Article
Dermatology
Joshua Burshtein, Andrew Strunk, Amit Garg
Summary: Psoriasis incidence in the United States increases with age, is similar between sexes, and is highest among Whites. The incidence rate appears to be stable within the recent 5-year period.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Oncology
Hanna Eriksson, Kari Nielsen, Ismini Vassilaki, Jan Lapins, Rasmus Mikiver, Johan Lyth, Karolin Isaksson
Summary: The study reveals an increasing trend in the age-standardised incidence of invasive cutaneous melanoma in Sweden since the 2000s, possibly due to more effective secondary prevention measures and increased awareness of melanoma.
Article
Biochemical Research Methods
Steffen Lange, Richard Mogwitz, Denis Huenniger, Anja Voss-Boehme
Summary: Cancer development is a complex process involving multiple steps, and the early phase of tumor growth and progression plays a major role in determining the fate of tumor development. In this study, a cell-based model focusing on the competition between wild-type and tumor cells in colonic crypts was proposed, which successfully reproduced the epidemiological incidence rates of colon cancer and predicted the fraction of cancerous tumors with precancerous lesions.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Oncology
Stephanie G. Lashway, Robin B. Harris, Leslie Farland, Mary Kay O'Rourke, Leslie K. Dennis
Summary: The incidence of malignant melanoma in the United States is increasing over time, possibly due to changes in ultraviolet radiation exposure, lifestyle factors, or increased awareness and diagnosis. Recent birth cohorts may experience higher rates of melanoma as they age. The increase in thin melanomas is a significant factor driving the overall rise in malignant melanoma cases.
Article
Ecology
Brian A. Millsap, Guthrie S. Zimmerman, William L. Kendall, Joseph G. Barnes, Melissa A. Braham, Bryan E. Bedrosian, Douglas A. Bell, Peter H. Bloom, Ross H. Crandall, Robert Domenech, Daniel Driscoll, Adam E. Duerr, Rick Gerhardt, Samantha E. J. Gibbs, Alan R. Harmata, Kenneth Jacobson, Todd E. Katzner, Robert N. Knight, J. Michael Lockhart, Carol McIntyre, Robert K. Murphy, Steven J. Slater, Brian W. Smith, Jeff P. Smith, Dale W. Stahlecker, James W. Watson
Summary: The Bald and Golden Eagle Protection Act in the United States prohibits the take of golden eagles unless authorized by permit and requires sustainable management of permitted take. Integrated population and prescribed take level models were used to estimate vital rates, population size, and allowable take levels for golden eagles in the western United States. The models indicated a stable population size and allowable take limit, but also highlighted the need for mitigation measures to ensure sustainable incidental take.
ECOLOGICAL APPLICATIONS
(2022)
Article
Nutrition & Dietetics
Jannie Nielsen, K. M. Venkat Narayan, Solveig A. Cunningham
Summary: The incidence of obesity in the United States increased by 18% from 2013 to 2017 compared to the previous period. Blacks and younger adults have the highest risk of obesity, and overweight individuals are also at high risk for developing obesity. People with lower education levels have higher obesity incidence compared to those with higher education.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Allergy
Christine C. Johnson, Suzanne L. Havstad, Dennis R. Ownby, Christine L. M. Joseph, Alexandra R. Sitarik, Jocelyn Biagini Myers, Tebeb Gebretsadik, Tina V. Hartert, Gurjit K. Khurana Hershey, Daniel J. Jackson, Robert F. Lemanske, Lisa J. Martin, Edward M. Zoratti, Cynthia M. Visness, Patrick H. Ryan, Diane R. Gold, Fernando D. Martinez, Rachel L. Miller, Christine M. Seroogy, Anne L. Wright, James E. Gern
Summary: The study found that asthma incidence rates in US children varied significantly by age, sex, parental asthma history, race/ethnicity, and calendar year, with the highest rates observed in the 0-4 year age group, especially between 1995 and 1999.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Weiya Li, Xinfan Qiu, Huan Ma, Qingshan Geng
Summary: The aim of this study was to investigate the incidence and mortality trends of metabolic syndrome (MetS) over the past few decades, as well as explore the gender and age differences. The results showed that the incidence of MetS significantly increased from 1999 to 2014, while the mortality rate of MetS had a considerable downward trend. Additionally, MetS was more prevalent in women but had lower mortality compared to men. Therefore, it is important to identify factors that can control the incidence and reduce mortality of MetS, especially in male patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Thuy T. T. Le, Kenneth E. Warner, David Mendez
Summary: This study aims to estimate the annual smoking cessation rates specific to different age groups in the US from 2009 to 2017 using a Kalman filter approach. The findings show that cessation rates followed a u-shaped curve over time with respect to age, and the approach offers real-time estimation of cessation rates that can be helpful for monitoring smoking cessation behavior.
Article
Economics
Boshen Jiao, Anirban Basu
Summary: This study aimed to develop a catalog of healthcare costs per capita among survivors and decedents in the US, providing valuable information for future cost calculations in cost-effectiveness analysis.
Article
Medicine, General & Internal
Antonio Fernando Boing, Priyanka deSouza, Alexandra Crispim Boing, Rockli Kim, S. V. Subramanian
Summary: This cross-sectional study found that census tracts with lower SES presented higher PM2.5 concentrations. ASMR and air pollution varied substantially across census tracts. There was an association between air pollution and ASMR across all age groups in the United States.
Article
Immunology
Namrata Prasad, Julia Rhodes, Li Deng, Natalie L. McCarthy, Heidi L. Moline, James Baggs, Sujan C. Reddy, John A. Jernigan, Fiona P. Havers, Daniel M. Sosin, Ann Thomas, Ruth Lynfield, William Schaffner, Arthur Reingold, Kari Burzlaff, Lee H. Harrison, Susan Petit, Monica M. Farley, Rachel Herlihy, Srinivas Nanduri, Tamara Pilishvili, Lucy A. McNamara, Stephanie J. Schrag, Katherine E. Fleming-Dutra, Miwako Kobayashi, Melissa Arvay
Summary: The incidence of invasive bacterial diseases (IBD) such as Streptococcus pneumoniae, Haemophilus influenzae, group A Streptococcus (GAS), and group B Streptococcus (GBS) significantly declined in the United States during the COVID-19 pandemic in 2020. The decline was likely due to COVID-19-related nonpharmaceutical interventions (NPIs), and not driven by reductions in testing. Blood and cerebrospinal fluid (CSF) culture testing rates during the pandemic remained comparable to previous years.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Qian Huang
Summary: This study proposes a community-based COVID-19 spatial disparity model that considers different geographic units, contextual variables, COVID-19 outcomes, and geographic elements. The study empirically identifies the age nonstationarity effect of health determinants on COVID-19 exposures. The results highlight the geographic disparities of COVID-19 incidence rates among age groups and provide guidance for pandemic recovery and preparedness in communities.
Article
Surgery
Abhilasha Borad, Ellie Deianni, Kayla Pena, Sathyaprasad Burjonrappa
Summary: Pediatric melanoma is the most common skin cancer in children, with its incidence increasing annually. Excessive UV radiation from sun exposure is an important risk factor, and its penetration varies throughout the United States. This study analyzed data from the SEER database to examine the geographic trends in pediatric melanoma and its relation to UV index.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Rongshou Zheng, Hong Zhao, Lan An, Siwei Zhang, Ru Chen, Shaoming Wang, Kexin Sun, Hongmei Zeng, Wenqiang Wei, Jie He
Summary: This study aimed to estimate the incidence and survival statistics of neuroendocrine neoplasms (NENs) in China, and compare them to those in the United States. The results showed that the incidence and survival rates of NENs were lower in China than in the United States, and there were disparities across sex, area, age group, and site.
CHINESE MEDICAL JOURNAL
(2023)
Article
Oncology
Christopher W. Lewis, Jamiluddin Qazi, Daniel S. Hippe, Kristina Lachance, Hannah Thomas, Maclean M. Cook, Ilsa Juhlin, Neha Singh, Zoe Thuesmunn, Seesha R. Takagishi, Aubriana McEvoy, Coley Doolittle-Amieva, Shailender Bhatia, Kelly G. Paulson, Ryan B. O'Malley, Carolyn L. Wang, Paul Nghiem
Article
Dermatology
Neha Singh, Nora A. Alexander, Kristina Lachance, Christopher W. Lewis, Aubriana McEvoy, Gensuke Akaike, David Byrd, Sanaz Behnia, Shailender Bhatia, Kelly G. Paulson, Paul Nghiem
Summary: Baseline imaging in patients with clinically node-negative Merkel cell carcinoma (MCC) identified occult metastatic disease at a higher rate than reported for melanoma (13.2% vs <1%). These findings suggest that baseline imaging is recommended for patients with clinically node-negative MCC, as it frequently leads to upstaging and significantly impacts management and prognosis.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Oncology
Dario Callegaro, Chandrajit P. Raut, Emily Z. Keung, Teresa Kim, Cecile Le Pechoux, Javier Martin-Broto, Alessandro Gronchi, Carol Swallow, Rebecca Gladdy
Summary: The COVID-19 pandemic has greatly impacted cancer patients' access to surgery, but surgical oncologists can adapt their decision-making by revisiting treatment options.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Karan Kohli, Venu G. Pillarisetty, Teresa S. Kim
Summary: Immune cell infiltration into solid tumors and their interactions with chemokine receptors play a crucial role in tumor growth and the balance between effector and immunosuppressive cells. This review discusses the implications of dysregulated chemokine signaling in the tumor microenvironment and the potential for targeting chemokine signaling in cancer immunotherapy.
CANCER GENE THERAPY
(2022)
Review
Dermatology
Miranda C. Lahman, Kelly G. Paulson, Paul T. Nghiem, Aude G. Chapuis
Summary: Merkel cell carcinoma is a rare skin malignancy that demonstrates responsiveness to anti-PD(L)1 therapy in patients associated with Merkel cell polyomavirus or chronic UV exposure. Despite the low mutational burden in virus-positive MCC, the quality of antigens determines immunotherapy responsiveness, highlighting the potential effectiveness of cell-based therapies. Additionally, diverse T-cell infiltration patterns in VP-MCC suggest microenvironment plasticity and multifactorial contributions to immune recognition, with VP-MCC serving as an example of how antitumor adaptive immunity can provide biomarkers for early detection and monitoring of the disease.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Oncology
Brett A. Schroeder, Natalie A. LaFranzo, Bonnie J. LaFleur, Rachel M. Gittelman, Marissa Vignali, Shihong Zhang, Kevin C. Flanagan, Julie Rytlewski, Laura Riolobos, Brian C. Schulte, Teresa S. Kim, Eleanor Chen, Kimberly S. Smythe, Michael J. Wagner, Jose G. Mantilla, Jean S. Campbell, Robert H. Pierce, Robin L. Jones, Lee D. Cranmer, Seth M. Pollack
Summary: In dedifferentiated liposarcoma (DDLPS), high TCR clonality combined with low T-cell fraction predicts worse outcomes, while CD4+ T-cell infiltration is associated with better outcomes; CD14+ monocytes and M2 macrophages are associated with worse outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Peter H. Goff, Laura Riolobos, Bonnie J. LaFleur, Matthew B. Spraker, Y. David Seo, Kimberly S. Smythe, Jean S. Campbell, Robert H. Pierce, Yuzheng Zhang, Qianchuan He, Edward Y. Kim, Stephanie K. Schaub, Gabrielle M. Kane, Jose G. Mantilla, Eleanor Y. Chen, Robert Ricciotti, Matthew J. Thompson, Lee D. Cranmer, Michael J. Wagner, Elizabeth T. Loggers, Robin L. Jones, Erin Murphy, Wendy M. Blumenschein, Terrill K. McClanahan, Jon Earls, Kevin C. Flanagan, Natalie A. LaFranzo, Teresa S. Kim, Seth M. Pollack
Summary: This study aims to characterize the changes in the soft-tissue sarcoma (STS) tumor immune microenvironment induced by standard neoadjuvant therapy and provides insights for neoadjuvant immunotherapy trial design. The results show that neoadjuvant therapy significantly increases immune cell infiltration in the tumor and affects the expression of immune-related genes and cytokines. These findings inform the incorporation of immune checkpoint inhibitors and novel immunotherapies into the neoadjuvant setting for STSs.
CLINICAL CANCER RESEARCH
(2022)
Article
Orthopedics
Lee D. Cranmer, Bonny Chau, Jose G. Mantilla, Elizabeth T. Loggers, Seth M. Pollack, Teresa S. Kim, Edward Y. Kim, Gabrielle M. Kane, Matthew J. Thompson, Jared L. Harwood, Michael J. Wagner
Summary: This study examined the association between perioperative chemotherapy and overall survival in patients with dedifferentiated chondrosarcoma. The results showed that there was no significant improvement in overall survival associated with chemotherapy treatment.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2022)
Article
Cell Biology
Miranda C. Lahman, Thomas M. Schmitt, Kelly G. Paulson, Nathalie Vigneron, Denise Buenrostro, Felecia D. Wagener, Valentin Voillet, Lauren Martin, Raphael Gottardo, Jason Bielas, Julie M. McElrath, Derek L. Stirewalt, Era L. Pogosova-Agadjanyan, Cecilia C. Yeung, Robert H. Pierce, Daniel N. Egan, Merav Bar, Paul C. Hendrie, Sinead Kinsella, Aesha Vakil, Jonah Butler, Mary Chaffee, Jonathan Linton, Megan S. McAfee, Daniel S. Hunter, Marie Bleakley, Anthony Rongvaux, Benoit J. Van den Eynde, Aude G. Chapuis, Philip D. Greenberg
Summary: Understanding the mechanisms underlying tumor control or resistance is crucial for designing effective antileukemic immunotherapy. This study identified an immune escape mechanism in an AML patient and found that targeting epitopes generated by immunoproteasome-deficient cells can effectively control AML growth, potentially improving therapeutic efficacy.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Joshua R. Veatch, Sylvia M. Lee, Carolyn Shasha, Naina Singhi, Julia L. Szeto, Ata S. Moshiri, Teresa S. Kim, Kimberly Smythe, Paul Kong, Matthew Fitzgibbon, Brenda Jesernig, Shailender Bhatia, Scott S. Tykodi, Evan T. Hall, David R. Byrd, John A. Thompson, Venu G. Pillarisetty, Thomas Duhen, A. McGarry Houghton, Evan Newell, Raphael Gottardo, Stanley R. Riddell
Summary: This study utilized single-cell RNA sequencing to investigate tumor-specific CD4(+) T cells infiltrating human melanoma and identified their phenotypes and functions. The expression of these tumor-specific CD4(+) T cells in the tumor microenvironment correlated with the transcriptional states of CD8(+) T cells and macrophages, maturation of B cells, and patient survival.
Article
Dermatology
Aubriana M. McEvoy, Kristina Lachance, Daniel S. Hippe, Kelsey Cahill, Yasman Moshiri, Christopher W. Lewis, Neha Singh, Song Y. Park, Zoe Thuesmunn, Maclean M. Cook, Nora A. Alexander, Lauren Zawacki, Hannah Thomas, Kelly G. Paulson, Paul Nghiem
Summary: This study aimed to estimate the risk of stage-specific MCC recurrence and mortality since diagnosis. The study included 618 MCC patients enrolled in a Seattle-based data repository from 2003 to 2019. The results showed a 5-year recurrence rate of 40% for MCC, with 95% of recurrences occurring within the first 3 years.
Article
Biotechnology & Applied Microbiology
Kevin P. Labadie, Shannon A. Kreuser, Katherine J. Brempelis, Sara K. Daniel, Xiuyun Jiang, Kevin M. Sullivan, Alan F. Utria, Heidi L. Kenerson, Teresa S. Kim, Courtney A. Crane, Venu G. Pillarisetty
Summary: Although IL-10 can promote effector T-cell function, its overall effect in the tumor microenvironment appears to be suppressive. Thus, blocking IL-10 has therapeutic potential for enhancing antitumor immune function. Using genetically engineered macrophages (GEMs) as delivery vehicles, researchers created IL-10-blocking antibodies and demonstrated their efficacy in tumor models. The GEMs produced sustained levels of the antibody and led to a significantly higher rate of tumor cell apoptosis.
CANCER GENE THERAPY
(2023)
Article
Oncology
Kristin G. Anderson, David A. Braun, Aitziber Buque, Sarah B. Gitto, Jennifer L. Guerriero, Brendan Horton, Bridget P. Keenan, Teresa S. Kim, Abigail Overacre-Delgoffe, Marco Ruella, Todd A. Triplett, Omkara Veeranki, Vivek Verma, Fan Zhang
Summary: Anticancer immunotherapies have shown improved outcomes in patients with various malignancies, but many patients do not respond or have durable responses due to immune resistance mechanisms. These mechanisms vary among patients with the same cancer type and involve multiple cell types. Advanced tumor profiling technologies can define immune resistance pathways, which can be used to categorize cancers into immune resistance archetypes. Targeted therapies addressing multiple cell axes and suppressive mechanisms based on these archetypes may improve efficacy and outcomes for individual patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Meeting Abstract
Dermatology
J. Lee, A. Colunga, J. Lee, T. Pulliam, K. Paulson, V. Voillet, A. Berndt, C. Church, K. Lachance, S. Park, N. Yamamoto, M. Cook, M. Kawasumi, P. Nghiem
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)