Article
Cardiac & Cardiovascular Systems
Ewa Jedrzejczyk-Patej, Michal Mazurek, Agnieszka Kotalczyk, Wiktoria Kowalska, Aleksandra Konieczny-Kozielska, Jonasz Kozielski, Tomasz Podolecki, Mariola Szulik, Adam Sokal, Oskar Kowalski, Zbigniew Kalarus, Beata Sredniawa, Radoslaw Lenarczyk
Summary: The study compared long-term mortality and predictors in patients with de novo cardiac resynchronization therapy defibrillators (CRT-D) versus those who upgraded from an implantable cardioverter-defibrillator (ICD) to CRT-D. It found that mortality was significantly higher in patients who upgraded from ICD to CRT-D compared to those who had de novo CRT-D implantations, with nearly 45% mortality within 4.5 years. A new CRT scale (Creatinine; Remodelling; Threshold for NYHA) was proposed to aid in predicting survival following CRT upgrade.
Article
Cardiac & Cardiovascular Systems
Kasun De Silva, Natasha Nassar, Tim Badgery-Parker, Saurabh Kumar, Lee Taylor, Pramesh Kovoor, Sarah Zaman, Andrew Wilson, Clara K. Chow
Summary: This study analyzed data from cardiovascular hospitalizations in New South Wales, Australia and found that women had lower rates of implantation and use of cardiac implantable electronic devices (CIEDs) compared to men. This difference existed across nearly all indications, and men and women had similar 30-day survival rates among those who received devices.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Meor Azraai, Daisuke Miura, Yuan-Hong Lin, Thalys Sampaio Rodrigues, Voltaire Nadurata
Summary: This study investigated the incidence and predictors of cardiac implantable electronic device (CIED) malfunction with radiotherapy (RT). The study found that photon beam energy ≥10 MV, anatomical location of RT above the diaphragm, and having a CIED from the ICD group were predictors of CIED malfunction.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Derek J. J. Bivona, Srikar Tallavajhala, Mohamad Abdi, Pim J. A. Oomen, Xu Gao, Rohit Malhotra, Andrew Darby, Oliver J. Monfredi, J. Michael Mangrum, Pamela Mason, Sula Mazimba, Michael Salerno, Christopher M. M. Kramer, Frederick H. H. Epstein, Jeffrey W. W. Holmes, Kenneth C. C. Bilchick
Summary: This study utilized cardiac magnetic resonance to identify different phenotypes of cardiac resynchronization therapy patients based on sex and cardiomyopathy type and found that female patients had better short-term response and long-term survival outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Jacopo Francesco Imberti, Davide Antonio Mei, Riccardo Fontanesi, Luigi Gerra, Niccolo Bonini, Marco Vitolo, Vincenzo Turco, Edoardo Casali, Giuseppe Boriani
Summary: This study describes the incidence of CIED-related infection and death in a contemporary cohort of CIED patients and identifies potential predictors. The results show a low incidence of CIED-related infections and a high mortality rate, which are associated with clinical factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Tardu oezkartal, Andrea Demarchi, Maria Luce Caputo, Enrico Baldi, Giulio Conte, Angelo Auricchio
Summary: With the aging population and increasingly complex comorbidities, the perioperative management of patients with cardiac implantable electronic devices (CIED) has become a challenge. The response to magnet application can vary depending on device type and manufacturer. This review article provides an overview of optimal perioperative management for CIED patients and discusses the different CIED responses to magnet application based on manufacturer and device type.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ido Goldenberg, Valentina Kutyifa, Wojciech Zareba, David Tsu-Chau Huang, Spencer Z. Rosero, Arwa Younis, Claudio Schuger, Anna Gao, Scott Mcnitt, Bronislava Polonsky, Jonathan S. Steinberg, Ilan Goldenberg, Mehmet K. Aktas
Summary: The benefit of the implantable cardioverter defibrillator (ICD) in patients with advanced chronic kidney disease (CKD) and heart failure is unclear. This study found that CKD patients receiving cardiac resynchronization therapy (CRT) may derive less benefit from the ICD due to the competing risk of death. Future trials should evaluate alternative treatment options for these patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Blandine Mondesert, Jeremy P. Moore, Paul Khairy
Summary: Due to advancements in surgical techniques and cardiology care, Fontan patients are living longer and require multidisciplinary expertise to manage complications in adulthood. Arrhythmias are common in Fontan patients and are influenced by anatomy, surgical technique, and postoperative care. Diagnostic tools, treatments, and device strategies for arrhythmias in Fontan patients should consider their specific anatomy, surgical repair, and clinical status. Cardiac implantable electronic devices (CIEDs) have greatly improved the management of Fontan patients, but the unique challenges of this patient population require careful consideration.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jacek T. Niedziela, Slawomir Blamek, Elibieta Gadula-Gacek, Jaroslaw Gorol, Anna Kurek, Mateusz Witek, Adam Wojtaszczyk, Przemyslaw Plaza, Leszek Miszczyk, Mariusz Gasior, Mateusz Tajstra
Summary: In a study involving 157 patients with cardiac implantable electronic devices (CIEDs) undergoing radiation therapy, only 2 events potentially related to radiation were recorded, indicating that radiation therapy is not associated with substantial risk to patients as long as current guidelines are followed for patient management.
KARDIOLOGIA POLSKA
(2021)
Review
Cardiac & Cardiovascular Systems
Meor Azraai, Daniel D'Souza, Yuan-Hong Lin, Voltaire Nadurata
Summary: The increasing number of patients with CIED undergoing RT highlights the need for consistent guidelines in managing these patients, as current clinical practice is inconsistent due to lack of universal guidelines from manufacturers and physician specialty societies.
Article
Cardiac & Cardiovascular Systems
Jeroen Dauw, Pieter Martens, Petra Nijst, Evelyne Meekers, Sebastien Deferm, Henri Gruwez, Maximo Rivero-Ayerza, Hugo Van Herendael, Laurent Pison, Dieter Nuyens, Matthias Dupont, Wilfried Mullens
Summary: The aim of this study was to evaluate the predictive ability of the MADIT-ICD benefit score in identifying heart failure patients who would benefit most from CRT-D and compare it with a multidisciplinary expert centre approach. The results showed that the MADIT-ICD benefit score can identify patients who would benefit most from CRT-D and its predictive power is comparable to multidisciplinary judgement.
Article
Cardiac & Cardiovascular Systems
Boglarka Veres, Walter Richard Schwertner, Marton Tokodi, Adam Szijarto, Attila Kovacs, Eperke Dora Merkel, Anett Behon, Luca Kuthi, Richard Masszi, Laszlo Geller, Endre Zima, Levente Molnar, Istvan Osztheimer, David Becker, Annamaria Kosztin, Bela Merkely
Summary: Topological data analysis (TDA) can identify phenogroups of CRT patients in whom CRT-D is associated with better survival than CRT-P.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Christine M. Tompkins, Wojciech Zareba, Henry Greenberg, Robert Goldstein, Scott McNitt, Bronislava Polonsky, Mary Brown, Valentina Kutyifa
Summary: Sex differences exist in mode of death and device efficacy following ICD and CRT-D implantation. Cardiac death is higher in men with ICM but similar in women. ICDs are equally effective at reducing mortality in both sexes, while CRT-D may be more effective in women.
Article
Cardiac & Cardiovascular Systems
Hilary C. Bowman, Kevin M. Shannon, Reshma Biniwale, Jeremy P. Moore
Summary: In adult congenital heart disease (ACHD) patients, overall dysfunction and reintervention rates of cardiac implantable electronic devices (CIEDs) are similar between transvenous (TV) and epicardial (EPI) approaches, but lead dysfunction is more severe in EPI devices.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Xu Gao, Mohamad Abdi, Daniel A. Auger, Changyu Sun, Christopher A. Hanson, Austin A. Robinson, Christopher Schumann, Pim J. Oomen, Sarah Ratcliffe, Rohit Malhotra, Andrew Darby, Oliver J. Monfredi, J. Michael Mangrum, Pamela Mason, Sula Mazimba, Jeffrey W. Holmes, Christopher M. Kramer, Frederick H. Epstein, Michael Salerno, Kenneth C. Bilchick
Summary: This study aimed to investigate the feasibility and effectiveness of CMR cine and strain imaging before and after CRT for assessing patient response and determining the optimal resynchronization pacing strategy. The results showed that CMR evaluation with assessment of multiple pacing modes after CRT is feasible and provides valuable information for patient care.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Maurizio Landolina, Giuseppe Boriani, Mauro Biffi, Giuseppe Cattafi, Alessandro Capucci, Antonio Dello Russo, Domenico Facchin, Roberto Rordorf, Antonio Sagone, Maurizio Del Greco, Giovanni Morani, Daniele Nicolis, Sarah Meloni, Andrea Grammatico, Maurizio Gasparini
Summary: This study aimed to evaluate the independent contribution of CRT-induced left ventricle reverse remodeling and occurrence of VT/VF to prognosis in CRT-D patients. The results showed that both CRT response and VT/VF occurrence independently contribute to the risk of death or HF-related hospitalizations.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2022)
Article
Urology & Nephrology
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: Frailty is highly prevalent among haemodialysis patients regardless of criteria used, with female gender being more associated with frailty. However, there is caution in interpreting heterogeneous definitions of frailty for haemodialysis patients, as they are not interchangeable, and consensus is needed on the optimal frailty definition for this population.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Endocrinology & Metabolism
Azm Hussain, Alice Culliford, Nuvreen Phagura, Felicity Evison, Suzy Gallier, Adnan Sharif
Summary: This study aimed to compare the impact of pre-transplant diabetes and post-transplantation diabetes on the management strategies and clinical outcomes of kidney transplant recipients. The results showed that pre-transplant diabetes was associated with higher mortality risk, while the effects of PTDM were time-dependent.
Correction
Cardiac & Cardiovascular Systems
Michele Brignole, Francesco Pentimalli, Pietro Palmisano, Maurizio Landolina, Fabio Quartieri, Eraldo Occhetta, Leonardo Calo, Giuseppe Mascia, Lluis Mont, Kevin Vernooy, Vincent van Dijk, Cor Allaart, Laurent Fauchier, Maurizio Gasparini, Gianfranco Parati, Davide Soranna, Michiel Rienstra, Isabelle C. Van Gelder
EUROPEAN HEART JOURNAL
(2022)
Article
Transplantation
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: Frailty among haemodialysis patients is associated with hospitalization and mortality, but further discrimination of risk is needed due to the high prevalence of frailty. This study found that incorporating self-reported health with frailty measurement can help identify the most at-risk frail individuals.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Health Care Sciences & Services
Kelly Ann Schmidtke, Felicity Evison, Amy Grove, Laura Kudrna, Olga Tucker, Andy Metcalfe, Andrew W. Bradbury, Aneel Bhangu, Richard Lilford
Summary: This study examines the effects and reasons for the uptake of six trials with actionable findings on clinical practice. The quantitative analysis reveals that practice changed in accordance with the findings for three trials, while the qualitative analysis found that evidence from other sources and various reasons influenced the non-adoption or delayed uptake of trial evidence.
BMJ QUALITY & SAFETY
(2023)
Article
Urology & Nephrology
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: Depression and frailty are common in haemodialysis recipients and are associated with negative outcomes. When taking frailty into account, depression is associated with lower hospitalization rates but poorer quality of life. Frailty is associated with higher admission rates, mortality, and poorer quality of life. The relationship between frailty and depression and their influence on outcomes is complex and requires further study.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Benjamin M. Anderson, Daisy V. Wilson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: This study investigates the relationship between ultrasound-derived anterior thigh thickness and frailty in haemodialysis recipients. The results show that anterior thigh thickness is associated with frailty by different frailty tools, but its association is not independent of other variables. Further research is needed to establish the added value of muscle mass measurement in frail haemodialysis patients.
Article
Health Care Sciences & Services
Tanya Pankhurst, Laurie Lucas, Steve Ryan, Chris Ragdale, Helen Gyves, Louise Denner, Ian Young, Laura Rathbone, Anwar Shah, Deborah McKee, Jamie J. Coleman, Felicity Evison, Jolene Atia, David Rosser, Mark Garrick, Richard Baker, Suzy Gallier, Simon Ball
Summary: This study aims to describe the benefits of implementing electronic observation charting in intensive care units (ICU). The study evaluated error reduction, time-savings, and costs associated with the transition from paper to digital records. Staff opinions were assessed during the COVID-19 pandemic to determine the efficacy of the electronic system.
Article
Urology & Nephrology
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: This study examined the accuracy of subjective and multidisciplinary assessment of the Clinical Frailty Scale (CFS-MDT) compared to the standard CFS score. The study found that there was weak correlation and minimal agreement between these two assessment methods. Both scores were associated with hospitalization and mortality, but only the CFS-MDT was associated with the length of hospital stay.
Article
Urology & Nephrology
Benjamin M. Anderson, Daisy V. Wilson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: This study explores the interplay between sarcopenia and frailty in haemodialysis, focusing on gender difference. The results show that male haemodialysis patients have a higher prevalence of low muscle mass and sarcopenia, while female patients have a lower prevalence. Sarcopenia is associated with reduced hand grip strength in males and slower walking speed in both males and females. Furthermore, sarcopenia is more strongly associated with frailty in male patients. Further research is needed to understand the underlying mechanisms and develop tailored treatments.
INTERNATIONAL JOURNAL OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: This study aims to explore the relationship between the Clinical Frailty Scale (CFS) and components of depression, as well as their association with frailty and outcomes. The findings reveal that somatic and cognitive depression symptoms are associated with higher CFS scores and poorer health-related quality of life. However, when adjusted for frailty, these symptoms are not associated with mortality or hospitalisation.
INTERNATIONAL JOURNAL OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Benjamin M. Anderson, Muhammad Qasim, Gonzalo Correa, Felicity Evison, Suzy Gallier, Charles J. Ferro, Thomas A. Jackson, Adnan Sharif
Summary: This study aimed to explore the relationship between frailty scores and cognition, and their associations with hospitalization and mortality. The results showed that increasing frailty by all definitions was associated with poorer cognition. However, cognitive impairment was not directly associated with mortality or hospitalization, but rather correlated with increasing frailty scores.
Article
Respiratory System
Camilla Dawson, Gemma Clunie, Felicity Evison, Sallyanne Duncan, Julie Whitney, Linzy Houchen-Wolloff, Charlotte E. Bolton, Olivia C. Leavy, Matthew Richardson, Elneima Omer, Hamish McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Ruth M. Saunders, Victoria C. Harris, Neil J. Greening, Claire Marie Nolan, Dan Gower Wootton, Enya Daynes, Gavin Donaldson, Jack Sargent, Janet Scott, John Pimm, Lettie Bishop, Melitta McNarry, Nicholas Hart, Rachael A. Evans, Sally Singh, Tom Yates, Trudie Chalder, William Man, Ewen Harrison, Annemarie Docherty, Nazir Lone, Jennifer K. Quint, James Chalmers, Ling-Pei Ho, Alex Robert Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Louise Wain, Chris Brightling, Neil PHOSP-COVID Collaborative Grp, Neil Sharma, Margaret Coffey, Amit Kulkarni, Sarah Wallace
Summary: This multicentre observational study in the UK examined the prevalence of self-reported swallowing, communication, voice, and cognitive problems in patients discharged from hospitals after COVID-19. The study found that compromised swallowing was reported by 20% of patients who had been admitted to the intensive care unit. Voice problems were reported by 34% of patients post-ICU admission. Communication compromise was reported by 23% of patients. Cognitive issues were reported by 70% of patients. These problems were associated with factors such as age, sex, social deprivation, and being a healthcare worker.
BMJ OPEN RESPIRATORY RESEARCH
(2023)
Article
Medicine, General & Internal
Mansoor N. Bangash, James Hodson, Felicity Evison, Jaimin M. Patel, Andrew McD Johnston, Suzy Gallier, Elizabeth Sapey, Dhruv Parekh
Summary: This study aimed to assess whether the accuracy of oxygen saturation measured by SpO(2) varies by ethnicity compared to arterial blood gas (SaO(2)). The study analyzed data from 16,818 paired measurements taken within a 20-minute interval, and found that SpO(2) readings were generally higher than SaO(2), with the magnitude of difference varying depending on the SaO(2) level and ethnicity. Specifically, there was a significant overestimation of SpO(2) in Black patients. This could lead to misclassification of hypoxia in Black patients when using SpO(2) as an indicator of oxygenation.