Article
Biochemistry & Molecular Biology
Maomao He, Ran Wang, Peiyuan Wan, Hexiang Wang, Yi Cheng, Pengcheng Miao, Zhiyong Wei, Xuefei Leng, Yang Li, Jianjun Du, Jiangli Fan, Wen Sun, Xiaojun Peng
Summary: A biodegradable Ru-containing polymer with high drug loading capacity has been developed for effective release of anticancer drug and inhibition of tumor growth under light stimulation. The method shows good biocompatibility and opens up opportunities for multi-therapeutic agent delivery and enhanced phototherapy.
Article
Chemistry, Multidisciplinary
Yuman Dong, Peng Liu
Summary: This study synthesized an amphiphilic triblock copolymer prodrug with pH/reduction dual-triggered drug delivery for tumor treatment, which showed reduced premature drug leakage and selective cytotoxicity to cancer cells.
Article
Engineering, Biomedical
Abdul Hakim Md Yusop, Ahmed Alsakkaf, Muhammad Azfar Noordin, Hasbullah Idris, Hadi Nur, Fatihhi Szali Januddi
Summary: This work investigates the drug-release control by degradation from biodegradable metallic surfaces. Curcumin-coated zinc had a higher degradation rate and a higher curcumin release compared to curcumin-coated iron, due to its different degradation structure. The unique degradation behaviors of degradable metallic surfaces can directly influence drug release without the need for external electrical stimulus.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Polymer Science
Tingyu He, Atsushi Narumi, Yanqiu Wang, Liang Xu, Shin-ichiro Sato, Xiande Shen, Toyoji Kakuchi
Summary: A synthetic method for a series of poly(glycidol)-based amphiphilic block copolymers was presented with controlled ring-opening polymerization, leading to well-defined diblock copolymers. These block copolymers demonstrated excellent micelle-forming properties in aqueous media, indicating their potential use in drug delivery systems or other applications.
Article
Instruments & Instrumentation
Shuanghu Wang, Xueying Tan, Quan Zhou, Peiwu Geng, Jinhui Wang, Ping Zou, Aiping Deng, Jingbo Hu
Summary: The study successfully constructed folate-targeted polymeric micellar carrier for co-delivery of doxorubicin (DOX) and SIS3 (FA/DOX/SIS3 micelles) to sensitize drug-resistant cancer cells, demonstrating superior anti-tumor activity and longer circulation time in blood, preferential accumulation in resistant tumor tissue. The FA/DOX/SIS3 micelles showed promising potential for synergistic treatment of drug-resistant tumors.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yi Li, Hong Yu Yang, Doo Sung Lee
Summary: Injectable hydrogels are a unique type of hydrogels formed upon injection into living bodies, with various features and potential applications. Biodegradability is an important property of injectable hydrogels, allowing removal after tasks completion.
Article
Multidisciplinary Sciences
Xin Li, Laura Hetjens, Nadja Wolter, Helin Li, Xiangyang Shi, Andrij Pich
Summary: In this study, lysozyme-responsive microgels were developed for the treatment of inflammatory bowel disease. Compared to other pH-responsive carriers, lysozyme-responsive microgels can better identify healthy and inflamed intestines, achieving effective treatment with fewer side effects.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Miusi Shi, Kevin J. McHugh
Summary: The global pharmaceutical market has seen a shift in focus towards peptide, protein, and nucleic acid drugs, which now dominate the top-selling pharmaceutical products. While these biologics offer advantages such as improved drug specificity and enhanced efficacy, they also pose challenges including increased degradation and the need for frequent administration via invasive routes. Controlled-release systems have the potential to address these challenges by providing better control over drug levels, targeting specific tissues, and reducing administration frequency. However, adapting controlled-release devices for biologics has proven challenging due to their poor stability.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Polymer Science
Xianshuo Zhang, Peipei Wang, Yaoyu Xu, Jun Wang, Yunfeng Shi, Wenxu Niu, Wenjing Song, Ruru Liu, Cui-Yun Yu, Hua Wei
Summary: A robust yet facile strategy for the synthesis of biodegradable hyperbranched amphiphilic copolymers is reported in this study. The block-statistical structure is identified as a better polymer architecture for controlled release applications.
Article
Materials Science, Biomaterials
Yue Ding, Yuxuan Ma, Lvming Zhu, Yue Xu, Chenwei Wang, Bing Lu, Yang Wang, Chang Du, Yong Yao
Summary: A supramolecular polypeptide nanomedicine was constructed to co-deliver doxorubicin and indocyanine green for drug resistance reversal. The generation of NO upon NIR irradiation down-regulated P-gp expression level and enhanced the tumoricidal potential through photothermal therapy. This nanomedicine provides an effective strategy to overcome multidrug resistance.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Biochemical Research Methods
Jean Felix Mukerabigwi, Rui Tang, Yufei Cao, Fathelrahman Mohammed, Qinghao Zhou, Min Zhou, Zhishen Ge
Summary: Multi-drug resistance (MDR) is a major obstacle in cancer therapy, and overcoming MDR is highly desired. The development of a polyprodrug that can target both cancer cells and mitochondria has shown great potential in reversing MDR. The polyprodrug, named TF@CNM + DOX, was designed using folic acid (FA) and tetraphenylphosphonium (TPP) targeting moieties to sequentially deliver CNM and DOX to cancer cells and mitochondria, respectively. This dual-targeting approach enhances intracellular oxidative stress and enables ROS-responsive drug release, effectively inhibiting the growth of DOX-resistant tumors.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Engineering, Biomedical
Yang Wu, Guiyun Deng, Kai Jiang, Huajuan Wang, Zhiyong Song, Heyou Han
Summary: An intelligent NO nanogenerator triggered by NIR light was constructed for targeted treatment of P. aeruginosa bacterial infection, achieving accurate release of therapeutic drugs at the infection site. In vivo experiments showed a 97.7% reduction in bacterial burden, along with promotion of growth factor secretion and regulation of inflammation and angiogenesis. This multifunctional antibacterial platform has potential for treating drug-resistant bacterial infections due to its efficient gas release performance.
Article
Polymer Science
Dandan Xia, Feilong Wang, Shuo Pan, Shenpo Yuan, Yunsong Liu, Yongxiang Xu
Summary: Biodegradable nanoparticles and micelles are potential nanosystems for targeted drug delivery of potent anticancer drugs. By developing redox/pH dual-responsive nanoparticles using specialized polymers, efficient drug release can be achieved, with the surface charges of the nanoparticles reversible through different mass ratios of the polymers.
Article
Chemistry, Multidisciplinary
Xianxian Yao, Danyang Chen, Bin Zhao, Binru Yang, Zhaokui Jin, Mingjian Fan, Geru Tao, Shucun Qin, Wuli Yang, Qianjun He
Summary: The development of stimuli-responsively degradable porous carriers for controlled drug release is important for clinical translation. In this study, a new type of Fe-MOF nanocrystals is engineered as an acid-degradable drug carrier and hydrogen donor. Fe-MOF nanocrystals exhibit acid-responsive degradation for H-2 generation and simultaneous drug release, and can effectively inhibit cancer metastasis and sensitize MDR cancer cells for enhanced chemotherapy. The high anti-MDR/antimetastasis efficacies and biocompatibility make Fe-MOF nanocrystals and Fe-MOF-based nanomedicine highly promising for clinical translation.
Article
Engineering, Biomedical
Chenyi Huang, Jia Tang, Yuanqi Liu, Ting Chen, Junyang Qi, Shengjie Sun, Huisong Hao, Weiwei Zeng, Jing Zhao, Meiying Wu
Summary: This study developed a multifunctional nanocatalyst Cu-doped polypyrrole (CuP) as an intelligent nanoplatform to deliver the NO precursor BNN6 and specifically release NO in tumors. Through the synergistic effect of hyperthermia, oxidative damage, and NO burst, almost complete tumor elimination is achieved in vivo.
ACTA BIOMATERIALIA
(2023)