Journal
CELL REPORTS
Volume 29, Issue 5, Pages 1074-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2019.09.055
Keywords
-
Categories
Funding
- Vinnova
- Carl Bennet AB
- Karolinska Institutet
- Getinge AB
- Stiftelsen Clas Groschinskys Minnesfond
- Jeanssons Stiftelse
- Svenska Lakaresaspacingdiaeresisllskapet
- Ake Wibergs Stiftelse
- Swedish Foundation for Strategic Research (SSF)
- Stockholms lans landsting (SLL) ALF
- Knut and Alice Wallenberg Foundation
Ask authors/readers for more resources
Staphylococcus aureus is a leading cause of skin and soft issue infection, but paradoxically, it also transiently, and often harmlessly, colonizes human skin. An obstacle to understanding this contradiction has been a shortage of in vivo models reproducing the unique structure and immunology of human skin. In this work, we developed a humanized model to study how healthy adult human skin responds to colonizing methicillin-resistant S. aureus (MRSA). We demonstrate the importance of the outer stratum corneum as the major site of bacterial colonization and how noninvasive MRSA adhesion to corneocytes induces a local inflammatory response in underlying skin layers. This signaling recruits neutrophils to the skin, where they control bacterial numbers, mediating transiency in colonization. This work highlights the spatiotemporal aspects of human skin colonization and demonstrates a subclinical inflammatory response to noninvasive MRSA that allows human skin to regulate the bacterial population at its outer surface.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available