Article
Materials Science, Multidisciplinary
Changkai Yang, Yanping Huang, Nianhua Dan, Yining Chen
Summary: Introducing carboxylated halloysite nanotubes (HNTs) nanomaterials can improve the mechanical properties of collagen composite membranes. In this study, the grafting of polyglutamic acid (gamma-PGA) onto the surface of HNTs enhances the tensile strength and elongation at the break of the collagen membranes and inhibits the negative effects on hydrophilicity. The modified collagen-sodium alginate oxide composite membrane is non-toxic and promotes wound healing.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Medicine, Research & Experimental
Ruoyu Mu, Zhe Zhang, Congwei Han, Yiming Niu, Zhen Xing, Zhencheng Liao, Jinzhi Xu, Ningyi Shao, Guokai Chen, Junfeng Zhang, Lei Dong, Chunming Wang
Summary: Nonhealing diabetic wounds can be effectively healed by training macrophages to mimic the reparative functions of tumor-associated macrophages (TAMs), which produce immunosuppressive and proliferative factors. These TAM-educated macrophages (TAMEMs) outperform other macrophage phenotypes in reducing inflammation, promoting angiogenesis, and activating fibroblasts. A nine-factor cocktail has also been developed to train human primary monocytes into TAMEMs, enabling the preparation of safer and autologous cells. This study demonstrates the potential of recapitulating TAMs' reparative activities in non-tumor cells for regenerative medicine.
EMBO MOLECULAR MEDICINE
(2023)
Article
Hematology
Sean P. Heffron, Ada Weinstock, Bianca Scolaro, Shiyu Chen, Brian E. Sansbury, Greg Marecki, Christina C. Rolling, Hanane El Bannoudi, Tessa Barrett, James W. Canary, Matthew Spite, Jeffrey S. Berger, Edward A. Fisher
Summary: Platelet-conditioned media induces an anti-inflammatory, pro-resolving phenotype in macrophages. This effect is partially mediated by prostaglandin E2 stimulating the EP4 receptor on macrophages, leading to altered gene expression and function.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Engineering, Biomedical
Pedro U. Munoz-Gonzalez, Maria C. Lona-Ramos, Luis D. Gutierrez-Verdin, Guadalupe H. Luevano-Colmenero, Fernando Tenorio-Rocha, Rene Garcia-Contreras, Gerardo Gonzalez-Garcia, Argelia Rosillo-de la Torre, Jorge Delgado, Laura E. Castellano, Birzabith Mendoza-Novelo
Summary: The study evaluated the effects of oligourethane and colloidal silica particles on collagen material properties and skin wound healing in rats, concluding that collagen-based composite dressings have promising modulatory effects in skin wound healing.
BIOMEDICAL MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Wei Peng, Dan Li, Kaili Dai, Yixi Wang, Ping Song, Hairui Li, Pei Tang, Zhenyu Zhang, Zhengyong Li, Yuchi Zhou, Changchun Zhou
Summary: This review summarizes the recent progress in skin repair and wound dressing regeneration biomaterials research, including clinical research, classification, composition, performance, and biological function characteristics of different biomaterials. The future development direction is also discussed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Feng Xie, Liangyu Zou, Zikai Xu, Xiaolan Ou, Wenlai Guo, Yang Gao, Guanghui Gao
Summary: A new foam gel wound dressing with rapid hemostasis and antibacterial properties is reported in this study. The dressing is composed of chitooligosaccharide modified graphene oxide nanocomposites and calcium alginate foam substrate. Experimental results show that the dressing can stop bleeding quickly and accelerate wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Article
Chemistry, Physical
Marta Michalska-Sionkowska, Oliwia Warzynska, Beata Kaczmarek-Szczepanska, Krzysztof Lukowicz, Anna Maria Osyczka, Maciej Walczak
Summary: The study analyzed the influence of beta-glucan on collagen material, finding that the addition of beta-glucan can increase the roughness of the material's surface, making it more rigid and providing a more hydrophilic character. All materials showed antioxidant activity and did not cause erythrocyte hemolysis.
Article
Biochemistry & Molecular Biology
Huda S. AlSalem, Abeer Abdulaziz H. Bukhari
Summary: Three biodegradable wound dressings were successfully prepared using freeze drying technique. The dressings were based on binary Collagen (COL), Hyaluronic acid (HA) crosslinked and loaded with silver nanoparticles (AgNPs), Gentamicin (GENT), or AgNPs/GENT. The dressings showed physically interaction between polymer network and the loaded antibiotic, superior swelling properties, and rapid degradation. They exhibited antibacterial activity against G+, G-, yeast, and fungi. Cytotoxicity and wound healing evaluations showed superior results for all dressings except the one mixed with AgNPs and Gentamicin. The results recommended individually loaded COL/HA with either AgNPs or Gentamicin as antibacterial and wound healing dressings.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yapeng Lu, Xiaopeng Zhu, Chao Hu, Peng Li, Meihui Zhao, Jinfeng Lu, Guanghua Xia
Summary: A tilapia fish skin gelatin-fucose gum-tannic acid hydrogel wound dressing was designed to promote wound healing. The hydrogel showed excellent properties and could effectively accelerate wound healing while reducing inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Pavel A. Markov, Iliya I. Vinogradov, Elena Kostromina, Petr S. Eremin, Ilmira R. Gilmutdinova, Irina S. Kudryashova, Anastasiya Greben, Andrey P. Rachin, Alexandr N. Nechaev
Summary: Ion track membranes have potential application as wound dressings, but their possibilities and prospects have not been fully explored. In this study, PET-based ion track membranes were tested and combined with electrospun fibers to create wound dressings with specific functional properties. The combination of ion track PET membranes and electrospun fibers from a mixture of chitosan and collagen can be used to produce wound dressings.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Zintle Mbese, Sibusiso Alven, Blessing Atim Aderibigbe
Summary: Skin regeneration after injury is crucial, but can be hindered by various factors. Regenerative medicine shows promise in decreasing the need for organ transplants. Challenges in wound management persist, particularly for chronic injuries, despite the availability of different wound dressing options.
Article
Biochemistry & Molecular Biology
Beata Kaczmarek-Szczepanska, Justyna Ostrowska, Justyna Kozlowska, Zofia Szota, Anna A. Brozyna, Rita Dreier, Russel J. Reiter, Andrzej T. Slominski, Kerstin Steinbrink, Konrad Kleszczynski
Summary: Melatonin does not negatively affect the biophysical properties of hybrid scaffolds, but significantly increases the cell viability of various types of skin cells. This indoleamine accelerates re-epithelialization and shows promise for future dermatotherapy and skin medicine research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Textiles
E. San Martin-Martinez, R. Casanas-Pimentel, A. Almaguer-Flores, G. Prado-Prone, A. Garcia-Garcia, C. Landa-Solis, A. Hernandez-Rangel
Summary: The addition of curcumin to PCL-COL composite membranes enhances their mechanical properties and antibacterial effects, making them promising candidates for wound management. The degradation rate and wettability of the membranes are also suitable for skin tissue regeneration.
FIBERS AND POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Katerina Tenorova, Ruta Masteikova, Sylvie Pavlokova, Klara Kostelanska, Jurga Bernatoniene, David Vetchy
Summary: Collagen plays a crucial role in wound healing and is commonly used in wound management. However, its application as a film wound dressing is limited due to its weak mechanical properties when wet. In this study, collagen was combined with partially modified microfibrillar carboxymethylcellulose (CMC) to strengthen collagen films. The resulting collagen-CMC films demonstrated satisfactory properties for wound healing, even after wetting.
Review
Biochemistry & Molecular Biology
Akbar Hossain, Milan Skalicky, Marian Brestic, Sagar Maitra, Sukamal Sarkar, Zahoor Ahmad, Hindu Vemuri, Sourav Garai, Mousumi Mondal, Rajan Bhatt, Pardeep Kumar, Pradipta Banerjee, Saikat Saha, Tofazzal Islam, Alison M. Laing
Summary: Selenium is a crucial trace element for many living organisms, playing vital roles in immune, reproductive, thyroid, brain functions, and enzyme activity. Increasing plant uptake of selenium is a potential pathway to overcome human deficiencies, with selenium biofortification already established as a pioneering approach. Molecular breeding, genetic engineering, and novel agronomic management approaches are essential for successful selenium biofortification.
Article
Dermatology
Amitava Das, Amit K. Madeshiya, Nirupam Biswas, Nandini Ghosh, Mahadeo Gorain, Atul Rawat, Sanskruti P. Mahajan, Savita Khanna, Chandan K. Sen, Sashwati Roy
Summary: This study found that excessive release of OSM in diabetic wounds contributes to impaired re-epithelialization and non-migratory wound epithelium. The activation of the Jak-STAT pathway by OSM promotes keratinocyte proliferation and migration, leading to improved wound closure. However, in diabetic wounds, the activity of OSM is compromised by glycation. The application of exogenous OSM can accelerate diabetic wound closure by restoring keratinocyte migration.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dinesh Kumar Chellappan, Richie R. Bhandare, Afzal B. Shaik, Krishna Prasad, Nurfatihah Azlyna Ahmad Suhaimi, Wei Sheng Yap, Arpita Das, Pradipta Banerjee, Nandini Ghosh, Tanner Guith, Amitava Das, Sarannya Balakrishnan, Mayuren Candasamy, Jayashree Mayuren, Kishneth Palaniveloo, Gaurav Gupta, Sachin Kumar Singh, Kamal Dua
Summary: Diabetes, a globally prevalent endocrinological disorder, has become a significant contributor to morbidity and mortality among young and middle-aged individuals. Recent advancements in understanding the autoimmune responses causing diabetes have raised concerns regarding the potential use of immunomodulatory agents for prevention. The mechanism of action of vaccines, including the removal of autoreactive T cells and inhibition of immune cell interactions, varies greatly. While diabetes vaccines have been tested in animal models, only a few human trials have shown positive outcomes. This review explores ongoing clinical trial studies for the development of a prototype diabetes vaccine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Ravichand Palakurti, Nirupam Biswas, Sashwati Roy, Surya C. Gnyawali, Mithun Sinha, Kanhaiya Singh, Subhadip Ghatak, Chandan K. Sen, Savita Khanna
Summary: The a-tocotrienol (TCT) form of natural vitamin E is more effective than alpha-tocopherol (α-TOC) in preventing stroke. TCT improves blood perfusion at the stroke-affected site by inducing miR-1224, which has angiogenic properties. Inhibiting Serpine1, a target of miR-1224, enhances the beneficial effects of TCT on stroke outcomes.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Review
Endocrinology & Metabolism
Dinesh Kumar Chellappan, Jestin Chellian, Nur Suraiza Nabila Rahmah, Wee Jin Gan, Priyanka Banerjee, Saptarshi Sanyal, Pradipta Banerjee, Nandini Ghosh, Tanner Guith, Amitava Das, Gaurav Gupta, Sachin Kumar Singh, Kamal Dua, Anil Philip Kunnath, Nur Azeyanti Norhashim, Kuan Hung Ong, Kishneth Palaniveloo
Summary: Diabetes mellitus (DM) is a global health problem due to defective insulin activity. Conventional therapies for DM are limited and often have adverse effects. Therefore, there is an increased focus on exploring potential therapeutic agents from natural resources. Marine organisms, including microorganisms, microalgae, macroalgae, corals, sponges, and fishes, have been evaluated for their anti-diabetic properties. The bioactive metabolites discovered show promising hypoglycaemic potential through various mechanisms of action and antioxidant activities. This review highlights marine-derived chemicals as potential treatments for DM.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Nutrition & Dietetics
Krishnendu Adhikary, Pradipta Banerjee, Saurav Barman, Bidyut Bandyopadhyay, Debasis Bagchi
Summary: Lemongrass contains various substances with antioxidant and disease-preventing properties. Its essential oil has been shown to improve diabetes and wound healing. Lemongrass has significant industrial potential and its essential oil has various health benefits.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2023)
Meeting Abstract
Cell Biology
Pradipta Banerjee, Grace Lander, Amitava Das, Rae Ritchie, Michael Hiles, Chandan K. Sen, Sashwati Roy
WOUND REPAIR AND REGENERATION
(2023)
Meeting Abstract
Cell Biology
Pradipta Banerjee, Amitava Das, Kanhaiya Singh, Subhadip Ghatak, Nandini Ghosh, Chandan K. Sen, Sashwati Roy
WOUND REPAIR AND REGENERATION
(2023)
Meeting Abstract
Cell Biology
Piya DasGhatak, Fabio M. Oliveira, Pradipta Banerjee, Subhadip Ghatak, Chandan K. Sen, Sashwati Roy
WOUND REPAIR AND REGENERATION
(2023)
Article
Nutrition & Dietetics
Amarjeet Singh, Shalini Gainder, Pradipta Banerjee, Apurva Goel, Pawan Kumar, Banashree Mondal, Samudra P. Banik, Debasis Bagchi
Summary: The study aimed to evaluate the efficacy of Furocyst (R) in 208 pre-menopausal women diagnosed with PCOS. The results showed that Furocyst (R) significantly reduced the number of cysts, ovarian volume, and hirsutism levels, and normalized the menstrual cycle.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2023)
Meeting Abstract
Cell Biology
Amitava Das, Karthik Gourishetti, Pradipta Banerjee, Nandini Ghosh, Tanner Guith, Chandan K. Sen, Sashwati Roy
WOUND REPAIR AND REGENERATION
(2022)
Meeting Abstract
Cell Biology
Amitava Das, Pradipta Banerjee, Karthik Gourishetti, Nandini Ghosh, Tanner Guith, Kanhaiya Singh, Mithun Sinha, Chandan K. Sen, Sashwati Roy
WOUND REPAIR AND REGENERATION
(2022)
Review
Materials Science, Biomaterials
Sheikh Tanzina Haque, Subbroto Kumar Saha, Md. Enamul Haque, Nirupam Biswas
Summary: Nanotechnology-based platforms show promising potential in deciphering the biological environment and offering personalized treatment methods for wound healing. Studies have demonstrated their essential role in influencing skin repair mechanisms.
BIOMATERIALS SCIENCE
(2021)
Meeting Abstract
Cell Biology
Amitava Das, Nirupam Biswas, Nandini Ghosh, Mahadeo Gorain, Savita Khanna, Chandan K. Sen, Sashwati Roy
WOUND REPAIR AND REGENERATION
(2021)
Article
Biotechnology & Applied Microbiology
Pradipta Banerjee, Preetha Bhadra
BIOSCIENCE BIOTECHNOLOGY RESEARCH COMMUNICATIONS
(2020)
