Article
Nanoscience & Nanotechnology
Shengnan Zhang, Qiujun Lu, Feiying Wang, Zhuyong Xiao, Lidan He, Dinggeng He, Le Deng
Summary: The study introduces a simple and fast synthesized gold-platinum nanodots that exhibit broad-spectrum antibacterial properties against bacterial infections and have been shown to promote wound healing in in vivo experiments. These nanodots have good biocompatibility and low toxicity, showing potential as a new option for future antibacterial therapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Wenwen Cao, Yu Zhu, Fapu Wu, Yang Tian, Zhaoming Chen, Weijia Xu, Senyao Liu, Tingting Liu, Hu Xiong
Summary: This study reports a heavy-atom-free NIR photosensitizer BHcy for synergistic PDT/PTT therapy. BHcy-NPs show efficient singlet oxygen generation and photothermal effect, resulting in significant cancer cell death and tumor growth inhibition.
Review
Chemistry, Inorganic & Nuclear
Christopher C. Rennie, Robert M. Edkins
Summary: Phototherapy, using light to selectively ablate cancerous tissue, shows promising prospects. The use of Pc-drug conjugates as targeted anticancer phototherapeutic systems has shown potential in improving treatment specificity and achieving precise, synergistic phototherapy.
DALTON TRANSACTIONS
(2022)
Article
Engineering, Biomedical
Xiang Liu, Qi Su, Huijuan Song, Xiaoguang Shi, Yuming Zhang, Chuangnian Zhang, Pingsheng Huang, Anjie Dong, Deling Kong, Weiwei Wang
Summary: The study demonstrates that PTT-induced in situ vaccination cancer therapy can effectively combat disseminated and metastatic tumors, showing promising anti-tumor immunity in mice. The use of gold nanorods covalently coupled with polyTLR7/8a and MMP-2-sensitive R9-PEG resulted in the formation of nanovaccines directly in vivo, activating dendritic cells and enhancing antitumor T-cell responses. Peritumoral administration of low-dose multifunctional AuNRs followed by noninvasive NIR laser irradiation inhibits local and distant metastatic tumors in mice, suggesting a potent therapeutic strategy for advanced cancers.
Review
Biochemistry & Molecular Biology
Su Woong Yoo, Gyungseok Oh, Jin Chul Ahn, Euiheon Chung
Summary: Phototherapy is widely used in various human diseases, and nanomedicine-based phototherapy can be classified into PDT and PTT. While PDT has been tried in dermatologic, ophthalmologic, cardiovascular, and dental diseases, PTT has been tested in atherosclerosis and dry eye syndrome. Despite promising results, there are still limitations in specificity, targeting efficiency, and tissue penetration using phototherapy, which nanomaterials are showing potential to overcome.
Article
Nanoscience & Nanotechnology
Runzan Zhang, Xianya Qin, Junyu Lu, Hongbo Xu, Siyu Zhao, Xiaonan Li, Conglian Yang, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Microbiota-based tumor immunotherapy has become a hotspot in cancer research. However, using microorganisms alone for antitumor therapy was unsatisfactory. In this study, gold nanoparticles and platinum nanoparticles were synthesized based on yeast microcapsules to activate the immune response for antitumor treatment in synergy with chemodynamic therapy and photothermal therapy. The results showed that this immunological nanomaterial significantly improved the tumor microenvironments, effectively inhibiting or even eradicating primary tumors and improving the overall survival of mice. Therefore, yeast microcapsule-based immunomodulatory nanoparticles could be an effective cancer treatment modality.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Medicine, Research & Experimental
Jihui Wang, He Zhao, Wenjing Song, Mingyang Gu, Yujia Liu, Bingnan Liu, Honglei Zhan
Summary: The article introduces a promising multifunctional nanocarrier that integrates chemotherapy and photothermal therapy to enhance anticancer efficacy, sensitize drug-resistant cancer cells, and diminish cancer stem cells.
MOLECULAR PHARMACEUTICS
(2022)
Article
Nanoscience & Nanotechnology
Eunkyeong Jung, Jeonghun Lee, Yeongjong Lee, Semee Seon, Miran Park, Chulgyu Song, Dongwon Lee
Summary: Phototherapy, using photosensitizers and light to kill cancer cells, has become a promising therapeutic modality, but combining photothermal therapy and photodynamic therapy along with antiangiogenic agents can maximize the therapeutic efficacy. Utilizing a single nanoplatform to integrate photosensitive agents and antiangiogenic agents presents an attractive strategy for anticancer therapy.
ACS APPLIED BIO MATERIALS
(2021)
Article
Chemistry, Organic
Chengming Li, Yinchan Wang, Sisi Wu, Weihua Zhuang, Zhenmei Huang, Linsen Zhou, Yinggang Li, Mao Chen, Jingsong You
Summary: The synthesis of isoquinoline-fused porphyrins 3 and 4 with remarkable NIR-absorbing capacity and their efficient singlet oxygen generation capabilities make them promising candidates for photodynamic therapy, showing excellent tumoricidal behavior and biocompatibility in the phototherapeutic window.
Review
Chemistry, Multidisciplinary
Fang Tang, Aixiang Ding, Yao Xu, Yingsong Ye, Lin Li, Rongjun Xie, Wei Huang
Summary: The integration of gene therapy and photothermal therapy offers a promising approach for cancer treatment, providing rapid response and improved effectiveness. Recent advancements in this field have resulted in notable achievements and progress towards potential clinical applications. However, challenges and future developments still need to be addressed. This comprehensive review explores the synergistic mechanisms, material systems, imaging-guided therapy, and anticancer applications of gene therapy and photothermal therapy integration, aiming to inspire further research in this promising area.
Article
Chemistry, Multidisciplinary
Weiran Gao, Xiangyi Fan, Yunlong Bi, Zipeng Zhou, Yajiang Yuan
Summary: In this study, a near-infrared responsive gold nanocage carrier was designed and synthesized to control the release of Epigallocatechin gallate (EGCG) for inhibiting the proliferation of hepatocellular carcinoma (HCC) cells. The nanomedicine demonstrated photothermal response and stability, leading to the promotion of HCC cell apoptosis. This study provides valuable insights into the potential of near-infrared responsive gold nanocage EGCG as a new type of nanomedicine for HCC.
FRONTIERS IN CHEMISTRY
(2022)
Review
Engineering, Biomedical
Tianyuan Zhong, Jie Yu, Yong Pan, Ning Zhang, Yanxin Qi, Yubin Huang
Summary: Platinum drugs are widely used in cancer treatment, but their toxicity and drug resistance pose challenges. Combination therapy with platinum drugs can effectively inhibit tumor growth and metastasis, reducing toxicity and overcoming resistance. This review summarizes the current progress and challenges in platinum-based combination therapy, including gene editing, ROS-based therapy, thermal therapy, immunotherapy, and imaging modality. It hopes to inspire researchers for the development of more effective platinum-based anti-cancer complexes in the future.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Xinzhu Shan, Xuanbo Zhang, Chen Wang, Zhiqiang Zhao, Shenwu Zhang, Yuequan Wang, Bingjun Sun, Cong Luo, Zhonggui He
Summary: This study presents a novel and convenient dual-drug co-assembly strategy for self-sensitized cancer therapy. The carrier-free co-delivery nanoassembly of a HSP90 inhibitor and DiR demonstrates potential as a new treatment approach for tumors.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Applied
Dongxin Wang, Xingchen Mu, Xin Chen, Heyong Huang, Lin Zhou, Shaohua Wei
Summary: The study utilized PCD as a linker to combine transition metal nanomaterials with functional molecules for synergistic photothermal and photodynamic tumor therapy.
CARBOHYDRATE POLYMERS
(2021)
Article
Biophysics
Bao Jiang, Liping Wang, Gang Wu, Lin Zhou, Shaohua Wei
Summary: Researchers have successfully synthesized a core-shell CDT drug FeCNB, which achieves high-efficiency CDT under physiological pH conditions through the galvanic cell structure formed in physiological electrolyte solution. FeCNB not only has T2-magnetic resonance imaging function and photothermal conversion ability, but also improves the CDT effect through tumor heating to achieve a satisfactory synergistic photothermal therapy (PTT)/CDT outcome.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Piotr Pawlik, Barbara Blasiak, Joanna Depciuch, Marcin Pruba, Diana Kitala, Svetlana Vorobyova, Malgorzata Stec, Maxim Bushinsky, Artem Konakov, Jaroslaw Baran, Julia Fedotova, Oleg Ivashkevich, Magdalena Parlinska-Wojtan, Alexey Maximenko
Summary: The novel iron-oxide nanoparticles stabilized with triethanolammonium oleate were found to have potential applications in MRI-guided hyperthermia and regenerative medicine.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Spectroscopy
Joanna Depciuch, Magdalena Parlinska-Wojtan, Kursat Rahmi Serin, Huri Bulut, Engin Ulukaya, Nevzat Tarhan, Zozan Guleken
Summary: This study investigated the use of Raman spectroscopy as a promising analytical tool in medical diagnostics and a method to distinguish between healthy individuals and those with cholangiocarcinoma. The results showed that there were differences in the Raman spectra of amino acids, proteins, and lipid vibrations between healthy individuals and cancer patients. Specific ranges in the Raman spectra were identified as effective in distinguishing between the two groups.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
Zozan Guleken, Huri Bulut, Berk Bulut, Wieslaw Paja, Barbara Orzechowska, Magdalena Parlinska-Wojtan, Joanna Depciuch
Summary: This study investigated the potential diagnostic tool of Raman spectroscopy for polycystic ovarian syndrome (PCOS) and found that Raman shifts of amides and CH2, CH3 lipid groups could be potential PCOS markers. The study also revealed a strong correlation between hormones and lipids, as well as between hormones and protein functional groups in PCOS women. These findings provide new insights into the diagnosis and treatment of PCOS.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
Zozan Guleken, Huri Bulut, Berk Bulut, Wieslaw Paja, Magdalena Parlinska-Wojtan, Joanna Depciuch
Summary: Endometriosis refers to the formation of the uterus lining outside the uterus. Raman spectroscopy analysis of serum showed that it is possible to distinguish between healthy women and those with endometriosis using specific Raman ranges. Lipid vibrations may serve as spectral markers of the disease.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Infectious Diseases
Ewelina Piktel, Urszula Wnorowska, Joanna Depciuch, Dawid Lysik, Mateusz Ciesluk, Krzysztof Fiedoruk, Joanna Mystkowska, Magdalena Parlinska-Wojtan, Paul A. Janmey, Robert Bucki
Summary: By modulating the EPS matrix, peanut-shaped gold nanoparticles showed significant efficiency in inhibiting the growth of Pseudomonas aeruginosa biofilms, especially when combined with NAC. The gold nanopeanuts not only reduced the viscosity of biofilms, but also increased their creep compliance. Additionally, AuP NPs exhibited synergistic effects with tobramycin, capable of eradicating antibiotic-resistant bacteria within biofilms.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Spectroscopy
Joanna Depciuch, Pawel Jakubczyk, Wieslaw Paja, Jaromir Sarzynski, Krzysztof Pancerz, Merve Acikel Elmas, Elif Keskinoz, Ozlem Bingol Ozakpinar, Serap Arbak, Gokce Ozgun, Sevde Altuntas, Zozan Guleken
Summary: In this study, the modulatory effects of Apocynum on MSG-induced oxidative damage in rat brain tissue were examined using biochemical assays, FTIR, and machine learning methods. The results showed that Apocynum treatment protects against MSG-induced oxidative damage by inhibiting reactive oxygen species and upregulating antioxidant capacity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Environmental Sciences
Ewa Szpunar-Krok, Joanna Depciuch, Barbara Drygas, Marta Janczak-Pieniazek, Katarzyna Mazurek, Renata Pawlak
Summary: Field studies conducted from 2016 to 2019 in south-eastern Poland revealed that the chemical composition of winter wheat grain can be altered by the application of biostimulants and hydro-thermal conditions. Biostimulants containing salicylic acid and nettle extracts show promise as a potential alternative to synthetic crop protection products.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Monika Kula-Maximenko, Kamil Jan Zielinski, Joanna Depciuch, Janusz Lekki, Marcin Niemiec, Ireneusz Slesak
Summary: In this study, the SOD activity in Synechocystis sp. PCC 6803, Gloeobacter violaceus CCALA 979, and Geitlerinema sp. ZHR1A was analyzed using selective spectroscopic techniques. The results showed the presence of different forms of FeSOD in these cyanobacteria, while no active Cu/ZnSOD was identified. This study has important implications for understanding the activity and evolution of SOD in cyanobacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Bartosz Klebowski, Malgorzata Stec, Joanna Depciuch, Agnieszka Panek, Dawid Krzempek, Wiktor Komenda, Adrianna Galuszka-Bulaga, Anna Pajor-Swierzy, Jarek Baran, Magdalena Parlinska-Wojtan
Summary: In this study, bimetallic PdPt nanoparticles with different nanostructures were prepared and their radiosensitizing properties were evaluated. The results showed that nano-alloy PdPt nanoparticles exhibited better enhancement of radiation-based therapy compared to PtPd core-shell nanoparticles. This research suggests the potential application of PdPt nanoparticles in improving the effectiveness of radiation-based anticancer therapies.
Article
Chemistry, Applied
Huri Bulut, Nevzat Tarhan, Melek Buyuk, Kursat Rahmi Serin, Engin Ulukaya, Joanna Depciuch, Magdalena Parlinska-Wojtan, Zozan Guleken
Summary: This study used FTIR spectroscopy to detect chemical changes in the serum of CCA patients and healthy individuals. The results showed decreased TAS and increased TOS, OSI, and total protein levels in CCA patients. The FTIR spectra were able to distinguish between CCA and controls, and changes in lipids and functional groups could be used to predict CCA.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Rezvan Noroozi, Aleksandra Pisarek, Joanna Rudnicka, Michal Boron, Kamila Migacz-Gruszka, Aneta Sitek, Andrzej Ossowski, Wojciech Branicki, Magdalena Spolnicka, Ewelina Pospiech
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Chemistry, Applied
Zozan Guleken, Devrim Saribal, Caglar Uyulan, Aybike Keles, Joanna Depciuch
Summary: The study found that chronic exposure to electromagnetic fields (EMF) affects blood serum parameters, potentially impairing oxidant-antioxidant function and increasing lipid peroxidation and oxidative stress levels.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)
