Article
Public, Environmental & Occupational Health
Faaizah Arshad, Martijn J. Schuemie, Fan Bu, Evan P. Minty, Thamir M. Alshammari, Lana Y. H. Lai, Talita Duarte-Salles, Stephen Fortin, Fredrik Nyberg, Patrick B. Ryan, George Hripcsak, Daniel Prieto-Alhambra, Marc A. Suchard
Summary: The overall performance of serial testing was assessed using three administrative claims and one electronic health record database. The study compared different designs in terms of type I and II errors and found that the serial combination had fewer false-positive signals but more false-negative signals compared to the most sensitive method. Using a combination of historical comparator design and self-controlled case series analysis resulted in decreased sensitivity in evaluating safety signals compared to a one-stage SCCS approach. It is important to explore single epidemiological designs as valuable approaches to detecting signals.
Article
Surgery
Liam T. Synan, Mark A. Eid, Casey R. Lamb, Sandra L. Wong
Summary: There are variations in consumer ratings of hospitals between different online platforms, with Facebook ratings being more favorable than Google and Yelp. These ratings are correlated with Hospital Consumer Assessment of Healthcare Providers and Systems scores but not consistently with postsurgical patient safety indicators.
Article
Surgery
Mohammed Banat, Johannes Wach, Abdallah Salemdawod, Gregor Bara, Ehab Shabo, Jasmin E. Scorzin, Martin Mueller, Hartmut Vatter, Lars Eichhorn
Summary: This study evaluates the early clinical outcomes of patients whose antithrombotic therapy was interrupted during spinal surgery, and the results show that surgery can be safely performed in patients with interrupted antithrombotic therapy.
FRONTIERS IN SURGERY
(2022)
Review
Medicine, General & Internal
Kevin T. Kavanagh, Lindsay E. Cormier
Summary: Promoting and maintaining patient safety in primary care requires different strategies and monitoring than utilized in large healthcare delivery systems. Providing a safe environment and maintaining a culture of safety are key factors in primary care, especially in rural settings. Patient involvement and monitoring are crucial for ensuring patient safety in primary care.
Review
Medicine, General & Internal
Sofia Guerra-Paiva, Maria Joao Lobao, Joao Diogo Simoes, Helena Donato, Irene Carrillo, Jose Joaquin Mira, Paulo Sousa
Summary: This study aims to investigate the effective implementation of healthcare worker support interventions for those physically and emotionally affected by patient safety incidents. The scoping review will identify key factors and provide a comprehensive search strategy and quality assessment tool.
Article
Pharmacology & Pharmacy
J. Hasford, F. Bruchmann, M. Lutz, P. Thuermann, S. Schmiedl
Summary: During the study period, a total of 13,515 patient reports were received, including 29,529 ADRs, with serious ADRs (SADRs) accounting for 4.5%. Women were affected in more than two-thirds of ADR reports. The most common patient-reported ADRs were nausea, dizziness, and headache, while arrhythmia, intestinal obstruction, and erectile dysfunction were the most frequent SADRs.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Health Care Sciences & Services
Lysanne Rivard, Pascale Lehoux, Hassane Alami
Summary: Health innovators generally support patient-driven initiatives but also call for the involvement of professionals with complementary skills and knowledge. They see Nightscout as a high-risk DIY solution that requires expert involvement and e-NABLE as a low-risk solution that fills a hard-to-meet gap.
BMJ QUALITY & SAFETY
(2021)
Article
Management
Li Li, Hsin-Hung Wu, Chih-Hsuan Huang, Yuanyang Zou, Xiao Ya Li
Summary: This study investigates the antecedents of patient safety culture among medical staff in China. The results show that working conditions, teamwork climate, and job satisfaction have significant positive effects on patient safety culture. Hospital managers should focus on these factors to improve the quality of medical services and patient safety.
Article
Public, Environmental & Occupational Health
David Healy, Dee Mangin, Jonathan Lochhead
Summary: This study investigates and describes the range and impact of adverse visual effects associated with serotonin reuptake inhibiting antidepressants. The data suggest that these drugs can cause various visual problems, some of which may persist after discontinuation of the medication.
INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE
(2022)
Article
Health Care Sciences & Services
Jessica Gaber, Julie Datta, Rebecca Clark, Larkin Lamarche, Fiona Parascandalo, Stephanie Di Pelino, Pamela Forsyth, Doug Oliver, Dee Mangin, David Price
Summary: This study examines the implementation of the Health TAPESTRY program in six communities in Ontario, Canada, and identifies differences in the implementation process. The study emphasizes the importance of context and local culture in shaping the implementation of complex interventions. The findings highlight the impact of community size, primary care practice size, and linkages between program elements on implementation outcomes. The study suggests the need for early engagement of stakeholders, clear role definition, and consideration of community and practice size in future implementation efforts.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Health Care Sciences & Services
Richard L. Morrow, Barbara Mintzes, Patrick C. Souverein, Marie L. De Bruin, Elizabeth Ellen Roughead, Joel Lexchin, Anna Kemp-Casey, Lorri Puil, Ingrid Sketris, Dee Mangin, Christine E. Hallgreen, Sallie-Anne Pearson, Ruth Lopert, Lisa Bero, Richard Ofori-Asenso, Danijela Gnjidic, Ameet Sarpatwari, Lucy T. Perry, Colin R. Dormuth
Summary: This study evaluated the association between regulatory drug safety advisories and changes in drug utilisation in four countries (Canada, Denmark, the UK, and the USA) from 2009 to 2015. The results showed that the impact of drug safety advisories on drug utilisation was variable, with an overall modest association.
BMJ QUALITY & SAFETY
(2022)
Correction
Economics
Caroline S. Clarke, Larisa Duffy, Glyn Lewis, Nick Freemantle, Simon Gilbody, Tony Kendrick, David Kessler, Michael King, Paul Lanham, Derelie Mangin, Michael Moore, Irwin Nazareth, Nicola Wiles, Louise Marston, Rachael Maree Hunter
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2022)
Article
Economics
Caroline S. Clarke, Larisa Duffy, Glyn Lewis, Nick Freemantle, Simon Gilbody, Tony Kendrick, David Kessler, Michael King, Paul Lanham, Derelie Mangin, Michael Moore, Irwin Nazareth, Nicola Wiles, Louise Marston, Rachael Maree Hunter
Summary: This study conducted a cost-utility analysis of discontinuing long-term antidepressant medication in currently well patients, using patient-level trial data. The findings suggest that discontinuation of antidepressants is unlikely to be cost effective compared with maintenance for preventing relapse. The study provides information that can facilitate shared patient-clinician decision making.
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2022)
Article
Public, Environmental & Occupational Health
David Healy, Audrey Bahrick, Maarten Bak, Angelo Barbato, Rocco Salvatore Calabro, Barbara M. Chubak, Fiammetta Cosci, Antonei B. Csoka, Barbara D'Avanzo, Silvia Diviccaro, Silvia Giatti, Irwin Goldstein, Heiko Graf, Wayne J. G. Hellstrom, Michael S. Irwig, Emmanuele A. Jannini, Paddy K. C. Janssen, Mohit Khera, Manoj Therayil Kumar, Joanna Le Noury, Michal Lew-Starowicz, David E. J. Linden, Celine Luning, Dee Mangin, Roberto Cosimo Melcangi, Omar Walid Muquebil Ali Al Shaban Rodriguez, Jalesh N. Panicker, Arianna Patacchini, Amy M. Pearlman, Caroline F. Pukall, Sanjana Raj, Yacov Reisman, Rachel S. Rubin, Rudy Schreiber, Stuart Shipko, Barbora Vaseckova, Ahad Waraich
Summary: This study aimed to develop diagnostic criteria for post-SSRI sexual dysfunction, persistent genital arousal disorder, post-finasteride syndrome, and post-retinoid sexual dysfunction. The criteria were agreed upon for each condition, and the study concluded that these criteria will be helpful in clinical and research settings.
INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE
(2022)
Article
Geriatrics & Gerontology
Amy Theresa Page, Kathleen Potter, Vasi Naganathan, Sarah Hilmer, Andrew J. McLachlan, Richard Lindley, Tracy Coman, D. Mangin, Christopher Etherton-Beer
Summary: This study analyzed medication regimens used by older people living in residential aged care facilities and found that almost all residents experienced potentially suboptimal prescribing, with the majority having highly complex medication regimens. These findings suggest that most older people in residential aged care facilities may be at risk of medication-related harm.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Primary Health Care
Dee Mangin, Larkin Lamarche, Doug Oliver, Gord Blackhouse, Sivan Bomze, Sayem Borhan, Tracey Carr, Rebecca Clark, Julie Datta, Lisa Dolovich, Jessica Gaber, Pamela Forsyth, Michelle Howard, Sarah Marentette-Brown, Cathy Risdon, Samina Talat, Jean-eric Tarride, Lehana Thabane, Ruta Valaitis, David Price
Summary: Health TAPESTRY was successfully implemented in diverse primary care practices for older adults. However, the implementation did not reproduce the effects on hospitalizations and physical activity found in the initial randomized controlled trial.
ANNALS OF FAMILY MEDICINE
(2023)
Article
Geriatrics & Gerontology
Hui Wen Quek, Christopher Etherton-Beer, Amy Page, Andrew J. McLachlan, Sarita Y. Lo, Vasi Naganathan, Leanne Kearney, Sarah N. Hilmer, Tracy Comans, Derelie Mangin, Richard Lindley, Kathleen Potter
Summary: This study aimed to investigate pharmacist deprescribing recommendations for residents in aged care facilities, the acceptance of these recommendations by doctors, and the actual implementation of the accepted recommendations at 12-month follow-up. The results showed that 77% of deprescribing recommendations were accepted by doctors, and 74% of the accepted recommendations were successfully implemented. The most common reason for deprescribing was medication no longer being needed. Pharmacist-led deprescribing recommendations based on an algorithm-based medication review are acceptable to doctors and can significantly reduce inappropriate medication use in aged care facilities.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Medicine, General & Internal
Dee Mangin, Jennifer Lawson, Cathy Risdon, Henry Yu-Hin Siu, Tamar Packer, Sabrina T. Wong, Michelle Howard
Summary: This study aims to investigate the associations between frailty levels and chronic conditions and socioeconomic status. The study found that as frailty levels increased, the prevalence of chronic diseases also increased, and there were significant associations with low income and high material deprivation in the community. Therefore, the study emphasizes the need for a health equity approach in frailty care, and demonstrates the utility and feasibility of collecting patient-level data in primary care to provide targeted interventions for those with the greatest need.
Article
Medicine, Research & Experimental
Dee Mangin, Larkin Lamarche, Gina Agarwal, Abbas Ali, Alan Cassels, Kiska Colwill, Lisa Dolovich, Naomi Dore Brown, Barbara Farrell, Karla Freeman, Kristina Frizzle, Scott R. Garrison, James Gillett, Anne Holbrook, Jane Jurcic-Vrataric, James McCormack, Jenna Parascandalo, Julie Richardson, Cathy Risdon, Diana Sherifali, Henry Siu, Sayem Borhan, Jeffery A. Templeton, Lehana Thabane, Johanna Trimble
Summary: The purpose of this study was to determine the feasibility of implementing an operationalized clinical pathway aimed to reduce polypharmacy in primary care and to pilot measurement tools suitable for assessing change in health outcomes in a larger RCT. Results from this feasibility study indicate that the clinical pathway for reducing polypharmacy is feasible to implement in a primary care team setting and in an RCT research framework.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Education, Scientific Disciplines
Barbara Farrell, Lalitha Raman-Wilms, Cheryl A. Sadowski, Laurie Mallery, Justin Turner, Camille Gagnon, Mollie Cole, Allan Grill, Jennifer E. Isenor, Dee Mangin, Lisa M. McCarthy, Brenda Schuster, Caroline Sirois, Winnie Sun, Ross Upshur
Summary: The article presents a proposed pre-licensure competency framework that outlines essential knowledge, teaching strategies, and assessment protocols to enhance interprofessional deprescribing skills. It also emphasizes the inclusion of patients and care partners in deprescribing decisions and provides an action plan and curriculum mapping exercise for educators to evaluate and integrate these concepts and strategies into their programs. The goal is to ensure that learners graduate with the necessary competencies to manage complex medication regimens as individuals age.
MEDICAL SCIENCE EDUCATOR
(2023)
Article
Geriatrics & Gerontology
Dee Mangin, Larkin Lamarche, Jeffrey A. Templeton, Jennifer Salerno, Henry Siu, Johanna Trimble, Abbas Ali, Jobin Varughese, Amy Page, Christopher Etherton-Beer
Summary: Polypharmacy, especially among older adults, poses significant health risks due to disease-drug and drug-drug interactions, side effects from multiple medications, and patient burden. Current single-disease clinical guidelines fail to address the complexity of optimizing treatments for patients with multiple conditions and medications. Efforts to develop interventions to reduce these risks have shown promise, but their theoretical basis is unclear or inadequately described. Understanding the theoretical basis is critical for interpreting effects and achieving effectiveness.
Article
Health Care Sciences & Services
Dee Mangin, Larkin Lamarche, Karla Freeman, Abbas Ali, Rebecca Clark, Nikki Shah, Amen Awan, Jessica Langevin, Jenna Parascandalo, Naomi Dore Brown, Jane Jurcic-Vrataric, Kiska Colwill, Steven Dragos, Sayem Borhan, Cathy Risdon, Henry Siu, Barbara Farrell, Johanna Trimble
Summary: Polypharmacy is associated with poorer health outcomes in older adults. Integrating patient input can balance the harmful effects of medications while maximizing benefits. This study aims to understand the goals, priorities, and preferences of participants and apply them to medication recommendations.
JOURNAL OF PATIENT EXPERIENCE
(2023)
Article
Primary Health Care
Shireen Fikree, Shuaib Hafid, Jennifer Lawson, Gina Agarwal, Lauren E. Griffith, Liisa Jaakkimainen, Dee Mangin, Michelle Howard
Summary: This study assessed the impact of the SARS-COV-2 pandemic on primary care management of older adults with common chronic conditions. The results showed that there was no notable change in the frequency of chronic condition care overall or among higher-risk patients during the first 14 months of the pandemic.
