Review
Biochemistry & Molecular Biology
Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama
Summary: In addition to lowering plasma glucose levels, SGLT2 inhibitors have been shown to significantly reduce hospitalization for heart failure and retard the progression of chronic kidney disease in patients with type 2 diabetes. This is achieved through the improvement of endothelial dysfunction and other factors such as oxidative stress, inflammation, mitochondrial dysfunction, and glucotoxicity.
Article
Nutrition & Dietetics
Anubhuti Gupta, Kunal Singh, Sameen Fatima, Saira Ambreen, Silke Zimmermann, Ruaa Younis, Shruthi Krishnan, Rajiv Rana, Ihsan Gadi, Constantin Schwab, Ronald Biemann, Khurrum Shahzad, Vibha Rani, Shakir Ali, Peter Rene Mertens, Shrey Kohli, Berend Isermann
Summary: Diabetic kidney disease (DKD) is a major metabolic disease with limited treatment options. This study discovers that sterile inflammation caused by neutrophil extracellular traps (NETs) may play a significant role in DKD. Inhibiting NETs may provide a promising therapeutic strategy for DKD.
Article
Endocrinology & Metabolism
Chenrui Li, Li Li, Ming Yang, Jinfei Yang, Chanyue Zhao, Yachun Han, Hao Zhao, Na Jiang, Ling Wei, Ying Xiao, Yan Liu, Xiaofen Xiong, Yiyun Xi, Shilu Luo, Fei Deng, Wei Chen, Shuguang Yuan, Xuejing Zhu, Li Xiao, Lin Sun
Summary: This study reveals the important role of phosphofurin acidic cluster sorting protein 2 (PACS-2) in ameliorating tubular injury in diabetic nephropathy. PACS-2 expression is decreased in renal tubules of patients with DN, and its expression is correlated with renal function and tubulointerstitial lesion severity. PACS-2 deletion in proximal tubules aggravates albuminuria and tubular injury in a mouse model of diabetes. Mechanistically, PACS-2 restores mitochondrial-associated endoplasmic reticulum membrane (MAM) integrity and enhances mitophagy, improving mitochondrial dysfunction in diabetic mice.
Review
Endocrinology & Metabolism
Suyan Duan, Fang Lu, Dandan Song, Chengning Zhang, Bo Zhang, Changying Xing, Yanggang Yuan
Summary: Studies have shown that morphological and functional changes in renal tubules play a significant role in diabetic kidney disease, with novel tubular biomarkers showing clinical importance. However, transitioning to personalized diagnosis and therapy still presents challenges.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Olufunke O. Arishe, R. Clinton Webb
Summary: This editorial discusses a study on the effects of VE-PTP inhibition on endothelial dysfunction and hypertension in patients with diabetes.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xia Gu, Yi Liu, Na Wang, Junhui Zhen, Bo Zhang, Shaoshuai Hou, Zhengguo Cui, Qiang Wan, Hong Feng
Summary: In diabetic kidney disease, decreased expression of mitochondrial ribosomal protein L7/L12 (MRPL12) leads to mitochondrial dysfunction, and Nrf2 may act as a potential transcription factor for MRPL12. Therefore, Nrf2 may play a crucial role in regulating mitochondrial function in DKD.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Eva Harlacher, Julia Wollenhaupt, Constance C. F. M. J. Baaten, Heidi Noels
Summary: Patients with chronic kidney disease (CKD) are at a highly increased risk of cardiovascular complications. This study systematically reviewed literature on CKD-associated endothelial dysfunction, revealing the role of inflammation, oxidative stress, leukocyte migration, and thrombosis in CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yachun Han, Shan Xiong, Hao Zhao, Shikun Yang, Ming Yang, Xuejing Zhu, Na Jiang, Xiaofen Xiong, Peng Gao, Ling Wei, Ying Xiao, Lin Sun
Summary: The deficiency of autophagy-mediated lipophagy plays a critical role in the ectopic lipid deposition and renal injury related to lipids in diabetic nephropathy (DN). Decreased lipophagy, increased ectopic lipid deposition and lipotoxicity were observed in tubular cells of DN patients and db/db mice, and these effects could be reversed by the autophagy-promoting adiponectin receptor activator AdipoRon.
CELL DEATH & DISEASE
(2021)
Review
Cell Biology
Simeng Liu, Yanggang Yuan, Yi Xue, Changying Xing, Bo Zhang
Summary: Podocytes are essential for maintaining the glomerular filtration barrier and their injury plays a critical role in the development of albuminuria and diabetic kidney disease (DKD). Mitochondrial dysfunction is a key driver in podocyte injury in DKD, leading to energy crisis, oxidative stress, inflammation, and cell death. This review summarizes the recent advances in understanding the molecular mechanisms of mitochondrial damage and its impact on podocytes. It discusses various mitochondrial pathways involved in podocyte injury in DKD, such as mitochondrial dynamics, mitophagy, mitochondrial biogenesis, oxidative stress, and protein quality control. The review also explores the formation of mitochondria-associated membranes (MAMs) and their role in podocyte mitochondrial function. Finally, it examines the experimental evidence and potential future directions for targeting podocyte mitochondrial function in the treatment of DKD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Shenghao Zhang, Xiaodan Li, Siyu Liu, Wanting Zhang, Meinuo Li, Chen Qiao
Summary: Diabetic kidney disease (DKD) is a common complication of diabetes mellitus, leading to end-stage renal disease and severe health damage. ET-1, closely associated with DKD progression, is elevated in response to high glucose stimulation and contributes to hemodynamic changes, inflammation, and renal dysfunction, ultimately causing proteinuria and decreased glomerular filtration. This review aims to summarize the molecular changes, regulatory mechanisms, and actions of ET-1 in DKD, recent clinical trials of ET-1 receptor antagonists, and current challenges, providing valuable information and research directions for DKD treatment and ET-1-related studies.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Lan Yao, Xianhui Liang, Yingjin Qiao, Bohan Chen, Pei Wang, Zhangsuo Liu
Summary: Diabetic kidney disease (DKD) is a severe complication associated with diabetes mellitus, characterized by not only glomerular lesions but also tubular lesions. Recent studies have found that mitochondrial dysfunction plays an important role in diabetic tubulopathy. Understanding the mechanism of mitochondrial dysfunction can help identify new biomarkers for DKD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Multidisciplinary Sciences
Yanru Duan, Shihan Zhang, Yuanyuan Xing, Ye Wu, Wen Zhao, Pinxue Xie, Huina Zhang, Xinxiao Gao, Yanwen Qin, Yajing Wang, Xinliang Ma, Yunhui Du, Huirong Liu
Summary: This study revealed that adiponectin inhibits diabetic endothelial inflammatory response by activating the Wnt/beta-catenin signaling pathway and promoting the expression of CD44 through APPL1. These findings provide a new avenue for the inhibition of diabetic endothelial inflammation.
Article
Multidisciplinary Sciences
Manjula Darshi, Jana Tumova, Afaf Saliba, Jiwan Kim, Judy Baek, Subramaniam Pennathur, Kumar Sharma
Summary: The Crabtree effect, characterized by rapid glucose-induced repression of mitochondrial oxidative metabolism, has been observed in yeasts and tumor cells. This study found the presence of the Crabtree effect in normal kidney proximal tubule epithelial cells (PTEC) but not in other kidney cells or mammalian cells. Glycolysis reduction with 2-deoxyglucose and pyruvate partially reversed the glucose-induced repression of respiration in PTEC. Late-stage glycolytic intermediates, but not early-stage intermediates or lactate, inhibited respiration in PTEC and kidney cortex mitochondria, mimicking the Crabtree effect. Findings from diabetic mice supported a similar pattern occurring in vivo. This study identifies the unique presence of the Crabtree effect in kidney PTEC and its major mediators.
Article
Peripheral Vascular Disease
Mouad Hamzaoui, Deborah Groussard, Dorian Nezam, Zoubir Djerada, Gaspard Lamy, Virginie Tardif, Anais Dumesnil, Sylvanie Renet, Valery Brunel, Dorien J. M. Peters, Laurence Chevalier, Melanie Hanoy, Paul Mulder, Vincent Richard, Jeremy Bellien, Dominique Guerrot
Summary: This study provides the first in vivo demonstration that specific deletion of Pkd1 in endothelial cells promotes endothelial dysfunction and hypertension, impairs arteriovenous fistula development, and potentiates the cardiovascular alterations associated with chronic kidney disease.
Review
Endocrinology & Metabolism
Yang Yang, Gaosi Xu
Summary: This paper summarizes the mechanisms of hyperfiltration in early diabetic kidney disease (DKD), including the effect of glucose reabsorption, renal growth, nitric oxide, adenosine, atrial natriuretic peptide, cyclooxygenase, renin-angiotensin-aldosterone system, and endothelin. Potential treatments targeting these mechanisms may provide new therapeutic opportunities for reducing renal burden in DKD patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Rheumatology
Michele Iudici, Christian Pagnoux, Delphine S. Courvoisier, Pascal Cohen, Antoine Neel, Achille Aouba, Francois Lifermann, Marc Ruivard, Olivier Aumaitre, Bernard Bonnotte, Francois Maurier, Thomas Le Gallou, Eric Hachulla, Alexandre Karras, Chahera Khouatra, Noemie Jourde-Chiche, Jean-Francois Viallard, Claire Blanchard-Delaunay, Pascal Godmer, Alain Le Quellec, Thomas Quemeneur, Claire de Moreuil, Alexis Regent, Benjamin Terrier, Luc Mouthon, Loic Guillevin, Xavier Puechal
Summary: Patients with localized granulomatosis with polyangiitis (L-GPA) present with different clinical features compared to systemic GPA (S-GPA), with younger age, less frequent saddle nose deformity or subglottic stenosis, and lower PR3-ANCA positivity. Treatment strategies also vary, with less frequent use of CYC and more frequent use of a combination of MTX and glucocorticoids in L-GPA patients. Despite similar relapse risks between L-GPA and S-GPA, L-GPA patients have higher overall survival rates and more frequent relapses in the ENT and lung regions.
Review
Rheumatology
Maxime Beydon, Christophe Rodriguez, Alexandre Karras, Alexandre Cez, Cedric Rafat, Noemie Jourde-Chiche, Olivier Fain, Carole Philipponnet, Xavier Puechal, Antoine Dossier, Nicolas Dupin, Dan Levy, Ines Aureau, Loic Guillevin, Benjamin Terrier
Summary: Through a case series and literature review, it was found that Bartonella infection can mimic PR3-ANCA-associated vasculitis with involvement of the kidneys and endocarditis, while Coxiella infection may induce vasculitis affecting vessels of all sizes, with 75% presenting as cryoglobulinaemia vasculitis.
Article
Urology & Nephrology
Dorian Nezam, Raphael Porcher, Francois Grolleau, Pauline Morel, Dimitri Titeca-Beauport, Stanislas Faguer, Alexandre Karras, Justine Solignac, Noemie Jourde-Chiche, Francois Maurier, Hamza Sakhi, Khalil El Karoui, Rafik Mesbah, Pierre Louis Carron, Vincent Audard, Didier Ducloux, Romain Paule, Jean-Fracois Augusto, Julien Aniort, Aurelien Tiple, Cedric Rafat, Severine Beaudreuil, Xavier Puechal, Pierre Gobert, Ziad Massy, Catherine Hanrotel, Stephane Bally, Nihal Martis, Cecile-Audrey Durel, Geoffroy Desbuissons, Pascal Godmer, Aurelie Hummel, Francois Perrin, Antoine Neel, Claire De Moreuil, Tiphaine Goulenok, Dominique Guerrot, Steven Grange, Aurelie Foucher, Alban Deroux, Carole Cordonnier, Celine Guilbeau-Frugier, Anne Modesto-Segonds, Dominique Nochy, Laurent Daniel, Anissa Moktefi, Marion Rabant, Loic Guillevin, Alexis Regent, Benjamin Terrier
Summary: The study found that PLEX did not improve the primary outcome in the entire population, but identified a subset of patients who could benefit from PLEX. However, these findings need to be validated before being used in clinical decision making.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Transplantation
Guillaume Lano, Marion Sallee, Marion Pelletier, Stanislas Bataille, Megan Fraisse, Nathalie McKay, Philippe Brunet, Laetitia Dou, Stephane Burtey
Summary: This study found that the neutrophil:lymphocyte ratio (NLR) can predict mortality and cardiovascular events in hemodialysis (HD) patients, and it is positively correlated with the level of the uremic toxin indoxyl sulfate (IS).
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Transplantation
Stanislas Bataille, Laetitia Dou, Marc Bartoli, Marion Sallee, Julien Aniort, Borhane Ferkak, Rania Chermiti, Nathalie McKay, Nathalie Da Silva, Stephane Burtey, Stephane Poitevin
Summary: In chronic kidney disease (CKD), the plasma concentrations of myostatin and activin A are increased, possibly due to reduced renal clearance. Furthermore, we observed increased production of activin A in the kidney and heart, which may be related to muscle wasting. Therefore, myostatin and activin A should be added to the list of uremic toxins.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Rheumatology
Noemie Jourde-Chiche, Nathalie Costedoat-Chalumeau, Karine Baumstarck, Anderson Loundou, Laurence Bouillet, Stephane Burtey, Valerie Caudwell, Laurent Chiche, Lionel Couzi, Laurent Daniel, Christophe Deligny, Bertrand Dussol, Stanislas Faguer, Pierre Gobert, Guillaume Gondran, Antoine Huart, Aurelie Hummel, Emilie Kalbacher, Adexandre Karras, Marc Lambert, Veronique Le Guern, Ludivine Lebourg, Sandrine Loubiere, Helene Maillard-Lefebvre, Francois Maurier, Micheline Pha, Viviane Queyrel, Philippe Remy, Francoise Sarrot-Reynauld, David Verhelst, Eric Hachulla, Zahir Amoura, Eric Daugas
Summary: For patients with proliferative lupus nephritis, discontinuation of maintenance immunosuppressive therapy (IST) after 2.3 years is not non-inferior to continuation of IST. However, IST discontinuation is associated with a higher risk of severe systemic lupus erythematosus (SLE) flares.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Dermatology
Xavier Heim, Julien Bermudez, Ahmad Joshkon, Elise Kaspi, Richard Bachelier, Marie Nollet, Melanie Velier, Laetitia Dou, Alexandre Brodovitch, Alexandrine Foucault-Bertaud, Aurelie S. Leroyer, Audrey Benyamine, Aurelie Daumas, Brigitte Granel, Florence Sabatier, Francoise Dignat-George, Marcel Blot-Chabaud, Nathalie Bardin
Summary: This study reveals the involvement of CD146 in the regulation of Wnt/ROS signaling in skin fibrosis of systemic sclerosis. The absence of CD146 leads to procanonical Wnt signaling, increased ROS content, and DNA oxidative damage. Furthermore, CD146 and its ligand are upregulated in fibroblasts from patients with systemic sclerosis. These findings highlight the importance of CD146 in the pathogenesis of systemic sclerosis and provide insights for innovative therapeutic strategies.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Urology & Nephrology
Sophie Chauvet, Jill J. Hauer, Florent Petitprez, Marion Rabant, Paula Vieira Martins, Veronique Baudouin, Yahsou Delmas, Noemie Jourde-Chiche, Alexandre Cez, David Ribes, Sylvie Cloarec, Aude Servais, Mohamad Zaidan, Eric Daugas, Michel Delahousse, Alain Wynckel, Amelie Ryckewaert, Anne Laure Sellier-Leclerc, Olivia Boyer, Eric Thervet, Alexandre Karras, Richard J. H. Smith, Veronique Fremeaux-Bacchi
Summary: C3 glomerulopathy (C3G) is a rare complement-mediated disease. The prognosis of this disease is associated with age, kidney function and genetic variants in complement genes. Blood biomarker analysis can predict the kidney outcome of patients.
KIDNEY INTERNATIONAL
(2022)
Letter
Urology & Nephrology
Justine Solignac, Noemie Jourde-Chiche
CLINICAL KIDNEY JOURNAL
(2023)
Article
Food Science & Technology
Manon Ebersolt, Tacy Santana Machado, Cecilia Mallmann, Nathalie Mc-Kay, Laetitia Dou, Dammar Bouchouareb, Philippe Brunet, Stephane Burtey, Marion Sallee
Summary: A low protein/fiber index is associated with lower concentrations of uremic toxins in anuric hemodialysis patients. Diets with increased fiber intake should be tested to determine if they can reduce serum concentrations of p-cresyl sulfate and indoxyl sulfate.
Article
Biochemistry & Molecular Biology
Ariane Duval-Sabatier, Stephane Burtey, Marion Pelletier, Manon Laforet, Laetitia Dou, Marion Sallee, Anne-Marie Lorec, Hafssa Knidiri, Floriane Darbon, Yvon Berland, Philippe Brunet
Summary: Hemodialysis can reduce uremic toxins, and hemodiafiltration improves the removal of middle molecules. However, it has no effect on indoles concentration, and different treatment methods do not significantly differ in the removal of protein-bound solutes.
Article
Rheumatology
Robin Arcani, Elisabeth Jouve, Laurent Chiche, Noemie Jourde-Chiche
Summary: We developed a type 2 score derived from the SF-36 to categorize SLE patients and compared immunological and transcriptomic profiles between groups.
CLINICAL RHEUMATOLOGY
(2023)
Article
Transplantation
Stanislas Bataille, Nathalie McKay, Laetitia Koppe, Alice Beau, Berengere Benoit, Marc Bartoli, Nathalie Da Silva, Stephane Poitevin, Julien Aniort, Rania Chermiti, Stephane Burtey, Laetitia Dou
Summary: Indoxyl sulfate (IS), an indolic uremic toxin, inhibits the expression of Myf6/MRF4 and MYH2 during muscle cell differentiation, leading to a defect in myotube structure. This provides new insights into the role of IS in muscle atrophy observed in CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Rheumatology
Francois Gaillard, Delphine Bachelet, Cecile Couchoud, Cedric Laouenan, Katell Peoc'h, Quentin Simon, Nicolas Charles, Noemie Jourde-Chiche, Eric Daugas
Summary: This study found that lupus activity decreases after the initiation of maintenance dialysis, but non-severe and severe lupus flares still occur. It emphasizes the importance of continued follow-up of lupus patients by specialists after dialysis initiation.
Article
Urology & Nephrology
Jonathan M. Chemouny, Mickael Bobot, Aurelie Sannier, Valentin Maisons, Noemie Jourde-Chiche, Elsa Ferriere, Dominique Joly, Cecile Vigneau, Nathalie Rioux-Leclercq, Christophe Barba, Laurent Daniel, Jean-Michel Halimi, Francois Vrtovsnik
Summary: Kidney biopsies are commonly performed on patients with type 2 diabetes to differentiate between non-diabetic or hypertensive kidney disease and diabetic or hypertensive nephropathy. This study evaluated the association of different patterns of atypical features or KB indications with non-diabetic or hypertensive kidney disease. Results showed that despite the presence of hematuria, it is not sufficient to indicate kidney biopsy in the absence of other atypical features, while rapid progression of proteinuria and deterioration of eGFR are major indicators of non-diabetic or hypertensive kidney disease.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
