Article
Obstetrics & Gynecology
M. L. Marinovich, A. K. Regan, M. Gissler, M. C. Magnus, S. E. Haberg, J. A. Mayo, G. M. Shaw, J. Bell, N. Nassar, S. Ball, A. T. Gebremedhin, C. Marston, N. de Klerk, A. P. Betran, A. M. Padula, G. Pereira
Summary: The effect of interpregnancy interval (IPI) on preterm birth (PTB) varies depending on whether the previous birth was preterm or term. Short and long IPIs are associated with higher risk of PTB after a previous PTB, suggesting a potentially modifiable risk factor for women with a history of PTB.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Jaimin S. Shah, Yael Eliner, Denis A. Vaughan, Blair J. Wylie, Ann Korkidakis, Angela Q. Leung, Alan S. Penzias, Denny Sakkas, Thomas L. Toth
Summary: The interpregnancy interval has an impact on perinatal outcomes, and this impact is influenced by the mode of conception. An interpregnancy interval of less than 12 months is associated with an increased risk of preterm birth and low birth weight, while IVF conception is not associated with these increased risks.
FERTILITY AND STERILITY
(2022)
Article
Public, Environmental & Occupational Health
Kanami Tanigawa, Satoyo Ikehara, Meishan Cui, Yoko Kawanishi, Tadashi Kimura, Kimiko Ueda, Kazumasa Yamagishi, Hiroyasu Iso
Summary: Both short and long interpregnancy intervals (IPIs) are associated with an increased risk of preterm birth, especially in women with inadequate intake of dietary folate and folic acid supplementation during pregnancy. These findings are based on a nationwide birth cohort study conducted in Asia.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Nutrition & Dietetics
Julie M. Petersen, Mahsa M. Yazdy, Kelly D. Getz, Marlene T. Anderka, Martha M. Werler
Summary: The study found that short interpregnancy intervals were associated with several birth defects, especially in the absence of folic acid (FA) supplement use. Among participants using any FA supplement, the risk of defects comparing <6 months with 6-23 months was lower.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Public, Environmental & Occupational Health
Amanuel T. Gebremedhin, Annette K. Regan, Siri E. Haberg, M. Luke Marinovich, Gizachew A. Tessema, Gavin Pereira
Summary: This study investigated the impact of adverse pregnancy outcomes on subsequent interpregnancy intervals (IPIs) and whether this effect varied with IPI distribution. It found that mothers with preeclampsia and gestational hypertension had slightly longer IPIs than those without these complications, but the delay was small (< 2 mo).
ANNALS OF EPIDEMIOLOGY
(2023)
Review
Medicine, General & Internal
Yumei Wang, Can Zeng, Yuhong Chen, Liu Yang, Di Tian, Xinghui Liu, Yonghong Lin
Summary: Short interpregnancy interval (IPI < 6 months) can result in adverse perinatal outcomes, while it is not a risk factor for gestational diabetes and gestational hypertension.
FRONTIERS IN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Katie Gifford, Mary Joan McDuffie, Hira Rashid, Erin K. Knight, Rebecca McColl, Michel Boudreaux, Michael S. Rendall
Summary: Women covered by Medicaid who received postpartum long-acting reversible contraceptive methods had significantly lower likelihood of a short interpregnancy interval resulting in a birth compared to those who did not use contraception or used moderately effective methods. The evidence supports the effectiveness of recent state policy changes in promoting postpartum LARC access for desired birth intervals.
Article
Medicine, General & Internal
Dvora Kluwgant, Tamar Wainstock, Eyal Sheiner, Gali Pariente
Summary: Placenta previa, multiple gestations, and placental abruption were identified as the strongest risk factors for extreme preterm birth. Risk factors including placental abruption and previa, lack of prenatal care, and recurrent pregnancy loss were observed in sub-populations with multiple gestations, previous PTB, and indicated PTBs. Placental abruption emerged as the most significant risk factor across all groups, with no significant differences observed between sub-populations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Karen J. Gibbins, Bharti Garg, Aaron B. Caughey
Summary: This study used a retrospective cohort of 5,581 individuals to investigate the association between interpregnancy interval (IPI) after stillbirth and various pregnancy outcomes. The findings suggest that none of the IPI categories, including the shortest one, were associated with an increased risk of adverse perinatal outcomes.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Can Liu, Jonathan M. Snowden, Deirdre J. Lyell, Elizabeth Wall-Wieler, Barbara Abrams, Peiyi Kan, Olof Stephansson, Audrey Lyndon, Suzan L. Carmichael
Summary: The study found that longer interpregnancy intervals were associated with an increased risk of severe maternal morbidity, potentially due to the health status during the interpregnancy period. The association did not vary significantly by maternal age or parity.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Computer Science, Information Systems
Ilia Rattsev, Natalie Flaks-Manov, Angie C. Jelin, Jiawei Bai, Casey Overby Taylor
Summary: This study developed a 4-step framework using a clinical phenotyping tool to assess risk factors for recurrent preterm birth, showing that the models stratified by delivery subtype performed better in predicting preterm birth risk.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Obstetrics & Gynecology
Sarah Cunningham, C. E. Algeo, E. A. DeFranco
Summary: In a population-based cohort study on all live births in Ohio from 2006 to 2012, the independent influence of interpregnancy interval (IPI) on uterine rupture was assessed. Of the 1,034,522 live births, 249 cases of uterine rupture were identified, with two-thirds occurring in women with a history of prior cesarean section. The study found that an IPI of 24-59 months was associated with the lowest frequency of uterine rupture, while IPI of 12-23 months and 60 months or more showed no significant association with the risk of uterine rupture.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Gizachew A. Tessema, M. Luke Marinovich, Siri E. Haberg, Mika Gissler, Jonathan A. Mayo, Natasha Nassar, Stephen Ball, Ana Pilar Betran, Amanuel T. Gebremedhin, Nick de Klerk, Maria C. Magnus, Cicely Marston, Annette K. Regan, Gary M. Shaw, Amy M. Padula, Gavin Pereira
Summary: The study found a consistent increase in the risk of adverse birth outcomes with long interpregnancy intervals, and a possible increase in the risk of spontaneous preterm birth with short intervals. However, there is insufficient evidence for the increased risk of other adverse birth outcomes. Waiting at least 24 months before conceiving again may be unnecessarily long in high-income countries.
Article
Obstetrics & Gynecology
Ellen Kupka, Susanne Hesselman, Roxanne Hastie, Riccardo Lomartire, Anna Karin Wikstrom, Lina Bergman
Summary: This study aimed to investigate the association between low-dose aspirin use and preterm birth among women with a previous preterm birth. A Swedish register-based cohort study found that low-dose aspirin use was associated with a reduced risk of preterm birth, particularly in spontaneous preterm births.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Medicine, General & Internal
Guoshuai Shi, Binyan Zhang, Yijun Kang, Shaonong Dang, Hong Yan
Summary: The study showed that both short and long interpregnancy intervals are associated with an increased risk of adverse birth outcomes. Short intervals were linked to a higher risk of small for gestational age and birth defects, while long intervals were associated with a higher risk of low birth weight and preterm birth. The relationship between interpregnancy interval and birth outcomes was non-linear, with different patterns observed for different outcomes.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Developmental Biology
Bo Yu, Chiyuan Amy Zhang, Shufeng Li, Tony Chen, Evan Mulloy, Gary M. Shaw, Michael L. Eisenberg
Summary: This study investigated the association between preconception paternal health and birth defects in offspring. The results showed that infants born to fathers with metabolic syndrome were more likely to have cardiac and respiratory defects.
BIRTH DEFECTS RESEARCH
(2023)
Article
Developmental Biology
Jonas G. Miller, Mahnoor Hyat, Susan B. Perlman, Ronald J. Wong, Gary M. Shaw, David K. Stevenson, Ian H. Gotlib
Summary: Exposure to adversity has negative effects on cognitive, behavioral, and mental health, and may even be transmitted across generations. Research shows that maternal exposure to adversity, including prior to childbirth, is related to offspring biobehavioral development. A study on preschool-age children found that maternal adversity was associated with brain activation during inhibitory control, which in turn affected children's emotions and self-control.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
Article
Environmental Sciences
Kari A. Weber, Wei Yang, Suzan L. Carmichael, R. Thomas Collins, Thomas J. Luben, Tania A. Desrosiers, Tabassum Z. Insaf, Mimi T. Le, Shannon Pruitt Evans, Paul A. Romitti, Mahsa M. Yazdy, Wendy N. Nembhard, Gary M. Shaw
Summary: This study examined the association between maternal residential proximity to greenspace and structural birth defects. The results showed that living closer to greenspace during pregnancy is associated with a reduced risk of certain birth defects, especially among those living in rural or high-income neighborhoods.
ENVIRONMENTAL RESEARCH
(2023)
Article
Oncology
Wayne R. Lawrence, Jasmine A. McDonald, Faustine Williams, Meredith S. Shiels, Neal D. Freedman, Ziqiang Lin, Jared W. Magnani
Summary: Chronic stress is hypothesized to be associated with breast cancer, but previous studies have shown mixed results. This study examined the association between self-reported stressful life events and incident breast cancer in postmenopausal women, taking into account estrogen receptor (ER) status and social support. The results showed that there was no relationship between stressful life events and ER-positive breast cancer, but there was an increased risk of ER-negative breast cancer in women with higher levels of stressful life events. This association was stronger in widowed women. Social support did not modify the relationship between stressful life events and ER-negative breast cancer.
CANCER PREVENTION RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Dayna A. Neo, Tania L. Desrosiers, Chantel L. Martin, Suzan Carmichael, Muge M. Gucsavas-Calikoglu, Kristin Conway, Shannon Pruitt L. Evans, Marcia M. Feldkamp, Suzanne Z. Gilboa, Tabassum I. Insaf, Fadi M. Musfee, Gary J. Shaw, Charles M. Shumate, Martha F. Werler, Andrew Olshan
Summary: This study explores the association between neighborhood-level socioeconomic position during early pregnancy and the risk of gastroschisis, a common birth defect. The results suggest that mothers residing in moderate or low socioeconomic neighborhoods are more likely to have infants with gastroschisis compared to those residing in high socioeconomic neighborhoods.
Correction
Pediatrics
Nicholas Crawford, D'Arcy Prendergast, John W. Oehlert, Gary M. Shaw, David K. Stevenson, Nadav Rappaport, Marina Sirota, Sarah A. Tishkoff, Neal Sondheimer
JOURNAL OF PEDIATRICS
(2023)
Article
Genetics & Heredity
Kelsey Robinson, Trenell J. Mosley, Kenneth S. Rivera-Gonzalez, Christopher R. Jabbarpour, Sarah W. Curtis, Wasiu Lanre Adeyemo, Terri H. Beaty, Azeez Butali, Carmen J. Buxo, David J. Cutler, Michael P. Epstein, Lord J. J. Gowans, Jacqueline T. Hecht, Jeffrey C. Murray, Gary M. Shaw, Lina Moreno Uribe, Seth M. Weinberg, Harrison Brand, Mary L. Marazita, Robert J. Lipinski, Elizabeth J. Leslie
Summary: Cleft palate is a common craniofacial birth defect, but there is limited understanding of its genetic risk factors. Through a genome-wide association study, we identified a significant genetic locus associated with cleft hard palate, as well as additional loci suggestive of association. This study provides important insights into the risk and subtype-specific risks of cleft palate.
HUMAN GENETICS AND GENOMICS ADVANCES
(2023)
Article
Genetics & Heredity
Elizabeth E. Blue, Janson J. White, Michael K. Dush, William W. Gordon, Brent H. Wyatt, Peter White, Colby T. Marvin, Emmi Helle, Tiina Ojala, James R. Priest, Mary M. Jenkins, Lynn M. Almli, Jennita Reefhuis, Faith Pangilinan, Lawrence C. Brody, Kim L. McBride, Vidu Garg, Gary M. Shaw, Paul A. Romitti, Wendy N. Nembhard, Marilyn L. Browne, Martha M. Werler, Denise M. Kay, Seema Mital, Jessica X. Chong, Nanette M. Nascone-Yoder, Michael J. Bamshad
Summary: Hypoplastic left heart syndrome (HLHS) is a severe congenital heart defect with unknown genetic basis. Variants in the CAPN2 gene have been found to be associated with increased risk of iHLHS, revealing a novel pathway in the pathogenesis of HLHS.
HUMAN GENETICS AND GENOMICS ADVANCES
(2023)
Article
Mathematical & Computational Biology
Mira N. Moufarrej, DianaW. Bianchi, Gary M. Shaw, David K. Stevenson, Stephen R. Quake
Summary: Prenatal screening using cell-free DNA sequencing has revolutionized obstetric care by reducing invasive diagnostic procedures. However, emergency care is still necessary for complications such as preeclampsia and preterm birth. Noninvasive prenatal testing has expanded the field of precision medicine in obstetrics. This review discusses advances, challenges, and potentials in providing proactive and personalized prenatal care, focusing on cell-free nucleic acids as well as other signals from metabolomics, proteomics, intact cells, and the microbiome. Ethical challenges in care provision are also discussed, along with the future possibilities of redefining disease taxonomy and establishing causal relationships.
ANNUAL REVIEW OF BIOMEDICAL DATA SCIENCE
(2023)
Review
Allergy
Sayantani B. Sindher, Andrew R. Chin, Nima Aghaeepour, Lawrence Prince, Holden Maecker, Gary M. Shaw, David K. Stevenson, Kari C. Nadeau, Michael Snyder, Purvesh Khatri, Scott D. Boyd, Virginia D. Winn, Martin S. Angst, R. Sharon Chinthrajah
Summary: The prevalence of food allergy is increasing globally, causing significant safety, economic, and emotional burdens. However, identifying patients who would benefit from preventive strategies is challenging due to the heterogeneity of allergy trajectories and clinical phenotypes. Further studies are needed to investigate the molecular mechanisms that differentiate these trajectories and drive food allergy development. Omics approaches have the potential to provide insights into these mechanisms, but their application in food allergy research is still in its early stages.
FRONTIERS IN ALLERGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Martin Becker, Huda Nassar, Camilo Espinosa, Ina A. Stelzer, Dorien Feyaerts, Eloise Berson, Neda H. Bidoki, Alan L. Chang, Geetha Saarunya, Anthony Culos, Davide De Francesco, Ramin Fallahzadeh, Qun Liu, Yeasul Kim, Ivana Maric, Samson J. Mataraso, Seyedeh Neelufar Payrovnaziri, Thanaphong Phongpreecha, Neal G. Ravindra, Natalie Stanley, Sayane Shome, Yuqi Tan, Melan Thuraiappah, Maria Xenochristou, Lei Xue, Gary Shaw, David Stevenson, Martin S. Angst, Brice Gaudilliere, Nima Aghaeepour
Summary: An open-source framework called CorALS is proposed to address the computational challenge of constructing large correlation networks in high-dimensional biological data. It enables the analysis of complex biological systems and is suitable for both personal and high-performance computers.
NATURE COMPUTATIONAL SCIENCE
(2023)
Meeting Abstract
Obstetrics & Gynecology
Danielle M. Panelli, Jonathan A. Mayo, Ronald J. Wong, Martin Becker, Ivana Maric, Erica Wu, Ian H. Gotlib, Nima Aghaeepour, Maurice L. Druzin, David K. Stevenson, Gary M. Shaw, Katherine Bianco
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Anne R. Waldrop, Yair J. Blumenfeld, Jonathan A. Mayo, Danielle M. Panelli, Sam Heft-Neal, Marshall Burke, Stephanie A. Leonard, Gary M. Shaw
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
