Article
Cell Biology
Lisa Donker, Ronja Houtekamer, Marjolein Vliem, Francois Sipieter, Helena Canever, Manuel Gomez-Gonzalez, Miquel Bosch-Padros, Willem-Jan Pannekoek, Xavier Trepat, Nicolas Borghi, Martijn Gloerich
Summary: Epithelial cells adapt their rate of cell division by sensing changes in cell number through mechanosensitive E-cadherin adhesions, which control G2/M cell-cycle progression.
Article
Biology
Alberto T. Gatta, Yolanda Olmos, Caroline L. Stoten, Qu Chen, Peter B. Rosenthal, Jeremy G. Carlton
Summary: The ESCRT-III machinery is crucial for sealing the nuclear envelope and repairing it during interphase rupture. The assembly of ESCRT-III at the nuclear envelope is regulated by the interaction between CHMP7 and LEM2, with CDK1 phosphorylation of CHMP7 playing a key role in controlling this process during mitotic exit. Spatial and temporal differences in CHMP7 dephosphorylation also play a role in regulating its assembly at different cellular locations during cell division.
Article
Cell Biology
Yixin Tong, Yuan Huang, Yuchao Zhang, Xiangtai Zeng, Mei Yan, Zhongsheng Xia, Dongming Lai
Summary: DPP3 plays an oncogene-like role in the development and progression of CRC by targeting CDK1, which is correlated with lymphatic metastasis, pathological stage, and number of positive lymph nodes. Downregulation of DPP3 inhibits cell proliferation, migration and promotes apoptosis by upregulating multiple apoptosis-related genes.
CELL DEATH & DISEASE
(2021)
Article
Biology
Yuta Tanizaki, Hongen Zhang, Yuki Shibata, Yun-Bo Shi
Summary: Tanizaki et al. used ChIP-Seq to identify TR-bound genes in the intestine of Xenopus tropicalis tadpoles. They found that cell cycle-related genes are highly enriched among TR target genes, and treatment with cell cycle inhibitors blocked T3-induced intestinal remodeling.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zheng Zhan, Ningyang Yuan, Xue You, Kai Meng, Rula Sha, Zhenzhen Wang, Qian Peng, Zhiqin Xie, Ruijiao Chen, Ying Feng
Summary: The study reveals the opposite regulation of Notch1-SMAD3 crosstalk by different isoforms of NUMB protein. The p65/p66 isoforms promote EMT and cancer cell migration, while the p71/p72 isoforms attenuate these effects. The interaction between N1ICD and SMAD3 is crucial for their own stabilization as well as for NUMB-mediated EMT response and cell migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Qiushi Wang, Ann M. Bode, Tianshun Zhang
Summary: Cyclin dependent kinases (CDKs) are proposed as promising candidate targets for cancer treatment, as they play a critical role in cell cycle progression and have higher expression in cancer tissues. CDK1 activation is closely associated with tumorigenesis and its associated proteins participate in multiple oncogenic pathways. Small molecules targeting CDK1 or multiple CDKs have been developed and evaluated in preclinical studies, including some human clinical trials.
NPJ PRECISION ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shigeaki Sunada, Hiroko Saito, Doudou Zhang, Zeyu Xu, Yoshio Miki
Summary: CDK1 inhibitors regulate cellular sensitivity to DNA damage by controlling cell cycle progression and DNA repair inhibition, providing insights for developing clinical strategies targeting CDK1 inhibition in tumor cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yuhan Liu, Jing Xu, Yanan Wang, Mingxi Gan, Qifan Hu, Jianbin Wang, Tianyu Han
Summary: This study reveals the high expression of USP14 in breast cancer cells and its impact on cell proliferation, stabilizing the key kinase CDK1 in the G2/M phase through its deubiquitinase activity.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Chemistry, Multidisciplinary
Pasquale Sacco, Francesco Piazza, Chiara Pizzolitto, Gabriele Baj, Francesco Brun, Eleonora Marsich, Ivan Donati
Summary: This study presents a strategy to control the dissipation rate of viscoplastic substrates while precisely regulating linear elasticity, and reveals the crucial link between this material property and cellular responses in 2D cultures.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Luis Cedeno-Rosario, David Honda, Autumn M. Sunderland, Mark D. Lewandowski, William R. Taylor, Deborah N. Chadee
Summary: MLK3 plays a crucial role in the cell cycle of ovarian cancer cells, with its activity being regulated by phosphorylation by CDK1 and CDK2, affecting the activities of both MLK3 and c-Jun N-terminal kinase in G1/S, G2, and M phases.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Laura Bozal-Basterra, Maria Gonzalez-Santamarta, Veronica Muratore, Natalia Martin-Martin, Amaia Ercilla, Jose A. Rodriguez, Arkaitz Carracedo, James D. Sutherland, Rosa Barrio
Summary: LUZP1 exhibits frequent genomic aberrations in cancer, particularly gene deletions, and its loss promotes cell migration, invasion, apoptosis, and alterations in cell morphology. Additionally, LUZP1 plays regulatory roles beyond actin filament bundling, affecting actin polymerization through changes in ACTR3 and phospho-cofilin ratios. These findings suggest a novel role for LUZP1 in cancer regulation through actin cytoskeleton control.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yang Huang, Yicheng Wang, Zhongmei Wu, Tao Li, Shupei Li, Chan Wang, Jine Ao, Changming Yang, Yu Zhou
Summary: The study found that CATSPER1 expression is significantly up-regulated in colorectal cancer (CRC) and associated with poor overall survival, related to the SOX11 transcription factor. CATSPER1 promotes CRC cell proliferation and may maintain the malignant process of CRC through activation of the PI3K/AKT signaling pathway.
Article
Cell Biology
Vera-Marie E. Dunlock, Abbey B. Arp, Simar Pal Singh, Stephanie Charrin, Viet Nguyen, Erik Jansen, Fleur Schaper, Martin Ter Beest, Malou Zuidscherwoude, Sjoerd J. Van Deventer, Britt Nakken, Peter Szodorey, Maria C. Demaria, Mark D. Wright, Laia Querol Cano, Eric Rubinstein, Annemiek B. Van Spriel
Summary: T cells rely on the phosphatase CD45 and its partner CD53 for optimal signaling and activation, with CD53 controlling CD45 function and stability on the cell membrane. Understanding the mechanisms of CD45 regulation and CD53-mediated T cell immunity is crucial for advancing our knowledge of immune responses.
Article
Biochemistry & Molecular Biology
Yandong Zhang, Zheping Cai, Guanglei Hu, Songhui Hu, Yafei Wang, Na Li, Saiyong Chen, Qiong Liu, Lanhui Zeng, Tianxiang Tang, Yilan Zhang, Lei Xiao, Yu Gu, Yunli Xie
Summary: Tcf4 regulates neuronal positioning, with its deficiency leading to clustering of neurons. By controlling the expression of cell adhesion molecules, Tcf4 plays a role in neuronal positioning. Mutations in TCF4 result in disrupted neuronal functions, and are associated with schizophrenia and Pitt-Hopkins syndrome.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Tracy L. Smith, Malika Oubaha, Gael Cagnone, Cecile Boscher, Jin Sung Kim, Yassine El Bakkouri, Ying Zhang, Rony Chidiac, Jeanne Corriveau, Chantal Delisle, Gregor U. Andelfinger, Przemyslaw Sapieha, Jean-Sebastien Joyal, Jean-Philippe Gratton
Summary: The study indicates that inhibition of eNOS alters the polarity program of endothelial cells, leading to increased cell polarization, regulated sprouting angiogenesis, and normalized pathological neovascularization during retinopathy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Olga Moiseeva, Stephane Lopes-Paciencia, Genevieve Huot, Frederic Lessard, Gerardo Ferbeyre
Article
Oncology
Mariana Acevedo, Mathieu Vernier, Lian Mignacca, Frederic Lessard, Genevieve Huot, Olga Moiseeva, Veronique Bourdeau, Gerardo Ferbeyre
Article
Biochemistry & Molecular Biology
Gregoire Rondelet, Thomas Dal Maso, Luc Willems, Johan Wouters
JOURNAL OF STRUCTURAL BIOLOGY
(2016)
Article
Cell Biology
Frederic Lessard, Sebastian Igelmann, Christian Trahan, Genevieve Huot, Emmanuelle Saint-Germain, Lian Mignacca, Neylen Del Toro, Stephane Lopes-Paciencia, Benjamin Le Calve, Marinieve Montero, Xavier Deschenes-Simard, Marina Bury, Olga Moiseeva, Marie-Camille Rowell, Cornelia E. Zorca, Daniel Zenklusen, Lea Brakier-Gingras, Veronique Bourdeau, Marlene Oeffinger, Gerardo Ferbeyre
NATURE CELL BIOLOGY
(2018)
Article
Pharmacology & Pharmacy
Sebastien Marx, Megane Van Gysel, Aurelie Breuer, Thomas Dal Maso, Carine Michiels, Johan Wouters, Benjamin Le Calve
BIOCHEMICAL PHARMACOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Frederic Lessard, Lea Brakier-Gingras, Gerardo Ferbeyre
Article
Cell Biology
Neylen Del Toro, Ana Fernandez-Ruiz, Lian Mignacca, Paloma Kalegari, Marie-Camille Rowell, Sebastian Igelmann, Emmanuelle Saint-Germain, Mehdi Benfdil, Stephane Lopes-Paciencia, Lea Brakier-Gingras, Veronique Bourdeau, Gerardo Ferbeyre, Frederic Lessard
Article
Oncology
Emmanuelle Saint-Germain, Lian Mignacca, Genevieve Huot, Mariana Acevedo, Karine Moineau-Vallee, Viviane Calabrese, Veronique Bourdeau, Marie-Camille Rowell, Subburaj Ilangumaran, Frederic Lessard, Gerardo Ferbeyre
Review
Oncology
Marx Sebastien, Dal Maso Thomas, Chen Jia-Wei, Bury Marina, Wouters Johan, Michiels Carine, Le Calve Benjamin
SEMINARS IN CANCER BIOLOGY
(2020)
Article
Genetics & Heredity
Michel G. Tremblay, Dany S. Sibai, Melissa Valere, Jean-Clement Mars, Frederic Lessard, Roderick T. Hori, Mohammad Moshahid Khan, Victor Y. Stefanovsky, Mark S. LeDoux, Tom Moss
Summary: The translation discusses the cellular mechanisms involved in the transcription of mouse and human ribosomal RNA genes, the cooperative relationship between UBTF and SL1 in cell growth and gene activation, and the impact of gene mutations on gene expression and cellular development.
Article
Multidisciplinary Sciences
Ranjan K. Singh, Ahmed Soliman, Giambattista Guaitoli, Eliza Stoermer, Felix von Zweydorf, Thomas Dal Maso, Asmaa Oun, Laura Van Rillaer, Sven H. Schmidt, Deep Chatterjee, Joshua A. David, Els Pardon, Thomas U. Schwartz, Stefan Knapp, Eileen J. Kennedy, Jan Steyaert, Friedrich W. Herberg, Arjan Kortholt, Christian Johannes Gloeckner, Wim Versees
Summary: Mutations in the LRRK2 gene are a leading cause of Parkinson's disease, while overactivation of LRRK2 is associated with idiopathic form of the disease. Researchers have identified and characterized nanobodies that can bind to different domains of LRRK2 and inhibit or activate its activity. These nanobodies act through an allosteric inhibitor mechanism and provide potential therapeutic strategies for Parkinson's disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Oncology
Sebastian Igelmann, Frederic Lessard, Gerardo Ferbeyre
Summary: Emerging evidence suggests that the organization of cells into membraneless sub-compartments, known as biological condensates, confers unique properties to cancer cells. Recent research has shown that genetic and epigenetic changes can drive the formation of these condensates, leading to the stable maintenance of cellular states. This review highlights the specific biological condensates in cancer, initiated by mutant oncoproteins, RNA-binding proteins, or lincRNAs, which regulate oncogenic gene expression programs and cancer metabolism. Targeting these oncogenic condensates with effective anticancer drugs could be a promising therapeutic approach.
Article
Biology
Joel Boutin, Frederic Lessard, Michel G. Tremblay, Tom Moss
YALE JOURNAL OF BIOLOGY AND MEDICINE
(2019)