Article
Pharmacology & Pharmacy
Li Zeng, Fei Lin, Baodong Ling
Summary: This study explored the inhibitory effect of thirty-four traditional Chinese medicine monomers on drug-resistant Acinetobacter baumannii. It was found that nine traditional Chinese medicine monomers could inhibit the bacterial quorum sensing and downregulate the expression of virulence-associated genes. These results suggest that traditional Chinese medicine monomers could be developed as novel anti-virulence compounds to control extensively drug-resistant A. baumannii infections.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Nattarika Chaichana, Nareenath Muneerungsee, Yaowapa Sukpondma, Natthawan Sermwittayawong
Summary: Staphylococcus warneri isolated from mangrove forests has the potential to produce bioactive compounds that interfere with quorum sensing system, inhibiting biofilm formation of Escherichia coli and demonstrating the potential to develop a novel biocontrol agent for decontamination of biofilm-forming bacteria in food production.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Zheng Pang, Qingjun Zhu
Summary: Pseudomonas aeruginosa is a dangerous pathogen causing life-threatening infections in cystic fibrosis patients and immunocompromised individuals, with challenging treatment due to antibiotic resistance. Traditional Chinese medicine shows promise as an alternative therapy, with natural products demonstrating significant antimicrobial effects on antibiotic-resistant strains of P. aeruginosa.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Yu-Bin Bai, Meng-Yan Shi, Wei-Wei Wang, Ling-Yu Wu, Yu-Ting Bai, Bing Li, Xu-Zheng Zhou, Ji-Yu Zhang
Summary: A new antibacterial strategy based on inhibiting bacterial quorum sensing has been identified as a promising method to reduce bacterial pathogenicity and prevent antibiotic resistance. Echinatin (Ech) was screened as a highly effective anti-quorum sensing compound. The results showed that Ech interfered with quorum sensing phenotype and synergistically enhanced the antibacterial activity of marketed antibiotics against Escherichia coli.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Food Science & Technology
Tao Yu, Muyuan Ma, Yaxi Sun, Xiaobo Xu, Shuxing Qiu, Junlei Yin, Leishan Chen
Summary: Sublethal concentrations of benzalkonium chloride can promote AI-2 production, enhance biofilm formation, and increase swimming motility of E. coli isolates, along with upregulating genes associated with biofilm formation and flagellar motility. Proper use of this disinfectant in food processing environments is crucial for controlling E. coli contamination.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Article
Plant Sciences
Lini Wei, Lulu Zhang, Yan Zhang, Lan Yan, Bin Liu, Zhiwen Cao, Ning Zhao, Xiaojuan He, Li Li, Cheng Lu
Summary: This review discusses the relationship between respiratory infectious diseases and intestinal flora, with a focus on the role of traditional Chinese medicine (TCM) in regulating intestinal E. coli and related immunity, gut barrier, and metabolism. It suggests that TCM therapy targeting intestinal E. coli could be a potential approach to alleviate respiratory infectious diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aditi Vashistha, Nikhil Sharma, Yerramsetti Nanaji, Deepak Kumar, Gurpal Singh, Ravi P. Barnwal, Ashok Kumar Yadav
Summary: The overuse and inappropriate use of antibiotics has led to the development of drug resistant bacterial strains. Biofilm, a complex microorganism aggregation, plays a crucial role in infectious diseases. Efforts to disrupt biofilms have identified molecules that can inhibit quorum sensing, offering potential treatments for bacterial infections with lower dosages of medications.
BIOORGANIC CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Lujun Yin, Yingjie Wang, Shiliang Xiang, Kaizhong Xu, Bo Wang, Ai-Qun Jia
Summary: In this study, it was found that tyramine could inhibit the production of virulence factors in Burkholderia cenocepacia by blocking the quorum sensing systems. It was also shown to have low toxicity and potential as a combination therapy with traditional antibiotics.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemical Research Methods
Yuki Soma, Masatomo Takahashi, Yuri Fujiwara, Tamaki Shinohara, Yoshihiro Izumi, Taizo Hanai, Takeshi Bamba
Summary: This study redesigned the QS-MTS to improve its stability and efficiency in metabolic regulation, which was confirmed through metabolome analysis. The redesigned QS-MTS showed better performance in long-term processes such as fed-batch fermentation compared to the conventional QS-MTS. A circuit redesign based on dynamic characteristic evaluation and metabolome analysis was presented for metabolic flux control.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Microbiology
Sepideh Asadi, Bahar Nayeri-Fasaei, Taghi Zahraei-Salehi, Ramak Yahya-Rayat, Nemat Shams, Aram Sharifi
Summary: The present study investigates the antibacterial and anti-biofilm activity of carvacrol alone and in combination with cefixime against Escherichia coli. The results show that carvacrol has synergistic effects with cefixime and can effectively inhibit biofilm formation and quorum sensing in E. coli.
Article
Pharmacology & Pharmacy
Yiming Wang, Yu Zhang, Xu Song, Chunlin Fang, Rui Xing, Lu Liu, Xinghong Zhao, Yuanfeng Zou, Lixia Li, Renyong Jia, Gang Ye, Fei Shi, Xun Zhou, Yingying Zhang, Hongping Wan, Qin Wei, Zhongqiong Yin
Summary: This study found that 1,8-cineole can affect bacterial biofilm formation and pathogenicity by suppressing the expression of luxS gene in E. coli O101.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Andrea Muras, Ana Parga, Celia Mayer, Ana Otero
Summary: Interfering with quorum sensing systems of bacteria is a promising strategy to control biofilm formation, and the xCELLigence(R) system is proposed as an efficient method for quantifying biofilm formation.
Article
Environmental Sciences
Zhuqiu Sun, Jinying Xi, Marvin Yeung, Lichao Lu
Summary: This study investigated the effects of two quorum sensing (QS) enhancement methods on the performance and biofilm of biofilters treating chlorobenzene. The results showed that adding exogenous AHLs had a more significant enhancing effect on biofilm, while AHLs producing bacteria helped improve bacterial community diversity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biotechnology & Applied Microbiology
A. Sharifi, B. Nayeri Fasaei
Summary: This study found that Thymus daenensis and Satureja hortensis essential oils have antibacterial and anti-biofilm properties against E. coli O157:H7, and also inhibit its quorum sensing system.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Microbiology
Yu-Bin Bai, Xiao-Rong Yang, Bing Li, Xu-Zheng Zhou, Wei-Wei Wang, Fu-Sheng Cheng, Ji-Yu Zhang
Summary: In this study, three AI-2 inhibitors (M414-3326, 3254-3286, and L413-0180) were obtained through virtual screening and their in vitro antibiofilm activities were validated. These inhibitors effectively inhibited biofilm formation of E. coli O157:H7 and are potential LuxS inhibitors that can be used to treat infections.
MICROBIOLOGY SPECTRUM
(2023)