Article
Biochemistry & Molecular Biology
Dariush Haghmorad, Bahman Yousefi, Majid Eslami, Ali Rashidy-Pour, Mahdieh Tarahomi, Maryam Jadid Tavaf, Azita Soltanmohammadi, Simin Zargarani, Aleksandr Kamyshnyi, Valentyn Oksenych
Summary: This study investigated the efficacy of oral administration of Myelin Oligodendrocyte Glycoprotein (MOG) in the treatment of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS). The results showed that MOG administration, both before and after EAE induction, efficiently controlled EAE development by modulating T cell proliferation and reducing pro-inflammatory cytokines.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiuli Lin, Yingying Liu, Lili Ma, Xiaomeng Ma, Liping Shen, Xueying Ma, Zhaoyu Chen, Hao Chen, Donghong Li, Zhumin Su, Xiaohong Chen
Summary: Constipation-induced gut microbiota dysbiosis exacerbates experimental autoimmune encephalomyelitis (EAE) by aggravating Treg/Th17 and Treg17/Teff17 imbalance and cytokines disturbance, which can be transferred via gut microbiota.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Ping Li, Zengli Guo, Yisong Y. Wan
Summary: Research has shown that SKI expression plays a critical role in the differentiation of pathogenic Th17 cells, and controlling SKI expression can modulate the function of these cells and treat Th17-related diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shishi Shen, Xi Cheng, Luyao Zhou, Yipeng Zhao, Hai Wang, Jie Zhang, Xiaobo Sun, Yuge Wang, Yaqing Shu, Yanteng Xu, Yu Tao, Mingqiang Li, Zhengqi Lu, Wei Cai, Guangjun Nie, Wei Qiu
Summary: This study developed neutrophil-derived nanovesicles (NNVs) to enhance the efficiency of myelin debris clearance in microglia for multiple sclerosis (MS) therapy. The results showed that NNVs treatment ameliorated lesional neuroinflammation and improved neurological functions and white matter integrity in a mouse model of MS. Additionally, NNVs treatment upregulated the expression of NRF2 in microglia and activated the transcription of RUBCN, leading to enhanced phagocytosis of myelin debris.
Article
Immunology
Matthew J. J. Butcher, Rama Krishna Gurram, Xiaoliang Zhu, Xi Chen, Gangqing Hu, Vanja Lazarevic, Keji Zhao, Jinfang Zhu
Summary: In this study, the researchers found that GATA3, a master transcription factor for Th2 cell differentiation, is also dynamically expressed in Th17 cells during their differentiation. Early deletion of Gata3 limited the pathogenicity of Th17 cells during EAE, while late deletion resulted in a failure to induce EAE symptoms. This highlights the critical role of GATA3 in promoting and maintaining the pathogenicity of T-bet-expressing Th17 cells in EAE.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Laetitia Pouzol, Nadege Baumlin, Anna Sassi, Melanie Tunis, Julia Marrie, Enrico Vezzali, Herve Farine, Ulrich Mentzel, Marianne M. Martinic
Summary: Current strategies for treating demyelinating diseases like multiple sclerosis focus on anti-inflammatory or immunomodulatory drugs. The CXCR7 receptor antagonist ACT-1004-1239 shows promise in reducing disease severity, decreasing neuroinflammation, and promoting myelin repair in experimental models.
Article
Immunology
Ling Xie, Jie Lv, Kaidireya Saimaier, Sanxing Han, Mengyao Han, Chun Wang, Guangyu Liu, Wei Zhuang, Xiangrui Jiang, Changsheng Du
Summary: TPN10518, an artemisinin derivative, protects against experimental autoimmune encephalomyelitis (EAE) by inhibiting the production of Th1 and Th17 cells through AP1 downregulation. This study suggests that TPN10518 could be a potential drug for the treatment of multiple sclerosis (MS).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rongbo Zhang, Jin Liu, Bin Xu, You Wu, Shunli Liang, Qiang Yuan
Summary: The study investigated the therapeutic effects of cornuside on EAE and its impact on Th17 and Treg cell infiltration. Cornuside showed anti-inflammatory and immunosuppressive effects, alleviating neurological deficits in EAE rats with Th17 cells possibly being one of its therapeutic targets.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Biochemistry & Molecular Biology
Zahra Maria, Emma Turner, Agnieshka Agasing, Gaurav Kumar, Robert C. Axtell
Summary: The study showed that pertussis toxin (PTX) significantly reduced Th17-EAE by inhibiting chemokine-receptor-dependent trafficking of Th17 cells and promoting the accumulation of B cells in the central nervous system. The data suggest that PTX inhibits the migration of pathogenic Th17 cells while promoting the accumulation of pathogenic B cells during Th17-EAE, providing useful information for adoptive-transfer Th17-EAE and studying the pathogenic mechanisms of B cells in multiple sclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ling Xie, Kaidireya Saimaier, Chun Wang, Jingshu Yang, Mengyao Han, Jie Lv, Wei Zhuang, Guangyu Liu, Changsheng Du
Summary: Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system mediated by immune cells. The study of MS has significance for other autoimmune diseases. Research shows that Methyl Acetate (MA) can reduce disease severity in Experimental Autoimmune Encephalomyelitis (EAE) by reducing inflammation and demyelination, and increasing Th1 cells in the periphery while inducing chemokines CXCR3 expression. Additionally, MA alleviates intestinal inflammation in EAE mice by enhancing IL-10 and inhibiting IL-6 secretion, suggesting therapeutic implications for autoimmune diseases like MS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Microbiology
Paola Bianchimano, Graham J. Britton, David S. Wallach, Emma M. Smith, Laura M. Cox, Shirong Liu, Kacper Iwanowski, Howard L. Weiner, Jeremiah J. Faith, Jose C. Clemente, Stephanie K. Tankou
Summary: The study found that the antibiotic vancomycin can improve the disease in the mouse model of experimental autoimmune encephalomyelitis (EAE) by modulating the gut microbiota. Meanwhile, the elevated levels of the gut microbiota strain Anaerotruncus colihominis may be associated with recovery in multiple sclerosis patients.
Article
Immunology
Bing Han, Yan-Yan Zhang, Ze-Qing Ye, Yun Xiao, Javad Rasouli, Wen-Cheng Wu, Su-Min Ye, Xin-Yue Guo, Lin Zhu, Abdolmohamad Rostami, Li-Bin Wang, Yuan Zhang, Xing Li
Summary: It has been shown that MS patients have higher expression of CysLTR1 in their circulation and central nervous system, with the majority of CD4(+) T cells in MS lesions expressing CysLTR1. Among T-cell subsets, Th17 cells exhibit the highest expression of CysLTR1. Blocking CysLTR1 signaling can inhibit the development of Th17 cells, thus preventing and treating EAE.
Review
Immunology
Judith Derdelinckx, Patrick Cras, Zwi N. Berneman, Nathalie Cools
Summary: Antigen-specific therapy for multiple sclerosis aims to induce tolerance to myelin-derived antigens for more effective treatment, but faces challenges from clinical trials and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Laura Ghezzi, Claudia Cantoni, Gabriela Pinget, Yanjiao Zhou, Laura Piccio
Summary: The gut-brain axis refers to interactions between gut microbiota and nervous, immune, and endocrine systems, potentially playing a role in multiple sclerosis pathogenesis. Studies have shown that pwMS are more likely to exhibit altered microbiota and metabolites, with approaches such as antibiotics and fecal microbiota transplantation showing promising outcomes in preventing CNS inflammation. However, more research is needed to establish consistent results and large-scale randomized controlled trials are lacking in this area.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Ana L. Vivinetto, Clara Castanares, Constanza Garcia-Keller, Cristian Falcon, Anabela Palandri, Victoria Rozes-Salvador, Juan I. Rojas, Liliana Patrucco, Clara Monferran, Liliana Cancela, Edgardo Cristiano, Ronald L. Schnaar, Ana Lis Moyano, Pablo H. H. Lopen
Summary: The activation of MAG triggers clearance of Glutamate and induces a protective antioxidant response, safeguarding oligodendrocytes and nearby neurons from damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Infectious Diseases
Aline Cuenod, Martina Aerni, Claudia Bagutti, Banu Bayraktar, Efe Serkan Boz, Cynthia Beisert Carneiro, Carlo Casanova, Alix T. Coste, Peter Damborg, Dirk W. van Dam, Mehmet Demirci, Pavel Drevinek, Olivier Dubuis, Jose Fernandez, Gilbert Greub, Jaroslav Hrabak, Gulen Hurkal Yigitler, Jakub Hurych, Thoger Gorm Jensen, Geraldine Jost, Greetje A. Kampinga, Sonja Kittl, Christine Lammens, Claudia Lang, Reto Lienhard, Julie Logan, Carola Maffioli, Ivana Marekovic, Matthias Marschal, Jacob Moran-Gilad, Oliver Nolte, Michael Oberle, Michael Pedersen, Valentin Pfluger, Sigrid Pranghofer, Julia Reichl, Rob J. Rentenaar, Arnaud Riat, Belen Rodriguez-Sanchez, Camille Schilt, Ann-Kathrin Schlotterbeck, Jacques Schrenzel, Shani Troib, Elise Willems, Mandy Wootton, Dominik Ziegler, Adrian Egli
Summary: The study assessed the mass spectral quality (MSQ) of MALDI-TOF MS and identified simple workflow adaptations to improve it. The intervention of providing feedback and instructions on acquiring MALDI-TOF mass spectra showed improvements in MSQs.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Endocrinology & Metabolism
Maria Papageorgiou, Emmanuel Biver, Julie Mareschal, Nicholas Edward Phillips, Alexandra Hemmer, Emma Biolley, Nathalie Schwab, Emily N. C. Manoogian, Elena Gonzalez Rodriguez, Daniel Aeberli, Didier Hans, Caroline Pot, Satchidananda Panda, Nicolas Rodondi, Serge L. Ferrari, Tinh-Hai Collet
Summary: This study investigated the impact of time-restricted eating (TRE) versus standard dietary advice (SDA) on bone health. The results showed that TRE had no detrimental effects on bone health in the overall population, but in weight loss responders, it was associated with some bone-sparing effects compared with SDA.
Review
Nursing
Tarsila Vieceli, Sofia Tejada, Raquel Martinez-Reviejo, Tomas Pumarola, Jacques Schrenzel, Grant W. Waterer, Jordi Rello
Summary: This review summarizes the evidence of the impact of air pollution on the respiratory microbiome. It suggests that air pollution can alter the composition of respiratory microbiota, increase the colonization of pathogenic microorganisms, and contribute to the development of respiratory infections with antimicrobial resistance.
INTENSIVE AND CRITICAL CARE NURSING
(2023)
Article
Biochemistry & Molecular Biology
Florian Ruiz, Benjamin Peter, Jessica Rebeaud, Solenne Vigne, Valentine Bressoud, Martin Roumain, Tania Wyss, Yannick Yersin, Ingrid Wagner, Mario Kreutzfeldt, Marisa Pimentel Mendes, Camille Kowalski, Gael Boivin, Leonard Roth, Markus Schwaninger, Doron Merkler, Giulio G. Muccioli, Stephanie Hugues, Tatiana Petrova, Caroline Pot
Summary: The vasculature plays a critical role in regulating leukocyte trafficking into the central nervous system (CNS) during inflammatory diseases such as multiple sclerosis (MS). However, the impact of endothelial-derived factors on CNS immune responses is still unclear. This study investigates the role of Cholesterol-25-hydroxylase (Ch25h)-derived bioactive lipids in promoting neuroinflammation and reveals that Ch25h deficiency in CNS endothelial cells attenuates experimental autoimmune encephalomyelitis (EAE), a mouse model of MS.
Article
Clinical Neurology
Stephanie Meier, Eline A. J. Willemse, Sabine Schaedelin, Johanna Oechtering, Johannes Lorscheider, Lester Melie-Garcia, Alessandro Cagol, Muhamed Barakovic, Riccardo Galbusera, Suvitha Subramaniam, Christian Barro, Ahmed Abdelhak, Simon Thebault, Lutz Achtnichts, Patrice Lalive, Stefanie Muller, Caroline Pot, Anke Salmen, Giulio Disanto, Chiara Zecca, Marcus D'Souza, Annette Orleth, Michael Khalil, Arabella Buchmann, Renaud Du Pasquier, Ozgur Yaldizli, Tobias Derfuss, Klaus Berger, Marco Hermesdorf, Heinz Wiendl, Fredrik Piehl, Marco Battaglini, Urs Fischer, Ludwig Kappos, Claudio Gobbi, Cristina Granziera, Claire Bridel, David Leppert, Aleksandra Maleska Maceski, Pascal Benkert, Jens Kuhle
Summary: This study found that serum glial fibrillary acidic protein (sGFAP) and serum neurofilament light chain (sNfL) are correlated with features of disease progression in multiple sclerosis (MS) and can predict disease progression. sGFAP may serve as a useful biomarker for disease progression in MS in individual patient management and drug development.
Article
Clinical Neurology
Amandine Mathias, Vasiliki Pantazou, Sylvain Perriot, Mathieu Canales, Samuel Jones, Larise Oberholster, Michael Moulin, Craig Fenwick, Raphael Bernard-Valnet, Marie Theaudin, Caroline Pot, Renaud A. Du Pasquier
Summary: This study aims to investigate the impact of ocrelizumab (OCRE) on immune cell subsets in patients with multiple sclerosis (pwMS). The results showed that OCRE not only depletes B cells, but also reduces memory CD8(+) T cells, which may increase the risk of infections. Therefore, clinicians should pay special attention to the increased infection risk when switching pwMS from other disease-modifying therapies (DMTs) to OCRE.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Review
Biochemistry & Molecular Biology
Patrice Francois, Jacques Schrenzel, Friedrich Goetz
Summary: Despite advances in medical procedures, staphylococci remain major pathogens causing disease, especially in patients with indwelling catheters and prosthetic devices. Biofilms produced by staphylococci increase resistance to treatment and host immunity. This review explores the composition and regulation of biofilm development, as well as its clinical significance. Recent studies on destroying biofilms as a therapeutic strategy are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Adele Rakotonirina, Tatiana Galperine, Maxime Audry, Marie Kroemer, Aurelie Baliff, Laurent Carrez, Farshid Sadeghipour, Jacques Schrenzel, Benoit Guery, Eric Allemann
Summary: Clostridioides difficile infection (CDI) is a severe nosocomial infection with a high mortality rate. Although antibiotic treatment is the standard of care, the relapse rate is high and less effective against recurrent infection. Fecal microbiota transplantation (FMT) is a recommended treatment with a high efficacy. The formulation of diluted donor stool needs innovation, and the administration routes should be optimized.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Genetics & Heredity
Aitana Neves, Daniel Walther, Trinidad Martin-Campos, Valerie Barbie, Claire Bertelli, Dominique Blanc, Gerard Bouchet, Frederic Erard, Gilbert Greub, Hans H. Hirsch, Michael Huber, Laurent Kaiser, Stephen L. Leib, Karoline Leuzinger, Vladimir Lazarevic, Mirjam Mausezahl, Jorge Molina, Richard A. Neher, Vincent Perreten, Alban Ramette, Tim Roloff, Jacques Schrenzel, Helena M. B. Seth-Smith, Roger Stephan, Dillenn Terumalai, Fanny Wegner, Adrian Egli
Summary: The SPSP is a secure platform that enables surveillance and monitoring of pathogens in human, veterinary, environmental, and foodborne sources. It utilizes whole genome sequencing data and metadata to quickly track and monitor the transmission and outbreak of pathogens. It provides controlled data access, complex dynamic queries, dedicated dashboards, and automated data sharing with international repositories, aiming to improve public health and societal well-being.
MICROBIAL GENOMICS
(2023)
Article
Microbiology
Florian Mauffrey, Nadia Gaia, Chiraz Chaabane, Gesuele Renzi, Adrien Fischer, Abdessalam Cherkaoui, Diane Bandeira, Jacques Schrenzel, Vladimir Lazarevic
Summary: We present the genome of a Neisseria meningitidis strain (GE-156) isolated from a bacteremia patient in Switzerland. This strain belongs to a rare mixed serogroup W/Y and sequence type 11847 (clonal complex 167), identified through both routine laboratory examination and genomic sequencing.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Letter
Critical Care Medicine
Sylvain Meyer, Nadia Gaia, Vladimir Lazarevic, Jacques Schrenzel, Bruno Francois, Olivier Barraud
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2023)
Editorial Material
Infectious Diseases
Aude Nguyen, Ludovica Ferrero, Vladimir Lazarevic, Nadia Gaia, Begona Martinez de Tejada, Jacques Schrenzel, Nadia Berkane
Summary: This article presents the first case of postpartum septic arthritis of the pubic symphysis caused by Sneathia sanguinegens, Sneathia vaginalis, and Mageeibacillus indolicus, identified using next generation sequencing.
NEW MICROBES AND NEW INFECTIONS
(2023)