Journal
MATERIALS EXPRESS
Volume 9, Issue 7, Pages 757-763Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/mex.2019.1552
Keywords
Nanogels; Glutathione-Responsive; Camptothecin; Drug Delivery
Funding
- Outstanding Doctor Funding Award of Shanxi Province [SXYBKY2018001]
- Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi [2019L0660]
- Doctoral Scientific Research Foundation of Changzhi Medical College [BS201909]
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PEGlyation nanogels have shown potential in cancer therapy due to their outstanding biodegradability and biocompatibility. In this study, glutathione (GSH)-responsive PEGlyation nanogels were loaded with camptothecin (CPT) (CPT@A(2)B(5)-PEG) by one-pot synthesis based on the monomers of disulfide-based diacrylate (A(2)) and N-(2-aminoethyl) ethane-1,2-diamine (B-5). The nanogels with responsive cross-linked networks were degraded into small molecules according to their GSH-sensitivity. The nanogels were of the correct size as measured by TEM and DLS, and uptake into A549 cells was observed within 6 h. Cell viability assays showed that CPT@A(2)B(5)-PEG produced similar anticancer efficacy to free CPT. The GSH-responsive CPT-loaded PEGlyation nanogels produced by one-pot synthesis are therefore promising platforms for anticancer drug delivery.
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