Guo, Mengmeng Yang, Yixin Cui, Yujing Sun, Zheng Sun, Fuqiang Liu, Ming Dong, Xinguo Hou, Li Chen
STEM CELL RESEARCH & THERAPY
(2020)
Article
Immunology
Ru-xing Zhao, Qin He, Sha Sha, Jia Song, Jun Qin, Peng Liu, Yu-jing Sun, Lei Sun, Xin-guo Hou, Li Chen
FRONTIERS IN IMMUNOLOGY
(2020)
Letter
Environmental Sciences
Liang Kai, Wang Chuan, Yan Fei, Yang Jun Peng, Tian Meng, Wang Ling Shu, Hou Xin Guo, Chen Li
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2020)
Article
Endocrinology & Metabolism
Kewei Wang, Fuqiang Liu, Chuanlong Wu, Yan Liu, Lin Qi, Xiaohan Yang, Huizhen Zheng, Aixia Ma, Jiahui Wu, Fei Yan, Xinguo Hou, Li Chen, Ming Dong, Weikai Hou
Article
Endocrinology & Metabolism
Pan Liu, Jia Song, He Liu, Fei Yan, Tianyi He, Lingshu Wang, Huying Shen, Xinguo Hou, Li Chen